Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 104166498 . A C CCDS783.1:NM_000699.2:c.1112gAt>gCt_NP_000690.1:p.371D>A Homo sapiens amylase, alpha 2A (pancreatic) (AMY2A), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1b2y 1 P04746 100.0 0.0 X-RAY
 2000-02-16 ASP A:356 A:356 37.0 0.247 T -69.5 -11.0 37.0 0.247 0.0 AC1
GLC
G6D
HOH
 9.707
7.261
7.655
2.910
 O
OD2
OD1
O
 O4
O3
O2
O
1bsi 1 P04746 99.8 0.0 X-RAY
 1999-05-18 ASP A:356 A:356 46.0 0.307 T -74.1 -8.0 46.0 0.307 0.0 HOH
 2.861
 OD1
 O
1cpu 1 P04746 99.8 0.0 X-RAY
 1999-06-14 ASP A:356 A:356 44.0 0.293 T -72.0 -6.1 44.0 0.293 0.0 GLC
GLC
HMC
HOH
 7.270
7.602
9.485
2.675
 OD2
OD1
O
OD1
 O3
O2
O3
O
1hny 1 P04746 99.8 0.0 X-RAY
 1996-03-08 ASP A:356 A:356 39.0 0.26 T -66.8 -11.7 39.0 0.26 0.0 HOH
 3.001
 OD1
 O
1u2y 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ASP A:356 A:356 46.0 0.307 T -71.2 -4.9 46.0 0.307 0.0 HOH
 2.707
 OD2
 O
1u30 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ASP A:356 A:356 46.0 0.307 T -69.7 -9.1 46.0 0.307 0.0 LAG
HOH
 7.627
2.529
 OD1
OD2
 OD2
O
1u33 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ASP A:356 A:356 44.0 0.293 T -68.8 -7.3 44.0 0.293 0.0 LM2
HOH
 7.166
2.607
 OD2
OD2
 OB3
O
1xcw 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ASP A:356 A:356 48.0 0.32 T -73.2 1.3 48.0 0.32 0.0 AC1
HOH
 9.664
2.811
 O
OD1
 O3B
O
1xcx 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ASP A:356 A:356 45.0 0.3 T -71.8 -4.6 45.0 0.3 0.0 AC1
HOH
 9.798
2.681
 O
OD1
 O3B
O
1xd0 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ASP A:356 A:356 47.0 0.313 T -69.2 -7.4 47.0 0.313 0.0 ARE
HOH
 7.020
3.223
 OD2
OD1
 O3B
O
1xd1 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ASP A:356 A:356 39.0 0.26 T -78.9 -2.2 39.0 0.26 0.0 6SA
HOH
 7.581
3.024
 OD2
OD1
 OP3
O
2qmk 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ASP A:356 A:356 41.0 0.273 T -58.5 -17.4 41.0 0.273 0.0 HOH
 2.577
 OD1
 O
2qv4 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ASP A:356 A:356 37.0 0.247 T -71.5 -3.2 37.0 0.247 0.0 QV4
HOH
 7.697
2.651
 O
OD1
 O2B
O
3bai 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ASP A:356 A:356 43.0 0.287 T -70.2 -2.2 43.0 0.287 0.0 HOH
 2.749
 OD1
 O
3baj 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ASP A:356 A:356 42.0 0.28 T -66.3 -10.3 42.0 0.28 0.0 ARE
HOH
 7.430
2.751
 OD2
OD1
 O3B
O
3baw 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ASP A:356 A:356 40.0 0.267 T -72.5 -5.9 40.0 0.267 0.0 HOH
 2.525
 OD1
 O
