Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10191593 . A C CCDS2597.1:NM_000551.3:c.586Aaa>Caa_NP_000542.1:p.196K>Q Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 LYS A:216 A:196 89.0 0.445 H -65.4 -33.9 89.0 0.445 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 LYS C:180 C:196 68.0 NA H -61.7 5.7 68.0 NA NA HOH
4.512
CB
O
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 LYS C:154 C:196 40.0 NA H -67.2 -32.0 40.0 NA NA HOH
3.357
CB
O
LYS F:154 F:196 40.0 NA H -66.7 -43.2 NA NA NA
LYS I:154 I:196 47.0 NA H -65.8 -36.3 NA NA NA
LYS L:154 L:196 47.0 NA H -65.2 -33.4 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 LYS C:145 C:196 52.0 0.26 H -59.6 -37.7 52.0 0.26 0.0 HOH
6.843
N
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 LYS C:145 C:196 47.0 NA H -43.2 -51.5 47.0 NA NA
LYS F:145 F:196 133.0 0.665 H -48.7 -54.4 NA NA NA
LYS I:145 I:196 31.0 NA H -56.8 -43.3 NA NA NA
LYS L:145 L:196 116.0 0.58 H -48.4 -60.2 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 LYS C:145 C:196 50.0 NA H -60.9 -40.4 50.0 NA NA HOH
7.027
N
O
LYS F:145 F:196 55.0 NA H -63.9 -37.0 NA NA NA
LYS I:145 I:196 54.0 NA H -61.9 -37.1 NA NA NA
LYS L:145 L:196 43.0 NA H -63.5 -37.1 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 LYS C:145 C:196 59.0 NA H -64.5 -42.4 59.0 NA NA HOH
5.181
CB
O
LYS F:145 F:196 52.0 NA H -68.0 -40.2 NA NA NA
LYS I:145 I:196 44.0 NA H -65.0 -38.6 NA NA NA
LYS L:145 L:196 114.0 0.57 H -63.6 -41.1 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 LYS C:145 C:196 67.0 NA H -63.6 -41.7 67.0 NA NA HOH
4.706
O
O
LYS F:145 F:196 114.0 0.57 H -63.3 -40.9 NA NA NA
LYS I:145 I:196 127.0 0.635 H -63.3 -39.9 NA NA NA
LYS L:145 L:196 117.0 0.585 H -62.6 -41.4 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LYS C:145 C:196 77.0 0.385 H -60.1 -41.2 77.0 0.385 0.0 HOH
5.418
NZ
O
LYS F:145 F:196 45.0 NA H -56.6 -47.0 NA NA NA
LYS I:145 I:196 119.0 0.595 H -56.7 -43.0 NA NA NA
LYS L:145 L:196 55.0 NA H -60.2 -40.7 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LYS C:145 C:196 73.0 0.365 H -59.0 -36.5 73.0 0.365 0.0 HOH
5.416
NZ
O
LYS F:145 F:196 40.0 NA H -60.7 -44.9 NA NA NA
LYS I:145 I:196 117.0 0.585 H -65.3 -38.9 NA NA NA
LYS L:145 L:196 60.0 NA H -62.3 -32.8 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LYS C:145 C:196 76.0 0.38 H -55.3 -50.5 76.0 0.38 0.0 HOH
5.405
NZ
O
LYS F:145 F:196 42.0 NA H -56.9 -48.9 NA NA NA
LYS I:145 I:196 114.0 0.57 H -55.7 -44.4 NA NA NA
LYS L:145 L:196 59.0 NA H -58.3 -34.6 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LYS C:145 C:196 46.0 NA H -58.3 -39.9 46.0 NA NA HOH
5.338
O
O
LYS F:145 F:196 46.0 NA H -58.2 -48.1 NA NA NA
LYS I:145 I:196 73.0 NA H -63.7 -38.9 NA NA NA
LYS L:145 L:196 42.0 NA H -58.9 -39.5 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LYS C:145 C:196 83.0 0.415 H -65.7 -45.3 83.0 0.415 0.0 HOH
5.868
NZ
O
LYS F:145 F:196 42.0 NA H -61.6 -48.6 NA NA NA
LYS I:145 I:196 117.0 0.585 H -61.0 -40.8 NA NA NA
LYS L:145 L:196 56.0 NA H -60.5 -38.2 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LYS C:145 C:196 80.0 0.4 H -56.5 -46.2 80.0 0.4 0.0 HOH
3.123
NZ
O
LYS F:145 F:196 42.0 NA H -60.4 -43.7 NA NA NA
LYS I:145 I:196 114.0 0.57 H -62.6 -46.6 NA NA NA
