Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr21 | 42622808 | . | C | A | CCDS13668.1:NM_012105.4:c.1114Cgt>Agt_NP_036237.2:p.372R>S | Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6uj0 | 1 | Q9Y5Z0 | 99.78 | 0.0 |
X-RAY |
2020-10-07 | ARG | A:372 | A:310 | 64.0 | 0.284 | E | -128.2 | 136.8 | 64.0 | 0.284 | 0.0 |
HOH |
2.743 |
NE |
O |
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| ARG | B:372 | B:310 | 63.0 | 0.28 | E | -128.2 | 137.3 | NA | NA | NA | |||||||||||||
| 6uj1 | 1 | Q9Y5Z0 | 99.78 | 0.0 |
X-RAY |
2020-10-07 | ARG | A:372 | A:310 | 48.0 | 0.213 | E | -139.7 | 138.0 | 48.0 | 0.213 | 0.0 | ||||||
| ARG | B:372 | B:310 | 50.0 | 0.222 | E | -138.5 | 133.6 | NA | NA | NA | |||||||||||||
| 3zkm | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | ARG | A:298 | A:310 | 58.0 | 0.258 | E | -122.8 | 125.3 | 58.0 | 0.258 | 0.0 |
HOH |
3.045 |
NE |
O |
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| ARG | B:298 | B:310 | 58.0 | 0.258 | E | -128.5 | 136.0 | NA | NA | NA | |||||||||||||
| 3zkn | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | ARG | A:298 | A:310 | 54.0 | 0.24 | E | -132.5 | 119.1 | NA | NA | NA | ||||||
| ARG | B:298 | B:310 | 51.0 | 0.227 | E | -140.4 | 124.4 | 51.0 | 0.227 | 0.0 |
HOH |
2.704 |
NE |
O |
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| 3zkq | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | ARG | A:298 | A:310 | 64.0 | 0.284 | E | -124.3 | 140.5 | 64.0 | 0.284 | 0.0 |
HOH |
2.868 |
NE |
O |
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| 3zks | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | ARG | A:298 | A:310 | 56.0 | 0.249 | E | -119.8 | 133.3 | 56.0 | 0.249 | 0.0 |
HOH |
6.382 |
NH2 |
O |
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| 4bel | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | ARG | A:298 | A:310 | 63.0 | 0.28 | E | -129.6 | 139.5 | 63.0 | 0.28 | 0.0 |
HOH |
3.019 |
NE |
O |
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| ARG | B:298 | B:310 | 62.0 | 0.276 | E | -125.8 | 139.6 | NA | NA | NA | |||||||||||||
| 4bfb | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2013-05-29 | ARG | A:298 | A:310 | 55.0 | 0.244 | E | -125.1 | 123.1 | 55.0 | 0.244 | 0.0 |
HOH |
2.578 |
NE |
O |
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| ARG | B:298 | B:310 | 58.0 | 0.258 | E | -123.1 | 138.9 | NA | NA | NA | |||||||||||||
| 6jsz | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2019-08-28 | ARG | A:298 | A:310 | 64.0 | 0.284 | E | -109.3 | 135.6 | 64.0 | 0.284 | 0.0 |
HOH |
3.244 |
NE |
O |
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| 7d5b | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-03-31 | ARG | A:298 | A:310 | 64.0 | 0.284 | E | -121.7 | 136.5 | 64.0 | 0.284 | 0.0 |
HOH |
3.003 |
NE |
O |
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| 7d5u | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-03-31 | ARG | A:298 | A:310 | 62.0 | 0.276 | E | -129.1 | 134.2 | 62.0 | 0.276 | 0.0 |
HOH |
3.080 |
NE |
O |
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| 7n4n | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2021-10-06 | ARG | A:298 | A:310 | 66.0 | 0.293 | E | -123.3 | 137.7 | 66.0 | 0.293 | 0.0 |
HOH |
2.412 |
HE |
O |
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| 3zkg | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | ARG | A:298 | A:310 | 58.0 | 0.258 | E | -133.4 | 128.9 | 58.0 | 0.258 | 0.0 |
HOH |
3.632 |
NH1 |
O |
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| ARG | B:298 | B:310 | 60.0 | 0.267 | E | -128.7 | 125.1 | NA | NA | NA | |||||||||||||
| 3zki | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | ARG | A:298 | A:310 | 60.0 | 0.267 | E | -125.5 | 143.3 | 60.0 | 0.267 | 0.0 |
HOH |
4.170 |
NH1 |
O |
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| ARG | B:298 | B:310 | 61.0 | 0.271 | E | -127.3 | 116.7 | NA | NA | NA | |||||||||||||
| 3zkx | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | ARG | A:298 | A:310 | 59.0 | 0.262 | E | -122.7 | 139.6 | 59.0 | 0.262 | 0.0 |
HOH |
2.839 |
NE |
O |
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| 3zl7 | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-29 | ARG | A:298 | A:310 | 52.0 | 0.231 | E | -135.2 | 130.2 | 52.0 | 0.231 | 0.0 | ||||||
| 3zlq | 1 | Q9Y5Z0 | 99.74 | 0.0 |
X-RAY |
2013-05-01 | ARG | A:298 | A:310 | 65.0 | 0.289 | E | -114.3 | 134.2 | 65.0 | 0.289 | 0.0 |
HOH |
8.442 |
CB |
O |
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| ARG | B:298 | B:310 | 63.0 | 0.28 | E | -129.3 | 119.5 | 63.0 | 0.28 | 0.0 |
HOH |
9.251 |
CB |
O |
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| 2ewy | 1 | Q9Y5Z0 | 100.0 | 0.0 |
X-RAY |
2006-11-07 | ARG | A:295 | A:310 | 59.0 | 0.262 | E | -137.7 | 137.5 | 59.0 | 0.262 | 0.0 |
HOH |
2.855 |
NE |
O |
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| ARG | B:295 | B:310 | 59.0 | 0.262 | E | -137.8 | 137.5 | NA | NA | NA | |||||||||||||
| ARG | C:295 | C:310 | 58.0 | 0.258 | E | -137.7 | 137.5 | NA | NA | NA | |||||||||||||
| ARG | D:295 | D:310 | 57.0 | 0.253 | E | -137.7 | 137.5 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9y5z0-f1 | 1 | Q9Y5Z0 | 100.0 | 0.0 | ARG | A:372 | A:372 | 62.0 | 0.276 | E | -121.5 | 138.4 | |