3ij7 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ASP A:356 A:356 38.0 0.253 T -75.8 -2.8 38.0 0.253 0.0 B9D
BGC
B8D
HOH
 9.519
7.405
7.724
2.740
 O
OD2
OD1
OD1
 O3
O3
O2
O
3ij8 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ASP A:356 A:356 30.0 0.2 T -71.6 -2.9 30.0 0.2 0.0 B9D
HOH
 9.506
2.655
 O
OD2
 O3
O
3ij9 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ASP A:356 A:356 37.0 0.247 T -70.9 -0.4 37.0 0.247 0.0 B9D
BGC
HOH
 9.581
7.882
2.648
 O
OD2
OD1
 O3
O3
O
4gqq 1 P04746 99.8 0.0 X-RAY
 2012-10-24 ASP A:356 A:356 67.0 0.447 -118.3 2.8 67.0 0.447 0.0 HOH
 9.802
 OD2
 O
4gqr 1 P04746 99.8 0.0 X-RAY
 2012-10-24 ASP A:356 A:356 30.0 0.2 T -65.9 -11.8 30.0 0.2 0.0 MYC
HOH
 9.510
3.028
 OD2
OD2
 O29
O
4w93 1 P04746 99.8 0.0 X-RAY
 2015-07-15 ASP A:356 A:356 42.0 0.28 T -62.6 -11.1 42.0 0.28 0.0 3L9
HOH
 6.267
2.971
 OD2
OD1
 O9F
O
4x9y 1 P04746 99.8 0.0 X-RAY
 2014-12-31 ASP A:356 A:356 40.0 0.267 T -68.6 -9.0 40.0 0.267 0.0 HOH
 2.641
 OD1
 O
5e0f 1 P04746 99.8 0.0 X-RAY
 2016-09-07 ASP A:356 A:356 41.0 0.273 T -71.3 -5.1 41.0 0.273 0.0 5J7
HOH
 5.729
2.681
 OD1
OD1
 H531
O
5emy 1 P04746 99.8 0.0 X-RAY
 2016-07-06 ASP A:356 A:356 44.0 0.293 T -67.5 -7.5 44.0 0.293 0.0 5QP
HOH
 7.141
2.531
 O
OD2
 H2
O
5kez 1 P04746 99.8 0.0 X-RAY
 2017-03-29 ASP A:356 A:356 42.0 0.28 T -70.3 -5.5 0.0 0.0 0.28 B:None:0.28
 HOH
 2.772
 OD1
 O
5u3a 1 P04746 99.8 0.0 X-RAY
 2017-12-06 ASP A:356 A:356 39.0 0.26 T -71.0 -8.2 39.0 0.26 0.0 HOH
 2.643
 OD1
 O
5va9 1 P04746 99.8 0.0 X-RAY
 2018-03-28 ASP A:356 A:356 47.0 0.313 T -71.9 0.4 0.0 0.0 0.313 C:None:0.313
 HOH
 2.946
 OD1
 O
ASP B:356 B:356 47.0 0.313 T -72.5 -0.2 NA NA NA
6obx 1 P04746 99.8 0.0 X-RAY
 2020-02-12 ASP A:356 A:356 37.0 0.247 T -68.5 -11.3 37.0 0.247 0.0 ZXU
HOH
 5.936
2.674
 OD1
OD1
 HA
O
6ocn 1 P04746 99.8 0.0 X-RAY
 2020-02-12 ASP A:356 A:356 33.0 0.22 T -68.3 -10.0 33.0 0.22 0.0 ZXY
HOH
 5.723
2.660
 OD1
OD1
 HA
O
3old 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ASP A:356 A:356 48.0 0.32 T -71.9 -3.1 48.0 0.32 0.0 GLC
GLC
ACI
MPD
HOH
 7.684
7.702
9.242
6.777
2.685
 OD2
OD1
O
OD2
OD1
 O3
O2
O3
C1
O
3ole 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ASP A:356 A:356 48.0 0.32 T -69.9 -2.1 48.0 0.32 0.0 GLC
G6D
ACI
MPD
HOH
 7.666
7.726
9.266
6.721
2.651
 OD2
OD1
O
OD2
OD2
 O3
O2
O3
C1
O
3olg 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ASP A:356 A:356 43.0 0.287 T -70.1 -12.3 43.0 0.287 0.0 GLC
G6D
HSD
HOH
 7.019
7.230
9.428
2.519
 OD2
OD1
O
OD2
 O3
O2
O3
O
3oli 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ASP A:356 A:356 45.0 0.3 T -70.0 -3.6 45.0 0.3 0.0 GLC
