Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10191605 . C A CCDS2597.1:NM_000551.3:c.598Cgg>Agg_NP_000542.1:p.200R>R Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 ARG A:220 A:200 85.0 0.378 H -61.7 -50.1 85.0 0.378 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 ARG C:184 C:200 65.0 NA H -52.5 -63.2 65.0 NA NA
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 ARG C:158 C:200 59.0 NA -101.1 160.4 59.0 NA NA HOH
8.895
C
O
ARG F:158 F:200 113.0 0.502 H -64.8 -49.0 NA NA NA
ARG I:158 I:200 80.0 NA H -64.4 -47.4 NA NA NA
ARG L:158 L:200 124.0 0.551 H -64.4 -45.4 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 ARG C:149 C:200 109.0 0.484 H -68.7 -44.9 109.0 0.484 0.0 HOH
7.395
NH1
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 ARG C:149 C:200 76.0 NA H -58.2 -54.5 76.0 NA NA
ARG F:149 F:200 142.0 0.631 H -62.2 -28.7 NA NA NA
ARG I:149 I:200 154.0 0.684 H -42.5 -58.8 NA NA NA
ARG L:149 L:200 64.0 NA H -48.9 -54.4 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 ARG C:149 C:200 78.0 NA H -60.0 -23.8 78.0 NA NA HOH
7.737
CB
O
ARG F:149 F:200 136.0 0.604 H -64.7 -46.6 NA NA NA
ARG I:149 I:200 134.0 0.596 H -66.1 -43.8 NA NA NA
ARG L:149 L:200 115.0 0.511 H -74.3 -30.4 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 ARG C:149 C:200 125.0 0.556 -153.7 161.7 125.0 0.556 0.0 HOH
2.995
O
O
ARG F:149 F:200 64.0 NA H -66.0 -38.5 NA NA NA
ARG I:149 I:200 92.0 0.409 H -63.4 -44.9 NA NA NA
ARG L:149 L:200 100.0 0.444 H -68.6 -39.5 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 ARG C:149 C:200 68.0 NA 51.9 74.4 68.0 NA NA HOH
4.460
N
O
ARG F:149 F:200 127.0 0.564 H -60.3 -50.1 NA NA NA
ARG I:149 I:200 82.0 0.364 H -58.4 -54.4 NA NA NA
ARG L:149 L:200 93.0 0.413 H -64.6 -40.4 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:149 C:200 75.0 NA H -62.0 -53.8 75.0 NA NA HOH
8.459
CB
O
ARG F:149 F:200 119.0 0.529 H -73.2 -40.9 NA NA NA
ARG I:149 I:200 115.0 0.511 H -57.4 -50.6 NA NA NA
ARG L:149 L:200 126.0 0.56 H -59.5 -48.5 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:149 C:200 74.0 NA H -60.8 -55.8 74.0 NA NA HOH
9.966
N
O
ARG F:149 F:200 130.0 0.578 H -70.0 -48.8 NA NA NA
ARG I:149 I:200 122.0 0.542 H -59.8 -42.9 NA NA NA
ARG L:149 L:200 122.0 0.542 H -54.3 -50.8 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:149 C:200 80.0 NA H -59.7 -48.1 80.0 NA NA
ARG F:149 F:200 125.0 0.556 H -73.0 -43.3 NA NA NA
ARG I:149 I:200 121.0 0.538 H -60.5 -43.4 NA NA NA
ARG L:149 L:200 124.0 0.551 H -63.8 -41.3 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:149 C:200 56.0 NA H -176.3 -56.1 56.0 NA NA HOH
4.495
CB
O
ARG F:149 F:200 124.0 0.551 H -65.7 -46.4 NA NA NA
ARG I:149 I:200 137.0 0.609 H -60.6 -50.2 NA NA NA
ARG L:149 L:200 116.0 0.516 H -57.4 -51.2 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:149 C:200 77.0 NA H -65.1 -60.6 77.0 NA NA
ARG F:149 F:200 126.0 0.56 H -69.5 -50.5 NA NA NA
ARG I:149 I:200 118.0 0.524 H -59.8 -52.6 NA NA NA
ARG L:149 L:200 126.0 0.56 H -64.2 -47.1 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:149 C:200 122.0 0.542 H -51.6 -59.1 122.0 0.542 0.0 HOH
5.857
NH2
O
ARG F:149 F:200 107.0 0.476 H -56.6 -44.2 NA NA NA
ARG I:149 I:200 112.0 0.498 H -52.9 -56.0 NA NA NA
ARG L:149 L:200 119.0 0.529 H -58.2 -49.2 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:149 C:200 137.0 0.609 H -53.2 -61.0 137.0 0.609 0.0 HOH
