Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 104162234 . G A CCDS783.1:NM_000699.2:c.572cGt>cAt_NP_000690.1:p.191R>H Homo sapiens amylase, alpha 2A (pancreatic) (AMY2A), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1b2y 1 P04746 100.0 0.0 X-RAY
 2000-02-16 ARG A:176 A:176 51.0 0.227 H -56.3 -40.3 51.0 0.227 0.0 HOH
 5.294
 NH1
 O
1bsi 1 P04746 99.8 0.0 X-RAY
 1999-05-18 ARG A:176 A:176 48.0 0.213 H -56.1 -39.0 48.0 0.213 0.0 HOH
 2.723
 NH1
 O
1cpu 1 P04746 99.8 0.0 X-RAY
 1999-06-14 ARG A:176 A:176 52.0 0.231 H -60.1 -37.2 52.0 0.231 0.0 HOH
 2.829
 NH1
 O
1hny 1 P04746 99.8 0.0 X-RAY
 1996-03-08 ARG A:176 A:176 53.0 0.236 H -50.3 -43.7 53.0 0.236 0.0 HOH
 2.844
 NH1
 O
1u2y 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ARG A:176 A:176 52.0 0.231 H -60.0 -37.3 52.0 0.231 0.0 HOH
 2.860
 NH1
 O
1u30 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ARG A:176 A:176 50.0 0.222 H -64.5 -39.8 50.0 0.222 0.0 HOH
 2.842
 NH1
 O
1u33 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ARG A:176 A:176 55.0 0.244 H -58.0 -38.5 55.0 0.244 0.0 HOH
 2.926
 NH1
 O
1xcw 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ARG A:176 A:176 54.0 0.24 H -58.2 -35.8 54.0 0.24 0.0 HOH
 2.861
 NH1
 O
1xcx 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ARG A:176 A:176 50.0 0.222 H -57.1 -37.8 50.0 0.222 0.0 HOH
 2.721
 NH1
 O
1xd0 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ARG A:176 A:176 53.0 0.236 H -60.1 -36.5 53.0 0.236 0.0 HOH
 5.270
 NH1
 O
1xd1 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ARG A:176 A:176 50.0 0.222 H -61.6 -38.0 50.0 0.222 0.0 HOH
 6.198
 NH1
 O
2qmk 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ARG A:176 A:176 54.0 0.24 H -59.3 -41.1 54.0 0.24 0.0 HOH
 3.124
 NH1
 O
2qv4 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ARG A:176 A:176 54.0 0.24 H -58.8 -41.0 54.0 0.24 0.0 HOH
 2.882
 NH1
 O
3bai 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ARG A:176 A:176 52.0 0.231 H -60.2 -37.3 52.0 0.231 0.0 HOH
 2.765
 NH1
 O
3baj 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ARG A:176 A:176 51.0 0.227 H -56.7 -39.8 51.0 0.227 0.0 HOH
 2.776
 NH1
 O
3baw 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ARG A:176 A:176 54.0 0.24 H -58.9 -38.3 54.0 0.24 0.0 HOH
 2.873
 NH1
 O
3ij7 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ARG A:176 A:176 55.0 0.244 H -58.0 -39.8 55.0 0.244 0.0 HOH
 2.995
 NH1
 O
3ij8 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ARG A:176 A:176 55.0 0.244 H -58.1 -37.9 55.0 0.244 0.0 B0D
B0D
HOH
 3.870
8.858
2.873
 NH2
NH2
NH1
 O4
O4
O
3ij9 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ARG A:176 A:176 54.0 0.24 H -58.0 -40.9 54.0 0.24 0.0 B0D
B0D
HOH
 3.798
8.452
2.896
 NH2
NH2
NH1
 O4
O4
O
4gqq 1 P04746 99.8 0.0 X-RAY
 2012-10-24 ARG A:176 A:176 47.0 0.209 H -61.4 -36.0 47.0 0.209 0.0 HOH
 2.783
 NH2
 O
4gqr 1 P04746 99.8 0.0 X-RAY
