Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 160105667 . T A CCDS1196.1:NM_000702.3:c.2323Tac>Aac_NP_000693.1:p.775Y>N Homo sapiens ATPase Na+/K+ transporting subunit alpha 2 (ATP1A2), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4xe5 1 Q08DA1 86.79 0.0 X-RAY
 2016-03-09 TYR A:776 A:776 0.0 0.0 H -51.6 -55.8 0.0 0.0 0.0 MG
HOH
 7.880
5.968
 O
O
 MG
O
3wgu 1 I7HD36 87.32 0.0 X-RAY
 2013-10-09 TYR A:771 A:771 0.0 0.0 H -68.5 -47.1 0.0 0.0 0.0 NA
NA
NA
HOH
 9.004
6.519
2.369
7.164
 O
O
O
O
 NA
NA
NA
O
TYR D:771 C:771 0.0 0.0 H -68.5 -36.0 NA NA NA
3wgv 1 I7HD36 87.32 0.0 X-RAY
 2013-10-09 TYR A:771 A:771 0.0 0.0 H -66.3 -49.0 0.0 0.0 0.0 NA
NA
NA
HOH
 9.334
6.618
2.283
7.118
 O
O
O
O
 NA
NA
NA
O
TYR D:771 C:771 0.0 0.0 H -67.8 -31.5 NA NA NA
4hqj 1 P05024 86.69 0.0 X-RAY
 2013-10-02 TYR A:776 A:771 0.0 0.0 H -48.0 -51.0 0.0 0.0 0.0 NA
NA
NA
 9.713
7.331
3.246
 CE2
O
O
 NA
NA
NA
TYR D:776 C:771 0.0 0.0 H -48.7 -51.0 NA NA NA
4hyt 1 P05024 86.69 0.0 X-RAY
 2013-06-26 TYR A:776 A:771 0.0 0.0 H -52.3 -56.6 0.0 0.0 0.0 MG
HOH
 8.395
6.398
 O
O
 MG
O
TYR D:776 C:771 0.0 0.0 H -52.3 -56.8 NA NA NA
4res 1 P05024 86.69 0.0 X-RAY
 2015-01-28 TYR A:776 A:771 0.0 0.0 H -49.1 -55.1 0.0 0.0 0.0 K
 6.104
 O
 K
TYR D:776 C:771 0.0 0.0 H -50.1 -55.0 NA NA NA
4ret 1 P05024 86.69 0.0 X-RAY
 2015-01-28 TYR A:776 A:771 0.0 0.0 H -51.9 -56.1 0.0 0.0 0.0 MG
HOH
 8.228
6.274
 O
O
 MG
O
TYR D:776 C:771 0.0 0.0 H -52.1 -55.8 NA NA NA
7evx 1 P05024 86.69 0.0 X-RAY
 2021-07-07 TYR A:776 A:771 0.0 0.0 H -68.2 -48.6 0.0 0.0 0.0 MG
HOH
 8.221
6.152
 O
O
 MG
O
TYR D:776 C:771 0.0 0.0 H -67.4 -49.0 NA NA NA
7d91 1 P05024 86.82 0.0 X-RAY
 2021-01-27 TYR A:771 A:771 0.0 0.0 H -66.2 -37.3 0.0 0.0 0.0 MG
 8.878
 O
 MG
7d92 1 P05024 86.82 0.0 X-RAY
 2021-01-27 TYR A:771 A:771 0.0 0.0 H -65.1 -40.2 0.0 0.0 0.0 MG
HOH
 8.803
6.823
 O
O
 MG
O
7d93 1 P05024 86.82 0.0 X-RAY
 2021-01-27 TYR A:771 A:771 1.0 0.004 H -69.3 -53.5 1.0 0.004 0.0 MG
HOH
 8.534
6.466
 O
O
 MG
O
TYR C:771 C:771 0.0 0.0 H -69.2 -52.9 NA NA NA
7d94 1 P05024 86.82 0.0 X-RAY
 2021-01-27 TYR A:771 A:771 0.0 0.0 H -69.8 -50.9 0.0 0.0 0.0 MG
RB
HOH
 9.839
6.082
7.136
 O
O
CD2
 MG
RB
O
TYR D:771 C:771 0.0 0.0 H -70.2 -50.6 NA NA NA
7ddf 1 P05024 86.82 0.0 X-RAY
 2021-01-27 TYR A:771 A:771 0.0 0.0 H -66.9 -52.1 0.0 0.0 0.0 MG
HOH
 8.652
6.460
 O
O
