Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10191563 . G A CCDS2597.1:NM_000551.3:c.556Gaa>Aaa_NP_000542.1:p.186E>K Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 GLU A:206 A:186 103.0 0.542 H -62.9 -40.2 93.0 0.489 0.053 D:Q13617:0.053
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 GLU C:170 C:186 132.0 0.695 H -68.7 -41.3 132.0 0.695 0.0 HOH
7.963
O
O
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 GLU C:144 C:186 117.0 0.616 H -64.7 -38.1 117.0 0.616 0.0 HOH
2.700
O
O
GLU F:144 F:186 123.0 0.647 H -63.1 -38.9 NA NA NA
GLU I:144 I:186 52.0 NA H -67.6 -39.8 NA NA NA
GLU L:144 L:186 49.0 NA H -66.7 -40.2 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 GLU C:135 C:186 80.0 0.421 H -65.7 -40.7 80.0 0.421 0.0 HOH
8.835
OE1
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 GLU C:135 C:186 137.0 0.721 H -71.4 -18.0 137.0 0.721 0.0
GLU F:135 F:186 132.0 0.695 H -63.3 -36.2 NA NA NA
GLU I:135 I:186 139.0 0.732 H -44.3 -49.3 NA NA NA
GLU L:135 L:186 114.0 0.6 H -61.6 -31.3 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 GLU C:135 C:186 60.0 NA H -64.9 -29.2 60.0 NA NA
GLU F:135 F:186 56.0 NA H -63.9 -33.4 NA NA NA
GLU I:135 I:186 64.0 NA H -63.3 -34.3 NA NA NA
GLU L:135 L:186 142.0 0.747 H -64.7 -37.7 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 GLU C:135 C:186 115.0 0.605 H -69.1 -40.0 115.0 0.605 0.0 HOH
2.951
O
O
GLU F:135 F:186 53.0 NA H -62.5 -34.8 NA NA NA
GLU I:135 I:186 54.0 NA H -61.8 -39.7 NA NA NA
GLU L:135 L:186 119.0 0.626 H -61.2 -42.1 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 GLU C:135 C:186 56.0 NA H -69.9 -37.6 56.0 NA NA HOH
5.248
O
O
GLU F:135 F:186 56.0 NA H -65.7 -37.2 NA NA NA
GLU I:135 I:186 113.0 0.595 H -65.5 -35.7 NA NA NA
GLU L:135 L:186 54.0 NA H -63.5 -55.9 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:135 C:186 118.0 0.621 H -64.7 -38.3 118.0 0.621 0.0 HOH
3.180
OE1
O
GLU F:135 F:186 48.0 NA H -62.5 -42.3 NA NA NA
GLU I:135 I:186 52.0 NA H -67.3 -36.7 NA NA NA
GLU L:135 L:186 114.0 0.6 H -54.8 -51.2 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:135 C:186 114.0 0.6 H -65.2 -36.9 114.0 0.6 0.0 HOH
5.768
OE1
O
GLU F:135 F:186 50.0 NA H -61.9 -39.5 NA NA NA
GLU I:135 I:186 50.0 NA H -67.1 -46.0 NA NA NA
GLU L:135 L:186 132.0 0.695 H -54.7 -41.4 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:135 C:186 120.0 0.632 H -65.1 -39.8 120.0 0.632 0.0 HOH
6.896
O
O
GLU F:135 F:186 52.0 NA H -62.6 -32.2 NA NA NA
GLU I:135 I:186 55.0 NA H -61.4 -38.9 NA NA NA
GLU L:135 L:186 134.0 0.705 H -72.1 -36.5 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:135 C:186 58.0 NA H -60.8 -40.4 58.0 NA NA HOH
2.678
O
O
GLU F:135 F:186 51.0 NA H -60.2 -41.6 NA NA NA
GLU I:135 I:186 51.0 NA H -61.3 -43.7 NA NA NA
GLU L:135 L:186 111.0 NA 360.0 -59.2 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:135 C:186 122.0 0.642 H -69.3 -32.9 122.0 0.642 0.0 HOH
6.610
O
O
GLU F:135 F:186 52.0 NA H -63.1 -35.9 NA NA NA
GLU I:135 I:186 55.0 NA H -63.0 -34.8 NA NA NA
GLU L:135 L:186 133.0 0.7 H -69.6 -38.0 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:135 C:186 115.0 0.605 H -67.2 -36.0 115.0 0.605 0.0 HOH
5.339
OE1
O
GLU F:135 F:186 47.0 NA H -59.7 -40.0 NA NA NA
GLU I:135 I:186 50.0 NA H -66.2 -40.8 NA NA NA
GLU L:135 L:186 128.0 0.674 H -46.9 -50.9 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:135 C:186 119.0 0.626 H -61.6 -44.5 119.0 0.626 0.0 HOH
