Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 104163266 . G A CCDS783.1:NM_000699.2:c.838Gtt>Att_NP_000690.1:p.280V>I Homo sapiens amylase, alpha 2A (pancreatic) (AMY2A), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1b2y 1 P04746 100.0 0.0 X-RAY
 2000-02-16 VAL A:265 A:265 0.0 0.0 H -66.5 -49.5 0.0 0.0 0.0 HOH
 6.151
 CG2
 O
1bsi 1 P04746 99.8 0.0 X-RAY
 1999-05-18 VAL A:265 A:265 0.0 0.0 H -66.1 -46.5 0.0 0.0 0.0 HOH
 2.800
 O
 O
1cpu 1 P04746 99.8 0.0 X-RAY
 1999-06-14 VAL A:265 A:265 0.0 0.0 H -70.5 -40.9 0.0 0.0 0.0 HOH
 2.793
 O
 O
1hny 1 P04746 99.8 0.0 X-RAY
 1996-03-08 VAL A:265 A:265 0.0 0.0 H -59.8 -56.0 0.0 0.0 0.0 HOH
 2.822
 O
 O
1u2y 1 P04746 99.8 0.0 X-RAY
 2004-09-07 VAL A:265 A:265 0.0 0.0 H -68.2 -47.7 0.0 0.0 0.0 HOH
 2.834
 O
 O
1u30 1 P04746 99.8 0.0 X-RAY
 2004-09-07 VAL A:265 A:265 0.0 0.0 H -66.7 -49.4 0.0 0.0 0.0 HOH
 2.690
 O
 O
1u33 1 P04746 99.8 0.0 X-RAY
 2004-09-07 VAL A:265 A:265 0.0 0.0 H -65.2 -54.2 0.0 0.0 0.0 HOH
 2.821
 O
 O
1xcw 1 P04746 99.8 0.0 X-RAY
 2004-12-07 VAL A:265 A:265 0.0 0.0 H -63.5 -49.8 0.0 0.0 0.0 HOH
 6.091
 O
 O
1xcx 1 P04746 99.8 0.0 X-RAY
 2004-12-07 VAL A:265 A:265 0.0 0.0 H -66.2 -49.3 0.0 0.0 0.0 HOH
 2.760
 O
 O
1xd0 1 P04746 99.8 0.0 X-RAY
 2004-12-07 VAL A:265 A:265 0.0 0.0 H -66.1 -47.3 0.0 0.0 0.0 HOH
 2.760
 O
 O
1xd1 1 P04746 99.8 0.0 X-RAY
 2004-12-07 VAL A:265 A:265 0.0 0.0 H -65.2 -48.1 0.0 0.0 0.0 HOH
 8.327
 N
 O
2qmk 1 P04746 99.8 0.0 X-RAY
 2008-03-25 VAL A:265 A:265 0.0 0.0 H -63.5 -57.1 0.0 0.0 0.0 HOH
 2.824
 O
 O
2qv4 1 P04746 99.8 0.0 X-RAY
 2008-03-25 VAL A:265 A:265 0.0 0.0 H -64.4 -51.5 0.0 0.0 0.0 HOH
 2.816
 O
 O
3bai 1 P04746 99.8 0.0 X-RAY
 2008-03-25 VAL A:265 A:265 0.0 0.0 H -70.2 -49.2 0.0 0.0 0.0 HOH
 2.641
 O
 O
3baj 1 P04746 99.8 0.0 X-RAY
 2008-03-25 VAL A:265 A:265 0.0 0.0 H -65.8 -46.7 0.0 0.0 0.0 HOH
 2.681
 O
 O
3baw 1 P04746 99.8 0.0 X-RAY
 2008-03-25 VAL A:265 A:265 0.0 0.0 H -69.4 -43.6 0.0 0.0 0.0 HOH
 2.760
 O
 O
3ij7 1 P04746 99.8 0.0 X-RAY
 2009-10-27 VAL A:265 A:265 0.0 0.0 H -71.0 -49.0 0.0 0.0 0.0 HOH
