Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10188262 . A C CCDS2597.1:NM_000551.3:c.405ttA>ttC_NP_000542.1:p.135L>F Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 LEU A:155 A:135 33.0 0.194 -118.3 147.6 33.0 0.194 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 LEU C:119 C:135 37.0 0.218 -116.5 126.4 37.0 0.218 0.0 HOH
2.718
O
O
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 LEU C:93 C:135 59.0 0.347 -114.0 145.9 59.0 0.347 0.0 HOH
2.917
O
O
LEU F:93 F:135 47.0 0.276 -114.4 144.6 NA NA NA
LEU I:93 I:135 37.0 0.218 -114.9 144.8 NA NA NA
LEU L:93 L:135 42.0 0.247 -114.7 146.4 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 LEU C:84 C:135 41.0 0.241 -121.7 147.6 41.0 0.241 0.0 HOH
4.968
N
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 LEU C:84 C:135 57.0 0.335 -116.6 129.4 57.0 0.335 0.0
LEU F:84 F:135 50.0 0.294 -114.1 142.9 NA NA NA
LEU I:84 I:135 48.0 0.282 -125.4 140.9 NA NA NA
LEU L:84 L:135 51.0 0.3 -120.5 147.5 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 LEU C:84 C:135 55.0 0.324 -108.0 150.5 55.0 0.324 0.0 HOH
4.981
N
O
LEU F:84 F:135 51.0 0.3 -108.0 150.2 NA NA NA
LEU I:84 I:135 50.0 0.294 -107.5 150.9 NA NA NA
LEU L:84 L:135 31.0 0.182 -110.2 152.4 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 LEU C:84 C:135 48.0 0.282 -113.4 144.8 48.0 0.282 0.0 HOH
3.195
N
O
LEU F:84 F:135 50.0 0.294 -115.3 143.9 NA NA NA
LEU I:84 I:135 46.0 0.271 -114.1 145.1 NA NA NA
LEU L:84 L:135 45.0 0.265 -115.2 146.3 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 LEU C:84 C:135 48.0 0.282 -112.5 139.8 48.0 0.282 0.0 HOH
2.780
N
O
LEU F:84 F:135 46.0 0.271 -112.5 139.1 NA NA NA
LEU I:84 I:135 44.0 0.259 -112.7 141.1 NA NA NA
LEU L:84 L:135 38.0 0.224 -113.1 140.7 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:84 C:135 53.0 0.312 -109.9 147.7 53.0 0.312 0.0 HOH
2.811
O
O
LEU F:84 F:135 46.0 0.271 -105.6 141.9 NA NA NA
LEU I:84 I:135 46.0 0.271 -110.4 148.3 NA NA NA
LEU L:84 L:135 42.0 0.247 -114.3 144.3 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:84 C:135 55.0 0.324 -118.6 141.2 55.0 0.324 0.0 HOH
2.811
O
O
LEU F:84 F:135 44.0 0.259 -115.5 142.8 NA NA NA
LEU I:84 I:135 47.0 0.276 -106.3 146.0 NA NA NA
LEU L:84 L:135 44.0 0.259 -114.4 147.3 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:84 C:135 55.0 0.324 -111.6 142.0 55.0 0.324 0.0 HOH
3.011
O
O
LEU F:84 F:135 48.0 0.282 -107.6 146.6 NA NA NA
LEU I:84 I:135 49.0 0.288 -107.1 143.5 NA NA NA
LEU L:84 L:135 46.0 0.271 -114.9 143.4 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:84 C:135 52.0 0.306 -110.1 147.8 52.0 0.306 0.0 HOH
2.868
O
O
LEU F:84 F:135 42.0 0.247 -107.6 145.4 NA NA NA
LEU I:84 I:135 46.0 0.271 -113.6 142.7 NA NA NA
LEU L:84 L:135 46.0 0.271 -115.2 145.0 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:84 C:135 59.0 0.347 -108.2 148.0 59.0 0.347 0.0 HOH
2.927
O
O
LEU F:84 F:135 45.0 0.265 -106.6 151.7 NA NA NA
LEU I:84 I:135 44.0 0.259 -110.6 150.1 NA NA NA
LEU L:84 L:135 42.0 0.247 -109.3 149.0 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:84 C:135 46.0 0.271 -107.6 141.7 46.0 0.271 0.0 HOH
2.813
N
O
LEU F:84 F:135 44.0 0.259 -102.7 143.2 NA NA NA
LEU I:84 I:135 45.0 0.265 -110.9 143.4 NA NA NA