G6D
HSD
HOH
 7.118
7.209
9.204
2.695
 OD2
OD1
O
OD2
 O3
O2
O3
O
1kgw 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ASP A:356 A:356 40.0 0.267 T -73.7 -7.8 40.0 0.267 0.0 HOH
 3.074
 O
 O
1xgz 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ASP A:356 A:356 43.0 0.287 T -72.4 -3.2 43.0 0.287 0.0 HOH
 2.667
 OD1
 O
1xh0 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ASP A:356 A:356 44.0 0.293 T -72.0 -4.3 44.0 0.293 0.0 AAO
HOH
 7.086
2.844
 OD2
OD1
 O3B
O
1xh1 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ASP A:356 A:356 41.0 0.273 T -74.4 -2.2 41.0 0.273 0.0 HOH
 2.713
 OD1
 O
1xh2 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ASP A:356 A:356 46.0 0.307 T -73.3 -10.1 46.0 0.307 0.0 ARE
HOH
 7.613
2.707
 OD1
OD1
 O2A
O
3bak 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ASP A:356 A:356 42.0 0.28 T -71.2 -3.7 42.0 0.28 0.0 HOH
 2.666
 OD1
 O
3bax 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ASP A:356 A:356 44.0 0.293 T -70.1 -4.8 44.0 0.293 0.0 HOH
 2.529
 OD1
 O
3bay 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ASP A:356 A:356 40.0 0.267 T -69.4 -4.2 40.0 0.267 0.0 ARE
HOH
 7.634
2.755
 OD1
OD1
 O3B
O
1kgx 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ASP A:356 A:356 40.0 0.267 T -76.2 -5.8 40.0 0.267 0.0 HOH
 2.837
 OD1
 O
6z8l 1 P04746 99.6 0.0 X-RAY
 2020-12-02 ASP A:356 A:356 44.0 0.293 T -65.5 -10.2 44.0 0.293 0.0 GLC
GLC
GLC
GLC
HOH
 6.599
6.904
9.769
8.811
2.577
 OD2
OD1
OD2
OD1
OD1
 HO3
HO2
H62
O4
O
1kgu 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ASP A:356 A:356 44.0 0.293 T -73.9 -6.7 44.0 0.293 0.0 HOH
 2.895
 OD1
 O
2cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 ASP A:356 A:356 42.0 0.28 T -75.1 -3.7 42.0 0.28 0.0 HOH
 2.807
 OD1
 O
3cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 ASP A:356 A:356 41.0 0.273 T -76.8 -4.5 41.0 0.273 0.0 GLC
GLC
HOH
 6.997
7.241
3.574
 OD2
OD1
O
 O3
O2
O
5td4 1 P04746 99.6 0.0 X-RAY
 2016-11-02 ASP A:356 A:356 43.0 0.287 T -67.7 -5.0 43.0 0.287 0.0 GLC
GLC
GLC
GLC
GLC
GLC
HOH
 8.794
5.405
9.461
9.951
6.945
7.252
2.236
 OD1
OD1
OD2
O
OD2
OD1
OD2
 O4
O3
O6
O3
O3
O2
O
1kb3 1 P04746 99.6 0.0 X-RAY
 2002-05-01 ASP A:356 A:356 42.0 0.28 T -75.4 -4.7 42.0 0.28 0.0 HOH
 2.969
 OD1
 O
1kbb 1 P04746 99.6 0.0 X-RAY
 2002-04-10 ASP A:356 A:356 29.0 0.193 T -73.5 -3.9 29.0 0.193 0.0 HOH
 3.501
 O
 O
1kbk 1 P04746 99.6 0.0 X-RAY
 2002-04-10 ASP A:356 A:356 39.0 0.26 T -72.3 -6.2 39.0 0.26 0.0 HOH
 3.105
 OD1
 O
1c8q 1 P04745 96.98 0.0 X-RAY
 2001-06-13 ASP A:356 A:356 20.0 0.133 T -69.5 -12.1 20.0 0.133 0.0 HOH