 2.860
 O
 O
3ij8 1 P04746 99.8 0.0 X-RAY
 2009-10-27 VAL A:265 A:265 0.0 0.0 H -68.9 -50.6 0.0 0.0 0.0 HOH
 2.763
 O
 O
3ij9 1 P04746 99.8 0.0 X-RAY
 2009-10-27 VAL A:265 A:265 0.0 0.0 H -66.5 -50.5 0.0 0.0 0.0 HOH
 2.657
 O
 O
4gqq 1 P04746 99.8 0.0 X-RAY
 2012-10-24 VAL A:265 A:265 0.0 0.0 H -69.0 -45.3 0.0 0.0 0.0 HOH
 2.799
 O
 O
4gqr 1 P04746 99.8 0.0 X-RAY
 2012-10-24 VAL A:265 A:265 0.0 0.0 H -67.5 -49.5 0.0 0.0 0.0 HOH
 2.694
 O
 O
4w93 1 P04746 99.8 0.0 X-RAY
 2015-07-15 VAL A:265 A:265 0.0 0.0 H -63.9 -48.9 0.0 0.0 0.0 HOH
 2.759
 O
 O
4x9y 1 P04746 99.8 0.0 X-RAY
 2014-12-31 VAL A:265 A:265 0.0 0.0 H -67.1 -50.3 0.0 0.0 0.0 HOH
 2.796
 O
 O
5e0f 1 P04746 99.8 0.0 X-RAY
 2016-09-07 VAL A:265 A:265 0.0 0.0 H -63.5 -49.2 0.0 0.0 0.0 HOH
 2.644
 O
 O
5emy 1 P04746 99.8 0.0 X-RAY
 2016-07-06 VAL A:265 A:265 0.0 0.0 H -66.7 -50.2 0.0 0.0 0.0 HOH
 2.767
 O
 O
5kez 1 P04746 99.8 0.0 X-RAY
 2017-03-29 VAL A:265 A:265 0.0 0.0 H -65.3 -51.9 0.0 0.0 0.0 HOH
 2.792
 O
 O
5u3a 1 P04746 99.8 0.0 X-RAY
 2017-12-06 VAL A:265 A:265 0.0 0.0 H -65.5 -52.0 0.0 0.0 0.0 HOH
 2.795
 O
 O
5va9 1 P04746 99.8 0.0 X-RAY
 2018-03-28 VAL A:265 A:265 0.0 0.0 H -63.2 -44.3 0.0 0.0 0.0 HOH
 2.678
 O
 O
VAL B:265 B:265 0.0 0.0 H -63.6 -44.2 NA NA NA
6obx 1 P04746 99.8 0.0 X-RAY
 2020-02-12 VAL A:265 A:265 0.0 0.0 H -66.4 -50.1 0.0 0.0 0.0 HOH
 2.784
 O
 O
6ocn 1 P04746 99.8 0.0 X-RAY
 2020-02-12 VAL A:265 A:265 0.0 0.0 H -65.9 -51.0 0.0 0.0 0.0 HOH
 2.789
 O
 O
3old 1 P04746 99.8 0.0 X-RAY
 2011-04-13 VAL A:265 A:265 0.0 0.0 H -64.9 -48.7 0.0 0.0 0.0 HOH
 2.813
 O
 O
3ole 1 P04746 99.8 0.0 X-RAY
 2011-04-13 VAL A:265 A:265 0.0 0.0 H -67.2 -50.8 0.0 0.0 0.0 HOH
 2.718
 O
 O
3olg 1 P04746 99.8 0.0 X-RAY
 2011-04-13 VAL A:265 A:265 0.0 0.0 H -69.3 -51.8 0.0 0.0 0.0 HOH
 2.863
 O
 O
3oli 1 P04746 99.8 0.0 X-RAY
 2011-04-13 VAL A:265 A:265 0.0 0.0 H -63.5 -50.4 0.0 0.0 0.0 HOH
 2.759
 O
 O
1kgw 1 P04746 99.6 0.0 X-RAY
 2002-01-16 VAL A:265 A:265 0.0 0.0 H -65.0 -50.0 0.0 0.0 0.0 HOH
 2.717
 O
 O
1xgz 1 P04746 99.6 0.0 X-RAY
