Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 104162273 . T A CCDS783.1:NM_000699.2:c.611aTt>aAt_NP_000690.1:p.204I>N Homo sapiens amylase, alpha 2A (pancreatic) (AMY2A), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1b2y 1 P04746 100.0 0.0 X-RAY
 2000-02-16 ILE A:189 A:189 10.0 0.057 H -67.6 -28.5 10.0 0.057 0.0 HOH
 5.341
 C
 O
1bsi 1 P04746 99.8 0.0 X-RAY
 1999-05-18 ILE A:189 A:189 15.0 0.086 H -70.4 -28.3 15.0 0.086 0.0 HOH
 3.625
 CG1
 O
1cpu 1 P04746 99.8 0.0 X-RAY
 1999-06-14 ILE A:189 A:189 20.0 0.114 H -73.6 -29.3 20.0 0.114 0.0 HOH
 3.730
 CG1
 O
1hny 1 P04746 99.8 0.0 X-RAY
 1996-03-08 ILE A:189 A:189 11.0 0.063 H -62.0 -33.1 11.0 0.063 0.0 HOH
 2.827
 O
 O
1u2y 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ILE A:189 A:189 18.0 0.103 H -72.7 -32.7 18.0 0.103 0.0 HOH
 3.647
 CG1
 O
1u30 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ILE A:189 A:189 20.0 0.114 H -72.4 -33.0 20.0 0.114 0.0 HOH
 5.284
 C
 O
1u33 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ILE A:189 A:189 16.0 0.091 H -77.0 -33.1 16.0 0.091 0.0 HOH
 2.636
 O
 O
1xcw 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ILE A:189 A:189 20.0 0.114 H -73.2 -29.3 20.0 0.114 0.0 HOH
 5.246
 C
 O
1xcx 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ILE A:189 A:189 18.0 0.103 H -74.0 -33.1 18.0 0.103 0.0 HOH
 5.215
 C
 O
1xd0 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ILE A:189 A:189 19.0 0.109 H -72.3 -31.8 19.0 0.109 0.0 HOH
 5.266
 C
 O
1xd1 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ILE A:189 A:189 7.0 0.04 H -73.9 -29.7 7.0 0.04 0.0 HOH
 5.340
 C
 O
2qmk 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ILE A:189 A:189 3.0 0.017 H -75.4 -25.3 3.0 0.017 0.0 HOH
 2.958
 O
 O
2qv4 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ILE A:189 A:189 3.0 0.017 H -73.2 -27.7 3.0 0.017 0.0 HOH
 2.663
 O
 O
3bai 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ILE A:189 A:189 15.0 0.086 H -75.0 -28.9 15.0 0.086 0.0 HOH
 3.543
 CG1
 O
3baj 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ILE A:189 A:189 17.0 0.097 H -73.3 -30.1 17.0 0.097 0.0 HOH
 5.135
 C
 O
3baw 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ILE A:189 A:189 38.0 0.217 H -70.7 -20.1 38.0 0.217 0.0 HOH
 2.634
 O
 O
3ij7 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ILE A:189 A:189 6.0 0.034 H -66.7 -31.0 6.0 0.034 0.0 HOH
 2.697
 O
 O
3ij8 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ILE A:189 A:189 6.0 0.034 H -67.5 -30.6 6.0 0.034 0.0 HOH
 3.504
 CG1
 O
3ij9 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ILE A:189 A:189 5.0 0.029 H -67.9 -32.6 5.0 0.029 0.0 HOH
 5.156
 C
 O
4gqq 1 P04746 99.8 0.0 X-RAY