3.295
OE2
O
GLU F:135 F:186 51.0 NA H -62.2 -37.5 NA NA NA
GLU I:135 I:186 54.0 NA H -62.2 -39.7 NA NA NA
GLU L:135 L:186 102.0 0.537 H -55.3 -45.6 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:135 C:186 114.0 0.6 H -57.3 -44.0 114.0 0.6 0.0 HOH
2.812
OE1
O
GLU F:135 F:186 46.0 NA H -55.4 -51.2 NA NA NA
GLU I:135 I:186 57.0 NA H -60.1 -38.2 NA NA NA
GLU L:135 L:186 101.0 0.532 H -61.9 -34.8 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:135 C:186 119.0 0.626 H -52.9 -50.9 119.0 0.626 0.0 HOH
7.000
O
O
GLU F:135 F:186 51.0 NA H -60.9 -40.1 NA NA NA
GLU I:135 I:186 56.0 NA H -65.8 -44.3 NA NA NA
GLU L:135 L:186 125.0 0.658 H -64.2 -44.4 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:135 C:186 127.0 0.668 H -60.7 -36.3 127.0 0.668 0.0 HOH
7.059
O
O
GLU F:135 F:186 51.0 NA H -63.6 -38.4 NA NA NA
GLU I:135 I:186 57.0 NA H -61.9 -35.4 NA NA NA
GLU L:135 L:186 130.0 0.684 H -57.5 -42.8 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 GLU C:135 C:186 104.0 0.547 H -58.0 -44.2 104.0 0.547 0.0 HOH
3.347
OE1
O
GLU F:135 F:186 107.0 0.563 H -59.1 -43.2 NA NA NA
GLU I:135 I:186 49.0 NA H -69.1 -53.1 NA NA NA
GLU L:135 L:186 100.0 0.526 H -54.6 -45.4 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:135 C:186 101.0 0.532 H -65.6 -40.2 101.0 0.532 0.0 HOH
3.422
OE1
O
GLU F:135 F:186 100.0 0.526 H -63.9 -41.6 NA NA NA
GLU I:135 I:186 50.0 NA H -68.5 -45.2 NA NA NA
GLU L:135 L:186 100.0 0.526 H -51.2 -44.8 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:135 C:186 110.0 0.579 H -61.5 -41.5 110.0 0.579 0.0 HOH
2.942
O
O
GLU F:135 F:186 110.0 0.579 H -63.1 -41.4 NA NA NA
GLU I:135 I:186 51.0 NA H -65.8 -44.1 NA NA NA
GLU L:135 L:186 102.0 0.537 H -51.4 -46.1 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:135 C:186 112.0 0.589 H -62.6 -41.4 112.0 0.589 0.0 HOH
2.888
O
O
GLU F:135 F:186 103.0 0.542 H -64.9 -38.3 NA NA NA
GLU I:135 I:186 52.0 NA H -67.9 -42.8 NA NA NA
GLU L:135 L:186 104.0 0.547 H -52.8 -43.4 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:135 C:186 131.0 0.689 H -66.5 -33.6 131.0 0.689 0.0 HOH
3.007
O
O
GLU F:135 F:186 118.0 0.621 H -63.5 -28.2 NA NA NA
GLU I:135 I:186 142.0 0.747 H -64.4 -32.3 NA NA NA
GLU L:135 L:186 130.0 0.684 H -64.5 -43.2 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:135 C:186 114.0 0.6 H -61.8 -48.5 114.0 0.6 0.0 HOH
7.079
O
O
GLU F:135 F:186 105.0 0.553 H -58.0 -38.8 NA NA NA
GLU I:135 I:186 57.0 NA H -60.5 -44.6 NA NA NA
GLU L:135 L:186 98.0 0.516 H -58.1 -48.2 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:135 C:186 97.0 0.511 H -63.2 -40.4 97.0 0.511 0.0 HOH
3.042
OE1
O
GLU F:135 F:186 94.0 0.495 H -66.4 -40.8 NA NA NA
GLU I:135 I:186 56.0 NA H -55.8 -43.5 NA NA NA
GLU L:135 L:186 112.0 0.589 H -57.8 -41.2 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:135 C:186 109.0 0.574 H -59.6 -45.6 109.0 0.574 0.0 HOH
2.674
OE2
O
GLU F:135 F:186 110.0 0.579 H -62.1 -43.4 NA NA NA
GLU I:135 I:186 113.0 0.595 H -59.4 -39.1 NA NA NA
GLU L:135 L:186 95.0 0.5 H -58.2 -39.9 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:135 C:186 108.0 0.568 H -59.3 -45.0 108.0 0.568 0.0 HOH
3.249
OE1
O
GLU F:135 F:186 113.0 0.595 H -61.1 -40.6 NA NA NA
GLU I:135 I:186 97.0 0.511 H -59.1 -33.0 NA NA NA
