Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196715125 . C A CCDS1385.1:NM_000186.3:c.3489tgC>tgA_NP_000177.2:p.1163C>* Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3sw0 1 P08603 100.0 2e-126 X-RAY
 2012-03-14 CYS A:120 X:1163 8.0 0.059 E -112.7 107.5 8.0 0.059 0.0 GOL
HOH
 6.846
2.804
 SG
O
 O3
O
6zh1 2 P08603 100.0 4e-83 X-RAY
 2022-01-12 CYS B:65 B:1163 8.0 0.059 E -117.1 103.1 8.0 0.059 0.0 HOH
 2.699
 O
 O
3kxv 1 P08603 99.22 5e-83 X-RAY
 2010-05-19 CYS A:65 A:1163 8.0 0.059 E -98.0 105.5 8.0 0.059 0.0 HOH
 2.726
 O
 O
3kzj 1 P08603 99.22 6e-83 X-RAY
 2010-05-19 CYS A:65 A:1163 12.0 0.089 E -100.3 106.8 12.0 0.089 0.0 HOH
 2.717
 O
 O
5nbq 2 P08603 100.0 3e-82 X-RAY
 2017-12-06 CYS D:60 D:1163 9.0 0.067 E -103.7 102.0 9.0 0.067 0.0
CYS E:60 E:1163 8.0 0.059 E -103.0 100.7 NA NA NA
CYS F:60 F:1163 9.0 0.067 E -104.7 101.8 NA NA NA
2xqw 2 P08603 98.45 5e-82 X-RAY
 2011-02-02 CYS C:65 C:1163 10.0 0.074 E -104.2 102.4 10.0 0.074 0.0 HOH
 2.906
 N
 O
4j38 2 P08603 98.45 6e-82 X-RAY
 2013-05-15 CYS B:61 B:1163 11.0 0.081 E -110.7 105.1 11.0 0.081 0.0 HOH
 6.101
 C
 O
3oxu 2 Q14006 100.0 4e-81 X-RAY
 2011-02-16 CYS D:61 D:1163 10.0 0.074 E -114.3 105.1 NA NA NA
CYS E:61 E:1163 9.0 0.067 E -110.5 105.2 NA NA NA
CYS F:61 F:1163 8.0 0.059 E -113.0 105.2 8.0 0.059 0.0 HOH
 2.603
 O
 O
4ont 1 P08603 100.0 4e-81 X-RAY
 2014-11-26 CYS A:61 F:1163 9.0 0.067 E -118.7 113.0 9.0 0.067 0.0 HOH
 2.661
 O
 O
CYS C:61 D:1163 6.0 0.044 E -111.6 101.5 NA NA NA
CYS E:61 E:1163 10.0 0.074 E -114.1 113.1 NA NA NA
4zh1 2 P08603 100.0 4e-81 X-RAY
 2016-01-13 CYS D:61 D:1163 10.0 0.074 E -110.6 104.8 NA NA NA
CYS E:61 E:1163 10.0 0.074 E -113.8 108.8 10.0 0.074 0.0 HOH
 2.570
 O
 O
CYS F:61 F:1163 10.0 0.074 E -114.5 107.4 NA NA NA
2g7i 1 P08603 100.0 6e-81 X-RAY
 2006-05-23 CYS A:57 A:1163 12.0 0.089 E -100.0 106.9 12.0 0.089 0.0 HOH
 2.715
 O
 O
3r62 1 P08603 99.2 3e-80 X-RAY
 2011-06-29 CYS A:61 A:1163 11.0 0.081 E -111.4 108.7 11.0 0.081 0.0 GOL
HOH
 6.664
2.646
 O
O
 C3
O
CYS B:61 B:1163 9.0 0.067 E -110.3 106.0 NA NA NA
3rj3 2 Q03591 99.2 3e-80 X-RAY
 2012-03-14 CYS D:61 D:1163 10.0 0.074 E -112.7 99.0 10.0 0.074 0.0 HOH
 2.847
 O
 O
CYS E:61 E:1163 10.0 0.074 E -117.4 107.9 NA NA NA
CYS F:61 F:1163 9.0 0.067 E -123.8 103.8 NA NA NA
4muc 1 Q03591 98.4 1e-79 X-RAY
 2015-02-18 CYS A:58 A:262 9.0 0.067 E -105.5 90.9 9.0 0.067 0.0
CYS B:58 B:262 10.0 0.074 E -107.4 114.4 10.0 0.074 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 CYS A:1163 A:1163 12.0 0.089 E -108.3 105.2