 2012-10-24 ILE A:189 A:189 9.0 0.051 H -70.6 -28.7 9.0 0.051 0.0 HOH
 2.578
 O
 O
4gqr 1 P04746 99.8 0.0 X-RAY
 2012-10-24 ILE A:189 A:189 8.0 0.046 H -72.6 -26.9 8.0 0.046 0.0 HOH
 2.736
 O
 O
4w93 1 P04746 99.8 0.0 X-RAY
 2015-07-15 ILE A:189 A:189 7.0 0.04 H -58.4 -27.5 7.0 0.04 0.0 HOH
 2.720
 O
 O
4x9y 1 P04746 99.8 0.0 X-RAY
 2014-12-31 ILE A:189 A:189 7.0 0.04 H -65.8 -31.6 7.0 0.04 0.0 HOH
 2.634
 HG23
 O
5e0f 1 P04746 99.8 0.0 X-RAY
 2016-09-07 ILE A:189 A:189 7.0 0.04 H -60.0 -34.5 7.0 0.04 0.0 HOH
 2.662
 HG23
 O
5emy 1 P04746 99.8 0.0 X-RAY
 2016-07-06 ILE A:189 A:189 5.0 0.029 H -66.2 -31.8 5.0 0.029 0.0 HOH
 2.640
 HG23
 O
5kez 1 P04746 99.8 0.0 X-RAY
 2017-03-29 ILE A:189 A:189 5.0 0.029 H -59.5 -34.7 5.0 0.029 0.0 HOH
 2.911
 O
 O
5u3a 1 P04746 99.8 0.0 X-RAY
 2017-12-06 ILE A:189 A:189 6.0 0.034 H -66.5 -31.9 6.0 0.034 0.0 HOH
 2.599
 HG23
 O
5va9 1 P04746 99.8 0.0 X-RAY
 2018-03-28 ILE A:189 A:189 8.0 0.046 H -65.9 -25.5 8.0 0.046 0.0 HOH
 6.860
 O
 O
ILE B:189 B:189 5.0 0.029 H -65.4 -25.5 NA NA NA
6obx 1 P04746 99.8 0.0 X-RAY
 2020-02-12 ILE A:189 A:189 6.0 0.034 H -66.0 -31.1 6.0 0.034 0.0 HOH
 2.700
 HG23
 O
6ocn 1 P04746 99.8 0.0 X-RAY
 2020-02-12 ILE A:189 A:189 6.0 0.034 H -65.1 -33.2 6.0 0.034 0.0 HOH
 2.654
 HG23
 O
3old 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ILE A:189 A:189 6.0 0.034 H -69.3 -30.1 6.0 0.034 0.0 HOH
 2.740
 O
 O
3ole 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ILE A:189 A:189 6.0 0.034 H -73.5 -28.1 6.0 0.034 0.0 HOH
 2.625
 O
 O
3olg 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ILE A:189 A:189 5.0 0.029 H -68.8 -28.0 5.0 0.029 0.0 HOH
 2.732
 O
 O
3oli 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ILE A:189 A:189 6.0 0.034 H -65.9 -31.3 6.0 0.034 0.0 MPD
HOH
 7.784
2.691
 O
O
 O4
O
1kgw 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ILE A:189 A:189 12.0 0.069 H -68.6 -30.8 12.0 0.069 0.0 HOH
 4.294
 O
 O
1xgz 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ILE A:189 A:189 21.0 0.12 H -70.7 -35.2 21.0 0.12 0.0 HOH
 3.415
 CD1
 O
1xh0 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ILE A:189 A:189 19.0 0.109 H -69.7 -30.8 19.0 0.109 0.0 HOH
 3.448
 CG1
 O
1xh1 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ILE A:189 A:189 14.0 0.08 H -74.0 -29.5 14.0 0.08 0.0 HOH
 3.538
 CG1
 O
1xh2 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ILE A:189 A:189 3.0 0.017 H -72.0 -31.8 3.0 0.017 0.0 HOH
 3.621
 CG1
 O
3bak 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ILE A:189 A:189 16.0 0.091 H -73.0 -29.4 16.0 0.091 0.0 HOH
 2.646
 O
 O
3bax 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ILE A:189 A:189 4.0 0.023 T -88.5 -0.9 4.0 0.023 0.0 HOH
 2.691
 O
 O