GLU L:135 L:186 99.0 0.521 H -54.2 -43.6 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 GLU D:135 D:186 103.0 0.542 H -54.2 -46.4 103.0 0.542 0.0 HOH
6.649
O
O
GLU H:135 H:186 53.0 NA H -54.6 -46.0 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 GLU A:135 V:186 55.0 NA H -65.2 -33.2 55.0 NA NA HOH
6.724
O
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 GLU C:135 C:186 107.0 0.563 H -65.6 -40.3 107.0 0.563 0.0 HOH
3.060
O
O
GLU F:135 F:186 109.0 0.574 H -63.4 -33.8 NA NA NA
GLU I:135 I:186 56.0 NA H -67.1 -38.2 NA NA NA
GLU L:135 L:186 105.0 0.553 H -58.5 -45.6 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 GLU C:135 C:186 101.0 0.532 H -57.0 -41.8 101.0 0.532 0.0 HOH
3.160
OE1
O
GLU F:135 F:186 98.0 0.516 H -59.9 -44.0 NA NA NA
GLU I:135 I:186 53.0 NA H -64.7 -43.9 NA NA NA
GLU L:135 L:186 95.0 0.5 H -52.4 -44.0 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 GLU C:135 C:186 114.0 0.6 H -73.2 -35.6 114.0 0.6 0.0 HOH
2.749
O
O
GLU F:135 F:186 79.0 0.416 H -73.1 -42.1 NA NA NA
GLU L:135 L:186 115.0 0.605 H -73.2 -37.8 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 GLU I:135 I:186 120.0 0.632 H -76.0 -35.1 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 GLU C:135 C:186 146.0 0.768 H -69.3 -37.0 146.0 0.768 0.0 HOH
4.550
O
O
GLU F:135 F:186 125.0 0.658 H -68.9 -34.7 NA NA NA
GLU I:135 I:186 137.0 0.721 H -71.0 -35.3 NA NA NA
GLU L:135 L:186 122.0 0.642 H -68.0 -35.3 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 GLU C:135 C:186 130.0 0.684 H -65.1 -37.8 130.0 0.684 0.0 HOH
7.710
O
O
GLU F:135 F:186 116.0 0.611 H -63.1 -35.2 NA NA NA
GLU I:135 I:186 55.0 NA H -63.4 -36.5 NA NA NA
GLU L:135 L:186 137.0 0.721 H -60.9 -41.8 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 GLU B:135 B:186 102.0 0.537 H -67.5 -31.7 102.0 0.537 0.0 EPE
HOH
6.434
6.613
OE1
OE1
O3S
O
GLU F:135 F:186 104.0 0.547 H -67.1 -31.6 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 GLU B:135 B:186 105.0 0.553 H -70.6 -34.0 105.0 0.553 0.0 HOH
2.701
O
O
GLU F:135 F:186 103.0 0.542 H -68.2 -33.8 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 GLU D:135 D:186 107.0 0.563 H -61.9 -42.7 107.0 0.563 0.0
GLU H:135 H:186 107.0 0.563 H -62.0 -42.6 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 GLU D:135 L:186 98.0 0.516 H -64.8 -38.3 98.0 0.516 0.0 HOH
2.541
OE1
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 GLU C:135 L:186 116.0 0.611 H -65.4 -42.3 116.0 0.611 0.0 HOH
6.994
O
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 GLU C:136 C:186 146.0 0.768 H -74.3 -33.2 146.0 0.768 0.0
GLU F:136 F:186 80.0 0.421 H -38.0 -52.0 NA NA NA
GLU I:136 I:186 149.0 0.784 H -38.0 -31.9 NA NA NA
GLU L:136 L:186 132.0 0.695 H -66.3 1.0 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 GLU C:136 C:186 137.0 0.721 H -81.5 -34.6 137.0 0.721 0.0
GLU F:136 F:186 123.0 0.647 H -82.9 -26.5 NA NA NA
GLU I:136 I:186 123.0 0.647 H -81.7 -6.0 NA NA NA
GLU L:136 L:186 133.0 0.7 H -63.9 -56.1 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 GLU C:136 C:186 115.0 0.605 H -64.3 -42.7 115.0 0.605 0.0 HOH
4.474
O
O
GLU F:136 F:186 112.0 0.589 H -64.4 -53.0 NA NA NA
GLU I:136 I:186 122.0 0.642 H -69.5 -49.8 NA NA NA
GLU L:136 L:186 131.0 0.689 H -63.2 -49.5 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 GLU C:136 C:186 128.0 0.674 H -83.4 -16.0 128.0 0.674 0.0
GLU F:136 F:186 122.0 0.642 H -66.4 -34.1 NA NA NA