LEU L:84 L:135 42.0 0.247 -113.5 146.9 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:84 C:135 46.0 0.271 -106.6 144.3 46.0 0.271 0.0 HOH
2.924
O
O
LEU F:84 F:135 43.0 0.253 -103.9 141.4 NA NA NA
LEU I:84 I:135 45.0 0.265 -100.9 147.0 NA NA NA
LEU L:84 L:135 42.0 0.247 -105.4 147.3 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:84 C:135 51.0 0.3 -112.1 149.8 51.0 0.3 0.0 HOH
2.656
O
O
LEU F:84 F:135 43.0 0.253 -110.7 146.2 NA NA NA
LEU I:84 I:135 46.0 0.271 -102.5 147.0 NA NA NA
LEU L:84 L:135 41.0 0.241 -105.2 147.5 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:84 C:135 57.0 0.335 -109.4 148.2 57.0 0.335 0.0 HOH
2.856
O
O
LEU F:84 F:135 46.0 0.271 -113.6 138.2 NA NA NA
LEU I:84 I:135 46.0 0.271 -113.7 138.1 NA NA NA
LEU L:84 L:135 43.0 0.253 -111.9 146.8 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:84 C:135 54.0 0.318 -115.8 149.7 54.0 0.318 0.0 HOH
2.809
O
O
LEU F:84 F:135 47.0 0.276 -115.3 143.1 NA NA NA
LEU I:84 I:135 47.0 0.276 -111.6 143.0 NA NA NA
LEU L:84 L:135 44.0 0.259 -110.3 147.4 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 LEU C:84 C:135 54.0 0.318 -117.8 145.9 54.0 0.318 0.0 HOH
2.993
O
O
LEU F:84 F:135 47.0 0.276 -105.7 145.1 NA NA NA
LEU I:84 I:135 48.0 0.282 -103.5 145.1 NA NA NA
LEU L:84 L:135 45.0 0.265 -109.7 145.5 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:84 C:135 53.0 0.312 -111.5 141.3 53.0 0.312 0.0 HOH
2.941
O
O
LEU F:84 F:135 44.0 0.259 -104.8 144.7 NA NA NA
LEU I:84 I:135 43.0 0.253 -113.2 144.3 NA NA NA
LEU L:84 L:135 44.0 0.259 -113.1 146.7 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:84 C:135 54.0 0.318 -114.6 144.8 54.0 0.318 0.0 HOH
2.898
O
O
LEU F:84 F:135 45.0 0.265 -109.6 145.1 NA NA NA
LEU I:84 I:135 45.0 0.265 -111.8 143.1 NA NA NA
LEU L:84 L:135 43.0 0.253 -116.4 145.5 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:84 C:135 56.0 0.329 -111.9 142.9 56.0 0.329 0.0 HOH
2.978
O
O
LEU F:84 F:135 44.0 0.259 -107.8 143.8 NA NA NA
LEU I:84 I:135 47.0 0.276 -109.2 142.7 NA NA NA
LEU L:84 L:135 42.0 0.247 -112.3 146.1 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:84 C:135 41.0 0.241 -112.7 146.0 41.0 0.241 0.0 HOH
3.184
O
O
LEU F:84 F:135 44.0 0.259 -88.1 143.8 NA NA NA
LEU I:84 I:135 44.0 0.259 -103.9 154.7 NA NA NA
LEU L:84 L:135 38.0 0.224 -113.8 144.9 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:84 C:135 58.0 0.341 -117.7 149.9 58.0 0.341 0.0 HOH
3.029
O
O
LEU F:84 F:135 47.0 0.276 -116.0 145.4 NA NA NA
LEU I:84 I:135 49.0 0.288 -112.1 145.0 NA NA NA
LEU L:84 L:135 46.0 0.271 -115.5 148.6 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:84 C:135 56.0 0.329 -111.2 148.1 56.0 0.329 0.0 HOH
2.880
O
O
LEU F:84 F:135 46.0 0.271 -105.8 145.1 NA NA NA
LEU I:84 I:135 47.0 0.276 -110.6 145.7 NA NA NA
LEU L:84 L:135 45.0 0.265 -110.7 145.8 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:84 C:135 58.0 0.341 -119.1 146.5 58.0 0.341 0.0 HOH
2.906
O
O
LEU F:84 F:135 47.0 0.276 -110.3 146.6 NA NA NA
LEU I:84 I:135 48.0 0.282 -110.6 143.4 NA NA NA
LEU L:84 L:135 46.0 0.271 -113.0 146.1 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:84 C:135 56.0 0.329 -118.7 146.8 56.0 0.329 0.0 HOH
2.934
O
O
LEU F:84 F:135 45.0 0.265 -108.8 144.9 NA NA NA
LEU I:84 I:135 47.0 0.276 -107.2 145.2 NA NA NA