3bay 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ILE A:189 A:189 18.0 0.103 H -73.0 -30.2 18.0 0.103 0.0 HOH
 2.719
 O
 O
1kgx 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ILE A:189 A:189 18.0 0.103 H -75.4 -29.4 18.0 0.103 0.0 HOH
 5.253
 C
 O
6z8l 1 P04746 99.6 0.0 X-RAY
 2020-12-02 ILE A:189 A:189 7.0 0.04 H -61.1 -33.1 7.0 0.04 0.0 HOH
 2.784
 O
 O
1kgu 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ILE A:189 A:189 7.0 0.04 H -63.9 -30.3 7.0 0.04 0.0 HOH
 2.727
 O
 O
2cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 ILE A:189 A:189 7.0 0.04 H -72.0 -29.9 7.0 0.04 0.0 HOH
 5.245
 C
 O
3cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 ILE A:189 A:189 7.0 0.04 H -66.4 -31.3 7.0 0.04 0.0 HOH
 5.307
 C
 O
5td4 1 P04746 99.6 0.0 X-RAY
 2016-11-02 ILE A:189 A:189 7.0 0.04 H -58.8 -33.1 7.0 0.04 0.0 HOH
 4.574
 CG2
 O
1kb3 1 P04746 99.6 0.0 X-RAY
 2002-05-01 ILE A:189 A:189 19.0 0.109 H -75.4 -30.2 19.0 0.109 0.0 HOH
 3.430
 CG1
 O
1kbb 1 P04746 99.6 0.0 X-RAY
 2002-04-10 ILE A:189 A:189 8.0 0.046 H -70.2 -32.1 8.0 0.046 0.0 HOH
 5.276
 C
 O
1kbk 1 P04746 99.6 0.0 X-RAY
 2002-04-10 ILE A:189 A:189 7.0 0.04 H -72.0 -30.9 7.0 0.04 0.0 HOH
 5.248
 C
 O
1c8q 1 P04745 96.98 0.0 X-RAY
 2001-06-13 ILE A:189 A:189 8.0 0.046 H -70.0 -25.0 8.0 0.046 0.0 HOH
 2.707
 O
 O
1mfv 1 P04745 96.98 0.0 X-RAY
 2002-11-20 ILE A:189 A:189 7.0 0.04 H -54.7 -34.2 7.0 0.04 0.0 HOH
 2.637
 O
 O
1smd 1 P04745 96.98 0.0 X-RAY
 1996-07-11 ILE A:189 A:189 8.0 0.046 H -65.9 -33.6 8.0 0.046 0.0 HOH
 4.512
 O
 O
1xv8 1 P04745 96.98 0.0 X-RAY
 2005-10-11 ILE A:189 A:189 5.0 0.029 H -74.8 -35.4 5.0 0.029 0.0 HOH
 5.126
 CG1
 O
ILE B:189 B:189 5.0 0.029 H -74.8 -35.4 5.0 0.029 0.0 HOH
 5.127
 CG1
 O
1z32 1 P04745 96.77 0.0 X-RAY
 2005-05-31 ILE A:189 X:189 8.0 0.046 H -59.0 -33.1 8.0 0.046 0.0 HOH
 2.662
 O
 O
1jxj 1 P04745 96.77 0.0 X-RAY
 2001-09-14 ILE A:189 A:189 8.0 0.046 H -65.2 -32.6 8.0 0.046 0.0 HOH
 4.755
 CG2
 O
1q4n 1 P04745 96.77 0.0 X-RAY
 2004-03-16 ILE A:189 X:189 7.0 0.04 H -61.3 -33.2 7.0 0.04 0.0 HOH
 2.760
 O
 O
1nm9 1 P04745 96.77 0.0 X-RAY
 2004-01-20 ILE A:189 A:189 7.0 0.04 H -56.9 -34.7 7.0 0.04 0.0 HOH
 2.616
 O
 O
3blk 1 P04745 96.77 0.0 X-RAY
 2008-11-25 ILE A:189 A:189 8.0 0.046 H -60.8 -35.6 8.0 0.046 0.0 HOH
 2.668
 O
 O
3blp 1 P04745 96.77 0.0 X-RAY
 2008-11-18 ILE A:189 X:189 7.0 0.04 H -63.1 -31.7 7.0 0.04 0.0 HOH
 2.711
 O
 O
1jxk 1 P04745 95.97 0.0 X-RAY
 2001-09-14 ILE A:189 A:189 7.0 0.04 H -66.4 -34.4 7.0 0.04 0.0 HOH
 2.607
 O
 O
1mfu 1 P04745 95.97 0.0 X-RAY
 2002-11-20 ILE A:189 A:189 7.0 0.04 H -57.7 -36.2 7.0 0.04 0.0 HOH
 2.712
 O
 O
3dhp 1 P04745 95.77 0.0 X-RAY
 2008-07-01 ILE A:189 A:189 7.0 0.04 H -62.6 -31.4 7.0 0.04 0.0 HOH
 2.755