6.706
NH2
O
ARG F:149 F:200 111.0 0.493 H -74.0 -49.8 NA NA NA
ARG I:149 I:200 117.0 0.52 H -60.7 -52.6 NA NA NA
ARG L:149 L:200 121.0 0.538 H -65.7 -52.8 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:149 C:200 82.0 NA H -59.3 -44.7 82.0 NA NA HOH
7.369
N
O
ARG F:149 F:200 107.0 0.476 H -59.9 -48.6 NA NA NA
ARG I:149 I:200 111.0 0.493 H -62.5 -44.0 NA NA NA
ARG L:149 L:200 118.0 0.524 H -61.7 -48.1 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:149 C:200 83.0 NA H -65.7 -36.9 83.0 NA NA HOH
8.145
CB
O
ARG F:149 F:200 122.0 0.542 H -59.4 -46.3 NA NA NA
ARG I:149 I:200 112.0 0.498 H -54.5 -47.3 NA NA NA
ARG L:149 L:200 122.0 0.542 H -61.5 -47.5 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 ARG C:149 C:200 144.0 0.64 H -64.2 -51.2 144.0 0.64 0.0 HOH
6.428
NH2
O
ARG F:149 F:200 116.0 0.516 H -68.0 -40.9 NA NA NA
ARG I:149 I:200 125.0 0.556 H -54.3 -46.8 NA NA NA
ARG L:149 L:200 118.0 0.524 H -63.0 -46.1 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 ARG C:149 C:200 67.0 NA H -51.8 -49.8 67.0 NA NA HOH
3.977
CB
O
ARG F:149 F:200 121.0 0.538 H -68.4 -45.5 NA NA NA
ARG I:149 I:200 121.0 0.538 H -52.2 -50.4 NA NA NA
ARG L:149 L:200 123.0 0.547 H -70.6 -47.2 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:149 C:200 77.0 NA H -55.6 -55.8 77.0 NA NA HOH
3.708
N
O
ARG F:149 F:200 121.0 0.538 H -68.6 -41.3 NA NA NA
ARG I:149 I:200 122.0 0.542 H -59.0 -53.2 NA NA NA
ARG L:149 L:200 121.0 0.538 H -57.4 -49.2 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:149 C:200 72.0 NA H -58.6 -57.5 72.0 NA NA HOH
3.921
N
O
ARG F:149 F:200 118.0 0.524 H -74.4 -44.1 NA NA NA
ARG I:149 I:200 120.0 0.533 H -59.0 -54.5 NA NA NA
ARG L:149 L:200 121.0 0.538 H -59.0 -51.1 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:149 C:200 73.0 NA H -61.5 -68.1 73.0 NA NA HOH
3.657
N
O
ARG F:149 F:200 124.0 0.551 H -74.9 -43.6 NA NA NA
ARG I:149 I:200 119.0 0.529 H -60.6 -54.3 NA NA NA
ARG L:149 L:200 121.0 0.538 H -61.9 -49.4 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:149 C:200 146.0 0.649 H -63.2 -60.2 146.0 0.649 0.0 HOH
3.381
N
O
ARG F:149 F:200 99.0 0.44 H -68.3 -48.5 NA NA NA
ARG I:149 I:200 97.0 0.431 H -66.3 -49.8 NA NA NA
ARG L:149 L:200 119.0 0.529 H -63.4 -49.1 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:149 C:200 122.0 0.542 H -59.0 -60.4 122.0 0.542 0.0 HOH
9.079
NH2
O
ARG F:149 F:200 124.0 0.551 H -70.6 -48.4 NA NA NA
ARG I:149 I:200 121.0 0.538 H -58.1 -46.3 NA NA NA
ARG L:149 L:200 124.0 0.551 H -60.4 -49.4 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:149 C:200 75.0 NA H -63.6 -56.9 75.0 NA NA HOH
3.933
N
O
ARG F:149 F:200 110.0 0.489 H -76.4 -38.9 NA NA NA
ARG I:149 I:200 120.0 0.533 H -58.0 -46.0 NA NA NA
ARG L:149 L:200 120.0 0.533 H -60.4 -50.8 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:149 C:200 150.0 0.667 H -67.6 -68.9 150.0 0.667 0.0 HOH
3.640
N
O
ARG F:149 F:200 119.0 0.529 H -72.9 -42.4 NA NA NA
ARG I:149 I:200 125.0 0.556 H -59.0 -49.5 NA NA NA
ARG L:149 L:200 122.0 0.542 H -62.0 -47.9 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 ARG C:149 C:200 147.0 0.653 H -51.3 -51.6 147.0 0.653 0.0 HOH
3.722
N
O
ARG F:149 F:200 123.0 0.547 H -66.3 -32.1 NA NA NA
ARG I:149 I:200 123.0 0.547 H -56.6 -45.8 NA NA NA