LEU L:84 L:135 46.0 0.271 -112.5 145.5 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 LEU D:84 D:135 27.0 0.159 -104.2 156.0 27.0 0.159 0.0 HOH
2.854
O
O
LEU H:84 H:135 27.0 0.159 -105.1 156.5 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 LEU A:84 V:135 40.0 0.235 -122.3 149.6 40.0 0.235 0.0 HOH
2.084
H
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 LEU C:84 C:135 57.0 0.335 -110.3 146.6 57.0 0.335 0.0 HOH
3.107
O
O
LEU F:84 F:135 46.0 0.271 -106.1 146.1 NA NA NA
LEU I:84 I:135 48.0 0.282 -103.1 146.3 NA NA NA
LEU L:84 L:135 45.0 0.265 -109.6 145.4 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 LEU C:84 C:135 53.0 0.312 -113.5 144.3 53.0 0.312 0.0 HOH
2.972
O
O
LEU F:84 F:135 43.0 0.253 -106.4 145.1 NA NA NA
LEU I:84 I:135 43.0 0.253 -105.0 146.0 NA NA NA
LEU L:84 L:135 44.0 0.259 -110.3 147.9 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU C:84 C:135 47.0 0.276 -120.1 146.7 47.0 0.276 0.0 HOH
2.777
O
O
LEU F:84 F:135 44.0 0.259 -121.1 148.3 NA NA NA
LEU L:84 L:135 43.0 0.253 -120.7 146.7 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU I:84 I:135 42.0 0.247 -121.1 146.9 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 LEU C:84 C:135 53.0 0.312 -127.0 140.5 53.0 0.312 0.0 HOH
2.905
N
O
LEU F:84 F:135 60.0 0.353 -130.0 143.6 NA NA NA
LEU I:84 I:135 46.0 0.271 -127.3 145.2 NA NA NA
LEU L:84 L:135 43.0 0.253 -126.8 142.4 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU C:84 C:135 49.0 0.288 -120.2 142.8 49.0 0.288 0.0 HOH
3.990
O
O
LEU F:84 F:135 43.0 0.253 -121.8 144.0 NA NA NA
LEU I:84 I:135 45.0 0.265 -122.8 146.0 NA NA NA
LEU L:84 L:135 44.0 0.259 -122.2 145.0 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 LEU B:84 B:135 45.0 0.265 -107.1 142.1 45.0 0.265 0.0 HOH
3.281
O
O
LEU F:84 F:135 43.0 0.253 -108.1 142.0 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 LEU B:84 B:135 42.0 0.247 -115.2 149.6 42.0 0.247 0.0 HOH
2.950
O
O
LEU F:84 F:135 41.0 0.241 -116.2 150.0 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 LEU D:84 D:135 23.0 0.135 -97.4 142.7 23.0 0.135 0.0
LEU H:84 H:135 23.0 0.135 -97.5 142.4 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 LEU D:84 L:135 43.0 0.253 -112.4 138.5 43.0 0.253 0.0 HOH
2.302
O
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 LEU C:84 L:135 41.0 0.241 -110.3 146.3 41.0 0.241 0.0 HOH
2.797
O
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 LEU C:85 C:135 62.0 0.365 -136.9 129.2 62.0 0.365 0.0
LEU F:85 F:135 62.0 0.365 -126.5 158.7 NA NA NA
LEU I:85 I:135 67.0 0.394 E -134.7 147.4 NA NA NA
LEU L:85 L:135 49.0 0.288 -127.3 141.0 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 LEU C:85 C:135 73.0 0.429 -89.8 110.9 73.0 0.429 0.0 HOH
9.012
O
O
LEU F:85 F:135 54.0 0.318 S -147.4 138.3 NA NA NA
LEU I:85 I:135 51.0 0.3 -126.8 147.5 NA NA NA
LEU L:85 L:135 59.0 0.347 -131.1 139.7 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 LEU C:85 C:135 66.0 0.388 -106.3 160.4 66.0 0.388 0.0
LEU F:85 F:135 64.0 0.376 -109.4 155.3 NA NA NA
LEU I:85 I:135 44.0 0.259 -118.5 155.6 NA NA NA
LEU L:85 L:135 41.0 0.241 -120.6 145.2 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 LEU C:85 C:135 50.0 0.294 -116.2 142.3 50.0 0.294 0.0 HOH
4.877
N
O
