Variant
Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr10 | 115481454 | . | T | A | CCDS7580.1:NM_033338.5:c.391Ttc>Atc_NP_203124.1:p.131F>I | Homo sapiens caspase 7 (CASP7), transcript variant a, mRNA. |
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PDB
Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
5v6u | 1 | P55210 | 100.0 | 0.0 |
X-RAY |
2017-10-18 | PHE | A:98 | A:98 | 80.0 | 0.381 | H | -57.5 | -48.2 | 80.0 | 0.381 | 0.0 |
HOH |
6.176 |
C |
O |
||
PHE | B:98 | B:98 | 49.0 | 0.233 | H | -53.5 | -45.7 | 49.0 | 0.233 | 0.0 |
HOH |
7.300 |
O |
O |
|||||||||
5v6z | 1 | P55210 | 100.0 | 0.0 |
X-RAY |
2018-03-21 | PHE | A:98 | A:98 | 80.0 | 0.381 | H | -61.9 | -47.0 | 80.0 | 0.381 | 0.0 |
HOH |
9.864 |
CZ |
O |
||
PHE | B:98 | B:98 | 61.0 | 0.29 | H | -73.1 | -33.2 | 61.0 | 0.29 | 0.0 |
HOH |
5.240 |
O |
O |
|||||||||
4fdl | 1 | P55210 | 100.0 | 0.0 |
X-RAY |
2012-08-01 | PHE | A:100 | A:98 | 83.0 | 0.395 | H | -54.0 | -45.8 | 83.0 | 0.395 | 0.0 |
HOH |
5.714 |
CD2 |
O |
||
PHE | B:100 | B:98 | 41.0 | 0.195 | H | -61.0 | -41.9 | 41.0 | 0.195 | 0.0 |
HOH |
8.262 |
O |
O |
|||||||||
1kmc | 1 | P55210 | 99.67 | 0.0 |
X-RAY |
2002-01-16 | PHE | A:98 | A:190 | 51.0 | 0.243 | H | -48.0 | -49.1 | 51.0 | 0.243 | 0.0 |
HOH |
4.809 |
O |
O |
||
PHE | B:98 | B:190 | 47.0 | 0.224 | H | -47.7 | -48.7 | 47.0 | 0.224 | 0.0 | |||||||||||||
1f1j | 1 | P55210 | 99.67 | 0.0 |
X-RAY |
2001-05-23 | PHE | A:100 | A:98 | 72.0 | 0.343 | H | -63.0 | -47.2 | 72.0 | 0.343 | 0.0 |
HOH |
4.686 |
O |
O |
||
PHE | B:100 | B:398 | 55.0 | 0.262 | H | -56.3 | -54.9 | NA | NA | NA | |||||||||||||
3r5k | 1 | P55210 | 99.01 | 0.0 |
X-RAY |
2011-06-29 | PHE | A:98 | A:98 | 80.0 | 0.381 | H | -72.0 | -50.6 | 80.0 | 0.381 | 0.0 |
HOH |
7.416 |
C |
O |
||
PHE | B:98 | B:398 | 63.0 | 0.3 | H | -66.1 | -37.6 | 63.0 | 0.3 | 0.0 |
HOH |
7.154 |
CE2 |
O |
|||||||||
1i4o | 1 | P55210 | 100.0 | 0.0 |
X-RAY |
2001-03-21 | PHE | A:75 | A:98 | 85.0 | 0.405 | H | -56.9 | -55.2 | 85.0 | 0.405 | 0.0 |
HOH |
5.065 |
O |
O |
||
PHE | B:75 | B:98 | 51.0 | 0.243 | H | -60.3 | -49.9 | NA | NA | NA | |||||||||||||
1gqf | 1 | P55210 | 99.61 | 0.0 |
X-RAY |
2002-01-04 | PHE | A:52 | A:190 | 73.0 | 0.348 | H | -62.6 | -56.3 | 73.0 | 0.348 | 0.0 | ||||||
PHE | B:52 | B:190 | 44.0 | 0.21 | H | -50.7 | -53.7 | 44.0 | 0.21 | 0.0 | |||||||||||||
1shj | 1 | P55210 | 99.61 | 0.0 |