 O
 O
1kxq 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ILE A:189 A:189 14.0 0.08 H -64.2 -33.4 14.0 0.08 0.0 HOH
 2.922
 O
 O
ILE B:189 B:189 9.0 0.051 H -69.5 -28.4 NA NA NA
ILE C:189 C:189 9.0 0.051 H -71.3 -29.5 NA NA NA
ILE D:189 D:189 11.0 0.063 H -67.0 -29.4 NA NA NA
1kxt 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ILE A:189 A:189 14.0 0.08 H -69.4 -28.0 14.0 0.08 0.0 HOH
 4.487
 CG1
 O
ILE C:189 C:189 10.0 0.057 H -57.7 -39.2 NA NA NA
ILE E:189 E:189 10.0 0.057 H -67.1 -27.6 NA NA NA
1kxv 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ILE A:189 A:189 5.0 0.029 H -66.1 -26.9 5.0 0.029 0.0 HOH
 2.792
 O
 O
ILE B:189 B:189 11.0 0.063 H -71.4 -29.2 NA NA NA
1dhk 1 P00690 86.9 0.0 X-RAY
 1997-12-24 ILE A:189 A:189 11.0 0.063 H -68.7 -27.5 11.0 0.063 0.0 HOH
 3.026
 CG1
 H2
1ppi 1 P00690 86.9 0.0 X-RAY
 1995-05-24 ILE A:189 A:189 11.0 0.063 H -54.5 -30.4 11.0 0.063 0.0 HOH
 2.836
 O
 O
1vah 1 P00690 86.69 0.0 X-RAY
 2005-04-26 ILE A:189 A:189 10.0 0.057 H -68.5 -31.4 10.0 0.057 0.0 HOH
 5.407
 C
 O
3l2l 1 P00690 86.69 0.0 X-RAY
 2010-04-14 ILE A:189 A:189 10.0 0.057 H -65.9 -31.5 10.0 0.057 0.0 HOH
 2.646
 HG23
 O
3l2m 1 P00690 86.69 0.0 X-RAY
 2010-04-14 ILE A:189 A:189 13.0 0.074 H -64.5 -32.8 13.0 0.074 0.0 HOH
 2.687
 O
 O
1ua3 1 P00690 86.69 0.0 X-RAY
 2003-10-14 ILE A:189 A:189 11.0 0.063 H -61.8 -33.1 11.0 0.063 0.0 HOH
 2.813
 O
 O
1jfh 1 P00690 86.69 0.0 X-RAY
 1998-12-02 ILE A:189 A:189 9.0 0.051 H -69.4 -31.3 9.0 0.051 0.0 HOH
 2.842
 O
 O
1ose 1 P00690 86.49 0.0 X-RAY
 1997-04-01 ILE A:189 A:189 8.0 0.046 H -63.1 -32.6 8.0 0.046 0.0 HOH
 3.057
 O
 O
1hx0 1 P00690 86.49 0.0 X-RAY
 2001-08-08 ILE A:189 A:189 11.0 0.063 H -62.9 -32.7 11.0 0.063 0.0 HOH
 2.782
 O
 O
1wo2 1 P00690 86.49 0.0 X-RAY
 2005-03-15 ILE A:189 A:189 12.0 0.069 H -66.9 -31.9 12.0 0.069 0.0 HOH
 2.832
 O
 O
1bvn 1 P00690 86.49 0.0 X-RAY
 1998-09-23 ILE A:189 P:189 11.0 0.063 H -63.6 -25.4 11.0 0.063 0.0 HOH
 5.219
 C
 O
1pif 1 P00690 86.29 0.0 X-RAY
 1996-12-07 ILE A:189 A:189 13.0 0.074 H -65.6 -34.6 13.0 0.074 0.0 HOH
 3.653
 CG1
 O
1pig 1 P00690 86.29 0.0 X-RAY
 1996-12-07 ILE A:189 A:189 11.0 0.063 H -68.6 -31.2 11.0 0.063 0.0 HOH
 5.204
 C
 O
4x0n 1 P00690 86.29 0.0 X-RAY
 2015-11-25 ILE A:189 A:189 9.0 0.051 H -63.1 -33.8 9.0 0.051 0.0 HOH
 4.905
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04746-f1 1 P04746 100.0 0.0 ILE A:204 A:204 5.0 0.029 H -62.7 -35.3
af-p19961-f1 1 P19961 98.83 0.0 ILE A:204 A:204 8.0 0.046 H -63.3 -35.8
af-p0dte7-f1 1 P0DTE7 96.87 0.0 ILE A:204 A:204 7.0 0.04 H -63.7 -35.6
af-p0dte8-f1 1 P0DTE8 96.87 0.0 ILE A:204 A:204 9.0 0.051 H -63.3 -35.4
af-p0dub6-f1 1 P0DUB6 96.87 0.0 ILE A:204 A:204 8.0 0.046 H -63.3 -33.8