 MG
O
TYR D:771 C:771 0.0 0.0 H -68.8 -52.4 NA NA NA
7ddh 1 P05024 86.82 0.0 X-RAY
 2021-01-27 TYR A:771 A:771 0.0 0.0 H -66.2 -60.7 0.0 0.0 0.0 MG
HOH
 8.612
6.669
 O
O
 MG
O
TYR D:771 C:771 0.0 0.0 H -66.4 -59.8 NA NA NA
7ddi 1 P05024 86.82 0.0 X-RAY
 2021-01-27 TYR A:771 A:771 0.0 0.0 H -56.9 -57.9 0.0 0.0 0.0 MG
HOH
 8.682
6.484
 O
O
 MG
O
TYR D:771 C:771 0.0 0.0 H -56.8 -56.9 NA NA NA
7ddj 1 P05024 86.82 0.0 X-RAY
 2021-01-27 TYR A:771 A:771 0.0 0.0 H -68.7 -53.4 0.0 0.0 0.0 MG
HOH
 8.694
6.769
 O
O
 MG
O
TYR D:771 C:771 0.0 0.0 H -69.4 -52.7 NA NA NA
7ddk 1 P05024 86.82 0.0 X-RAY
 2021-01-27 TYR A:771 A:771 0.0 0.0 H -66.0 -56.0 0.0 0.0 0.0 MG
HOH
 8.818
6.744
 O
O
 MG
O
TYR D:771 C:771 0.0 0.0 H -66.8 -55.8 NA NA NA
7ddl 1 P05024 86.82 0.0 X-RAY
 2021-01-27 TYR A:771 A:771 0.0 0.0 H -71.0 -51.6 0.0 0.0 0.0 MG
HOH
 8.469
6.492
 O
O
 MG
O
TYR D:771 C:771 0.0 0.0 H -70.2 -52.1 NA NA NA
3b8e 1 P05024 87.56 0.0 X-RAY
 2007-12-18 TYR A:753 A:771 0.0 0.0 H -47.9 -58.8 0.0 0.0 0.0 RB
RB
 5.606
9.539
 O
O
 RB
RB
TYR D:753 C:771 0.0 0.0 H -32.8 -51.4 NA NA NA
3kdp 1 P05024 87.56 0.0 X-RAY
 2010-02-16 TYR A:753 A:771 0.0 0.0 H -45.7 -38.1 0.0 0.0 0.0 RB
RB
 5.804
9.937
 O
O
 RB
RB
TYR D:753 C:771 0.0 0.0 H -45.4 -37.4 NA NA NA
3n23 1 P05024 87.8 0.0 X-RAY
 2011-01-19 TYR A:747 A:771 0.0 0.0 H -37.9 -55.9 0.0 0.0 0.0
TYR D:747 C:771 0.0 0.0 H -38.9 -55.6 NA NA NA
2zxe 1 Q4H132 84.65 0.0 X-RAY
 2009-05-19 TYR A:783 A:778 0.0 0.0 H -60.6 -43.5 0.0 0.0 0.0 K
K
HOH
 5.757
9.764
2.669
 O
O
OH
 K
K
O
3a3y 1 Q4H132 84.65 0.0 X-RAY
 2009-09-08 TYR A:783 A:778 0.0 0.0 H -54.3 -48.4 0.0 0.0 0.0 K
K
HOH
 5.972
9.835
2.645
 O
O
OH
 K
K
O
5avq 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.6 -43.5 0.0 0.0 0.0 K
TL
K
TL
HOH
 5.757
5.757
9.766
9.766
5.480
 O
O
O
O
O
 K
TL
K
TL
O
5avr 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.6 -43.4 0.0 0.0 0.0 K
TL
K
TL
HOH
 5.756
5.756
9.764
9.764
5.481
 O
O
O
O
O
 K
TL
K
TL
O
5avs 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.6 -43.5 0.0 0.0 0.0 K
TL
TL
HOH
 5.757
5.757
9.764
5.479
 O
O
O
O
 K
TL
TL
O
5avt 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.5 -43.5 0.0 0.0 0.0 K
TL
TL
HOH
 5.756
5.756
9.764
5.480
 O
O
O
O
 K
TL
TL
O
5avu 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.7 -43.4 0.0 0.0 0.0 K
TL
TL
HOH
 5.757
5.757
9.765