 2005-05-24 VAL A:265 A:265 0.0 0.0 H -67.8 -50.1 0.0 0.0 0.0 HOH
 2.779
 O
 O
1xh0 1 P04746 99.6 0.0 X-RAY
 2005-05-24 VAL A:265 A:265 0.0 0.0 H -64.0 -49.0 0.0 0.0 0.0 HOH
 2.834
 O
 O
1xh1 1 P04746 99.6 0.0 X-RAY
 2005-05-24 VAL A:265 A:265 0.0 0.0 H -68.9 -47.4 0.0 0.0 0.0 HOH
 2.701
 O
 O
1xh2 1 P04746 99.6 0.0 X-RAY
 2005-05-24 VAL A:265 A:265 0.0 0.0 H -67.2 -46.4 0.0 0.0 0.0 HOH
 2.741
 O
 O
3bak 1 P04746 99.6 0.0 X-RAY
 2008-03-25 VAL A:265 A:265 0.0 0.0 H -68.5 -47.9 0.0 0.0 0.0 HOH
 2.752
 O
 O
3bax 1 P04746 99.6 0.0 X-RAY
 2008-03-25 VAL A:265 A:265 0.0 0.0 H -73.8 -38.0 0.0 0.0 0.0 HOH
 2.654
 O
 O
3bay 1 P04746 99.6 0.0 X-RAY
 2008-03-25 VAL A:265 A:265 0.0 0.0 H -68.9 -50.5 0.0 0.0 0.0 HOH
 2.784
 O
 O
1kgx 1 P04746 99.6 0.0 X-RAY
 2002-01-16 VAL A:265 A:265 0.0 0.0 H -70.8 -48.9 0.0 0.0 0.0 HOH
 2.770
 O
 O
6z8l 1 P04746 99.6 0.0 X-RAY
 2020-12-02 VAL A:265 A:265 0.0 0.0 H -62.6 -50.3 0.0 0.0 0.0 GLC
GLC
HOH
 7.785
5.059
2.668
 HG22
HG22
O
 H5
H2
O
1kgu 1 P04746 99.6 0.0 X-RAY
 2002-01-16 VAL A:265 A:265 0.0 0.0 H -69.1 -50.0 0.0 0.0 0.0 HOH
 2.743
 O
 O
2cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 VAL A:265 A:265 0.0 0.0 H -69.5 -49.4 0.0 0.0 0.0 HOH
 2.602
 O
 O
3cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 VAL A:265 A:265 0.0 0.0 H -77.3 -43.3 0.0 0.0 0.0 HOH
 4.676
 CG1
 O
5td4 1 P04746 99.6 0.0 X-RAY
 2016-11-02 VAL A:265 A:265 0.0 0.0 H -63.4 -46.8 0.0 0.0 0.0 HOH
 7.492
 O
 O
1kb3 1 P04746 99.6 0.0 X-RAY
 2002-05-01 VAL A:265 A:265 0.0 0.0 H -74.4 -49.3 0.0 0.0 0.0 HOH
 6.994
 O
 O
1kbb 1 P04746 99.6 0.0 X-RAY
 2002-04-10 VAL A:265 A:265 1.0 0.006 H -66.6 -47.9 1.0 0.006 0.0 HOH
 2.742
 O
 O
1kbk 1 P04746 99.6 0.0 X-RAY
 2002-04-10 VAL A:265 A:265 0.0 0.0 H -66.5 -52.2 0.0 0.0 0.0 HOH
 2.771
 O
 O
1c8q 1 P04745 96.98 0.0 X-RAY
 2001-06-13 VAL A:265 A:265 0.0 0.0 H -67.5 -53.1 0.0 0.0 0.0 HOH
 2.701
 O
 O
1mfv 1 P04745 96.98 0.0 X-RAY
 2002-11-20 VAL A:265 A:265 0.0 0.0 H -58.0 -51.0 0.0 0.0 0.0 BGC
GLC
AGL
HOH
 8.869
6.550
7.845
2.562
 CG2
CG2
CG2
O
 O4
C2
O2
O