X-RAY |
2004-08-17 | PHE | A:49 | A:98 | 82.0 | 0.39 | H | -58.2 | -54.1 | 82.0 | 0.39 | 0.0 | ||||||
PHE | B:49 | B:98 | 50.0 | 0.238 | H | -65.2 | -47.4 | 50.0 | 0.238 | 0.0 | |||||||||||||
4hq0 | 1 | P55210 | 97.34 | 0.0 |
X-RAY |
2013-09-11 | PHE | A:53 | A:98 | 73.0 | 0.348 | H | -54.9 | -52.5 | 73.0 | 0.348 | 0.0 | ||||||
PHE | B:53 | B:98 | 60.0 | 0.286 | H | -65.2 | -43.8 | 60.0 | 0.286 | 0.0 | |||||||||||||
4hqr | 1 | P55210 | 97.34 | 0.0 |
X-RAY |
2013-09-11 | PHE | A:53 | A:98 | 76.0 | 0.362 | H | -65.4 | -43.3 | 76.0 | 0.362 | 0.0 | ||||||
PHE | B:53 | B:98 | 76.0 | 0.362 | H | -50.7 | -50.4 | 76.0 | 0.362 | 0.0 | |||||||||||||
1k86 | 1 | P55210 | 99.6 | 0.0 |
X-RAY |
2001-11-21 | PHE | A:48 | A:98 | 81.0 | 0.386 | H | -58.4 | -56.6 | 81.0 | 0.386 | 0.0 |
HOH |
9.685 |
CE1 |
O |
||
PHE | B:48 | B:98 | 47.0 | 0.224 | H | -63.9 | -48.2 | 47.0 | 0.224 | 0.0 |
HOH |
6.872 |
CE2 |
O |
|||||||||
3h1p | 1 | P55210 | 99.21 | 0.0 |
X-RAY |
2009-06-30 | PHE | A:49 | A:98 | 74.0 | 0.352 | H | -65.0 | -50.4 | 74.0 | 0.352 | 0.0 |
HOH |
8.946 |
CD1 |
O |
||
PHE | B:49 | B:98 | 52.0 | 0.248 | H | -61.0 | -55.0 | 52.0 | 0.248 | 0.0 |
HOH |
4.245 |
CD2 |
O |
|||||||||
1k88 | 1 | P55210 | 99.21 | 0.0 |
X-RAY |
2001-11-21 | PHE | A:48 | A:98 | 77.0 | 0.367 | H | -61.9 | -57.1 | 77.0 | 0.367 | 0.0 |
HOH |
5.942 |
N |
O |
||
PHE | B:48 | B:98 | 53.0 | 0.252 | H | -61.2 | -42.0 | 53.0 | 0.252 | 0.0 |
HOH |
5.188 |
CE1 |
O |
|||||||||
4fea | 1 | P55210 | 100.0 | 0.0 |
X-RAY |
2012-08-01 | PHE | A:42 | A:98 | 85.0 | 0.405 | H | -56.0 | -58.7 | 85.0 | 0.405 | 0.0 | ||||||
PHE | B:42 | B:98 | 53.0 | 0.252 | H | -52.8 | -51.5 | 53.0 | 0.252 | 0.0 | |||||||||||||
4jj8 | 1 | P55210 | 100.0 | 0.0 |
X-RAY |
2013-06-12 | PHE | A:42 | A:98 | 78.0 | 0.371 | H | -61.2 | -41.9 | 78.0 | 0.371 | 0.0 | ||||||
PHE | B:42 | B:98 | 58.0 | 0.276 | H | -63.4 | -37.4 | NA | NA | NA | |||||||||||||
4jr1 | 1 | P55210 | 99.6 | 0.0 |
X-RAY |
2013-05-08 | PHE | A:45 | A:98 | 56.0 | 0.267 | H | -61.3 | -42.5 | 56.0 | 0.267 | 0.0 |
HOH |
4.119 |
CE1 |
O |
||
PHE | B:45 | B:98 | 48.0 | 0.229 | H | -61.1 | -38.9 | 48.0 | 0.229 | 0.0 |
HOH |
4.441 |
CE1 |
O |
|||||||||
4jr2 | 1 | P55210 | 99.6 | 0.0 |
X-RAY |
2013-05-08 | PHE | A:45 | A:98 | 85.0 | 0.405 | H | -56.6 | -49.9 | 85.0 | 0.405 | 0.0 |
HOH |
3.747 |
CB |
O |
||
PHE | B:45 | B:98 | 75.0 | 0.357 | H | -55.2 | -47.7 | 75.0 | 0.357 | 0.0 |
