Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196715058 . T A CCDS1385.1:NM_000186.3:c.3422tTg>tAg_NP_000177.2:p.1141L>* Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
pdb_id: 
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auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3sw0 1 P08603 100.0 2e-126 X-RAY
 2012-03-14 LEU A:98 X:1141 56.0 0.329 T 78.0 -9.4 56.0 0.329 0.0 GOL
HOH
 3.099
2.746
 N
O
 O2
O
6zh1 2 P08603 100.0 4e-83 X-RAY
 2022-01-12 LEU B:43 B:1141 50.0 0.294 T -98.3 5.9 50.0 0.294 0.0 HOH
 2.704
 N
 O
3kxv 1 P08603 99.22 5e-83 X-RAY
 2010-05-19 LEU A:43 A:1141 62.0 0.365 T -87.6 1.7 22.0 0.129 0.236 A:P08603:0.235
 HOH
 2.486
 N
 O
3kzj 1 P08603 99.22 6e-83 X-RAY
 2010-05-19 LEU A:43 A:1141 64.0 0.376 T -93.5 8.1 23.0 0.135 0.241 A:P08603:0.241
 HOH
 2.666
 O
 O
5nbq 2 P08603 100.0 3e-82 X-RAY
 2017-12-06 LEU D:38 D:1141 47.0 0.276 T -107.3 17.2 25.0 0.147 0.129 A:P01024:0.124
G:Q45001:0.006
LEU E:38 E:1141 35.0 0.206 T -108.9 21.9 NA NA NA
LEU F:38 F:1141 39.0 0.229 T 79.7 -1.4 NA NA NA
2xqw 2 P08603 98.45 5e-82 X-RAY
 2011-02-02 LEU C:43 C:1141 40.0 0.235 T 80.9 -3.8 29.0 0.171 0.064 A:P01024:0.065
 HOH
 2.913
 N
 O
4j38 2 P08603 98.45 6e-82 X-RAY
 2013-05-15 LEU B:39 B:1141 50.0 0.294 T -105.2 4.9 50.0 0.294 0.0 HOH
 2.756
 O
 O
3oxu 2 Q14006 100.0 4e-81 X-RAY
 2011-02-16 LEU D:39 D:1141 32.0 0.188 T 80.7 -5.2 NA NA NA
LEU E:39 E:1141 40.0 0.235 T 78.6 -8.0 NA NA NA
LEU F:39 F:1141 28.0 0.165 T 77.5 -5.9 18.0 0.106 0.059 B:P01024:0.059
 HOH
 2.715
 O
 O
4ont 1 P08603 100.0 4e-81 X-RAY
 2014-11-26 LEU A:39 F:1141 45.0 0.265 T 77.5 1.9 32.0 0.188 0.077 D:P01024:0.076
 SIA
HOH
 7.790
5.072
 CD2
N
 C11
O
LEU C:39 D:1141 47.0 0.276 T 84.8 -10.1 NA NA NA
LEU E:39 E:1141 43.0 0.253 T 77.1 5.9 NA NA NA
4zh1 2 P08603 100.0 4e-81 X-RAY
 2016-01-13 LEU D:39 D:1141 53.0 0.312 T 74.8 9.8 NA NA NA
LEU E:39 E:1141 43.0 0.253 T 76.5 9.2 27.0 0.159 0.094 A:P01024:0.094
 SIA
HOH
 8.146
2.337
 CD1
N
 C11
O
LEU F:39 F:1141 41.0 0.241 T 75.4 9.4 NA NA NA
2g7i 1 P08603 100.0 6e-81 X-RAY
 2006-05-23 LEU A:35 A:1141 61.0 0.359 T -90.8 6.0 23.0 0.135 0.224 A:P08603:0.224
 HOH
 2.573
 N
 O
3r62 1 P08603 99.2 3e-80 X-RAY
 2011-06-29 LEU A:39 A:1141 49.0 0.288 T -77.8 -2.8 49.0 0.288 0.0 GOL
HOH
 7.079
2.742
 CD1
O
 C1
O
LEU B:39 B:1141 52.0 0.306 T -79.7 -12.3 NA NA NA
3rj3 2 Q03591 99.2 3e-80 X-RAY
 2012-03-14 LEU D:39 D:1141 45.0 0.265 T 79.1 -9.5 45.0 0.265 0.0 HOH
 2.611
 O
 O
LEU E:39 E:1141 40.0 0.235 T 76.6 -2.2 NA NA NA
LEU F:39 F:1141 34.0 0.2 T 79.5 1.7 NA NA NA
4muc 1 Q03591 98.4 1e-79 X-RAY
 2015-02-18 LEU A:36 A:240 53.0 0.312 T -88.9 4.4 53.0 0.312 0.0 SO4
 4.261
 CD1
 O1
LEU B:36 B:240 64.0 0.376 T -90.7 14.2 64.0 0.376 0.0 SO4
 5.132
 CD1
 O4

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 LEU A:1141 A:1141 48.0 0.282 T 78.8 -15.2