Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 104162293 . C A CCDS783.1:NM_000699.2:c.631Ctt>Att_NP_000690.1:p.211L>I Homo sapiens amylase, alpha 2A (pancreatic) (AMY2A), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1b2y 1 P04746 100.0 0.0 X-RAY
 2000-02-16 LEU A:196 A:196 1.0 0.006 E -90.2 101.5 1.0 0.006 0.0 AC1
CL
PCA
HOH
 6.882
7.242
8.751
6.573
 O
O
CD1
O
 O3
CL
CB
O
1bsi 1 P04746 99.8 0.0 X-RAY
 1999-05-18 LEU A:196 A:196 1.0 0.006 E -89.3 103.7 1.0 0.006 0.0 CL
HOH
 7.296
5.380
 O
C
 CL
O
1cpu 1 P04746 99.8 0.0 X-RAY
 1999-06-14 LEU A:196 A:196 1.0 0.006 E -85.6 104.1 1.0 0.006 0.0 AGL
CL
HMC
HOH
 6.988
7.200
7.329
5.387
 O
O
O
C
 O3
CL
C1
O
1hny 1 P04746 99.8 0.0 X-RAY
 1996-03-08 LEU A:196 A:196 1.0 0.006 E -93.0 102.7 1.0 0.006 0.0 CL
HOH
 7.318
5.404
 O
C
 CL
O
1u2y 1 P04746 99.8 0.0 X-RAY
 2004-09-07 LEU A:196 A:196 1.0 0.006 E -91.0 106.2 1.0 0.006 0.0 CL
GOX
HOH
 7.258
6.935
5.388
 O
O
C
 CL
O2
O
1u30 1 P04746 99.8 0.0 X-RAY
 2004-09-07 LEU A:196 A:196 1.0 0.006 E -92.2 103.4 1.0 0.006 0.0 LAG
CL
GOX
HOH
 6.534
7.176
8.651
5.310
 O
O
O
C
 OA7
CL
O7
O
1u33 1 P04746 99.8 0.0 X-RAY
 2004-09-07 LEU A:196 A:196 1.0 0.006 E -91.2 100.8 1.0 0.006 0.0 LM2
CL
HOH
 6.625
7.188
5.276
 O
O
C
 OA7
CL
O
1xcw 1 P04746 99.8 0.0 X-RAY
 2004-12-07 LEU A:196 A:196 2.0 0.012 E -87.5 108.8 2.0 0.012 0.0 AC1
CL
HOH
 7.142
7.215
5.662
 O
O
C
 O3
CL
O
1xcx 1 P04746 99.8 0.0 X-RAY
 2004-12-07 LEU A:196 A:196 1.0 0.006 E -86.4 104.2 1.0 0.006 0.0 AC1
CL
HOH
 7.147
7.265
5.454
 O
O
C
 O3
CL
O
1xd0 1 P04746 99.8 0.0 X-RAY
 2004-12-07 LEU A:196 A:196 1.0 0.006 E -89.7 99.1 1.0 0.006 0.0 ARE
CL
HOH
 7.001
7.324
5.480
 O
O
C
 O3C
CL
O
1xd1 1 P04746 99.8 0.0 X-RAY
 2004-12-07 LEU A:196 A:196 1.0 0.006 E -82.2 106.6 1.0 0.006 0.0 6SA
CL
HOH
 6.876
7.296
5.254
 O
O
C
 OY3
CL
O
2qmk 1 P04746 99.8 0.0 X-RAY
 2008-03-25 LEU A:196 A:196 0.0 0.0 E -87.3 93.6 0.0 0.0 0.0 NO2
HOH
 7.165
5.382
 O
C
 O1
O
2qv4 1 P04746 99.8 0.0 X-RAY
 2008-03-25 LEU A:196 A:196 1.0 0.006 E -91.1 99.6 1.0 0.006 0.0 NO2
QV4
HOH
 6.756
7.254
5.318
 O
O
C