HOH |
3.893 |
CD2 |
O |
|||||||||
1shl | 1 | P55210 | 95.55 | 1e-177 |
X-RAY |
2004-08-17 | PHE | A:42 | A:98 | 79.0 | 0.376 | H | -58.0 | -53.6 | 79.0 | 0.376 | 0.0 | ||||||
PHE | B:42 | B:98 | 50.0 | 0.238 | H | -64.8 | -42.9 | 50.0 | 0.238 | 0.0 | |||||||||||||
4zvo | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2016-04-20 | PHE | A:98 | A:98 | 76.0 | 0.362 | H | -62.8 | -47.7 | 76.0 | 0.362 | 0.0 | ||||||
PHE | C:98 | C:398 | 60.0 | 0.286 | H | -69.8 | -39.2 | 60.0 | 0.286 | 0.0 | |||||||||||||
4zvp | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2016-04-20 | PHE | A:98 | A:98 | 76.0 | 0.362 | H | -59.6 | -47.6 | 76.0 | 0.362 | 0.0 | ||||||
PHE | C:98 | C:398 | 48.0 | 0.229 | H | -59.8 | -49.8 | 48.0 | 0.229 | 0.0 |
HOH |
4.200 |
CZ |
O |
|||||||||
4zvq | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2016-04-20 | PHE | A:98 | A:98 | 78.0 | 0.371 | H | -59.6 | -50.3 | 78.0 | 0.371 | 0.0 |
HOH |
7.649 |
N |
O |
||
PHE | C:98 | C:398 | 48.0 | 0.229 | H | -58.8 | -53.7 | 48.0 | 0.229 | 0.0 |
HOH |
3.995 |
CZ |
O |
|||||||||
4zvr | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2016-04-20 | PHE | A:98 | A:98 | 74.0 | 0.352 | H | -64.0 | -46.8 | 74.0 | 0.352 | 0.0 |
HOH |
8.164 |
N |
O |
||
PHE | C:98 | C:398 | 60.0 | 0.286 | H | -68.8 | -38.0 | 60.0 | 0.286 | 0.0 |
HOH |
6.088 |
O |
O |
|||||||||
4zvs | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2016-04-20 | PHE | A:98 | A:98 | 74.0 | 0.352 | H | -58.3 | -50.6 | 74.0 | 0.352 | 0.0 | ||||||
PHE | C:98 | C:398 | 60.0 | 0.286 | H | -57.7 | -52.6 | 60.0 | 0.286 | 0.0 |
HOH |
4.028 |
CZ |
O |
|||||||||
4zvt | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2016-04-20 | PHE | A:98 | A:98 | 78.0 | 0.371 | H | -54.2 | -51.7 | 78.0 | 0.371 | 0.0 | ||||||
PHE | C:98 | C:398 | 66.0 | 0.314 | H | -51.5 | -53.0 | 66.0 | 0.314 | 0.0 | |||||||||||||
4zvu | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2016-04-20 | PHE | A:98 | A:98 | 75.0 | 0.357 | H | -57.7 | -48.8 | 75.0 | 0.357 | 0.0 |
HOH |
7.785 |
N |
O |
||
PHE | C:98 | C:398 | 44.0 | 0.21 | H | -61.3 | -42.0 | 44.0 | 0.21 | 0.0 |
HOH |
6.157 |
O |
O |
|||||||||
5ic6 | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2016-07-20 | PHE | A:98 | A:98 | 48.0 | 0.229 | H | -60.8 | -47.8 | 48.0 | 0.229 | 0.0 | ||||||
PHE | C:98 | C:98 | 82.0 | 0.39 | H | -61.9 | -50.0 | NA | NA | NA | |||||||||||||