1smd 1 P04745 96.98 0.0 X-RAY
 1996-07-11 VAL A:265 A:265 0.0 0.0 H -61.7 -48.9 0.0 0.0 0.0 HOH
 8.266
 N
 O
1xv8 1 P04745 96.98 0.0 X-RAY
 2005-10-11 VAL A:265 A:265 0.0 0.0 H -73.0 -41.2 0.0 0.0 0.0 HOH
 2.630
 O
 O
VAL B:265 B:265 0.0 0.0 H -73.0 -41.2 0.0 0.0 0.0 HOH
 2.630
 O
 O
1z32 1 P04745 96.77 0.0 X-RAY
 2005-05-31 VAL A:265 X:265 0.0 0.0 H -59.7 -51.6 0.0 0.0 0.0 HOH
 2.727
 O
 O
1jxj 1 P04745 96.77 0.0 X-RAY
 2001-09-14 VAL A:265 A:265 0.0 0.0 H -56.4 -50.9 0.0 0.0 0.0 HOH
 2.758
 O
 O
1q4n 1 P04745 96.77 0.0 X-RAY
 2004-03-16 VAL A:265 X:265 0.0 0.0 H -58.1 -46.8 0.0 0.0 0.0 HOH
 2.633
 O
 O
1nm9 1 P04745 96.77 0.0 X-RAY
 2004-01-20 VAL A:265 A:265 0.0 0.0 H -62.0 -51.2 0.0 0.0 0.0 GLC
AGL
GLC
HOH
 6.279
7.719
9.231
2.602
 CG2
CG2
CG2
O
 C2
O2
O4
O
3blk 1 P04745 96.77 0.0 X-RAY
 2008-11-25 VAL A:265 A:265 0.0 0.0 H -53.8 -55.5 0.0 0.0 0.0 HOH
 2.714
 O
 O
3blp 1 P04745 96.77 0.0 X-RAY
 2008-11-18 VAL A:265 X:265 0.0 0.0 H -61.8 -52.9 0.0 0.0 0.0 HOH
 2.812
 O
 O
1jxk 1 P04745 95.97 0.0 X-RAY
 2001-09-14 VAL A:265 A:265 0.0 0.0 H -61.5 -50.4 0.0 0.0 0.0 HOH
 2.809
 O
 O
1mfu 1 P04745 95.97 0.0 X-RAY
 2002-11-20 VAL A:265 A:265 0.0 0.0 H -64.7 -48.9 0.0 0.0 0.0 GLC
GLC
AGL
HOH
 8.801
6.439
7.572
2.656
 CG2
CG2
CG2
O
 O4
O3
O2
O
3dhp 1 P04745 95.77 0.0 X-RAY
 2008-07-01 VAL A:265 A:265 2.0 0.013 H -62.0 -47.7 2.0 0.013 0.0 HOH
 2.625
 O
 O
1kxq 1 P00690 86.9 0.0 X-RAY
 2002-06-19 VAL A:265 A:265 1.0 0.006 H -64.2 -51.7 1.0 0.006 0.0 HOH
 2.766
 O
 O
VAL B:265 B:265 0.0 0.0 H -66.6 -47.7 NA NA NA
VAL C:265 C:265 1.0 0.006 H -64.0 -51.0 NA NA NA
VAL D:265 D:265 0.0 0.0 H -64.3 -48.1 NA NA NA
1kxt 1 P00690 86.9 0.0 X-RAY
 2002-06-19 VAL A:265 A:265 0.0 0.0 H -60.4 -54.7 0.0 0.0 0.0 HOH
 3.169
 O
 O
VAL C:265 C:265 0.0 0.0 H -70.0 -46.6 NA NA NA
VAL E:265 E:265 0.0 0.0 H -67.6 -54.0 NA NA NA
1kxv 1 P00690 86.9 0.0 X-RAY
 2002-06-19 VAL A:265 A:265 0.0 0.0 H -67.0 -47.3 0.0 0.0 0.0 HOH
 2.833
 O
 O
VAL B:265 B:265 0.0 0.0 H -68.5 -49.2 NA NA NA
1dhk 1 P00690 86.9 0.0 X-RAY
 1997-12-24 VAL A:265 A:265 0.0 0.0 H -65.1 -52.3 0.0 0.0 0.0 HOH
