Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10183722 . G A CCDS2597.1:NM_000551.3:c.191cGc>cAc_NP_000542.1:p.64R>H Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 ARG A:84 A:64 87.0 0.387 -160.3 160.3 87.0 0.387 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 ARG C:48 C:64 76.0 0.338 S -150.1 162.5 76.0 0.338 0.0 8KH
9.942
C
O2
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 ARG C:22 C:64 85.0 NA -149.3 159.1 85.0 NA NA HOH
4.863
N
O
ARG F:22 F:64 132.0 0.587 -150.7 162.2 NA NA NA
ARG I:22 I:64 82.0 NA -150.8 159.8 NA NA NA
ARG L:22 L:64 122.0 0.542 -150.4 161.6 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 ARG C:13 C:64 90.0 0.4 -172.0 156.6 90.0 0.4 0.0 HOH
4.265
O
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 ARG C:13 C:64 157.0 0.698 -136.9 168.6 157.0 0.698 0.0 HOH
9.933
C
O
ARG F:13 F:64 144.0 0.64 -159.1 169.4 NA NA NA
ARG I:13 I:64 156.0 0.693 -147.6 172.2 NA NA NA
ARG L:13 L:64 153.0 0.68 -134.6 166.5 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 ARG C:13 C:64 162.0 0.72 -105.2 172.9 162.0 0.72 0.0 HOH
3.521
O
O
ARG F:13 F:64 173.0 0.769 -146.8 171.9 NA NA NA
ARG I:13 I:64 44.0 NA -143.7 171.0 NA NA NA
ARG L:13 L:64 138.0 0.613 -148.1 172.8 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 ARG C:13 C:64 151.0 0.671 -146.8 161.3 151.0 0.671 0.0 HOH
4.144
O
O
ARG F:13 F:64 168.0 0.747 -148.4 162.2 NA NA NA
ARG I:13 I:64 140.0 0.622 -149.1 163.7 NA NA NA
ARG L:13 L:64 134.0 0.596 -149.2 162.3 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 ARG C:13 C:64 128.0 0.569 -152.1 165.0 128.0 0.569 0.0 HOH
4.642
O
O
ARG F:13 F:64 37.0 NA -151.5 164.9 NA NA NA
ARG I:13 I:64 121.0 0.538 -152.5 167.3 NA NA NA
ARG L:13 L:64 128.0 0.569 -154.0 168.2 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:13 C:64 126.0 0.56 -150.8 158.7 126.0 0.56 0.0 HOH
4.476
O
O
ARG F:13 F:64 35.0 NA -143.8 152.6 NA NA NA
ARG I:13 I:64 130.0 0.578 -152.8 162.6 NA NA NA
ARG L:13 L:64 128.0 0.569 -152.9 160.1 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:13 C:64 125.0 0.556 -152.6 157.2 125.0 0.556 0.0 HOH
7.794
NH1
O
ARG F:13 F:64 30.0 NA -152.6 154.3 NA NA NA
ARG I:13 I:64 131.0 0.582 -146.9 166.1 NA NA NA
ARG L:13 L:64 131.0 0.582 -152.1 159.2 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:13 C:64 136.0 0.604 -142.1 160.7 136.0 0.604 0.0 HOH
7.999
CB
O
ARG F:13 F:64 36.0 NA -142.8 162.4 NA NA NA
ARG I:13 I:64 130.0 0.578 -143.9 171.1 NA NA NA
ARG L:13 L:64 128.0 0.569 -146.8 167.7 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:13 C:64 73.0 NA -149.9 154.2 73.0 NA NA HOH
3.206
CD
O
ARG F:13 F:64 84.0 NA -160.9 159.2 NA NA NA
ARG I:13 I:64 81.0 NA -147.7 162.1 NA NA NA
ARG L:13 L:64 82.0 NA -147.9 160.5 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:13 C:64 139.0 0.618 -144.3 151.9 139.0 0.618 0.0 HOH
7.503
CB
O
ARG F:13 F:64 33.0 NA -139.5 165.5 NA NA NA
ARG I:13 I:64 136.0 0.604 -152.4 168.8 NA NA NA
ARG L:13 L:64 132.0 0.587 -150.2 171.6 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:13 C:64 124.0 0.551 -151.4 157.2 124.0 0.551 0.0 HOH
4.942
O
O
ARG F:13 F:64 28.0 NA -159.3 155.9 NA NA NA
ARG I:13 I:64 126.0 0.56 -156.3 165.9 NA NA NA
ARG L:13 L:64 124.0 0.551 -156.8 162.1 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:13 C:64 137.0 0.609 -150.0 158.3 137.0 0.609 0.0 HOH