GLU I:136 I:186 120.0 0.632 H -60.2 -38.5 NA NA NA
GLU L:136 L:186 129.0 0.679 H -73.2 -28.9 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 GLU D:136 V:186 137.0 0.721 H -69.7 -36.7 137.0 0.721 0.0 HOH
4.170
CB
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 GLU C:136 C:186 131.0 0.689 H -73.8 -42.6 131.0 0.689 0.0 HOH
6.882
O
O
GLU F:136 F:186 120.0 0.632 H -62.8 -32.6 NA NA NA
GLU I:136 I:186 132.0 0.695 H -79.9 -25.4 NA NA NA
GLU L:136 L:186 125.0 0.658 H -75.7 -15.2 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 GLU D:136 V:186 118.0 0.621 H -65.4 -33.7 118.0 0.621 0.0 HOH
2.674
O
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 GLU C:133 V:186 79.0 0.416 H -63.0 -39.9 79.0 0.416 0.0 HOH
2.702
O
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 GLU C:133 C:186 91.0 0.479 H -61.8 -47.6 91.0 0.479 0.0 HOH
5.116
O
O
GLU F:133 F:186 91.0 0.479 H -64.5 -48.0 NA NA NA
GLU I:133 I:186 93.0 0.489 H -63.4 -47.6 NA NA NA
GLU L:133 L:186 92.0 0.484 H -64.1 -48.6 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 GLU B:133 V:186 97.0 0.511 T -73.2 -14.0 84.0 0.442 0.069 A:Q13617:0.068
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 GLU C:133 C:186 72.0 0.379 H -67.9 -34.4 72.0 0.379 0.0 HOH
2.684
O
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 GLU D:133 V:186 138.0 0.726 H -66.9 -33.1 138.0 0.726 0.0 HOH
2.149
H
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 GLU D:133 V:186 139.0 0.732 H -58.1 -38.9 139.0 0.732 0.0 HOH
2.194
H
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 GLU I:133 V:186 109.0 0.574 H -65.8 -38.7 109.0 0.574 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 GLU C:148 C:186 95.0 0.5 H -59.0 -32.2 95.0 0.5 0.0 HOH
2.817
O
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 GLU A:136 A:186 127.0 0.668 H -54.0 -46.3 127.0 0.668 0.0
GLU E:136 E:186 99.0 0.521 H -53.9 -46.5 NA NA NA
GLU I:136 I:186 88.0 0.463 H -53.3 -47.2 NA NA NA
GLU M:136 M:186 92.0 0.484 H -54.0 -46.7 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 GLU A:128 AAA:186 89.0 0.468 H -67.9 -35.5 89.0 0.468 0.0 HOH
2.592
O
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 GLU A:128 AAA:186 103.0 0.542 H -62.7 -39.7 103.0 0.542 0.0 HOH
2.779
OE2
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 GLU C:135 C:186 109.0 0.574 H -62.1 -40.2 109.0 0.574 0.0 HOH
6.585
OE1
O
GLU F:135 F:186 127.0 0.668 H -64.3 -33.3 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 GLU C:135 C:186 120.0 0.632 H -71.6 -37.3 120.0 0.632 0.0 HOH
3.579
OE1
O
GLU F:135 F:186 115.0 0.605 H -65.7 -34.6 NA NA NA
GLU I:135 I:186 56.0 NA H -63.2 -34.6 NA NA NA
GLU L:135 L:186 105.0 0.553 H -56.7 -41.0 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 GLU C:135 C:186 121.0 0.637 H -69.7 -31.6 121.0 0.637 0.0 HOH
3.245
O
O
GLU F:135 F:186 118.0 0.621 H -64.7 -30.2 NA NA NA
GLU I:135 I:186 123.0 0.647 H -63.4 -34.4 NA NA NA
GLU L:135 L:186 123.0 0.647 H -59.3 -39.6 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 GLU B:126 B:186 126.0 0.663 H -68.7 -34.4 126.0 0.663 0.0 HOH
5.188
O
O
GLU F:126 F:186 139.0 0.732 H -65.7 -41.1 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 GLU L:127 V:186 116.0 0.611 H -59.1 -29.0 91.0 0.479 0.132 H:Q13617:0.132

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 GLU A:186 A:186 131.0 0.689 H -62.4 -43.3