 O2
O3S
O
3bai 1 P04746 99.8 0.0 X-RAY
 2008-03-25 LEU A:196 A:196 1.0 0.006 E -93.6 105.3 1.0 0.006 0.0 NO3
HOH
 6.724
5.266
 O
C
 O1
O
3baj 1 P04746 99.8 0.0 X-RAY
 2008-03-25 LEU A:196 A:196 2.0 0.012 E -89.4 101.3 2.0 0.012 0.0 ARE
NO3
HOH
 6.882
6.719
5.102
 O
O
C
 O3C
O1
O
3baw 1 P04746 99.8 0.0 X-RAY
 2008-03-25 LEU A:196 A:196 1.0 0.006 E -93.4 97.5 1.0 0.006 0.0 CL
AZI
NA
HOH
 7.511
6.357
7.626
5.284
 O
O
O
C
 CL
N1
NA
O
3ij7 1 P04746 99.8 0.0 X-RAY
 2009-10-27 LEU A:196 A:196 1.0 0.006 E -89.2 100.9 1.0 0.006 0.0 B9D
CL
HOH
 7.010
7.365
5.230
 C
O
C
 C5
CL
O
3ij8 1 P04746 99.8 0.0 X-RAY
 2009-10-27 LEU A:196 A:196 1.0 0.006 E -90.9 101.9 1.0 0.006 0.0 B0D
B0D
B9D
CL
HOH
 7.003
9.784
6.913
7.279
5.268
 O
CD1
C
O
C
 O3
O6
C5
CL
O
3ij9 1 P04746 99.8 0.0 X-RAY
 2009-10-27 LEU A:196 A:196 1.0 0.006 E -87.3 101.5 1.0 0.006 0.0 B9D
B0D
CL
HOH
 6.840
9.759
7.341
5.259
 C
CD1
O
C
 C5
O6
CL
O
4gqq 1 P04746 99.8 0.0 X-RAY
 2012-10-24 LEU A:196 A:196 0.0 0.0 E -92.8 102.9 0.0 0.0 0.0 CL
HOH
 6.499
5.294
 O
C
 CL
O
4gqr 1 P04746 99.8 0.0 X-RAY
 2012-10-24 LEU A:196 A:196 1.0 0.006 E -89.2 100.7 1.0 0.006 0.0 CL
MYC
HOH
 7.210
6.978
5.082
 O
O
C
 CL
O24
O
4w93 1 P04746 99.8 0.0 X-RAY
 2015-07-15 LEU A:196 A:196 1.0 0.006 E -93.8 104.7 1.0 0.006 0.0 CL
3L9
HOH
 7.439
7.123
5.280
 O
O
C
 CL
O4F
O
4x9y 1 P04746 99.8 0.0 X-RAY
 2014-12-31 LEU A:196 A:196 1.0 0.006 E -93.9 100.6 1.0 0.006 0.0 CL
HOH
 7.274
5.338
 O
C
 CL
O
5e0f 1 P04746 99.8 0.0 X-RAY
 2016-09-07 LEU A:196 A:196 1.0 0.006 E -94.1 101.4 1.0 0.006 0.0 5J7
CL
HOH
 6.967
7.367
5.312
 O
O
C
 H66
CL
O
5emy 1 P04746 99.8 0.0 X-RAY
 2016-07-06 LEU A:196 A:196 1.0 0.006 E -92.6 99.1 1.0 0.006 0.0 5QP
CL
HOH
 6.714
7.393
5.364
 C
O
C
 HAG1
CL
O
5kez 1 P04746 99.8 0.0 X-RAY
 2017-03-29 LEU A:196 A:196 0.0 0.0 E -94.4 100.4 0.0 0.0 0.0 CL
HOH
 7.427
5.420
 O
C
 CL
O
5u3a 1 P04746 99.8 0.0 X-RAY
 2017-12-06 LEU A:196 A:196 1.0 0.006 E -93.7 101.9 1.0 0.006 0.0 CL
HOH
 7.261
5.334
 O
C
 CL
O
5va9 1 P04746 99.8 0.0 X-RAY
 2018-03-28 LEU A:196 A:196 0.0 0.0 E -87.1 102.7 0.0 0.0 0.0 CL