5.480
 O
O
O
O
 K
TL
TL
O
5avv 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.6 -43.5 0.0 0.0 0.0 TL
TL
HOH
 5.757
9.765
5.480
 O
O
O
 TL
TL
O
5avw 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.6 -43.4 0.0 0.0 0.0 TL
TL
HOH
 5.758
9.765
5.480
 O
O
O
 TL
TL
O
5avx 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.6 -43.5 0.0 0.0 0.0 TL
TL
HOH
 5.757
9.765
5.480
 O
O
O
 TL
TL
O
5avy 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.7 -43.5 0.0 0.0 0.0 TL
TL
HOH
 5.756
9.764
5.479
 O
O
O
 TL
TL
O
5avz 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.7 -43.5 0.0 0.0 0.0 TL
TL
HOH
 5.757
9.765
5.480
 O
O
O
 TL
TL
O
5aw0 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.7 -43.5 0.0 0.0 0.0 TL
TL
HOH
 5.757
9.764
5.479
 O
O
O
 TL
TL
O
5aw1 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.7 -43.4 0.0 0.0 0.0 K
TL
TL
HOH
 5.757
5.757
9.764
5.479
 O
O
O
O
 K
TL
TL
O
5aw2 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.5 -43.5 0.0 0.0 0.0 TL
TL
HOH
 5.757
9.765
5.481
 O
O
O
 TL
TL
O
5aw3 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.6 -43.5 0.0 0.0 0.0 TL
TL
HOH
 5.757
9.765
5.480
 O
O
O
 TL
TL
O
5aw4 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.5 -43.5 0.0 0.0 0.0 K
RB
K
RB
HOH
 5.757
5.757
9.764
9.764
5.480
 O
O
O
O
O
 K
RB
K
RB
O
5aw5 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.6 -43.4 0.0 0.0 0.0 K
RB
K
RB
HOH
 5.757
5.757
9.764
9.764
5.480
 O
O
O
O
O
 K
RB
K
RB
O
5aw6 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.6 -43.4 0.0 0.0 0.0 K
RB
K
RB
HOH
 5.758
5.758
9.766
9.766
5.480
 O
O
O
O
O
 K
RB
K
RB
O
5aw7 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.6 -43.4 0.0 0.0 0.0 K
RB
RB
HOH
 5.757
5.757
9.764
5.481
 O
O
O
O
 K
RB
RB
O
5aw8 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -60.5 -43.5 0.0 0.0 0.0 RB
RB
HOH
 5.758
9.765
5.480
 O
O
O
 RB
RB
O
5aw9 1 Q4H132 84.65 0.0 X-RAY
 2015-09-02 TYR A:783 A:778 0.0 0.0 H -65.6 -45.4 0.0 0.0 0.0 K
K
HOH
 5.717
9.607
2.650
 O
O
OH
 K
K
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p50993-f1 1 P50993 100.0 0.0 TYR A:775 A:775 0.0 0.0 H -56.7 -50.5
af-p13637-f1 1 P13637 88.37 0.0 TYR A:768 A:768 0.0 0.0 H -57.2 -50.4
af-p05023-f1 1 P05023 86.71 0.0 TYR A:778 A:778 0.0 0.0 H -58.1 -53.4
af-q13733-f1 1 Q13733 80.48 0.0 TYR A:784 A:784 0.0 0.0 H -55.8 -50.1