Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196716289 . T A CCDS1385.1:NM_000186.3:c.3542tTa>tAa_NP_000177.2:p.1181L>* Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
pdb_id: 
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label_seq_id: 
label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3sw0 1 P08603 100.0 2e-126 X-RAY
 2012-03-14 LEU A:138 X:1181 29.0 0.171 E -74.8 143.2 29.0 0.171 0.0 HOH
 2.952
 N
 O
6zh1 2 P08603 100.0 4e-83 X-RAY
 2022-01-12 LEU B:83 B:1181 9.0 0.053 E -75.1 132.8 4.0 0.024 0.029 A:W5SB08:0.029
 EDO
EDO
SO4
HOH
 8.123
8.979
6.889
2.912
 O
O
CD1
O
 O1
C2
O1
O
3kxv 1 P08603 99.22 5e-83 X-RAY
 2010-05-19 LEU A:83 A:1181 22.0 0.129 E -65.8 139.6 22.0 0.129 0.0 SO4
HOH
 6.032
2.695
 O
O
 O4
O
3kzj 1 P08603 99.22 6e-83 X-RAY
 2010-05-19 LEU A:83 A:1181 24.0 0.141 E -65.1 139.8 24.0 0.141 0.0 HOH
 2.712
 O
 O
5nbq 2 P08603 100.0 3e-82 X-RAY
 2017-12-06 LEU D:78 D:1181 22.0 0.129 E -61.3 126.3 16.0 0.094 0.035 G:Q45001:0.035
LEU E:78 E:1181 24.0 0.141 B -95.0 120.5 NA NA NA
LEU F:78 F:1181 21.0 0.124 E -59.9 127.0 NA NA NA
2xqw 2 P08603 98.45 5e-82 X-RAY
 2011-02-02 LEU C:83 C:1181 8.0 0.047 E -74.0 146.1 7.0 0.041 0.006 B:P01024:0.006
 HOH
 3.906
 CB
 O
4j38 2 P08603 98.45 6e-82 X-RAY
 2013-05-15 LEU B:79 B:1181 16.0 0.094 E -70.2 128.4 12.0 0.071 0.023 A:E4QGX1:0.024
 SO4
HOH
 7.657
7.349
 O
C
 O4
O
3oxu 2 Q14006 100.0 4e-81 X-RAY
 2011-02-16 LEU D:79 D:1181 26.0 0.153 E -75.3 136.9 NA NA NA
LEU E:79 E:1181 40.0 0.235 E -97.1 150.2 NA NA NA
LEU F:79 F:1181 21.0 0.124 E -76.0 135.9 21.0 0.124 0.0 HOH
 4.140
 CB
 O
4ont 1 P08603 100.0 4e-81 X-RAY
 2014-11-26 LEU A:79 F:1181 36.0 0.212 E -73.6 124.2 36.0 0.212 0.0 BGC
SIA
 9.379
3.774
 O
CD2
 O6
O9
LEU C:79 D:1181 35.0 0.206 E -64.1 136.1 NA NA NA
LEU E:79 E:1181 24.0 0.141 E -60.2 126.9 NA NA NA
4zh1 2 P08603 100.0 4e-81 X-RAY
 2016-01-13 LEU D:79 D:1181 28.0 0.165 E -70.4 139.9 NA NA NA
LEU E:79 E:1181 55.0 0.324 E -69.4 136.0 55.0 0.324 0.0 BGC
GAL
SIA
HOH
 9.775
9.580
3.778
4.975
 C
CB
CB
O
 C6
O2
O9
O
LEU F:79 F:1181 25.0 0.147 -76.7 133.1 NA NA NA
2g7i 1 P08603 100.0 6e-81 X-RAY
 2006-05-23 LEU A:75 A:1181 22.0 0.129 E -68.8 140.4 22.0 0.129 0.0 HOH
 2.754
 O
 O
3r62 1 P08603 99.2 3e-80 X-RAY
 2011-06-29 LEU A:79 A:1181 25.0 0.147 E -67.8 146.8 25.0 0.147 0.0 HOH
 2.713
 O
 O
LEU B:79 B:1181 25.0 0.147 E -61.5 142.9 NA NA NA
3rj3 2 Q03591 99.2 3e-80 X-RAY
 2012-03-14 LEU D:79 D:1181 13.0 0.076 E -77.0 138.6 13.0 0.076 0.0 HOH
 2.837
 O
 O
LEU E:79 E:1181 40.0 0.235 E -92.3 146.7 NA NA NA
LEU F:79 F:1181 21.0 0.124 E -104.9 156.9 NA NA NA
4muc 1 Q03591 98.4 1e-79 X-RAY
 2015-02-18 LEU A:76 A:280 29.0 0.171 E -69.7 137.3 29.0 0.171 0.0
LEU B:76 B:280 36.0 0.212 E -86.5 135.0 36.0 0.212 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 LEU A:1181 A:1181 32.0 0.188 E -63.4 134.6