HOH
 7.306
5.148
 O
C
 CL
O
LEU B:196 B:196 1.0 0.006 E -86.0 101.7 NA NA NA
6obx 1 P04746 99.8 0.0 X-RAY
 2020-02-12 LEU A:196 A:196 1.0 0.006 E -94.6 103.0 1.0 0.006 0.0 CL
ZXU
HOH
 7.327
6.893
5.337
 O
C
C
 CL
HO60
O
6ocn 1 P04746 99.8 0.0 X-RAY
 2020-02-12 LEU A:196 A:196 1.0 0.006 E -95.0 101.5 1.0 0.006 0.0 ZXY
CL
HOH
 7.223
7.344
5.322
 O
O
C
 O37
CL
O
3old 1 P04746 99.8 0.0 X-RAY
 2011-04-13 LEU A:196 A:196 1.0 0.006 E -92.5 101.6 1.0 0.006 0.0 G6D
CL
ACI
PCA
HOH
 7.011
7.307
7.762
8.467
5.412
 O
O
O
CD1
C
 O3
CL
C7
CB
O
3ole 1 P04746 99.8 0.0 X-RAY
 2011-04-13 LEU A:196 A:196 1.0 0.006 E -92.5 102.2 1.0 0.006 0.0 G6D
CL
ACI
PCA
HOH
 7.047
7.204
7.788
8.499
5.342
 O
O
O
CD1
C
 O3
CL
O2
CB
O
3olg 1 P04746 99.8 0.0 X-RAY
 2011-04-13 LEU A:196 A:196 0.0 0.0 E -86.3 103.5 0.0 0.0 0.0 G6D
CL
HSD
PCA
HOH
 7.024
7.102
7.849
8.472
5.558
 O
O
O
CD1
C
 O3
CL
N1
CB
O
3oli 1 P04746 99.8 0.0 X-RAY
 2011-04-13 LEU A:196 A:196 1.0 0.006 E -91.5 101.4 1.0 0.006 0.0 G6D
CL
HSD
PCA
HOH
 7.058
7.296
7.844
8.554
5.417
 O
O
O
CD1
C
 O3
CL
O4
CB
O
1kgw 1 P04746 99.6 0.0 X-RAY
 2002-01-16 LEU A:196 A:196 1.0 0.006 E -86.5 98.3 1.0 0.006 0.0 HOH
 5.590
 C
 O
1xgz 1 P04746 99.6 0.0 X-RAY
 2005-05-24 LEU A:196 A:196 1.0 0.006 E -86.5 105.6 1.0 0.006 0.0 HOH
 5.187
 O
 O
1xh0 1 P04746 99.6 0.0 X-RAY
 2005-05-24 LEU A:196 A:196 1.0 0.006 E -88.8 106.7 1.0 0.006 0.0 AAO
HOH
 7.081
5.330
 O
C
 O3C
O
1xh1 1 P04746 99.6 0.0 X-RAY
 2005-05-24 LEU A:196 A:196 2.0 0.012 E -85.1 103.7 2.0 0.012 0.0 CL
HOH
 7.279
5.388
 O
C
 CL
O
1xh2 1 P04746 99.6 0.0 X-RAY
 2005-05-24 LEU A:196 A:196 2.0 0.012 E -83.8 107.5 2.0 0.012 0.0 ARE
CL
HOH
 7.076
7.298
5.305
 O
O
C
 O3C
CL
O
3bak 1 P04746 99.6 0.0 X-RAY
 2008-03-25 LEU A:196 A:196 1.0 0.006 E -89.4 102.7 1.0 0.006 0.0 NO3
HOH
 6.354
5.275
 O
C
 O1
O
3bax 1 P04746 99.6 0.0 X-RAY
 2008-03-25 LEU A:196 A:196 1.0 0.006 E -92.8 102.3 1.0 0.006 0.0 CL
AZI
NA
HOH
 7.536
6.465
7.242
5.327
 O
O
O
C
 CL
N1
NA
O
3bay 1 P04746 99.6 0.0 X-RAY
 2008-03-25 LEU A:196 A:196 1.0 0.006 E -91.4 104.4 1.0 0.006 0.0 ARE