8.063
CB
O
ARG F:13 F:64 29.0 NA -140.2 161.7 NA NA NA
ARG I:13 I:64 133.0 0.591 -148.6 174.2 NA NA NA
ARG L:13 L:64 133.0 0.591 -147.1 162.5 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:13 C:64 119.0 0.529 -147.9 157.3 119.0 0.529 0.0 3JH
HOH
9.341
6.405
NH1
N
OAC
O
ARG F:13 F:64 30.0 NA -146.9 147.8 NA NA NA
ARG I:13 I:64 131.0 0.582 -148.2 163.2 NA NA NA
ARG L:13 L:64 118.0 0.524 -154.3 154.6 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:13 C:64 122.0 0.542 -140.3 150.4 122.0 0.542 0.0 HOH
7.852
CB
O
ARG F:13 F:64 31.0 NA -144.9 157.5 NA NA NA
ARG I:13 I:64 133.0 0.591 -150.4 164.1 NA NA NA
ARG L:13 L:64 123.0 0.547 -152.6 160.8 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:13 C:64 118.0 0.524 -139.7 158.0 118.0 0.524 0.0 3JJ
HOH
9.358
7.710
NH1
NH1
OAC
O
ARG F:13 F:64 31.0 NA -143.5 150.3 NA NA NA
ARG I:13 I:64 128.0 0.569 -147.7 164.8 NA NA NA
ARG L:13 L:64 121.0 0.538 -149.7 158.0 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 ARG C:13 C:64 129.0 0.573 -162.1 156.5 129.0 0.573 0.0 HOH
4.562
O
O
ARG F:13 F:64 30.0 NA -158.7 161.5 NA NA NA
ARG I:13 I:64 130.0 0.578 -147.5 166.2 NA NA NA
ARG L:13 L:64 127.0 0.564 -153.4 163.2 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:13 C:64 119.0 0.529 -153.7 156.0 119.0 0.529 0.0 HOH
4.602
O
O
ARG F:13 F:64 30.0 NA -154.0 156.0 NA NA NA
ARG I:13 I:64 130.0 0.578 -149.7 163.0 NA NA NA
ARG L:13 L:64 127.0 0.564 -156.6 157.4 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:13 C:64 116.0 0.516 -160.3 153.9 116.0 0.516 0.0 HOH
4.532
O
O
ARG F:13 F:64 27.0 NA -156.9 150.3 NA NA NA
ARG I:13 I:64 124.0 0.551 -156.5 160.3 NA NA NA
ARG L:13 L:64 124.0 0.551 -153.5 159.8 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:13 C:64 121.0 0.538 -159.1 155.6 121.0 0.538 0.0 HOH
4.563
O
O
ARG F:13 F:64 29.0 NA -151.6 151.6 NA NA NA
ARG I:13 I:64 124.0 0.551 -155.1 165.4 NA NA NA
ARG L:13 L:64 126.0 0.56 -156.7 160.4 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:13 C:64 136.0 0.604 -140.2 158.0 136.0 0.604 0.0 HOH
3.017
NE
O
ARG F:13 F:64 138.0 0.613 -146.4 153.5 NA NA NA
ARG I:13 I:64 125.0 0.556 -141.2 176.4 NA NA NA
ARG L:13 L:64 132.0 0.587 -151.1 164.8 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:13 C:64 128.0 0.569 -160.3 153.4 128.0 0.569 0.0 HOH
7.578
NH1
O
ARG F:13 F:64 34.0 NA -143.5 157.3 NA NA NA
ARG I:13 I:64 124.0 0.551 -149.0 170.1 NA NA NA
ARG L:13 L:64 129.0 0.573 -154.4 165.0 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:13 C:64 118.0 0.524 -161.0 156.4 118.0 0.524 0.0 HOH
4.692
O
O
ARG F:13 F:64 30.0 NA -152.5 156.6 NA NA NA
ARG I:13 I:64 128.0 0.569 -157.6 165.8 NA NA NA
ARG L:13 L:64 127.0 0.564 -152.8 162.7 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:13 C:64 118.0 0.524 -157.2 154.9 118.0 0.524 0.0 HOH
4.599
O
O
ARG F:13 F:64 31.0 NA -144.3 155.0 NA NA NA
ARG I:13 I:64 127.0 0.564 -156.2 167.3 NA NA NA
ARG L:13 L:64 126.0 0.56 -153.9 159.6 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:13 C:64 124.0 0.551 -153.7 154.8 124.0 0.551 0.0 HOH
2.673
O
O
ARG F:13 F:64 29.0 NA -144.3 162.0 NA NA NA
ARG I:13 I:64 128.0 0.569 -141.3 170.9 NA NA NA