 3.155
 OD1
 O
1mfv 1 P04745 96.98 0.0 X-RAY
 2002-11-20 ASP A:356 A:356 16.0 0.107 T -65.7 -8.2 16.0 0.107 0.0 GLC
AGL
AGL
HMC
HOH
 7.281
7.315
9.958
9.339
2.450
 OD2
OD1
OD2
O
OD2
 O3
O2
C6
O3
O
1smd 1 P04745 96.98 0.0 X-RAY
 1996-07-11 ASP A:356 A:356 14.0 0.093 T -73.7 0.7 14.0 0.093 0.0 HOH
 2.544
 OD2
 O
1xv8 1 P04745 96.98 0.0 X-RAY
 2005-10-11 ASP A:356 A:356 16.0 0.107 T -64.8 1.5 16.0 0.107 0.0
ASP B:356 B:356 16.0 0.107 T -64.8 1.5 16.0 0.107 0.0
1z32 1 P04745 96.77 0.0 X-RAY
 2005-05-31 ASP A:356 X:356 11.0 0.073 T -69.1 -3.0 11.0 0.073 0.0 GLC
HMC
HOH
 7.000
9.623
3.027
 OD1
O
OD1
 O3
O3
O
1jxj 1 P04745 96.77 0.0 X-RAY
 2001-09-14 ASP A:356 A:356 16.0 0.107 T -75.6 -4.3 16.0 0.107 0.0 HOH
 3.363
 O
 O
1q4n 1 P04745 96.77 0.0 X-RAY
 2004-03-16 ASP A:356 X:356 13.0 0.087 T -73.3 -11.8 13.0 0.087 0.0 TAM
HOH
 8.719
2.754
 O
OD1
 O5
O
1nm9 1 P04745 96.77 0.0 X-RAY
 2004-01-20 ASP A:356 A:356 10.0 0.067 T -64.8 -13.0 10.0 0.067 0.0 AGL
HMC
HOH
 9.933
9.201
3.050
 OD2
O
OD1
 C6
O3
O
3blk 1 P04745 96.77 0.0 X-RAY
 2008-11-25 ASP A:356 A:356 18.0 0.12 T -67.5 -8.0 18.0 0.12 0.0 GLC
AGL
HMC
HOH
 7.386
7.320
9.327
2.874
 OD2
OD1
O
OD1
 O3
O2
O3
O
3blp 1 P04745 96.77 0.0 X-RAY
 2008-11-18 ASP A:356 X:356 15.0 0.1 T -66.5 -4.1 15.0 0.1 0.0 GLC
AGL
HMC
HOH
 7.309
7.421
9.254
2.506
 OD2
OD1
O
OD2
 O3
O2
O3
O
1jxk 1 P04745 95.97 0.0 X-RAY
 2001-09-14 ASP A:351 A:351 49.0 0.327 T -71.8 -3.5 49.0 0.327 0.0 HOH
 2.913
 OD2
 O
1mfu 1 P04745 95.97 0.0 X-RAY
 2002-11-20 ASP A:351 A:351 36.0 0.24 T -69.5 -6.7 36.0 0.24 0.0 GLC
AGL
HMC
HOH
 7.447
7.359
9.290
2.837
 OD2
OD1
O
OD2
 O3
O2
O3
O
3dhp 1 P04745 95.77 0.0 X-RAY
 2008-07-01 ASP A:356 A:356 44.0 0.293 T -67.0 -2.1 44.0 0.293 0.0 GLC
HMC
HOH
 7.304
9.360
2.627
 OD2
O
OD2
 O3
O3
O
1kxq 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ASP A:356 A:356 29.0 0.193 T -66.0 -11.4 2.0 0.013 0.18 H:None:0.18
 HOH
 2.647
 OD1
 O
ASP B:356 B:356 30.0 0.2 T -70.8 -7.5 NA NA NA
ASP C:356 C:356 27.0 0.18 T -65.5 -9.3 NA NA NA
ASP D:356 D:356 50.0 0.333 T -65.9 -7.9 NA NA NA
1kxt 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ASP A:356 A:356 22.0 0.147 T -64.5 -4.0 22.0 0.147 0.0 HOH
 2.278
 OD2
 O
ASP C:356 C:356 32.0 0.213 T -75.5 2.9 NA NA NA
ASP E:356 E:356 30.0 0.2 T -63.4 -3.1 NA NA NA
1kxv 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ASP A:356 A:356 30.0 0.2 T -73.3 -3.2 30.0 0.2 0.0 HOH
 2.889
 OD2
 O
ASP B:356 B:356 38.0 0.253 T -62.5 -7.4 NA NA NA
1dhk 1 P00690 86.9 0.0 X-RAY
 1997-12-24 ASP A:356 A:356 46.0 0.307 T -71.9 -12.8 8.0 0.053 0.254 B:P02873:0.253
