Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196716295 . G A CCDS1385.1:NM_000186.3:c.3548tGg>tAg_NP_000177.2:p.1183W>* Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
pdb_id: 
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label_seq_id: 
label_comp_id: 
auth_asym_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3sw0 1 P08603 100.0 2e-126 X-RAY
 2012-03-14 TRP A:140 X:1183 166.0 0.651 -110.1 99.0 166.0 0.651 0.0 HOH
 3.031
 N
 O
6zh1 2 P08603 100.0 4e-83 X-RAY
 2022-01-12 TRP B:85 B:1183 201.0 0.788 T 72.8 -15.8 4.0 0.016 0.772 A:W5SB08:0.773
 EDO
HOH
 7.283
3.402
 O
CH2
 C2
O
3kxv 1 P08603 99.22 5e-83 X-RAY
 2010-05-19 TRP A:85 A:1183 121.0 0.475 -114.9 100.7 121.0 0.475 0.0 SO4
HOH
 3.277
2.938
 CA
N
 O3
O
3kzj 1 P08603 99.22 6e-83 X-RAY
 2010-05-19 TRP A:85 A:1183 116.0 0.455 -105.9 96.9 116.0 0.455 0.0 HOH
 2.901
 N
 O
5nbq 2 P08603 100.0 3e-82 X-RAY
 2017-12-06 TRP D:80 D:1183 186.0 0.729 S -92.0 -6.7 2.0 0.008 0.721 G:Q45001:0.722
TRP E:80 E:1183 210.0 0.824 S 78.7 7.9 NA NA NA
TRP F:80 F:1183 181.0 0.71 S -100.2 6.0 NA NA NA
2xqw 2 P08603 98.45 5e-82 X-RAY
 2011-02-02 TRP C:85 C:1183 183.0 0.718 S -107.9 84.6 174.0 0.682 0.036 B:P01024:0.035
 HOH
 3.261
 N
 O
4j38 2 P08603 98.45 6e-82 X-RAY
 2013-05-15 TRP B:81 B:1183 176.0 0.69 S -99.3 -23.7 10.0 0.039 0.651 A:E4QGX1:0.651
 SO4
HOH
 4.650
6.134
 CZ3
NE1
 O4
O
3oxu 2 Q14006 100.0 4e-81 X-RAY
 2011-02-16 TRP D:81 D:1183 140.0 0.549 -114.4 95.0 NA NA NA
TRP E:81 NA:NA DO NA DO DO DO NA NA NA
TRP F:81 F:1183 185.0 0.725 S 39.0 47.9 185.0 0.725 0.0 HOH
 4.253
 CB
 O
4ont 1 P08603 100.0 4e-81 X-RAY
 2014-11-26 TRP A:81 F:1183 196.0 0.769 S -90.5 -74.2 196.0 0.769 0.0 BGC
GAL
SIA
 3.891
3.386
2.971
 CE3
NE1
N
 O6
C1
O9
TRP C:81 D:1183 178.0 0.698 S -114.3 109.5 NA NA NA
TRP E:81 E:1183 193.0 0.757 S -115.1 -20.3 NA NA NA
4zh1 2 P08603 100.0 4e-81 X-RAY
 2016-01-13 TRP D:81 D:1183 173.0 0.678 -112.5 103.7 NA NA NA
TRP E:81 E:1183 158.0 0.62 -119.6 -178.4 158.0 0.62 0.0 BGC
GAL
NGA
SIA
HOH
 3.548
3.808
7.016
3.037
4.182
 CZ3
CE2
NE1
N
C
 O5
C1
C1
O9
O
TRP F:81 F:1183 172.0 0.675 T -96.5 15.8 NA NA NA
2g7i 1 P08603 100.0 6e-81 X-RAY
 2006-05-23 TRP A:77 A:1183 121.0 0.475 -109.5 93.7 121.0 0.475 0.0 HOH
 3.053
 N
 O
3r62 1 P08603 99.2 3e-80 X-RAY
 2011-06-29 TRP A:81 A:1183 99.0 0.388 T -121.9 68.8 99.0 0.388 0.0 HOH
 2.879
 N
 O
TRP B:81 B:1183 126.0 0.494 S -119.6 90.5 NA NA NA
3rj3 2 Q03591 99.2 3e-80 X-RAY
 2012-03-14 TRP D:81 D:1183 145.0 0.569 -116.3 100.0 145.0 0.569 0.0 HOH
 2.642
 O
 O
TRP E:81 NA:NA DO NA DO DO DO NA NA NA
TRP F:81 F:1183 258.0 1.0 S 81.6 -1.0 NA NA NA
4muc 1 Q03591 98.4 1e-79 X-RAY
 2015-02-18 TRP A:78 A:282 189.0 0.741 G -51.5 -43.7 189.0 0.741 0.0
TRP B:78 B:282 17.0 NA T -105.6 78.3 17.0 NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 TRP A:1183 A:1183 172.0 0.675 -115.3 98.2