 1.877
 O
 H1
1ppi 1 P00690 86.9 0.0 X-RAY
 1995-05-24 VAL A:265 A:265 0.0 0.0 H -61.2 -47.5 0.0 0.0 0.0 HOH
 2.784
 O
 O
1vah 1 P00690 86.69 0.0 X-RAY
 2005-04-26 VAL A:265 A:265 0.0 0.0 H -68.9 -45.1 0.0 0.0 0.0 HOH
 6.117
 O
 O
3l2l 1 P00690 86.69 0.0 X-RAY
 2010-04-14 VAL A:265 A:265 0.0 0.0 H -68.9 -52.4 0.0 0.0 0.0 HOH
 2.819
 O
 O
3l2m 1 P00690 86.69 0.0 X-RAY
 2010-04-14 VAL A:265 A:265 0.0 0.0 H -66.1 -49.9 0.0 0.0 0.0 HOH
 2.720
 O
 O
1ua3 1 P00690 86.69 0.0 X-RAY
 2003-10-14 VAL A:265 A:265 0.0 0.0 H -63.7 -49.8 0.0 0.0 0.0 GLC
GLC
GLC
HOH
 8.605
6.482
7.439
2.901
 CG2
CG2
CG2
O
 O4
C2
O2
O
1jfh 1 P00690 86.69 0.0 X-RAY
 1998-12-02 VAL A:265 A:265 0.0 0.0 H -66.0 -49.4 0.0 0.0 0.0 HOH
 2.667
 O
 O
1ose 1 P00690 86.49 0.0 X-RAY
 1997-04-01 VAL A:265 A:265 0.0 0.0 H -65.9 -51.2 0.0 0.0 0.0 BGC
HOH
 6.304
2.838
 CG2
O
 O3
O
1hx0 1 P00690 86.49 0.0 X-RAY
 2001-08-08 VAL A:265 A:265 0.0 0.0 H -63.0 -49.9 0.0 0.0 0.0 GLC
GLC
EDO
HOH
 6.433
7.420
8.624
2.784
 CG2
CG2
CG2
O
 C2
O2
O2
O
1wo2 1 P00690 86.49 0.0 X-RAY
 2005-03-15 VAL A:265 A:265 0.0 0.0 H -64.9 -51.3 0.0 0.0 0.0 BGC
GLC
GLC
HOH
 8.780
6.521
7.478
2.840
 CG2
CG2
CG2
O
 O4
O3
O2
O
1bvn 1 P00690 86.49 0.0 X-RAY
 1998-09-23 VAL A:265 P:265 0.0 0.0 H -76.3 -47.8 0.0 0.0 0.0 HOH
 7.210
 O
 O
1pif 1 P00690 86.29 0.0 X-RAY
 1996-12-07 VAL A:265 A:265 0.0 0.0 H -67.0 -49.5 0.0 0.0 0.0 HOH
 2.632
 O
 O
1pig 1 P00690 86.29 0.0 X-RAY
 1996-12-07 VAL A:265 A:265 0.0 0.0 H -66.7 -47.7 0.0 0.0 0.0 GLC
BGC
HOH
 6.362
7.608
2.859
 CG2
CG2
O
 O3
O2
O
4x0n 1 P00690 86.29 0.0 X-RAY
 2015-11-25 VAL A:265 A:265 0.0 0.0 H -63.6 -50.5 0.0 0.0 0.0 HOH
 2.807
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04746-f1 1 P04746 100.0 0.0 VAL A:280 A:280 0.0 0.0 H -63.5 -49.5
af-p19961-f1 1 P19961 98.83 0.0 VAL A:280 A:280 0.0 0.0 H -63.6 -49.5
af-p0dte7-f1 1 P0DTE7 96.87 0.0 VAL A:280 A:280 0.0 0.0 H -63.6 -49.5
af-p0dte8-f1 1 P0DTE8 96.87 0.0 VAL A:280 A:280 0.0 0.0 H -63.7 -49.6
af-p0dub6-f1 1 P0DUB6 96.87 0.0 VAL A:280 A:280 0.0 0.0 H -63.5 -49.8