 CA
HOH
 8.612
3.255
 OD2
C
 CA
H1
1ppi 1 P00690 86.9 0.0 X-RAY
 1995-05-24 ASP A:356 A:356 30.0 0.2 T -69.7 -0.1 30.0 0.2 0.0 GLC
GLC
DAF
HOH
 7.499
7.298
9.331
2.745
 OD1
OD1
O
OD2
 O3
O2
O3H
O
1vah 1 P00690 86.69 0.0 X-RAY
 2005-04-26 ASP A:356 A:356 57.0 0.38 T -72.9 0.0 57.0 0.38 0.0 NPO
HOH
 8.131
3.321
 O
O
 O3
O
3l2l 1 P00690 86.69 0.0 X-RAY
 2010-04-14 ASP A:356 A:356 36.0 0.24 T -69.8 -7.1 36.0 0.24 0.0 HOH
 3.362
 O
 O
3l2m 1 P00690 86.69 0.0 X-RAY
 2010-04-14 ASP A:356 A:356 36.0 0.24 T -69.8 -10.2 36.0 0.24 0.0 GLC
GLC
GLC
GLC
GLC
GLC
GLC
HOH
 8.029
8.710
5.307
8.956
9.959
7.212
4.271
2.362
 OD1
OD1
OD1
OD1
OD2
OD2
OD2
OD1
 HO3
O2
HO2
HO2
HO3
HO3
HO3
O
1ua3 1 P00690 86.69 0.0 X-RAY
 2003-10-14 ASP A:356 A:356 29.0 0.193 T -72.9 -1.8 29.0 0.193 0.0 GLC
GLC
GLC
HOH
 9.698
6.993
7.710
2.553
 O
OD1
OD1
OD2
 O3
O3
O2
O
1jfh 1 P00690 86.69 0.0 X-RAY
 1998-12-02 ASP A:356 A:356 40.0 0.267 T -67.9 -1.7 40.0 0.267 0.0 MA3
MA2
GLC
HOH
 7.120
7.837
9.408
2.877
 OD2
OD1
OD2
OD2
 O3
O2
O6
O
1ose 1 P00690 86.49 0.0 X-RAY
 1997-04-01 ASP A:356 A:356 28.0 0.187 T -64.7 -8.8 28.0 0.187 0.0 BGC
AC1
GLC
AC1
HOH
 9.641
9.514
7.208
7.598
2.852
 OD2
O
OD2
OD2
OD2
 O6
O3B
O3
O2
O
1hx0 1 P00690 86.49 0.0 X-RAY
 2001-08-08 ASP A:356 A:356 27.0 0.18 T -67.3 -3.0 27.0 0.18 0.0 BGC
AC1
GLC
AC1
EDO
HOH
 9.870
9.365
7.191
7.238
8.465
2.536
 OD2
O
OD2
OD1
CB
OD2
 O6
O3B
O3
O2
O2
O
1wo2 1 P00690 86.49 0.0 X-RAY
 2005-03-15 ASP A:356 A:356 33.0 0.22 T -65.5 -8.6 33.0 0.22 0.0 BGC
GLC
GLC
HOH
 9.496
6.768
7.855
2.821
 O
OD2
OD1
OD2
 O3
O3
O2
O
1bvn 1 P00690 86.49 0.0 X-RAY
 1998-09-23 ASP A:356 P:356 43.0 0.287 T -67.6 -1.2 9.0 0.06 0.227 B:P01092:0.227
 HOH
 2.831
 OD2
 O
1pif 1 P00690 86.29 0.0 X-RAY
 1996-12-07 ASP A:356 A:356 26.0 0.173 T -71.4 -5.4 26.0 0.173 0.0 HOH
 3.323
 O
 O
1pig 1 P00690 86.29 0.0 X-RAY
 1996-12-07 ASP A:356 A:356 31.0 0.207 T -64.7 -8.5 31.0 0.207 0.0 GLC
AGL
AGL
HMC
HOH
 7.023
7.380
9.877
9.346
2.864
 OD2
OD1
OD2
O
OD1
 O3
O2
C6
O3
O
4x0n 1 P00690 86.29 0.0 X-RAY
 2015-11-25 ASP A:356 A:356 44.0 0.293 T -70.2 -2.7 36.0 0.24 0.053 B:None:0.053
 GOL
HOH
 2.881
3.405
 OD2
O
 O2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04746-f1 1 P04746 100.0 0.0 ASP A:371 A:371 45.0 0.3 T -58.3 -24.2
af-p19961-f1 1 P19961 98.83 0.0 ASP A:371 A:371 44.0 0.293 T -58.8 -25.9
af-p0dte7-f1 1 P0DTE7 96.87 0.0 ASP A:371 A:371 13.0 0.087 T -59.2 -18.7
af-p0dte8-f1 1 P0DTE8 96.87 0.0 ASP A:371 A:371 16.0 0.107 T -53.2 -26.6
af-p0dub6-f1 1 P0DUB6 96.87 0.0 ASP A:371 A:371 12.0 0.08 T -56.8 -21.1