ARG L:13 L:64 131.0 0.582 -151.8 160.9 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 ARG D:13 D:64 118.0 0.524 -166.5 156.6 118.0 0.524 0.0 HOH
9.819
C
O
ARG H:13 H:64 127.0 0.564 -166.1 155.9 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 ARG A:13 V:64 84.0 0.373 -163.4 152.9 84.0 0.373 0.0 HOH
4.516
O
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 ARG C:13 C:64 133.0 0.591 -159.6 151.9 133.0 0.591 0.0 HOH
8.214
CB
O
ARG F:13 F:64 33.0 NA -149.9 156.2 NA NA NA
ARG I:13 I:64 128.0 0.569 -154.1 168.4 NA NA NA
ARG L:13 L:64 125.0 0.556 -155.8 167.5 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 ARG C:13 C:64 112.0 0.498 -159.5 156.0 112.0 0.498 0.0 HOH
3.257
NH1
O
ARG F:13 F:64 32.0 NA -149.7 152.1 NA NA NA
ARG I:13 I:64 129.0 0.573 -153.9 156.4 NA NA NA
ARG L:13 L:64 124.0 0.551 -155.7 160.1 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 ARG C:13 C:64 136.0 0.604 -146.2 137.1 136.0 0.604 0.0 HOH
3.273
CG
O
ARG F:13 F:64 41.0 NA -149.6 149.3 NA NA NA
ARG L:13 L:64 138.0 0.613 -152.1 153.0 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 ARG I:13 I:64 130.0 0.578 -153.0 156.7 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 ARG C:13 C:64 158.0 0.702 -150.6 171.1 158.0 0.702 0.0 HOH
7.647
CB
O
ARG F:13 F:64 159.0 0.707 -145.7 167.1 NA NA NA
ARG I:13 I:64 128.0 0.569 -145.3 161.9 NA NA NA
ARG L:13 L:64 127.0 0.564 -143.3 160.7 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 ARG C:13 C:64 129.0 0.573 -147.1 167.1 129.0 0.573 0.0 HOH
7.516
CB
O
ARG F:13 F:64 155.0 0.689 -138.3 159.2 NA NA NA
ARG I:13 I:64 121.0 0.538 -138.3 159.4 NA NA NA
ARG L:13 L:64 120.0 0.533 -144.0 155.7 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 ARG B:13 B:64 84.0 0.373 -166.9 173.2 84.0 0.373 0.0 HOH
2.754
NE
O
ARG F:13 F:64 113.0 0.502 S -164.1 162.4 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 ARG B:13 B:64 81.0 0.36 -160.1 161.8 81.0 0.36 0.0 HOH
2.788
NE
O
ARG F:13 F:64 80.0 0.356 -160.3 160.7 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 ARG D:13 D:64 112.0 0.498 -158.3 153.3 112.0 0.498 0.0
ARG H:13 H:64 110.0 0.489 -158.0 153.2 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 ARG D:13 L:64 95.0 0.422 -156.5 157.2 95.0 0.422 0.0 VKA
HOH
9.116
3.938
NH2
NH1
C38
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 ARG C:13 L:64 117.0 0.52 -155.9 152.8 117.0 0.52 0.0 HOH
2.287
NH1
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 ARG C:14 C:64 87.0 NA -126.0 161.2 87.0 NA NA
ARG F:14 F:64 30.0 NA -154.7 178.1 NA NA NA
ARG I:14 I:64 137.0 0.609 -131.2 163.8 NA NA NA
ARG L:14 L:64 137.0 0.609 -145.6 163.9 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 ARG C:14 C:64 93.0 NA -130.9 156.5 93.0 NA NA
ARG F:14 F:64 157.0 0.698 -151.6 166.0 NA NA NA
ARG I:14 I:64 114.0 0.507 -153.0 168.0 NA NA NA
ARG L:14 L:64 136.0 0.604 -118.0 157.6 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 ARG C:14 C:64 90.0 NA -138.0 165.3 90.0 NA NA HOH
9.883
NE
O
ARG F:14 F:64 151.0 0.671 -145.2 178.0 NA NA NA
ARG I:14 I:64 121.0 0.538 -150.2 171.0 NA NA NA
ARG L:14 L:64 78.0 NA -141.0 157.2 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 ARG C:14 C:64 86.0 NA -128.7 160.0 86.0 NA NA HOH
8.463
CB
O
ARG F:14 F:64 159.0 0.707 -139.7 170.3 NA NA NA
ARG I:14 I:64 129.0 0.573 S -146.1 174.6 NA NA NA