LYS L:145 L:196 56.0 NA H -61.7 -33.8 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LYS C:145 C:196 80.0 0.4 H -64.3 -43.3 80.0 0.4 0.0 HOH
5.460
NZ
O
LYS F:145 F:196 42.0 NA H -60.8 -49.4 NA NA NA
LYS I:145 I:196 117.0 0.585 H -62.2 -47.0 NA NA NA
LYS L:145 L:196 55.0 NA H -72.2 -38.8 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LYS C:145 C:196 73.0 0.365 H -67.5 -41.8 73.0 0.365 0.0 HOH
2.869
NZ
O
LYS F:145 F:196 40.0 NA H -66.3 -36.7 NA NA NA
LYS I:145 I:196 119.0 0.595 H -64.7 -39.1 NA NA NA
LYS L:145 L:196 55.0 NA H -63.7 -36.4 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LYS C:145 C:196 66.0 0.33 H -59.3 -47.1 66.0 0.33 0.0 HOH
2.884
NZ
O
LYS F:145 F:196 36.0 NA H -57.5 -48.8 NA NA NA
LYS I:145 I:196 115.0 0.575 H -62.6 -40.4 NA NA NA
LYS L:145 L:196 50.0 NA H -59.0 -39.7 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LYS C:145 C:196 76.0 0.38 H -67.8 -37.9 76.0 0.38 0.0 HOH
5.435
NZ
O
LYS F:145 F:196 46.0 NA H -65.3 -37.3 NA NA NA
LYS I:145 I:196 118.0 0.59 H -62.9 -39.4 NA NA NA
LYS L:145 L:196 57.0 NA H -66.4 -36.6 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 LYS C:145 C:196 73.0 0.365 H -57.0 -46.0 73.0 0.365 0.0 HOH
2.761
NZ
O
LYS F:145 F:196 39.0 NA H -58.1 -49.5 NA NA NA
LYS I:145 I:196 114.0 0.57 H -65.4 -43.9 NA NA NA
LYS L:145 L:196 61.0 NA H -68.4 -36.3 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LYS C:145 C:196 71.0 0.355 H -54.8 -43.2 71.0 0.355 0.0 HOH
2.895
O
O
LYS F:145 F:196 39.0 NA H -56.0 -45.3 NA NA NA
LYS I:145 I:196 115.0 0.575 H -60.7 -45.7 NA NA NA
LYS L:145 L:196 56.0 NA H -61.2 -35.1 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LYS C:145 C:196 70.0 0.35 H -49.8 -47.3 70.0 0.35 0.0 HOH
2.957
NZ
O
LYS F:145 F:196 38.0 NA H -54.9 -46.3 NA NA NA
LYS I:145 I:196 114.0 0.57 H -57.5 -48.1 NA NA NA
LYS L:145 L:196 54.0 NA H -60.6 -34.9 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LYS C:145 C:196 71.0 0.355 H -55.4 -45.3 71.0 0.355 0.0 HOH
2.903
NZ
O
LYS F:145 F:196 39.0 NA H -56.7 -44.3 NA NA NA
LYS I:145 I:196 114.0 0.57 H -62.0 -45.8 NA NA NA
LYS L:145 L:196 58.0 NA H -64.7 -38.4 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LYS C:145 C:196 70.0 0.35 H -55.5 -49.9 70.0 0.35 0.0 HOH
3.024
O
O
LYS F:145 F:196 116.0 0.58 H -61.1 -41.2 NA NA NA
LYS I:145 I:196 109.0 0.545 H -66.7 -32.1 NA NA NA
LYS L:145 L:196 115.0 0.575 H -55.9 -36.4 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LYS C:145 C:196 77.0 0.385 H -51.2 -49.9 77.0 0.385 0.0 HOH
6.796
NZ
O
LYS F:145 F:196 43.0 NA H -47.0 -46.9 NA NA NA
LYS I:145 I:196 111.0 0.555 H -64.0 -49.4 NA NA NA
LYS L:145 L:196 58.0 NA H -55.6 -38.4 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LYS C:145 C:196 73.0 0.365 H -53.8 -49.6 73.0 0.365 0.0 HOH
2.743
NZ
O
LYS F:145 F:196 73.0 0.365 H -53.8 -47.3 NA NA NA
LYS I:145 I:196 114.0 0.57 H -61.5 -45.9 NA NA NA
LYS L:145 L:196 57.0 NA H -63.5 -36.8 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LYS C:145 C:196 77.0 0.385 H -55.2 -40.9 77.0 0.385 0.0 HOH
2.783
O
O
LYS F:145 F:196 42.0 NA H -55.0 -46.1 NA NA NA
LYS I:145 I:196 114.0 0.57 H -61.0 -45.2 NA NA NA
LYS L:145 L:196 55.0 NA H -64.5 -37.2 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LYS C:145 C:196 72.0 0.36 H -52.7 -44.4 72.0 0.36 0.0 HOH
2.868
O
O
LYS F:145 F:196 38.0 NA H -54.1 -45.0 NA NA NA
LYS I:145 I:196 114.0 0.57 H -59.3 -44.9 NA NA NA