NO3
HOH
 6.610
6.296
5.403
 O
O
C
 O3C
O1
O
1kgx 1 P04746 99.6 0.0 X-RAY
 2002-01-16 LEU A:196 A:196 1.0 0.006 E -82.3 106.3 1.0 0.006 0.0 HOH
 6.298
 C
 O
6z8l 1 P04746 99.6 0.0 X-RAY
 2020-12-02 LEU A:196 A:196 0.0 0.0 E -91.0 104.6 0.0 0.0 0.0 GLC
CL
HOH
 7.089
6.980
6.237
 O
O
O
 O2
CL
O
1kgu 1 P04746 99.6 0.0 X-RAY
 2002-01-16 LEU A:196 A:196 1.0 0.006 E -85.1 98.9 1.0 0.006 0.0 HOH
 5.537
 C
 O
2cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 LEU A:196 A:196 1.0 0.006 E -90.7 102.9 1.0 0.006 0.0 CL
HOH
 7.269
4.908
 O
C
 CL
O
3cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 LEU A:196 A:196 1.0 0.006 E -93.5 106.5 1.0 0.006 0.0 CL
HOH
 7.102
7.068
 O
O
 CL
O
5td4 1 P04746 99.6 0.0 X-RAY
 2016-11-02 LEU A:196 A:196 0.0 0.0 E -91.4 104.4 0.0 0.0 0.0 GLC
GLC
CL
HOH
 7.054
7.362
7.032
5.451
 O
O
O
C
 O3
O2
CL
O
1kb3 1 P04746 99.6 0.0 X-RAY
 2002-05-01 LEU A:196 A:196 1.0 0.006 E -81.8 106.4 1.0 0.006 0.0 HOH
 3.371
 N
 O
1kbb 1 P04746 99.6 0.0 X-RAY
 2002-04-10 LEU A:196 A:196 1.0 0.006 E -93.1 103.7 1.0 0.006 0.0 CL
HOH
 7.314
5.467
 O
C
 CL
O
1kbk 1 P04746 99.6 0.0 X-RAY
 2002-04-10 LEU A:196 A:196 1.0 0.006 E -89.3 104.3 1.0 0.006 0.0 CL
HOH
 7.365
3.882
 O
C
 CL
O
1c8q 1 P04745 96.98 0.0 X-RAY
 2001-06-13 ILE A:196 A:196 0.0 0.0 E -92.6 101.4 0.0 0.0 0.0 CL
HOH
 7.178
5.433
 O
C
 CL
O
1mfv 1 P04745 96.98 0.0 X-RAY
 2002-11-20 ILE A:196 A:196 1.0 0.006 E -86.8 104.1 1.0 0.006 0.0 AGL
HMC
CL
HOH
 6.983
7.457
7.032
5.341
 O
O
O
C
 O3
C1
CL
O
1smd 1 P04745 96.98 0.0 X-RAY
 1996-07-11 ILE A:196 A:196 1.0 0.006 E -93.4 105.7 1.0 0.006 0.0 CL
HOH
 7.259
5.348
 O
C
 CL
O
1xv8 1 P04745 96.98 0.0 X-RAY
 2005-10-11 ILE A:196 A:196 1.0 0.006 E -77.2 104.2 1.0 0.006 0.0 CL
HOH
 7.594
8.118
 O
CA
 CL
O
ILE B:196 B:196 1.0 0.006 E -77.2 104.2 1.0 0.006 0.0 CL
HOH
 7.594
8.118
 O
CA
 CL
O
1z32 1 P04745 96.77 0.0 X-RAY
 2005-05-31 ILE A:196 X:196 1.0 0.006 E -89.1 105.6 1.0 0.006 0.0 AGL
HMC
CL
HOH
 7.150
7.481
6.976
5.419
 O
O
O
C
 O3
C1
CL
O
1jxj 1 P04745 96.77 0.0 X-RAY
 2001-09-14 ILE A:196 A:196 0.0 0.0 E -91.3 105.2 0.0 0.0 0.0 CL
