Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196716261 . G A CCDS1385.1:NM_000186.3:c.3514Gaa>Aaa_NP_000177.2:p.1172E>K Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3sw0 1 P08603 100.0 2e-126 X-RAY
 2012-03-14 GLU A:129 X:1172 145.0 0.763 H -68.2 -44.4 145.0 0.763 0.0 HOH
 2.707
 OE2
 O
6zh1 2 P08603 100.0 4e-83 X-RAY
 2022-01-12 GLU B:74 B:1172 124.0 0.653 H -64.3 -42.8 124.0 0.653 0.0 SO4
SO4
HOH
 8.853
3.403
2.791
 N
N
OE2
 O4
O4
O
3kxv 1 P08603 99.22 5e-83 X-RAY
 2010-05-19 GLU A:74 A:1172 158.0 0.832 H -61.9 -45.2 118.0 0.621 0.211 A:P08603:0.211
 SO4
SO4
HOH
 3.039
7.755
4.596
 N
N
CB
 O1
O4
O
3kzj 1 P08603 99.22 6e-83 X-RAY
 2010-05-19 GLU A:74 A:1172 159.0 0.837 H -62.6 -47.2 121.0 0.637 0.2 A:P08603:0.2
 SO4
HOH
 7.839
2.525
 N
OE2
 O2
O
5nbq 2 P08603 100.0 3e-82 X-RAY
 2017-12-06 GLU D:69 D:1172 149.0 0.784 H -58.1 -50.5 137.0 0.721 0.063 A:P01024:0.063
GLU E:69 E:1172 76.0 NA H -55.8 -56.4 NA NA NA
GLU F:69 F:1172 110.0 0.579 H -61.4 -56.6 NA NA NA
2xqw 2 P08603 98.45 5e-82 X-RAY
 2011-02-02 GLU C:74 C:1172 152.0 0.8 H -51.7 -47.9 152.0 0.8 0.0 HOH
 2.482
 O
 O
4j38 2 P08603 98.45 6e-82 X-RAY
 2013-05-15 GLU B:70 B:1172 47.0 NA H -57.6 -47.5 47.0 NA NA
3oxu 2 Q14006 100.0 4e-81 X-RAY
 2011-02-16 GLU D:70 D:1172 146.0 0.768 H -61.4 -47.7 NA NA NA
GLU E:70 E:1172 138.0 0.726 H -74.4 -41.0 NA NA NA
GLU F:70 F:1172 63.0 0.332 T -147.8 105.8 63.0 0.332 0.0 HOH
 8.392
 O
 O
4ont 1 P08603 100.0 4e-81 X-RAY
 2014-11-26 GLU A:70 F:1172 72.0 NA H -66.6 -56.4 72.0 NA NA
GLU C:70 D:1172 146.0 0.768 H -59.4 -46.9 NA NA NA
GLU E:70 E:1172 158.0 0.832 H -75.0 -44.9 NA NA NA
4zh1 2 P08603 100.0 4e-81 X-RAY
 2016-01-13 GLU D:70 D:1172 149.0 0.784 H -68.7 -47.4 NA NA NA
GLU E:70 E:1172 137.0 0.721 H -70.8 -48.1 137.0 0.721 0.0
GLU F:70 F:1172 133.0 0.7 H -66.1 -51.0 NA NA NA
2g7i 1 P08603 100.0 6e-81 X-RAY
 2006-05-23 GLU A:66 A:1172 152.0 0.8 H -67.9 -40.6 112.0 0.589 0.211 A:P08603:0.211
 HOH
 2.582
 CD
 O
3r62 1 P08603 99.2 3e-80 X-RAY
 2011-06-29 GLU A:70 A:1172 109.0 0.574 H -72.7 -46.8 109.0 0.574 0.0 HOH
 3.260
 O
 O
GLU B:70 B:1172 135.0 0.711 H -58.5 -52.7 NA NA NA
3rj3 2 Q03591 99.2 3e-80 X-RAY
 2012-03-14 GLU D:70 D:1172 150.0 0.789 H -69.2 -45.4 80.0 0.421 0.368 A:P01024:0.368
 HOH
 3.382
 OE1
 O
GLU E:70 E:1172 143.0 0.753 H -60.9 -40.0 NA NA NA
GLU F:70 F:1172 115.0 0.605 S -90.1 136.9 NA NA NA
4muc 1 Q03591 98.4 1e-79 X-RAY
 2015-02-18 GLU A:67 A:271 75.0 NA H -55.1 -49.9 65.0 NA NA B:Q03591:NA
 SO4
 8.097
 CA
 O3
GLU B:67 B:271 146.0 0.768 H -48.9 -41.9 56.0 0.295 0.473 A:Q03591:0.474
 SO4
 8.000
 N
 O2

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 GLU A:1172 A:1172 149.0 0.784 H -64.5 -42.8