LYS L:145 L:196 54.0 NA H -60.1 -37.0 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 LYS D:145 D:196 76.0 0.38 H -53.3 -41.0 76.0 0.38 0.0 HOH
4.896
N
O
LYS H:145 H:196 78.0 0.39 H -52.3 -41.5 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 LYS A:145 V:196 120.0 0.6 H -65.7 -32.9 120.0 0.6 0.0 HOH
4.130
HB2
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 LYS C:145 C:196 95.0 0.475 H -59.4 -45.4 95.0 0.475 0.0 HOH
7.566
NZ
O
LYS F:145 F:196 41.0 NA H -46.7 -52.6 NA NA NA
LYS I:145 I:196 111.0 0.555 H -64.1 -45.0 NA NA NA
LYS L:145 L:196 60.0 NA H -57.6 -36.9 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 LYS C:145 C:196 78.0 0.39 H -56.1 -43.4 78.0 0.39 0.0 HOH
3.166
O
O
LYS F:145 F:196 39.0 NA H -58.6 -48.5 NA NA NA
LYS I:145 I:196 115.0 0.575 H -62.9 -44.5 NA NA NA
LYS L:145 L:196 55.0 NA H -59.6 -40.0 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 LYS C:145 C:196 39.0 NA H -64.8 -45.3 39.0 NA NA HOH
4.970
CB
O
LYS F:145 F:196 35.0 NA H -57.8 -46.5 NA NA NA
LYS L:145 L:196 116.0 0.58 H -62.0 -46.9 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 LYS I:145 I:196 41.0 NA H -61.9 -45.7 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 LYS C:145 C:196 42.0 NA H -63.7 -53.2 42.0 NA NA HOH
5.413
N
O
LYS F:145 F:196 42.0 NA H -60.8 -51.7 NA NA NA
LYS I:145 I:196 97.0 0.485 H -61.7 -50.5 NA NA NA
LYS L:145 L:196 112.0 0.56 H -63.9 -50.9 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 LYS C:145 C:196 46.0 NA H -58.6 -51.1 46.0 NA NA HOH
7.327
CB
O
LYS F:145 F:196 50.0 NA H -52.7 -53.7 NA NA NA
LYS I:145 I:196 42.0 NA H -58.1 -46.9 NA NA NA
LYS L:145 L:196 45.0 NA H -61.5 -49.3 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 LYS B:145 B:196 52.0 NA H -61.1 -43.8 52.0 NA NA HOH
4.877
O
O
LYS F:145 F:196 50.0 NA H -61.7 -43.3 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 LYS B:145 B:196 45.0 NA H -69.9 -36.3 45.0 NA NA HOH
3.666
O
O
LYS F:145 F:196 81.0 0.405 H -65.4 -49.9 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 LYS D:145 D:196 80.0 0.4 H -69.0 -39.7 80.0 0.4 0.0
LYS H:145 H:196 77.0 0.385 H -69.0 -39.6 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 LYS D:145 L:196 78.0 0.39 H -60.8 -45.6 78.0 0.39 0.0 HOH
3.196
NZ
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 LYS C:145 L:196 82.0 0.41 H -56.5 -40.1 82.0 0.41 0.0 HOH
3.640
CE
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 LYS C:146 C:196 53.0 NA H -52.6 -71.5 53.0 NA NA
LYS F:146 F:196 99.0 0.495 H -47.7 -66.4 NA NA NA
LYS I:146 I:196 48.0 NA H -68.5 -36.2 NA NA NA
LYS L:146 L:196 109.0 0.545 H -55.3 -65.9 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 LYS C:146 C:196 43.0 NA H -54.0 -68.7 43.0 NA NA HOH
6.748
CB
O
LYS F:146 F:196 124.0 0.62 H -47.0 -56.5 NA NA NA
LYS I:146 I:196 106.0 0.53 H -28.3 -62.4 NA NA NA
LYS L:146 L:196 95.0 0.475 H -36.0 -57.4 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 LYS C:146 C:196 47.0 NA H -47.9 -60.2 47.0 NA NA
LYS F:146 F:196 120.0 0.6 H -47.0 -54.9 NA NA NA
LYS I:146 I:196 123.0 0.615 H -55.7 -49.7 NA NA NA
LYS L:146 L:196 112.0 0.56 H -59.9 -50.8 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 LYS C:146 C:196 48.0 NA H -61.6 -47.2 48.0 NA NA HOH
8.632
N
O
LYS F:146 F:196 53.0 NA H -45.0 -48.3 NA NA NA
