Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196659340 . G A CCDS1385.1:NM_000186.3:c.1307tGg>tAg_NP_000177.2:p.436W>* Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2uwn 1 P08603 100.0 2e-127 X-RAY
 2007-10-02 TRP A:117 A:436 39.0 0.153 E -65.4 143.8 39.0 0.153 0.0 GU4
YYJ
SO4
HOH
 9.848
5.368
8.284
3.473
 NE1
CD1
CH2
CD1
 O22
O2S4
O4
O
2v8e 1 P08603 100.0 2e-127 X-RAY
 2007-10-02 TRP A:117 A:436 33.0 0.129 E -66.6 142.8 33.0 0.129 0.0 YYJ
SO4
SO4
HOH
 6.628
9.660
8.072
8.630
 NE1
CZ2
CH2
CH2
 O2S4
O1
O4
O
4ayd 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 TRP A:118 A:436 41.0 0.161 E -72.0 132.5 41.0 0.161 0.0 HOH
 2.904
 N
 O
TRP B:118 B:436 40.0 0.157 E -65.3 132.9 NA NA NA
TRP E:118 E:436 39.0 0.153 E -64.6 135.9 NA NA NA
4aye 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 TRP A:118 A:436 42.0 0.165 E -70.1 129.6 42.0 0.165 0.0 HOH
 7.785
 CD1
 O
TRP B:118 B:436 46.0 0.18 E -71.7 136.9 NA NA NA
TRP E:118 E:436 38.0 0.149 E -70.2 125.7 NA NA NA
4ayi 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 TRP A:118 A:436 42.0 0.165 E -66.3 136.2 42.0 0.165 0.0 HOH
 3.449
 O
 O
TRP C:118 E:436 41.0 0.161 E -65.9 137.7 NA NA NA
4aym 1 P08603 100.0 1e-82 X-RAY
 2012-11-07 TRP A:118 A:436 40.0 0.157 E -68.0 134.8 NA NA NA
TRP B:118 B:436 40.0 0.157 E -68.1 134.3 40.0 0.157 0.0
TRP E:118 E:436 39.0 0.153 E -68.0 135.9 NA NA NA
TRP F:118 F:436 41.0 0.161 E -68.0 135.8 NA NA NA
2w80 1 P08603 100.0 1e-82 X-RAY
 2009-03-03 TRP A:116 A:436 38.0 0.149 E -61.1 130.5 38.0 0.149 0.0 HOH
 2.663
 N
 O
TRP B:116 B:436 42.0 0.165 E -63.6 131.9 NA NA NA
TRP E:116 E:436 43.0 0.169 E -65.9 134.6 NA NA NA
TRP G:116 G:436 42.0 0.165 E -62.0 137.6 NA NA NA
2w81 1 P08603 100.0 1e-82 X-RAY
 2009-03-03 TRP A:116 A:436 43.0 0.169 E -67.7 136.7 43.0 0.169 0.0 HOH
 8.556
 CZ3
 O
TRP B:116 B:436 43.0 0.169 E -67.2 139.0 NA NA NA
TRP E:116 E:436 41.0 0.161 E -67.2 136.7 NA NA NA
2jgw 1 P08603 100.0 2e-36 NMR
 2007-03-20 TRP A:51 A:436 27.0 0.106 B -60.9 109.2 27.0 0.106 0.0
2jgx 1 P08603 98.36 1e-35 NMR
 2007-03-20 TRP A:51 A:436 6.0 0.024 40.6 111.3 6.0 0.024 0.0
6atg 1 A0A024R962 100.0 5e-35 X-RAY
 2018-09-12 TRP A:51 A:418 31.0 0.122 E -69.7 138.2 31.0 0.122 0.0 HOH
 2.776
 O
 O
TRP D:51 D:418 31.0 0.122 E -64.8 142.1 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 TRP A:436 A:436 42.0 0.165 E -74.7 127.9