ARG L:149 L:200 124.0 0.551 H -57.2 -54.4 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 ARG D:149 D:200 89.0 0.396 H -60.5 -44.6 89.0 0.396 0.0 HOH
7.020
NH2
O
ARG H:149 H:200 79.0 0.351 H -60.5 -44.4 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 ARG A:149 V:200 94.0 0.418 H -62.9 -39.6 94.0 0.418 0.0 HOH
4.991
HH22
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 ARG C:149 C:200 141.0 0.627 H -52.2 -58.6 141.0 0.627 0.0 HOH
8.985
NH2
O
ARG F:149 F:200 121.0 0.538 H -66.2 -50.9 NA NA NA
ARG I:149 I:200 121.0 0.538 H -62.4 -55.6 NA NA NA
ARG L:149 L:200 123.0 0.547 H -68.3 -49.9 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 ARG C:149 C:200 70.0 NA H -53.3 -66.0 70.0 NA NA HOH
3.477
CB
O
ARG F:149 F:200 131.0 0.582 H -55.2 -49.8 NA NA NA
ARG I:149 I:200 114.0 0.507 H -59.1 -53.0 NA NA NA
ARG L:149 L:200 116.0 0.516 H -57.9 -52.6 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 ARG C:149 C:200 167.0 0.742 T -166.3 -12.4 167.0 0.742 0.0 HOH
6.623
NH2
O
ARG F:149 F:200 113.0 0.502 H -62.4 -57.4 NA NA NA
ARG L:149 L:200 101.0 0.449 H -61.0 -56.7 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 ARG I:149 I:200 86.0 0.382 H -59.8 -55.6 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 ARG C:149 C:200 82.0 NA -54.8 98.6 82.0 NA NA HOH
8.694
N
O
ARG F:149 F:200 75.0 NA H -56.4 -39.0 NA NA NA
ARG I:149 I:200 103.0 0.458 H -54.7 -43.7 NA NA NA
ARG L:149 L:200 101.0 0.449 H -58.5 -47.0 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 ARG C:149 C:200 101.0 0.449 175.7 139.1 101.0 0.449 0.0 HOH
7.056
NH2
O
ARG F:149 F:200 116.0 0.516 H -76.5 -45.2 NA NA NA
ARG I:149 I:200 88.0 0.391 H -67.9 -41.4 NA NA NA
ARG L:149 L:200 105.0 0.467 H -67.6 -43.2 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 ARG B:149 B:200 101.0 0.449 H -58.4 -45.8 101.0 0.449 0.0 HOH
3.334
NE
O
ARG F:149 F:200 81.0 0.36 H -59.0 -45.6 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 ARG B:149 B:200 86.0 0.382 H -60.6 -48.6 86.0 0.382 0.0 HOH
3.165
NE
O
ARG F:149 F:200 91.0 0.404 H -56.5 -49.1 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 ARG D:149 D:200 88.0 0.391 H -70.6 -52.7 88.0 0.391 0.0
ARG H:149 H:200 87.0 0.387 H -70.8 -52.6 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 ARG D:149 L:200 88.0 0.391 H -67.7 -49.7 88.0 0.391 0.0 HOH
4.305
NH1
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 ARG C:149 L:200 109.0 0.484 H -56.8 -53.3 109.0 0.484 0.0 HOH
5.792
NE
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 ARG C:150 C:200 60.0 NA H -70.4 -72.1 60.0 NA NA
ARG F:150 F:200 69.0 NA H -80.9 -32.8 NA NA NA
ARG I:150 I:200 55.0 NA H -52.8 -64.1 NA NA NA
ARG L:150 L:200 175.0 0.778 H -51.6 -70.1 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 ARG C:150 C:200 112.0 NA H -53.3 -61.6 112.0 NA NA HOH
7.101
CD
O
ARG F:150 F:200 76.0 NA H -47.6 -54.9 NA NA NA
ARG I:150 I:200 108.0 0.48 H -56.4 -58.9 NA NA NA
ARG L:150 L:200 183.0 0.813 H -63.7 -51.4 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 ARG C:150 C:200 67.0 NA H -49.6 -62.5 67.0 NA NA
ARG F:150 F:200 73.0 NA H -72.8 -32.6 NA NA NA
ARG I:150 I:200 128.0 0.569 H -61.3 -53.0 NA NA NA
ARG L:150 L:200 135.0 0.6 H -48.1 -54.6 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 ARG C:150 C:200 74.0 NA H -67.4 -13.6 74.0 NA NA
ARG F:150 F:200 60.0 NA H -62.1 -49.5 NA NA NA
