Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196659303 . A C CCDS1385.1:NM_000186.3:c.1270Aaa>Caa_NP_000177.2:p.424K>Q Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
pdb_id: 
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label_seq_id: 
label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2uwn 1 P08603 100.0 2e-127 X-RAY
 2007-10-02 LYS A:105 A:424 153.0 0.765 S -167.3 93.6 153.0 0.765 0.0 ACT
HOH
 4.870
2.913
 CE
CE
 O
O
2v8e 1 P08603 100.0 2e-127 X-RAY
 2007-10-02 LYS A:105 A:424 172.0 0.86 S -165.6 92.8 172.0 0.86 0.0 HOH
 4.232
 NZ
 O
4ayd 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 LYS A:106 A:424 171.0 0.855 T -146.1 79.7 171.0 0.855 0.0 HOH
 5.064
 NZ
 O
LYS B:106 NA:NA DO NA DO DO DO NA NA NA
LYS E:106 E:424 173.0 0.865 G 61.4 22.3 NA NA NA
4aye 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 LYS A:106 A:424 201.0 1.0 T 56.4 52.9 201.0 1.0 0.0
LYS B:106 B:424 183.0 0.915 T -119.8 106.4 NA NA NA
LYS E:106 E:424 174.0 0.87 G 58.5 30.5 NA NA NA
4ayi 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 LYS A:106 A:424 191.0 0.955 G 57.1 31.6 191.0 0.955 0.0 HOH
 3.409
 CG
 O
LYS C:106 E:424 202.0 1.0 G 59.7 27.3 NA NA NA
4aym 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 LYS A:106 A:424 198.0 0.99 G 57.6 32.0 NA NA NA
LYS B:106 B:424 189.0 0.945 G 58.2 30.7 189.0 0.945 0.0
LYS E:106 E:424 195.0 0.975 G 58.0 30.6 NA NA NA
LYS F:106 F:424 182.0 0.91 G 57.9 28.9 NA NA NA
2w80 1 P08603 100.0 1e-82 X-RAY
 2009-03-03 LYS A:104 A:424 198.0 0.99 G 52.3 28.1 198.0 0.99 0.0 HOH
 2.927
 N
 O
LYS B:104 B:424 188.0 0.94 G 52.7 26.9 NA NA NA
LYS E:104 E:424 190.0 0.95 G 50.9 22.4 NA NA NA
LYS G:104 G:424 195.0 0.975 G 35.7 57.4 NA NA NA
2w81 1 P08603 100.0 1e-82 X-RAY
 2009-03-03 LYS A:104 A:424 241.0 1.0 360.0 74.4 241.0 1.0 0.0 HOH
 2.346
 N
 O
LYS B:104 B:424 190.0 0.95 G 58.2 40.3 NA NA NA
LYS E:104 E:424 190.0 0.95 G 65.2 36.6 NA NA NA
2jgw 1 P08603 100.0 2e-36 NMR
 2007-03-20 LYS A:39 A:424 187.0 0.935 G 61.8 28.4 187.0 0.935 0.0
2jgx 1 P08603 98.36 1e-35 NMR
 2007-03-20 LYS A:39 A:424 184.0 0.92 G 63.7 26.2 184.0 0.92 0.0
6atg 1 A0A024R962 100.0 5e-35 X-RAY
 2018-09-12 LYS A:39 A:406 188.0 0.94 G 60.7 24.7 188.0 0.94 0.0 HOH
 2.512
 N
 O
LYS D:39 D:406 190.0 0.95 G 59.6 24.5 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 LYS A:424 A:424 195.0 0.975 G 61.8 27.0