 2012-10-24 ARG A:176 A:176 52.0 0.231 H -57.0 -38.9 52.0 0.231 0.0 HOH
 2.980
 NH1
 O
4w93 1 P04746 99.8 0.0 X-RAY
 2015-07-15 ARG A:176 A:176 53.0 0.236 H -56.6 -41.0 53.0 0.236 0.0 HOH
 2.778
 NH2
 O
4x9y 1 P04746 99.8 0.0 X-RAY
 2014-12-31 ARG A:176 A:176 52.0 0.231 H -54.4 -38.8 52.0 0.231 0.0 HOH
 2.072
 HH11
 O
5e0f 1 P04746 99.8 0.0 X-RAY
 2016-09-07 ARG A:176 A:176 53.0 0.236 H -57.1 -38.9 53.0 0.236 0.0 HOH
 2.051
 HH11
 O
5emy 1 P04746 99.8 0.0 X-RAY
 2016-07-06 ARG A:176 A:176 53.0 0.236 H -54.6 -39.2 53.0 0.236 0.0 HOH
 2.037
 HH12
 O
5kez 1 P04746 99.8 0.0 X-RAY
 2017-03-29 ARG A:176 A:176 54.0 0.24 H -57.1 -36.3 54.0 0.24 0.0 HOH
 2.811
 NH1
 O
5u3a 1 P04746 99.8 0.0 X-RAY
 2017-12-06 ARG A:176 A:176 52.0 0.231 H -54.7 -39.9 52.0 0.231 0.0 HOH
 2.064
 HH11
 O
5va9 1 P04746 99.8 0.0 X-RAY
 2018-03-28 ARG A:176 A:176 54.0 0.24 H -61.5 -35.8 54.0 0.24 0.0 HOH
 4.947
 NH1
 O
ARG B:176 B:176 50.0 0.222 H -61.7 -36.3 NA NA NA
6obx 1 P04746 99.8 0.0 X-RAY
 2020-02-12 ARG A:176 A:176 52.0 0.231 H -55.0 -39.5 52.0 0.231 0.0 HOH
 2.130
 HH11
 O
6ocn 1 P04746 99.8 0.0 X-RAY
 2020-02-12 ARG A:176 A:176 52.0 0.231 H -55.0 -39.0 52.0 0.231 0.0 HOH
 2.066
 HH11
 O
3old 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ARG A:176 A:176 55.0 0.244 H -58.8 -41.6 55.0 0.244 0.0 GLC
GLC
HOH
 8.535
9.660
2.909
 N
N
NH1
 O3
O2
O
3ole 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ARG A:176 A:176 55.0 0.244 H -57.5 -40.0 55.0 0.244 0.0 GLC
GLC
HOH
 8.537
9.609
2.892
 N
N
NH1
 O3
O2
O
3olg 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ARG A:176 A:176 51.0 0.227 H -57.1 -40.2 51.0 0.227 0.0 GLC
GLC
BGC
GLC
HOH
 8.478
9.590
3.874
9.862
3.003
 N
N
NH2
NH2
NH1
 O3
O2
O1
C1
O
3oli 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ARG A:176 A:176 50.0 0.222 H -57.5 -39.6 50.0 0.222 0.0 GLC
GLC
GLC
GLC
HOH
 8.433
9.567
8.634
4.077
2.908
 N
N
NH2
NH2
NH1
 O3
O2
O4
O4
O
1kgw 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ARG A:176 A:176 50.0 0.222 H -62.2 -32.6 50.0 0.222 0.0 HOH
 4.259
 NH2
 O
1xgz 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ARG A:176 A:176 52.0 0.231 H -57.6 -37.3 52.0 0.231 0.0 HOH
 2.741
 NH1
 O
1xh0 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ARG A:176 A:176 49.0 0.218 H -61.2 -36.4 49.0 0.218 0.0 HOH
 2.694
 NH1
 O
1xh1 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ARG A:176 A:176 51.0 0.227 H -62.6 -35.7 51.0 0.227 0.0 HOH
 2.631
 NH1
 O
1xh2 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ARG A:176 A:176 50.0 0.222 H -61.1 -35.6 50.0 0.222 0.0 HOH
 2.636
 NH1
 O
3bak 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ARG A:176 A:176 54.0 0.24 H -60.2 -38.8 54.0 0.24 0.0 HOH
 2.959
 NH1
 O
3bax 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ARG A:176 A:176 55.0 0.244 H -57.5 -42.4 55.0 0.244 0.0 HOH
 2.851
 NH1
 O