ARG I:150 I:200 197.0 0.876 H -57.9 -54.2 NA NA NA
ARG L:150 L:200 66.0 NA H -50.5 -66.1 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 ARG D:150 V:200 91.0 0.404 H -60.4 -46.9 91.0 0.404 0.0 HOH
2.697
NH2
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 ARG C:150 C:200 249.0 1.0 -130.0 360.0 249.0 1.0 0.0 HOH
3.095
NE
O
ARG F:150 F:200 174.0 0.773 H -64.0 -46.5 NA NA NA
ARG I:150 I:200 92.0 0.409 H -68.5 -39.2 NA NA NA
ARG L:150 L:200 88.0 0.391 H -66.0 -43.9 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 ARG D:150 V:200 90.0 0.4 H -66.9 -46.6 90.0 0.4 0.0 F4K
HOH
4.541
3.049
NH1
NH1
C05
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 ARG C:147 V:200 85.0 0.378 H -62.3 -50.1 85.0 0.378 0.0 HOH
2.617
CD
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 ARG C:147 C:200 132.0 0.587 H -67.8 -58.1 132.0 0.587 0.0 HOH
2.725
CG
O
ARG F:147 F:200 129.0 0.573 H -67.0 -57.5 NA NA NA
ARG I:147 I:200 130.0 0.578 H -68.6 -56.4 NA NA NA
ARG L:147 L:200 133.0 0.591 H -67.6 -56.1 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 ARG B:147 NA:NA DO NA DO DO DO NA NA NA
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 ARG C:147 C:200 82.0 0.364 H -61.9 -47.4 82.0 0.364 0.0 HOH
5.528
NH2
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 ARG D:147 V:200 77.0 0.342 H -61.3 -43.9 77.0 0.342 0.0 HOH
3.321
HH22
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 ARG D:147 V:200 109.0 0.484 H -59.5 -45.8 109.0 0.484 0.0 HOH
2.187
HE
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 ARG I:147 V:200 84.0 0.373 H -63.6 -43.2 82.0 0.364 0.009 L:Q13617:0.009
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 ARG C:162 C:200 84.0 0.373 H -68.6 -46.6 84.0 0.373 0.0 HOH
2.837
NE
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 ARG A:150 A:200 90.0 0.4 H -61.4 -41.3 90.0 0.4 0.0
ARG E:150 E:200 95.0 0.422 H -61.8 -40.9 NA NA NA
ARG I:150 I:200 95.0 0.422 H -61.3 -41.2 NA NA NA
ARG M:150 M:200 93.0 0.413 H -61.1 -41.7 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 ARG A:142 AAA:200 93.0 0.413 H -63.6 -45.2 93.0 0.413 0.0 EDO
GOL
IOD
HOH
9.218
3.450
7.771
2.810
N
NH1
NH1
NE
C2
O3
I
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 ARG A:142 AAA:200 78.0 0.347 H -58.7 -47.6 78.0 0.347 0.0 HOH
4.729
NH1
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 ARG C:149 C:200 144.0 0.64 H -64.8 -49.2 144.0 0.64 0.0 HOH
6.134
N
O
ARG F:149 F:200 179.0 0.796 H -66.4 -29.6 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 ARG C:149 C:200 75.0 NA H -63.5 -49.7 75.0 NA NA HOH
3.208
CB
O
ARG F:149 F:200 121.0 0.538 H -75.4 -43.5 NA NA NA
ARG I:149 I:200 122.0 0.542 H -63.7 -48.0 NA NA NA
ARG L:149 L:200 113.0 0.502 H -67.1 -46.5 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 ARG C:149 C:200 73.0 NA H -63.2 -36.7 73.0 NA NA HOH
3.028
CB
O
ARG F:149 F:200 87.0 0.387 H -69.1 -52.1 NA NA NA
ARG I:149 I:200 97.0 0.431 H -66.0 -47.3 NA NA NA
ARG L:149 L:200 106.0 0.471 H -66.2 -43.9 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 ARG B:140 B:200 93.0 0.413 H -57.7 -48.7 93.0 0.413 0.0 HOH
3.380
HH22
O
ARG F:140 F:200 104.0 0.462 H -57.7 -48.5 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 ARG L:141 V:200 86.0 0.382 H -59.9 -46.2 86.0 0.382 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 ARG A:200 A:200 79.0 0.351 H -59.3 -52.1