LYS I:146 I:196 97.0 0.485 H -64.8 -47.8 NA NA NA
LYS L:146 L:196 43.0 NA H -61.5 -53.8 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 LYS D:146 V:196 122.0 0.61 H -61.3 -40.2 122.0 0.61 0.0 HOH
4.629
CD
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 LYS C:146 C:196 59.0 NA H -63.5 -49.9 59.0 NA NA HOH
5.877
N
O
LYS F:146 F:196 36.0 NA H -64.8 -37.7 NA NA NA
LYS I:146 I:196 120.0 0.6 H -63.9 -38.3 NA NA NA
LYS L:146 L:196 115.0 0.575 H -60.6 -44.9 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 LYS D:146 V:196 124.0 0.62 H -65.5 -35.1 124.0 0.62 0.0 F4K
HOH
7.581
2.653
C
O
C13
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 LYS C:143 V:196 107.0 0.535 H -66.8 -32.4 107.0 0.535 0.0 HOH
3.105
NZ
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 LYS C:143 C:196 86.0 0.43 H -64.5 -44.6 86.0 0.43 0.0 HOH
3.427
CG
O
LYS F:143 F:196 83.0 0.415 H -64.8 -42.7 NA NA NA
LYS I:143 I:196 80.0 0.4 H -62.4 -43.8 NA NA NA
LYS L:143 L:196 83.0 0.415 H -64.7 -44.4 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 LYS B:143 NA:NA DO NA DO DO DO NA NA NA
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 LYS C:143 C:196 114.0 0.57 H -65.3 -41.3 114.0 0.57 0.0 HOH
3.589
CD
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 LYS D:143 V:196 77.0 0.385 H -57.4 -49.6 77.0 0.385 0.0 HOH
2.376
HZ3
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 LYS D:143 V:196 126.0 0.63 H -61.3 -43.8 126.0 0.63 0.0 HOH
3.712
HB3
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 LYS I:143 V:196 94.0 0.47 H -62.7 -40.1 72.0 0.36 0.11 L:Q13617:0.11
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 LYS C:158 C:196 95.0 0.475 H -61.4 -43.9 95.0 0.475 0.0 HOH
2.954
NZ
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 LYS A:146 A:196 72.0 0.36 H -65.8 -33.1 72.0 0.36 0.0
LYS E:146 E:196 77.0 0.385 H -66.3 -32.4 NA NA NA
LYS I:146 I:196 107.0 0.535 H -65.4 -33.7 NA NA NA
LYS M:146 M:196 109.0 0.545 H -65.5 -33.6 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 LYS A:138 AAA:196 71.0 0.355 H -59.9 -45.1 71.0 0.355 0.0 EDO
GOL
IOD
IOD
HOH
6.419
6.474
7.645
9.781
2.650
N
CD
N
NZ
NZ
C2
O3
I
I
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 LYS A:138 AAA:196 66.0 0.33 H -54.2 -43.6 66.0 0.33 0.0 HOH
3.054
CD
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LYS C:145 C:196 82.0 0.41 H -61.0 -47.6 82.0 0.41 0.0 HOH
7.847
O
O
LYS F:145 F:196 40.0 0.2 H -54.3 -51.5 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LYS C:145 C:196 72.0 0.36 H -67.1 -45.3 72.0 0.36 0.0 HOH
2.697
NZ
O
LYS F:145 F:196 44.0 NA H -63.2 -46.7 NA NA NA
LYS I:145 I:196 114.0 0.57 H -67.0 -42.0 NA NA NA
LYS L:145 L:196 54.0 NA H -62.2 -38.1 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LYS C:145 C:196 73.0 0.365 H -65.5 -48.8 73.0 0.365 0.0 HOH
2.997
NZ
O
LYS F:145 F:196 110.0 0.55 H -63.1 -42.3 NA NA NA
LYS I:145 I:196 120.0 0.6 H -67.3 -43.0 NA NA NA
LYS L:145 L:196 109.0 0.545 H -69.7 -38.8 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 LYS B:136 B:196 104.0 0.52 H -69.5 -37.0 104.0 0.52 0.0 HOH
4.773
H
O
LYS F:136 F:196 106.0 0.53 H -69.4 -37.2 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 LYS L:137 V:196 87.0 0.435 H -62.0 -56.6 87.0 0.435 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 LYS A:196 A:196 85.0 0.425 H -61.1 -42.0