Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196659294 . G A CCDS1385.1:NM_000186.3:c.1261Gct>Act_NP_000177.2:p.421A>T Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2uwn 1 P08603 100.0 2e-127 X-RAY
 2007-10-02 ALA A:102 A:421 24.0 0.209 E -146.0 164.1 24.0 0.209 0.0 ACT
CL
HOH
 7.882
7.347
3.408
 O
O
CB
 OXT
CL
O
2v8e 1 P08603 100.0 2e-127 X-RAY
 2007-10-02 ALA A:102 A:421 20.0 0.174 E -142.6 171.3 20.0 0.174 0.0 CL
HOH
 7.127
4.004
 O
CA
 CL
O
4ayd 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 ALA A:103 A:421 44.0 0.383 -156.6 169.8 44.0 0.383 0.0 HOH
 3.411
 CA
 O
ALA B:103 B:421 60.0 0.522 -157.1 174.0 NA NA NA
ALA E:103 E:421 51.0 0.443 -154.2 159.1 NA NA NA
4aye 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 ALA A:103 A:421 47.0 0.409 -158.1 162.2 47.0 0.409 0.0 EDO
 6.968
 N
 O1
ALA B:103 B:421 54.0 0.47 -151.1 156.2 NA NA NA
ALA E:103 E:421 51.0 0.443 -155.6 157.6 NA NA NA
4ayi 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 ALA A:103 A:421 53.0 0.461 -155.5 167.5 53.0 0.461 0.0 HOH
 5.182
 N
 O
ALA C:103 E:421 45.0 0.391 -156.4 164.9 NA NA NA
4aym 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 ALA A:103 A:421 52.0 0.452 -160.7 166.7 NA NA NA
ALA B:103 B:421 67.0 0.583 -160.6 168.2 67.0 0.583 0.0
ALA E:103 E:421 49.0 0.426 -161.5 166.9 NA NA NA
ALA F:103 F:421 54.0 0.47 -161.0 166.0 NA NA NA
2w80 1 P08603 100.0 1e-82 X-RAY
 2009-03-03 ALA A:101 A:421 54.0 0.47 -159.1 171.1 54.0 0.47 0.0 HOH
 2.673
 N
 O
ALA B:101 B:421 49.0 0.426 -158.1 170.1 NA NA NA
ALA E:101 E:421 51.0 0.443 -160.4 168.6 NA NA NA
ALA G:101 G:421 49.0 0.426 -165.5 164.3 NA NA NA
2w81 1 P08603 100.0 1e-82 X-RAY
 2009-03-03 ALA A:101 A:421 48.0 0.417 176.2 -177.4 48.0 0.417 0.0 HOH
 5.041
 N
 O
ALA B:101 B:421 51.0 0.443 -178.2 163.5 NA NA NA
ALA E:101 E:421 44.0 0.383 179.1 164.9 NA NA NA
2jgw 1 P08603 100.0 2e-36 NMR
 2007-03-20 ALA A:36 A:421 32.0 0.278 E -161.5 156.3 32.0 0.278 0.0
2jgx 1 P08603 98.36 1e-35 NMR
 2007-03-20 ALA A:36 A:421 25.0 0.217 E -159.8 -172.3 25.0 0.217 0.0
6atg 1 A0A024R962 100.0 5e-35 X-RAY
 2018-09-12 ALA A:36 A:403 27.0 0.235 E -168.6 159.7 27.0 0.235 0.0 HOH
 3.342
 CB
 O
ALA D:36 D:403 32.0 0.278 E -167.0 161.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 ALA A:421 A:421 22.0 0.191 E -153.9 166.1