HOH
 7.134
5.412
 O
C
 CL
O
1q4n 1 P04745 96.77 0.0 X-RAY
 2004-03-16 ILE A:196 X:196 3.0 0.017 E -94.4 103.3 3.0 0.017 0.0 CL
TAM
HOH
 7.077
6.975
5.314
 O
O
C
 CL
O4
O
1nm9 1 P04745 96.77 0.0 X-RAY
 2004-01-20 ILE A:196 A:196 0.0 0.0 E -89.3 106.0 0.0 0.0 0.0 AGL
HMC
CL
HOH
 7.120
7.583
7.006
5.445
 O
O
O
C
 O3
C1
CL
O
3blk 1 P04745 96.77 0.0 X-RAY
 2008-11-25 ILE A:196 A:196 1.0 0.006 E -95.2 104.9 1.0 0.006 0.0 AGL
CL
HMC
HOH
 7.245
7.235
7.623
5.395
 O
O
O
C
 O3
CL
C1
O
3blp 1 P04745 96.77 0.0 X-RAY
 2008-11-18 ILE A:196 X:196 1.0 0.006 E -89.1 105.5 1.0 0.006 0.0 AGL
CL
HMC
HOH
 7.172
7.149
7.603
5.471
 O
O
O
C
 O3
CL
C1
O
1jxk 1 P04745 95.97 0.0 X-RAY
 2001-09-14 ILE A:196 A:196 0.0 0.0 E -91.2 104.8 0.0 0.0 0.0 CL
HOH
 7.069
5.350
 O
C
 CL
O
1mfu 1 P04745 95.97 0.0 X-RAY
 2002-11-20 ILE A:196 A:196 0.0 0.0 E -88.7 105.5 0.0 0.0 0.0 AGL
HMC
CL
HOH
 6.975
7.470
6.962
5.498
 O
O
O
C
 O3
C1
CL
O
3dhp 1 P04745 95.77 0.0 X-RAY
 2008-07-01 ILE A:196 A:196 1.0 0.006 E -88.4 104.1 1.0 0.006 0.0 AGL
CL
HMC
HOH
 7.120
7.121
7.609
5.389
 O
O
O
C
 O3
CL
C1
O
1kxq 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ILE A:196 A:196 0.0 0.0 E -91.3 101.4 0.0 0.0 0.0 CL
HOH
 7.286
5.275
 O
C
 CL
O
ILE B:196 B:196 3.0 0.017 E -92.6 100.6 NA NA NA
ILE C:196 C:196 6.0 0.034 E -94.4 102.1 NA NA NA
ILE D:196 D:196 0.0 0.0 E -93.2 102.2 NA NA NA
1kxt 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ILE A:196 A:196 5.0 0.029 E -90.0 101.2 5.0 0.029 0.0 CL
HOH
 7.135
5.432
 O
C
 CL
O
ILE C:196 C:196 2.0 0.011 E -78.3 108.9 NA NA NA
ILE E:196 E:196 0.0 0.0 E -91.4 102.8 NA NA NA
1kxv 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ILE A:196 A:196 3.0 0.017 E -91.9 102.0 3.0 0.017 0.0 HOH
 5.223
 C
 O
ILE B:196 B:196 1.0 0.006 E -95.2 100.3 NA NA NA
1dhk 1 P00690 86.9 0.0 X-RAY
 1997-12-24 ILE A:196 A:196 0.0 0.0 E -90.0 103.6 0.0 0.0 0.0 CL
HOH
 7.772
5.248
 O
CG2
 CL
H1
1ppi 1 P00690 86.9 0.0 X-RAY
 1995-05-24 ILE A:196 A:196 1.0 0.006 E -89.4 112.8 1.0 0.006 0.0 DAF
CL
HOH
 7.195
6.974
5.525
 O
O
C
 O3
CL
O
