Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr22 | 30057316 | . | C | A | CCDS13861.1:NM_000268.3:c.798taC>taA_NP_000259.1:p.266Y>* | Homo sapiens neurofibromin 2 (NF2), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6cds | 1 | P35240 | 99.71 | 0.0 |
X-RAY |
2018-07-18 | TYR | A:266 | A:266 | 70.0 | 0.304 | E | -121.7 | 136.5 | 70.0 | 0.304 | 0.0 |
HOH |
3.596 |
N |
O |
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| TYR | B:266 | B:266 | 66.0 | 0.287 | E | -121.4 | 136.2 | NA | NA | NA | |||||||||||||
| 7lwh | 1 | P35240 | 99.41 | 0.0 |
X-RAY |
2021-08-11 | TYR | A:266 | A:266 | 75.0 | 0.326 | E | -137.4 | 133.7 | 75.0 | 0.326 | 0.0 |
IMD HOH |
8.580 2.712 |
N OH |
N3 O |
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| 1isn | 1 | P46662 | 99.38 | 0.0 |
X-RAY |
2002-04-03 | TYR | A:249 | A:266 | 78.0 | 0.339 | E | -160.1 | 101.3 | 78.0 | 0.339 | 0.0 | ||||||
| 4zrj | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2015-06-17 | TYR | A:266 | A:266 | 81.0 | 0.352 | E | -144.9 | 141.2 | 81.0 | 0.352 | 0.0 |
GOL HOH |
8.078 4.140 |
OH CA |
O1 O |
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| 4zri | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2015-06-17 | TYR | A:270 | A:266 | 68.0 | 0.296 | E | -112.8 | 136.7 | 68.0 | 0.296 | 0.0 | ||||||
| TYR | B:270 | B:266 | 87.0 | 0.378 | E | -132.5 | 146.3 | NA | NA | NA | |||||||||||||
| 4zrk | 1 | P46662 | 99.38 | 0.0 |
X-RAY |
2015-06-17 | TYR | A:270 | A:266 | 72.0 | 0.313 | E | -126.3 | 131.3 | 72.0 | 0.313 | 0.0 |
HOH |
6.410 |
N |
O |
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| TYR | B:270 | B:266 | 59.0 | 0.257 | E | -125.3 | 133.8 | NA | NA | NA | |||||||||||||
| TYR | C:270 | C:266 | 82.0 | 0.357 | E | -127.6 | 130.9 | NA | NA | NA | |||||||||||||
| TYR | D:270 | D:266 | 64.0 | 0.278 | E | -127.4 | 131.9 | NA | NA | NA | |||||||||||||
| 1h4r | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2002-01-16 | TYR | A:267 | A:266 | 64.0 | 0.278 | E | -145.1 | 152.2 | 64.0 | 0.278 | 0.0 |
HOH |
2.156 |
O |
O |
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| TYR | B:267 | B:266 | 65.0 | 0.283 | E | -141.8 | 136.4 | 65.0 | 0.283 | 0.0 |
HOH |
3.003 |
N |
O |
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| 4p7i | 1 | P46662 | 99.36 | 0.0 |
X-RAY |
2014-04-09 | TYR | A:270 | A:266 | 70.0 | 0.304 | E | -142.9 | 137.8 | 24.0 | 0.104 | 0.2 |
C:Q9Y4B6:0.2 |
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| TYR | B:270 | B:266 | 73.0 | 0.317 | E | -153.3 | 136.8 | NA | NA | NA | |||||||||||||
| 3u8z | 1 | P35240 | 100.0 | 0.0 |
X-RAY |
2011-11-02 | TYR | A:254 | A:266 | 66.0 | 0.287 | E | -140.7 | 125.1 | 12.0 | 0.052 | 0.235 |
C:P35240:0.235 |
HOH |
4.078 |
CE2 |
O |
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| TYR | B:254 | B:266 | 74.0 | 0.322 | E | -133.9 | 128.6 | NA | NA | NA | |||||||||||||
| TYR | C:254 | C:266 | 66.0 | 0.287 | E | -136.8 | 134.9 | 16.0 | 0.07 | 0.217 |
A:P35240:0.217 |
HOH |
3.891 |
CA |
O |
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| TYR | D:254 | D:266 | 81.0 | 0.352 | E | -131.8 | 129.1 | NA | NA | NA | |||||||||||||
| 3wa0 | 1 | P46662 | 99.32 | 0.0 |
X-RAY |
2014-05-28 | TYR | A:253 | A:266 | 85.0 | 0.37 | E | -137.2 | 125.7 | 13.0 | 0.057 | 0.313 |
G:Q9Y4B6:0.313 |
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| TYR | B:253 | B:266 | 69.0 | 0.3 | E | -134.1 | 116.3 | NA | NA | NA | |||||||||||||
| TYR | C:253 | C:266 | 81.0 | 0.352 | E | -139.6 | 124.8 | NA | NA | NA | |||||||||||||
| TYR | D:253 | D:266 | 80.0 | 0.348 | E | -134.0 | 117.0 | NA | NA | NA | |||||||||||||
| TYR | E:253 | E:266 | 81.0 | 0.352 | E | -140.5 | 127.8 | NA | NA | NA | |||||||||||||
| TYR | F:253 | F:266 | 70.0 | 0.304 | E | -134.0 | 122.7 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p35240-f1 | 1 | P35240 | 100.0 | 0.0 | TYR | A:266 | A:266 | 70.0 | 0.304 | E | -143.0 | 154.9 | |