Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196716278 . T A CCDS1385.1:NM_000186.3:c.3531taT>taA_NP_000177.2:p.1177Y>* Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3sw0 1 P08603 100.0 2e-126 X-RAY
 2012-03-14 TYR A:134 X:1177 97.0 0.422 H -102.9 4.3 97.0 0.422 0.0 HOH
 3.137
 OH
 O
6zh1 2 P08603 100.0 4e-83 X-RAY
 2022-01-12 TYR B:79 B:1177 102.0 0.443 T -94.4 1.9 102.0 0.443 0.0 SO4
SO4
HOH
 7.395
8.239
4.071
 C
CE2
CE2
 O2
O1
O
3kxv 1 P08603 99.22 5e-83 X-RAY
 2010-05-19 TYR A:79 A:1177 80.0 0.348 H -86.0 -0.6 80.0 0.348 0.0 SO4
HOH
 6.526
3.412
 O
CE1
 O3
O
3kzj 1 P08603 99.22 6e-83 X-RAY
 2010-05-19 TYR A:79 A:1177 79.0 0.343 T -96.6 3.6 79.0 0.343 0.0 HOH
 2.928
 OH
 O
5nbq 2 P08603 100.0 3e-82 X-RAY
 2017-12-06 TYR D:74 D:1177 92.0 0.4 T -85.8 1.0 92.0 0.4 0.0
TYR E:74 E:1177 79.0 0.343 T -70.4 -3.5 NA NA NA
TYR F:74 F:1177 98.0 0.426 T -115.7 3.0 NA NA NA
2xqw 2 P08603 98.45 5e-82 X-RAY
 2011-02-02 TYR C:79 C:1177 82.0 0.357 T -97.9 2.3 82.0 0.357 0.0 HOH
 2.929
 OH
 O
4j38 2 P08603 98.45 6e-82 X-RAY
 2013-05-15 TYR B:75 B:1177 77.0 0.335 T -93.5 -11.3 77.0 0.335 0.0 HOH
 6.913
 O
 O
3oxu 2 Q14006 100.0 4e-81 X-RAY
 2011-02-16 TYR D:75 D:1177 91.0 0.396 H -99.2 1.9 NA NA NA
TYR E:75 E:1177 95.0 0.413 T -93.7 -0.7 NA NA NA
TYR F:75 F:1177 74.0 0.322 T -104.4 -1.6 74.0 0.322 0.0 HOH
 3.600
 CE1
 O
4ont 1 P08603 100.0 4e-81 X-RAY
 2014-11-26 TYR A:75 F:1177 102.0 0.443 H -46.7 2.9 102.0 0.443 0.0
TYR C:75 D:1177 87.0 0.378 H -92.8 4.0 NA NA NA
TYR E:75 E:1177 93.0 0.404 H -98.5 -5.1 NA NA NA
4zh1 2 P08603 100.0 4e-81 X-RAY
 2016-01-13 TYR D:75 D:1177 91.0 0.396 T -97.5 0.7 NA NA NA
TYR E:75 E:1177 95.0 0.413 H -98.8 0.4 95.0 0.413 0.0
TYR F:75 F:1177 136.0 0.591 H -99.8 -5.4 NA NA NA
2g7i 1 P08603 100.0 6e-81 X-RAY
 2006-05-23 TYR A:71 A:1177 80.0 0.348 H -93.2 1.8 80.0 0.348 0.0 HOH
 3.704
 CE1
 O
3r62 1 P08603 99.2 3e-80 X-RAY
 2011-06-29 TYR A:75 A:1177 95.0 0.413 H -99.2 5.4 95.0 0.413 0.0 HOH
 3.090
 OH
 O
TYR B:75 B:1177 91.0 0.396 H -102.2 -0.7 NA NA NA
3rj3 2 Q03591 99.2 3e-80 X-RAY
 2012-03-14 TYR D:75 D:1177 93.0 0.404 T -99.9 6.8 2.0 0.009 0.395 A:P01024:0.396
 HOH
 2.678
 OH
 O
TYR E:75 E:1177 95.0 0.413 H -96.8 -0.0 NA NA NA
TYR F:75 NA:NA DO NA DO DO DO NA NA NA
4muc 1 Q03591 98.4 1e-79 X-RAY
 2015-02-18 TYR A:72 A:276 81.0 0.352 T -97.9 11.5 81.0 0.352 0.0
TYR B:72 B:276 105.0 0.457 T -86.7 16.6 105.0 0.457 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 TYR A:1177 A:1177 97.0 0.422 T -90.0 3.7