3bay 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ARG A:176 A:176 50.0 0.222 H -52.2 -39.3 50.0 0.222 0.0 HOH
 2.704
 NH1
 O
1kgx 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ARG A:176 A:176 50.0 0.222 H -62.9 -39.1 50.0 0.222 0.0 HOH
 3.029
 NH1
 O
6z8l 1 P04746 99.6 0.0 X-RAY
 2020-12-02 ARG A:176 A:176 54.0 0.24 H -54.8 -38.9 54.0 0.24 0.0 GLC
HOH
 3.225
2.100
 HH21
HH12
 O4
O
1kgu 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ARG A:176 A:176 54.0 0.24 H -59.6 -36.2 54.0 0.24 0.0 HOH
 2.909
 NH1
 O
2cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 ARG A:176 A:176 50.0 0.222 H -60.2 -37.7 50.0 0.222 0.0 HOH
 4.761
 NH1
 O
3cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 ARG A:176 A:176 52.0 0.231 H -60.2 -36.4 52.0 0.231 0.0 HOH
 4.634
 NH1
 O
5td4 1 P04746 99.6 0.0 X-RAY
 2016-11-02 ARG A:176 A:176 51.0 0.227 H -55.2 -40.1 51.0 0.227 0.0 GLC
GLC
GLC
GLC
HOH
 8.766
9.984
8.264
3.809
2.688
 N
N
NH2
NH2
NH1
 O3
O2
O4
O4
O
1kb3 1 P04746 99.6 0.0 X-RAY
 2002-05-01 ARG A:176 A:176 51.0 0.227 H -61.2 -38.0 51.0 0.227 0.0 HOH
 2.763
 NH1
 O
1kbb 1 P04746 99.6 0.0 X-RAY
 2002-04-10 ARG A:176 A:176 51.0 0.227 H -59.4 -39.7 51.0 0.227 0.0 HOH
 4.726
 NH1
 O
1kbk 1 P04746 99.6 0.0 X-RAY
 2002-04-10 ARG A:176 A:176 52.0 0.231 H -62.1 -35.8 52.0 0.231 0.0 HOH
 2.704
 NH1
 O
1c8q 1 P04745 96.98 0.0 X-RAY
 2001-06-13 ARG A:176 A:176 58.0 0.258 H -54.5 -37.6 58.0 0.258 0.0 HOH
 5.234
 O
 O
1mfv 1 P04745 96.98 0.0 X-RAY
 2002-11-20 ARG A:176 A:176 54.0 0.24 H -56.7 -42.3 54.0 0.24 0.0 HOH
 3.704
 NH2
 O
1smd 1 P04745 96.98 0.0 X-RAY
 1996-07-11 ARG A:176 A:176 51.0 0.227 H -57.5 -36.5 51.0 0.227 0.0 HOH
 3.101
 NH1
 O
1xv8 1 P04745 96.98 0.0 X-RAY
 2005-10-11 ARG A:176 A:176 64.0 0.284 H -61.8 -36.6 64.0 0.284 0.0 HOH
 4.990
 O
 O
ARG B:176 B:176 62.0 0.276 H -61.9 -36.6 62.0 0.276 0.0 HOH
 4.990
 O
 O
1z32 1 P04745 96.77 0.0 X-RAY
 2005-05-31 ARG A:176 X:176 54.0 0.24 H -55.2 -39.7 54.0 0.24 0.0 HOH
 2.958
 NH1
 O
1jxj 1 P04745 96.77 0.0 X-RAY
 2001-09-14 ARG A:176 A:176 57.0 0.253 H -53.0 -40.3 57.0 0.253 0.0 HOH
 2.956
 NH1
 O
1q4n 1 P04745 96.77 0.0 X-RAY
 2004-03-16 ARG A:176 X:176 55.0 0.244 H -52.2 -39.4 55.0 0.244 0.0 HOH
 2.944
 NH1
 O
1nm9 1 P04745 96.77 0.0 X-RAY
 2004-01-20 ARG A:176 A:176 55.0 0.244 H -54.6 -43.1 55.0 0.244 0.0 HOH
 2.937
 NH1
 O
3blk 1 P04745 96.77 0.0 X-RAY
 2008-11-25 ARG A:176 A:176 57.0 0.253 H -57.3 -41.6 57.0 0.253 0.0 HOH
 3.025
 NH1
 O
3blp 1 P04745 96.77 0.0 X-RAY
 2008-11-18 ARG A:176 X:176 55.0 0.244 H -56.6 -40.6 55.0 0.244 0.0 HOH
 2.874
 NH1
 O
1jxk 1 P04745 95.97 0.0 X-RAY
 2001-09-14 ARG A:176 A:176 56.0 0.249 H -54.6 -39.9 56.0 0.249 0.0 HOH
 2.851
 NH1
 O
1mfu 1 P04745 95.97 0.0 X-RAY
 2002-11-20 ARG A:176 A:176 55.0 0.244 H -57.2 -42.8 55.0 0.244 0.0 GLC
GLC
GLC
HOH
 8.393
3.762
9.946
2.768
 NH2
NH2
N
NH1
 O4
O4
C6
O
3dhp 1 P04745 95.77 0.0 X-RAY
 2008-07-01 ARG A:176 A:176 56.0 0.249 H -52.7 -40.1 56.0 0.249 0.0 HOH
 2.981