LEU F:85 F:135 43.0 0.253 -118.5 149.1 NA NA NA
LEU I:85 I:135 57.0 0.335 -114.8 140.6 NA NA NA
LEU L:85 L:135 39.0 0.229 -114.4 137.6 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 LEU D:85 V:135 39.0 0.229 -126.2 142.9 39.0 0.229 0.0 HOH
2.859
O
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 LEU C:85 C:135 67.0 0.394 -115.2 134.3 67.0 0.394 0.0 HOH
3.956
O
O
LEU F:85 F:135 63.0 0.371 -112.3 139.6 NA NA NA
LEU I:85 I:135 48.0 0.282 -115.3 142.2 NA NA NA
LEU L:85 L:135 35.0 0.206 -121.7 143.3 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 LEU D:85 V:135 38.0 0.224 -116.1 146.2 38.0 0.224 0.0 F4K
HOH
5.802
2.918
CD2
O
C12
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 LEU C:82 V:135 41.0 0.241 -118.3 147.7 41.0 0.241 0.0 HOH
2.764
O
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 LEU C:82 C:135 42.0 0.247 -121.3 140.6 42.0 0.247 0.0 HOH
3.696
CD1
O
LEU F:82 F:135 41.0 0.241 -121.2 139.8 NA NA NA
LEU I:82 I:135 41.0 0.241 -121.8 140.8 NA NA NA
LEU L:82 L:135 41.0 0.241 -121.7 140.9 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 LEU B:82 NA:NA DO NA DO DO DO NA NA NA
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 LEU C:82 C:135 40.0 0.235 -128.6 150.6 40.0 0.235 0.0 HOH
2.878
O
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 LEU D:82 V:135 23.0 0.135 -111.1 141.1 23.0 0.135 0.0 HOH
2.316
H
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 LEU D:82 V:135 28.0 0.165 -108.4 140.0 28.0 0.165 0.0 HOH
2.111
H
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 LEU I:82 V:135 36.0 0.212 -121.8 150.4 36.0 0.212 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 LEU C:97 C:135 23.0 0.135 -114.6 156.9 23.0 0.135 0.0 HOH
2.943
O
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 LEU A:85 A:135 32.0 0.188 -117.6 148.5 32.0 0.188 0.0
LEU E:85 E:135 37.0 0.218 -116.5 148.0 NA NA NA
LEU I:85 I:135 21.0 0.124 -119.2 149.7 NA NA NA
LEU M:85 M:135 24.0 0.141 -117.5 148.4 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 LEU A:77 AAA:135 25.0 0.147 -109.3 138.1 25.0 0.147 0.0 GOL
GOL
HOH
3.836
8.464
2.825
O
N
O
O1
O1
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 LEU A:77 AAA:135 23.0 0.135 -114.4 145.1 23.0 0.135 0.0 HOH
2.595
O
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:84 C:135 65.0 0.382 -105.4 144.4 65.0 0.382 0.0 HOH
8.371
CD1
O
LEU F:84 F:135 50.0 0.294 -94.7 151.6 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:84 C:135 51.0 0.3 -107.8 144.1 51.0 0.3 0.0 HOH
3.011
N
O
LEU F:84 F:135 44.0 0.259 -100.0 139.0 NA NA NA
LEU I:84 I:135 43.0 0.253 -102.5 143.4 NA NA NA
LEU L:84 L:135 42.0 0.247 -114.5 144.2 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:84 C:135 47.0 0.276 -117.1 156.1 47.0 0.276 0.0 HOH
2.868
N
O
LEU F:84 F:135 46.0 0.271 -115.0 145.3 NA NA NA
LEU I:84 I:135 45.0 0.265 -104.7 154.2 NA NA NA
LEU L:84 L:135 42.0 0.247 -108.9 151.8 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 LEU B:75 B:135 26.0 0.153 -113.7 151.4 26.0 0.153 0.0 HOH
2.052
H
O
LEU F:75 F:135 37.0 0.218 -111.5 155.4 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 LEU L:76 V:135 48.0 0.282 -74.3 140.3 48.0 0.282 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 LEU A:135 A:135 34.0 0.2 S -118.6 144.6