Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196715105 . T A CCDS1385.1:NM_000186.3:c.3469Tgg>Agg_NP_000177.2:p.1157W>R Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
pdb_id: 
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label_seq_id: 
label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3sw0 1 P08603 100.0 2e-126 X-RAY
 2012-03-14 TRP A:114 X:1157 35.0 0.137 E -80.9 142.6 35.0 0.137 0.0 GOL
PO4
HOH
 9.404
6.984
2.834
 N
CH2
N
 O3
O1
O
6zh1 2 P08603 100.0 4e-83 X-RAY
 2022-01-12 TRP B:59 B:1157 42.0 0.165 E -81.0 145.5 42.0 0.165 0.0 EDO
HOH
 7.291
4.066
 O
CD1
 O2
O
3kxv 1 P08603 99.22 5e-83 X-RAY
 2010-05-19 TRP A:59 A:1157 39.0 0.153 E -76.0 146.7 39.0 0.153 0.0 SO4
SO4
HOH
 9.872
4.218
2.733
 CZ3
CD1
O
 O4
O2
O
3kzj 1 P08603 99.22 6e-83 X-RAY
 2010-05-19 TRP A:59 A:1157 39.0 0.153 E -73.8 145.1 39.0 0.153 0.0 HOH
 2.772
 O
 O
5nbq 2 P08603 100.0 3e-82 X-RAY
 2017-12-06 TRP D:54 D:1157 45.0 0.176 B -87.7 144.8 45.0 0.176 0.0
TRP E:54 E:1157 43.0 0.169 E -85.9 151.4 NA NA NA
TRP F:54 F:1157 44.0 0.173 E -90.4 144.1 NA NA NA
2xqw 2 P08603 98.45 5e-82 X-RAY
 2011-02-02 TRP C:59 C:1157 39.0 0.153 E -91.9 142.3 39.0 0.153 0.0 HOH
 7.813
 NE1
 O
4j38 2 P08603 98.45 6e-82 X-RAY
 2013-05-15 TRP B:55 B:1157 43.0 0.169 E -85.7 138.7 43.0 0.169 0.0 HOH
 3.045
 O
 O
3oxu 2 Q14006 100.0 4e-81 X-RAY
 2011-02-16 TRP D:55 D:1157 42.0 0.165 E -77.5 140.0 NA NA NA
TRP E:55 E:1157 41.0 0.161 E -81.2 142.3 NA NA NA
TRP F:55 F:1157 45.0 0.176 E -85.4 144.0 45.0 0.176 0.0 HOH
 6.144
 C
 O
4ont 1 P08603 100.0 4e-81 X-RAY
 2014-11-26 TRP A:55 F:1157 40.0 0.157 B -73.9 129.6 40.0 0.157 0.0 HOH
 7.228
 CH2
 O
TRP C:55 D:1157 41.0 0.161 E -79.7 139.3 NA NA NA
TRP E:55 E:1157 42.0 0.165 E -73.4 141.5 NA NA NA
4zh1 2 P08603 100.0 4e-81 X-RAY
 2016-01-13 TRP D:55 D:1157 45.0 0.176 E -77.5 146.7 NA NA NA
TRP E:55 E:1157 43.0 0.169 E -77.2 146.4 43.0 0.169 0.0 HOH
 2.839
 N
 O
TRP F:55 F:1157 47.0 0.184 B -84.0 146.5 NA NA NA
2g7i 1 P08603 100.0 6e-81 X-RAY
 2006-05-23 TRP A:51 A:1157 41.0 0.161 E -77.4 147.0 41.0 0.161 0.0 HOH
 2.806
 O
 O
3r62 1 P08603 99.2 3e-80 X-RAY
 2011-06-29 TRP A:55 A:1157 39.0 0.153 E -88.8 138.1 39.0 0.153 0.0 HOH
 2.926
 N
 O
TRP B:55 B:1157 39.0 0.153 E -71.3 144.6 NA NA NA
3rj3 2 Q03591 99.2 3e-80 X-RAY
 2012-03-14 TRP D:55 D:1157 44.0 0.173 E -79.1 141.9 44.0 0.173 0.0 HOH
 4.122
 CD1
 O
TRP E:55 E:1157 43.0 0.169 B -84.2 143.3 NA NA NA
TRP F:55 F:1157 41.0 0.161 E -96.3 151.0 NA NA NA
4muc 1 Q03591 98.4 1e-79 X-RAY
 2015-02-18 TRP A:52 A:256 36.0 0.141 E -76.0 131.6 23.0 0.09 0.051 B:Q03591:0.051
TRP B:52 B:256 40.0 0.157 E -86.2 134.0 40.0 0.157 0.0 SO4
SO4
 9.439
9.462
 NE1
CH2
 O4
O1

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 TRP A:1157 A:1157 41.0 0.161 E -82.3 144.2