5k20 | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2017-01-11 | PHE | A:98 | A:98 | 75.0 | 0.357 | H | -60.1 | -47.6 | 75.0 | 0.357 | 0.0 | ||||||
PHE | C:98 | C:398 | 46.0 | 0.219 | H | -59.3 | -47.5 | 46.0 | 0.219 | 0.0 |
HOH |
3.426 |
CE2 |
O |
|||||||||
6cl1 | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2019-03-06 | PHE | A:98 | A:98 | 76.0 | 0.362 | H | -60.4 | -49.5 | 76.0 | 0.362 | 0.0 |
HOH |
7.540 |
O |
O |
||
PHE | C:98 | C:98 | 47.0 | 0.224 | H | -62.0 | -46.8 | 47.0 | 0.224 | 0.0 |
HOH |
4.932 |
O |
O |
|||||||||
6cl2 | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2019-03-06 | PHE | A:98 | A:98 | 75.0 | 0.357 | H | -60.1 | -50.6 | 75.0 | 0.357 | 0.0 |
HOH |
5.170 |
O |
O |
||
PHE | C:98 | C:98 | 58.0 | 0.276 | H | -71.3 | -38.2 | 58.0 | 0.276 | 0.0 |
HOH |
4.836 |
O |
O |
|||||||||
6x8j | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2021-06-02 | PHE | A:98 | A:98 | 59.0 | 0.281 | H | -71.6 | -31.9 | 59.0 | 0.281 | 0.0 |
HOH |
4.640 |
CE1 |
O |
||
PHE | C:98 | B:98 | 72.0 | 0.343 | H | -64.0 | -40.0 | 72.0 | 0.343 | 0.0 |
HOH |
9.801 |
CE1 |
O |
|||||||||
6x8l | 1 | P55210 | 100.0 | 1e-146 |
X-RAY |
2021-06-02 | PHE | A:98 | A:98 | 56.0 | 0.267 | H | -54.5 | -43.1 | 56.0 | 0.267 | 0.0 |
HOH |
4.937 |
O |
O |
||
PHE | C:98 | B:98 | 73.0 | 0.348 | H | -58.4 | -48.0 | 73.0 | 0.348 | 0.0 |
HOH |
9.132 |
N |
O |
|||||||||
4jb8 | 1 | P55210 | 100.0 | 1e-128 |
X-RAY |
2013-08-21 | PHE | A:75 | A:98 | 59.0 | 0.281 | H | -55.7 | -52.2 | 20.0 | 0.095 | 0.186 |
C:None:0.186 |
HOH |
3.689 |
CE1 |
O |
|
4lsz | 1 | P55210 | 100.0 | 1e-128 |
X-RAY |
2014-07-02 | PHE | A:75 | A:98 | 53.0 | 0.252 | H | -57.0 | -44.0 | 10.0 | 0.048 | 0.204 |
E:None:0.205 |
HOH |
4.189 |
CE1 |
O |
|
PHE | C:75 | C:98 | 54.0 | 0.257 | H | -58.0 | -43.8 | 12.0 | 0.057 | 0.2 |
F:None:0.2 |
HOH |
4.026 |
CE1 |
O |
||||||||
2ql5 | 1 | P55210 | 100.0 | 4e-127 |
X-RAY |
2007-08-28 | PHE | A:75 | A:98 | 76.0 | 0.362 | H | -55.0 | -50.9 | 76.0 | 0.362 | 0.0 |
HOH |
4.902 |
O |
O |
||
PHE | C:75 | C:398 | 49.0 | 0.233 | H | -60.9 | -46.2 | 49.0 | 0.233 | 0.0 |
HOH |
4.309 |
CE1 |
O |
|||||||||
2ql7 | 1 | P55210 | 100.0 | 4e-127 |
X-RAY |
2007-08-28 | PHE | A:75 | A:98 | 76.0 | 0.362 | H | -56.3 | -52.9 | 76.0 | 0.362 | 0.0 |
HOH |
4.366 |
CE2 |
O |
||
PHE | C:75 | C:398 | 49.0 | 0.233 | H | -62.2 | -49.7 | 49.0 | 0.233 | 0.0 |