ARG L:14 L:64 84.0 NA S -132.2 168.2 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 ARG D:14 V:64 78.0 0.347 -161.3 154.3 78.0 0.347 0.0 HOH
2.810
O
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 ARG C:14 C:64 71.0 NA -118.9 166.4 71.0 NA NA HOH
3.995
CD
O
ARG F:14 F:64 157.0 0.698 -147.4 170.8 NA NA NA
ARG I:14 I:64 125.0 0.556 -156.2 169.9 NA NA NA
ARG L:14 L:64 134.0 0.596 -151.1 166.4 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 ARG D:14 V:64 77.0 0.342 -167.5 157.2 77.0 0.342 0.0 HOH
2.789
O
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 ARG C:11 V:64 77.0 0.342 -161.0 160.0 73.0 0.324 0.018 D:Q16665:0.018
HOH
2.659
O
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 ARG C:11 C:64 149.0 0.662 -142.4 168.1 149.0 0.662 0.0 HOH
3.757
O
O
ARG F:11 F:64 150.0 0.667 -143.1 169.8 NA NA NA
ARG I:11 I:64 152.0 0.676 -144.3 169.8 NA NA NA
ARG L:11 L:64 152.0 0.676 -142.5 169.1 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 ARG B:11 NA:NA DO NA DO DO DO NA NA NA
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 ARG C:11 C:64 89.0 0.396 -160.0 153.9 89.0 0.396 0.0 HOH
2.715
O
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 ARG D:11 V:64 87.0 0.387 -150.1 153.9 87.0 0.387 0.0 HOH
2.454
HH12
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 ARG D:11 V:64 84.0 0.373 -155.2 155.3 84.0 0.373 0.0 HOH
2.471
HH12
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 ARG I:11 V:64 34.0 0.151 -162.7 158.2 34.0 0.151 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 ARG C:26 C:64 99.0 0.44 -159.4 164.8 99.0 0.44 0.0 HOH
3.140
NH1
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 ARG A:14 A:64 73.0 0.324 -160.7 150.6 73.0 0.324 0.0
ARG E:14 E:64 89.0 0.396 -160.3 150.0 NA NA NA
ARG I:14 I:64 110.0 0.489 -163.0 150.7 NA NA NA
ARG M:14 M:64 113.0 0.502 -162.6 152.4 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 ARG A:6 AAA:64 72.0 0.32 -157.1 154.9 71.0 0.316 0.004 D:Q07817:0.004
QL8
EDO
IOD
IOD
IOD
HOH
9.307
8.786
6.008
8.985
6.825
2.622
NE
N
NE
O
CD
O
C48
C1
I
I
I
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 ARG A:6 AAA:64 79.0 0.351 -152.6 158.1 79.0 0.351 0.0 7QB
HOH
9.976
4.670
C
N
O4
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 ARG C:13 C:64 117.0 0.52 -164.0 162.4 117.0 0.52 0.0 HOH
6.681
N
O
ARG F:13 F:64 151.0 0.671 -143.3 151.9 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 ARG C:13 C:64 132.0 0.587 -149.7 161.1 132.0 0.587 0.0 HOH
4.989
O
O
ARG F:13 F:64 31.0 NA -144.5 162.6 NA NA NA
ARG I:13 I:64 127.0 0.564 -147.5 171.6 NA NA NA
ARG L:13 L:64 129.0 0.573 -154.3 166.5 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 ARG C:13 C:64 133.0 0.591 -155.5 151.7 133.0 0.591 0.0 HOH
2.750
NH2
O
ARG F:13 F:64 138.0 0.613 -151.1 150.4 NA NA NA
ARG I:13 I:64 135.0 0.6 -143.9 169.9 NA NA NA
ARG L:13 L:64 129.0 0.573 -153.1 168.8 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 ARG B:4 B:64 101.0 0.449 -156.3 164.0 101.0 0.449 0.0 FWZ
HOH
9.305
3.143
C
O
H21
O
ARG F:4 F:64 102.0 0.453 -156.0 163.9 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 ARG L:5 V:64 157.0 0.698 -107.8 171.9 157.0 0.698 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 ARG A:64 A:64 85.0 0.378 -159.7 161.4