Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr21 | 42622746 | . | C | A | CCDS13668.1:NM_012105.4:c.1052cCt>cAt_NP_036237.2:p.351P>H | Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6uj0 | 1 | Q9Y5Z0 | 99.78 | 0.0 |
X-RAY |
2020-10-07 | PRO | A:351 | A:289 | 2.0 | 0.014 | G | -77.0 | 1.4 | 2.0 | 0.014 | 0.0 |
HOH |
9.133 |
CD |
O |
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| PRO | B:351 | B:289 | 0.0 | 0.0 | G | -79.7 | -5.7 | NA | NA | NA | |||||||||||||
| 6uj1 | 1 | Q9Y5Z0 | 99.78 | 0.0 |
X-RAY |
2020-10-07 | PRO | A:351 | A:289 | 0.0 | 0.0 | G | -73.7 | -8.4 | 0.0 | 0.0 | 0.0 | ||||||
| PRO | B:351 | B:289 | 0.0 | 0.0 | G | -78.3 | -4.5 | NA | NA | NA | |||||||||||||
| 3zkm | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | PRO | A:277 | A:289 | 5.0 | 0.034 | S | -83.4 | -2.8 | 0.0 | 0.0 | 0.034 |
F:None:0.034 |
DMS HOH |
7.258 4.107 |
CB C |
O O |
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| PRO | B:277 | B:289 | 6.0 | 0.041 | S | -82.5 | -3.6 | NA | NA | NA | |||||||||||||
| 3zkn | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | PRO | A:277 | A:289 | 4.0 | 0.028 | S | -80.5 | -6.8 | NA | NA | NA | ||||||
| PRO | B:277 | B:289 | 4.0 | 0.028 | S | -84.8 | 0.2 | 0.0 | 0.0 | 0.028 |
D:None:0.028 |
DMS HOH |
6.985 3.801 |
CB C |
C2 O |
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| 3zkq | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | PRO | A:277 | A:289 | 20.0 | 0.138 | -83.6 | 66.2 | 20.0 | 0.138 | 0.0 |
HOH |
7.774 |
O |
O |
|||
| 3zks | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | PRO | A:277 | A:289 | 67.0 | 0.462 | 360.0 | 66.2 | 67.0 | 0.462 | 0.0 | |||||||
| 4bel | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | PRO | A:277 | A:289 | 64.0 | 0.441 | 360.0 | -44.2 | 64.0 | 0.441 | 0.0 |
HOH |
7.031 |
C |
O |
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| PRO | B:277 | B:289 | 0.0 | 0.0 | G | -65.4 | -18.0 | NA | NA | NA | |||||||||||||
| 4bfb | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | PRO | A:277 | A:289 | 6.0 | 0.041 | G | -62.8 | -14.1 | 6.0 | 0.041 | 0.0 |
HOH |
3.430 |
CD |
O |
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| PRO | B:277 | B:289 | 1.0 | 0.007 | G | -64.6 | -1.3 | NA | NA | NA | |||||||||||||
| 6jsz | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2019-08-28 | PRO | A:277 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 7d5b | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-03-31 | PRO | A:277 | A:289 | 0.0 | 0.0 | -79.3 | -11.8 | 0.0 | 0.0 | 0.0 |
HOH |
8.350 |
O |
O |
|||
| 7d5u | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-03-31 | PRO | A:277 | A:289 | 2.0 | 0.014 | S | -75.9 | -11.4 | 2.0 | 0.014 | 0.0 |
HOH |
9.182 |
CB |
O |
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| 7n4n | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-10-06 | PRO | A:277 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 3zkg | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | PRO | A:277 | A:289 | 0.0 | 0.0 | G | -69.9 | -10.0 | 0.0 | 0.0 | 0.0 |
HOH |
4.067 |
N |
O |
||
| PRO | B:277 | B:289 | 8.0 | 0.055 | G | -76.9 | -12.7 | NA | NA | NA | |||||||||||||
| 3zki | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | PRO | A:277 | A:289 | 1.0 | 0.007 | G | -62.8 | -21.1 | 1.0 | 0.007 | 0.0 |
HOH |
4.169 |
N |
O |
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| PRO | B:277 | B:289 | 10.0 | 0.069 | -77.5 | -14.9 | NA | NA | NA | ||||||||||||||
| 3zkx | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | PRO | A:277 | A:289 | 0.0 | 0.0 | S | -84.5 | -23.5 | 0.0 | 0.0 | 0.0 |
HOH |
4.642 |
N |
O |
||
| 3zl7 | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | PRO | A:277 | A:289 | 0.0 | 0.0 | G | -78.3 | -8.9 | 0.0 | 0.0 | 0.0 |
HOH |
6.279 |
O |
O |
||
| 3zlq | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-01 | PRO | A:277 | A:289 | 12.0 | 0.083 | G | -77.7 | -34.1 | 12.0 | 0.083 | 0.0 |
HOH |
2.750 |
CD |
O |
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| PRO | B:277 | B:289 | 3.0 | 0.021 | G | -41.9 | -39.3 | 3.0 | 0.021 | 0.0 |
HOH |
2.940 |
N |
O |
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| 2ewy | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2006-11-07 | PRO | A:274 | A:289 | 2.0 | 0.014 | G | -84.2 | 21.1 | 2.0 | 0.014 | 0.0 |
HOH |
6.692 |
CB |
O |
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| PRO | B:274 | B:289 | 2.0 | 0.014 | G | -84.3 | 21.1 | NA | NA | NA | |||||||||||||
| PRO | C:274 | C:289 | 2.0 | 0.014 | G | -84.3 | 21.2 | NA | NA | NA | |||||||||||||
| PRO | D:274 | D:289 | 2.0 | 0.014 | G | -84.2 | 21.1 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9y5z0-f1 | 1 | Q9Y5Z0 | 100.0 | 0.0 | PRO | A:351 | A:351 | 0.0 | 0.0 | S | -77.4 | -13.1 | |