1vah 1 P00690 86.69 0.0 X-RAY
 2005-04-26 ILE A:196 A:196 0.0 0.0 E -81.7 100.7 0.0 0.0 0.0 CL
HOH
 7.231
5.625
 O
C
 CL
O
3l2l 1 P00690 86.69 0.0 X-RAY
 2010-04-14 ILE A:196 A:196 1.0 0.006 E -96.2 102.5 1.0 0.006 0.0 GLC
CL
HOH
 6.946
7.211
6.132
 O
O
O
 HO1
CL
O
3l2m 1 P00690 86.69 0.0 X-RAY
 2010-04-14 ILE A:196 A:196 1.0 0.006 E -94.9 102.6 1.0 0.006 0.0 CA
CL
HOH
 9.952
7.220
7.040
 HG21
O
O
 CA
CL
O
1ua3 1 P00690 86.69 0.0 X-RAY
 2003-10-14 ILE A:196 A:196 0.0 0.0 E -88.4 102.0 0.0 0.0 0.0 GLC
CL
HOH
 7.111
7.258
5.301
 O
O
C
 C1
CL
O
1jfh 1 P00690 86.69 0.0 X-RAY
 1998-12-02 ILE A:196 A:196 0.0 0.0 E -88.5 104.6 0.0 0.0 0.0 GLC
CL
HOH
 8.061
7.190
5.435
 O
O
C
 O3
CL
O
1ose 1 P00690 86.49 0.0 X-RAY
 1997-04-01 ILE A:196 A:196 0.0 0.0 E -85.1 104.5 0.0 0.0 0.0 AC1
CL
HOH
 6.962
7.231
5.525
 O
O
C
 O3
CL
O
1hx0 1 P00690 86.49 0.0 X-RAY
 2001-08-08 ILE A:196 A:196 1.0 0.006 E -89.5 101.4 1.0 0.006 0.0 AC1
CL
HOH
 7.023
7.158
5.345
 O
O
C
 O3
CL
O
1wo2 1 P00690 86.49 0.0 X-RAY
 2005-03-15 ILE A:196 A:196 0.0 0.0 E -85.1 102.6 0.0 0.0 0.0 BGC
CL
EDO
HOH
 6.010
7.370
8.326
5.394
 O
O
CD1
C
 O1
CL
C2
O
1bvn 1 P00690 86.49 0.0 X-RAY
 1998-09-23 LEU A:196 P:196 4.0 0.024 E -84.7 106.9 4.0 0.024 0.0 CL
HOH
 7.217
5.530
 O
C
 CL
O
1pif 1 P00690 86.29 0.0 X-RAY
 1996-12-07 ILE A:196 A:196 0.0 0.0 E -86.3 108.9 0.0 0.0 0.0 CL
HOH
 7.162
5.768
 O
C
 CL
O
1pig 1 P00690 86.29 0.0 X-RAY
 1996-12-07 ILE A:196 A:196 0.0 0.0 E -87.6 106.7 0.0 0.0 0.0 AGL
HMC
CL
HOH
 7.035
7.506
7.122
4.678
 O
O
O
N
 O3
C1
CL
O
4x0n 1 P00690 86.29 0.0 X-RAY
 2015-11-25 ILE A:196 A:196 1.0 0.006 E -88.4 99.9 1.0 0.006 0.0 CL
HOH
 7.381
5.308
 O
C
 CL
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04746-f1 1 P04746 100.0 0.0 LEU A:211 A:211 1.0 0.006 E -89.4 105.8
af-p19961-f1 1 P19961 98.83 0.0 LEU A:211 A:211 1.0 0.006 E -91.0 101.6
af-p0dte7-f1 1 P0DTE7 96.87 0.0 ILE A:211 A:211 1.0 0.006 E -91.0 102.7
af-p0dte8-f1 1 P0DTE8 96.87 0.0 ILE A:211 A:211 1.0 0.006 E -91.7 102.7
af-p0dub6-f1 1 P0DUB6 96.87 0.0 ILE A:211 A:211 1.0 0.006 E -92.0 103.3