HOH |
4.213 |
CE1 |
O |
|||||||||
2ql9 | 1 | P55210 | 100.0 | 4e-127 |
X-RAY |
2007-08-28 | PHE | A:75 | A:98 | 75.0 | 0.357 | H | -56.3 | -51.9 | 75.0 | 0.357 | 0.0 |
HOH |
4.850 |
O |
O |
||
PHE | C:75 | C:398 | 46.0 | 0.219 | H | -58.0 | -50.5 | 46.0 | 0.219 | 0.0 |
HOH |
4.904 |
O |
O |
|||||||||
2qlb | 1 | P55210 | 100.0 | 4e-127 |
X-RAY |
2007-08-28 | PHE | A:75 | A:98 | 75.0 | 0.357 | H | -57.0 | -51.0 | 75.0 | 0.357 | 0.0 |
HOH |
5.234 |
O |
O |
||
PHE | C:75 | C:398 | 47.0 | 0.224 | H | -59.4 | -49.9 | 47.0 | 0.224 | 0.0 |
HOH |
4.166 |
CZ |
O |
|||||||||
2qlf | 1 | P55210 | 100.0 | 4e-127 |
X-RAY |
2007-08-28 | PHE | A:75 | A:98 | 76.0 | 0.362 | H | -56.4 | -32.4 | 76.0 | 0.362 | 0.0 |
HOH |
4.983 |
O |
O |
||
PHE | C:75 | C:398 | 47.0 | 0.224 | H | -57.4 | -48.5 | 47.0 | 0.224 | 0.0 |
HOH |
7.896 |
CE1 |
O |
|||||||||
2qlj | 1 | P55210 | 100.0 | 4e-127 |
X-RAY |
2007-08-28 | PHE | A:75 | A:98 | 74.0 | 0.352 | H | -57.2 | -46.8 | 74.0 | 0.352 | 0.0 |
HOH |
9.524 |
N |
O |
||
PHE | C:75 | C:398 | 50.0 | 0.238 | H | -60.0 | -48.6 | 50.0 | 0.238 | 0.0 |
HOH |
9.232 |
N |
O |
|||||||||
3edr | 1 | P55210 | 100.0 | 4e-127 |
X-RAY |
2008-10-28 | PHE | A:75 | A:98 | 75.0 | 0.357 | H | -61.2 | -48.5 | 75.0 | 0.357 | 0.0 |
HOH |
8.848 |
N |
O |
||
PHE | C:75 | C:398 | 48.0 | 0.229 | H | -58.1 | -52.8 | 48.0 | 0.229 | 0.0 |
HOH |
9.216 |
N |
O |
|||||||||
3ibc | 1 | P55210 | 100.0 | 4e-127 |
X-RAY |
2009-09-01 | PHE | A:75 | A:98 | 76.0 | 0.362 | H | -57.7 | -52.7 | 76.0 | 0.362 | 0.0 |
HOH |
9.294 |
N |
O |
||
PHE | C:75 | C:398 | 59.0 | 0.281 | H | -62.1 | -53.4 | 59.0 | 0.281 | 0.0 |
HOH |
9.437 |
N |
O |
|||||||||
3ibf | 1 | P55210 | 100.0 | 4e-127 |
X-RAY |
2009-09-01 | PHE | A:75 | A:98 | 73.0 | 0.348 | H | -62.1 | -42.2 | 73.0 | 0.348 | 0.0 |
HOH |
9.050 |
CD1 |
O |
||
PHE | C:75 | C:398 | 51.0 | 0.243 | H | -57.8 | -48.6 | 51.0 | 0.243 | 0.0 |
HOH |
5.565 |
CE1 |
O |
|||||||||
1i51 | 1 | P55210 | 99.32 | 6e-107 |
X-RAY |
2002-02-23 | PHE | A:48 | A:98 | 82.0 | 0.39 | H | -59.1 | -56.0 | 82.0 | 0.39 | 0.0 | ||||||
PHE | C:48 | C:98 | 68.0 | 0.324 | H | -63.4 | -49.5 | 68.0 | 0.324 | 0.0 |
AlphaFold DB
Entity | Residue | Monomer | View | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
af-p55210-f1 | 1 | P55210 | 100.0 | 0.0 | PHE | A:98 | A:98 | 67.0 | 0.319 | H | -58.3 | -49.6 |