 NH1
 O
1kxq 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ARG A:176 A:176 58.0 0.258 H -55.1 -41.6 58.0 0.258 0.0 HOH
 2.504
 NH1
 O
ARG B:176 B:176 56.0 0.249 H -61.1 -34.6 NA NA NA
ARG C:176 C:176 54.0 0.24 H -60.0 -38.2 NA NA NA
ARG D:176 D:176 52.0 0.231 H -58.0 -39.2 NA NA NA
1kxt 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ARG A:176 A:176 53.0 0.236 H -62.0 -42.7 53.0 0.236 0.0 HOH
 2.748
 NE
 O
ARG C:176 C:176 56.0 0.249 H -50.8 -44.7 NA NA NA
ARG E:176 E:176 57.0 0.253 H -68.2 -44.4 NA NA NA
1kxv 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ARG A:176 A:176 55.0 0.244 H -56.0 -35.4 45.0 0.2 0.044 C:None:0.044
 HOH
 2.720
 NH1
 O
ARG B:176 B:176 55.0 0.244 H -57.3 -38.6 NA NA NA
1dhk 1 P00690 86.9 0.0 X-RAY
 1997-12-24 ARG A:176 A:176 51.0 0.227 H -55.5 -41.3 51.0 0.227 0.0 HOH
 1.774
 HH11
 H2
1ppi 1 P00690 86.9 0.0 X-RAY
 1995-05-24 ARG A:176 A:176 57.0 0.253 H -48.3 -45.6 57.0 0.253 0.0 HOH
 2.918
 NE
 O
1vah 1 P00690 86.69 0.0 X-RAY
 2005-04-26 ARG A:176 A:176 52.0 0.231 H -59.5 -39.0 52.0 0.231 0.0 HOH
 6.646
 C
 O
3l2l 1 P00690 86.69 0.0 X-RAY
 2010-04-14 ARG A:176 A:176 51.0 0.227 H -56.2 -45.1 51.0 0.227 0.0 GLC
HOH
 3.275
2.495
 HH12
HH22
 HO4
O
3l2m 1 P00690 86.69 0.0 X-RAY
 2010-04-14 ARG A:176 A:176 53.0 0.236 H -56.7 -38.3 53.0 0.236 0.0 GLC
GLC
HOH
 9.061
8.537
2.367
 H
H
HH21
 H61
H1
O
1ua3 1 P00690 86.69 0.0 X-RAY
 2003-10-14 ARG A:176 A:176 54.0 0.24 H -50.5 -39.5 54.0 0.24 0.0 CL
BGC
EDO
HOH
 7.935
4.106
9.110
2.899
 NH2
NH2
N
NH1
 CL
O4
O2
O
1jfh 1 P00690 86.69 0.0 X-RAY
 1998-12-02 ARG A:176 A:176 58.0 0.258 H -56.2 -45.5 58.0 0.258 0.0 HOH
 2.997
 NH2
 O
1ose 1 P00690 86.49 0.0 X-RAY
 1997-04-01 ARG A:176 A:176 50.0 0.222 H -51.5 -44.3 50.0 0.222 0.0 HOH
 2.885
 NH2
 O
1hx0 1 P00690 86.49 0.0 X-RAY
 2001-08-08 ARG A:176 A:176 53.0 0.236 H -56.3 -39.1 53.0 0.236 0.0 CL
CL
HOH
 8.220
7.514
2.942
 NH1
NH1
NH2
 CL
CL
O
1wo2 1 P00690 86.49 0.0 X-RAY
 2005-03-15 ARG A:176 A:176 55.0 0.244 H -58.2 -40.8 55.0 0.244 0.0 HOH
 2.998
 NH1
 O
1bvn 1 P00690 86.49 0.0 X-RAY
 1998-09-23 ARG A:176 P:176 49.0 0.218 H -50.1 -49.3 49.0 0.218 0.0 HOH
 4.459
 NH1
 O
1pif 1 P00690 86.29 0.0 X-RAY
 1996-12-07 ARG A:176 A:176 50.0 0.222 H -53.8 -39.1 50.0 0.222 0.0 HOH
 3.042
 NE
 O
1pig 1 P00690 86.29 0.0 X-RAY
 1996-12-07 ARG A:176 A:176 49.0 0.218 H -57.9 -37.7 49.0 0.218 0.0 HOH
 5.323
 NH2
 O
4x0n 1 P00690 86.29 0.0 X-RAY
 2015-11-25 ARG A:176 A:176 48.0 0.213 H -56.0 -38.4 48.0 0.213 0.0 HOH
 3.291
 NH1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04746-f1 1 P04746 100.0 0.0 ARG A:191 A:191 51.0 0.227 H -57.0 -42.5
af-p19961-f1 1 P19961 98.83 0.0 ARG A:191 A:191 48.0 0.213 H -56.7 -41.7
af-p0dte7-f1 1 P0DTE7 96.87 0.0 ARG A:191 A:191 49.0 0.218 H -57.8 -41.3
af-p0dte8-f1 1 P0DTE8 96.87 0.0 ARG A:191 A:191 47.0 0.209 H -57.5 -41.2
af-p0dub6-f1 1 P0DUB6 96.87 0.0 ARG A:191 A:191 48.0 0.213 H -58.2 -41.8