Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196716387 . T A CCDS1385.1:NM_000186.3:c.3640Ttg>Atg_NP_000177.2:p.1214L>M Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3sw0 1 P08603 100.0 2e-126 X-RAY
 2012-03-14 LEU A:171 X:1214 50.0 0.294 S -75.4 -13.6 50.0 0.294 0.0 HOH
 2.885
 N
 O
6zh1 2 P08603 100.0 4e-83 X-RAY
 2022-01-12 LEU B:116 B:1214 53.0 0.312 T -70.9 -15.4 40.0 0.235 0.077 A:W5SB08:0.076
 EDO
SO4
HOH
 4.551
8.831
3.033
 CB
N
O
 O2
O1
O
3kxv 1 P08603 99.22 5e-83 X-RAY
 2010-05-19 LEU A:116 A:1214 46.0 0.271 S -67.3 -31.2 46.0 0.271 0.0 SO4
HOH
 7.741
3.097
 C
N
 O2
O
3kzj 1 P08603 99.22 6e-83 X-RAY
 2010-05-19 LEU A:116 A:1214 49.0 0.288 S -66.4 -28.2 49.0 0.288 0.0 SO4
HOH
 7.771
2.969
 C
N
 O2
O
5nbq 2 P08603 100.0 3e-82 X-RAY
 2017-12-06 LEU D:111 D:1214 50.0 0.294 G -77.0 -17.8 50.0 0.294 0.0
LEU E:111 E:1214 53.0 0.312 S -57.0 -36.1 NA NA NA
LEU F:111 F:1214 47.0 0.276 -62.1 -36.4 NA NA NA
2xqw 2 P08603 98.45 5e-82 X-RAY
 2011-02-02 LEU C:116 C:1214 45.0 0.265 S -97.1 -0.2 45.0 0.265 0.0 HOH
 3.225
 CD1
 O
4j38 2 P08603 98.45 6e-82 X-RAY
 2013-05-15 LEU B:112 B:1214 40.0 0.235 S -104.2 -3.0 40.0 0.235 0.0 SO4
HOH
 8.429
3.330
 CD1
CB
 O1
O
3oxu 2 Q14006 100.0 4e-81 X-RAY
 2011-02-16 LEU D:112 D:1214 40.0 0.235 S -68.2 -18.4 NA NA NA
LEU E:112 E:1214 50.0 0.294 S -57.0 -41.6 NA NA NA
LEU F:112 F:1214 50.0 0.294 T -80.2 -21.2 50.0 0.294 0.0 HOH
 3.655
 CD1
 O
4ont 1 P08603 100.0 4e-81 X-RAY
 2014-11-26 LEU A:112 F:1214 34.0 0.2 T -66.4 -16.1 34.0 0.2 0.0 GAL
SIA
 9.164
7.307
 O
O
 O6
O8
LEU C:112 D:1214 43.0 0.253 S -59.6 -24.9 NA NA NA
LEU E:112 E:1214 40.0 0.235 S -66.8 -31.3 NA NA NA
4zh1 2 P08603 100.0 4e-81 X-RAY
 2016-01-13 LEU D:112 D:1214 46.0 0.271 S -65.6 -21.9 NA NA NA
LEU E:112 E:1214 49.0 0.288 S -67.2 -26.7 49.0 0.288 0.0 GAL
SIA
HOH
 9.684
7.263
2.768
 O
O
N
 O6
O8
O
LEU F:112 F:1214 118.0 0.694 -64.6 -23.7 NA NA NA
2g7i 1 P08603 100.0 6e-81 X-RAY
 2006-05-23 LEU A:108 A:1214 40.0 0.235 S -63.3 -34.2 40.0 0.235 0.0 HOH
 2.945
 N
 O
3r62 1 P08603 99.2 3e-80 X-RAY
 2011-06-29 LEU A:112 A:1214 42.0 0.247 S -65.2 8.8 42.0 0.247 0.0 HOH
 2.863
 N
 O
LEU B:112 B:1214 67.0 0.394 S -78.2 -14.6 NA NA NA
3rj3 2 Q03591 99.2 3e-80 X-RAY
 2012-03-14 LEU D:112 D:1214 38.0 0.224 S -59.7 -21.7 38.0 0.224 0.0 HOH
 3.555
 CD1
 O
LEU E:112 E:1214 45.0 0.265 S -64.8 -39.9 NA NA NA
LEU F:112 F:1214 66.0 0.388 -112.4 21.9 NA NA NA
4muc 1 Q03591 98.4 1e-79 X-RAY
 2015-02-18 LEU A:109 A:313 55.0 0.324 S -59.3 -44.0 55.0 0.324 0.0
LEU B:109 B:313 52.0 0.306 S -85.4 -23.5 52.0 0.306 0.0 SO4
 7.252
 C
 O4
5wtb 2 P08603 100.0 8e-07 X-RAY
 2017-07-19 LEU E:9 E:1214 181.0 1.0 -138.5 145.3 NA NA NA
LEU F:9 F:1214 141.0 0.829 -99.6 63.9 NA NA NA
LEU G:9 G:1214 154.0 0.906 -72.2 76.8 NA NA NA
LEU H:9 H:1214 180.0 1.0 -145.0 130.9 129.0 0.759 0.241 A:Q932F7:0.3

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 LEU A:1214 A:1214 60.0 0.353 S -61.6 -10.2