Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 196716391 . G A CCDS1385.1:NM_000186.3:c.3644cGa>cAa_NP_000177.2:p.1215R>Q Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3sw0 1 P08603 100.0 2e-126 X-RAY
 2012-03-14 ARG A:172 X:1215 145.0 0.644 E -122.7 129.5 145.0 0.644 0.0 GOL
HOH
 9.508
2.885
 NH2
NH2
 O2
O
6zh1 2 P08603 100.0 4e-83 X-RAY
 2022-01-12 ARG B:117 B:1215 146.0 0.649 E -122.8 115.2 96.0 0.427 0.222 A:W5SB08:0.222
 EDO
HOH
 3.776
3.163
 CB
O
 C2
O
3kxv 1 P08603 99.22 5e-83 X-RAY
 2010-05-19 ARG A:117 A:1215 146.0 0.649 E -88.6 126.1 146.0 0.649 0.0 SO4
HOH
 4.058
3.076
 O
N
 O2
O
3kzj 1 P08603 99.22 6e-83 X-RAY
 2010-05-19 ARG A:117 A:1215 122.0 0.542 E -90.2 128.6 122.0 0.542 0.0 SO4
HOH
 4.028
2.776
 O
NH2
 O2
O
5nbq 2 P08603 100.0 3e-82 X-RAY
 2017-12-06 ARG D:112 D:1215 140.0 0.622 E -119.9 119.8 26.0 0.116 0.506 G:Q45001:0.507
ARG E:112 E:1215 139.0 0.618 E -94.7 126.3 NA NA NA
ARG F:112 F:1215 156.0 0.693 E -95.4 131.8 NA NA NA
2xqw 2 P08603 98.45 5e-82 X-RAY
 2011-02-02 ARG C:117 C:1215 132.0 0.587 E -116.7 121.7 132.0 0.587 0.0 HOH
 6.145
 N
 O
4j38 2 P08603 98.45 6e-82 X-RAY
 2013-05-15 ARG B:113 B:1215 138.0 0.613 E -109.7 107.6 21.0 0.093 0.52 A:E4QGX1:0.52
 HOH
 3.746
 NH2
 O
3oxu 2 Q14006 100.0 4e-81 X-RAY
 2011-02-16 ARG D:113 D:1215 132.0 0.587 E -105.0 121.2 NA NA NA
ARG E:113 E:1215 130.0 0.578 E -79.9 129.4 NA NA NA
ARG F:113 F:1215 146.0 0.649 E -111.9 125.0 146.0 0.649 0.0 HOH
 3.254
 O
 O
4ont 1 P08603 100.0 4e-81 X-RAY
 2014-11-26 ARG A:113 F:1215 151.0 0.671 E -122.4 114.3 151.0 0.671 0.0 BGC
GAL
SIA
 8.186
4.204
2.932
 NH2
NH2
NH2
 O4
C4
O1A
ARG C:113 D:1215 124.0 0.551 E -103.9 119.1 NA NA NA
ARG E:113 E:1215 130.0 0.578 E -92.9 124.8 NA NA NA
4zh1 2 P08603 100.0 4e-81 X-RAY
 2016-01-13 ARG D:113 D:1215 125.0 0.556 E -102.7 123.6 NA NA NA
ARG E:113 E:1215 130.0 0.578 E -97.3 124.2 130.0 0.578 0.0 BGC
GAL
NGA
GAL
SIA
HOH
 7.916
4.228
3.202
7.373
2.981
2.766
 NH2
NH2
NH1
NH1
NH1
O
 O4
O6
O6
C1
O1B
O
ARG F:113 F:1215 148.0 0.658 B -101.8 126.5 NA NA NA
2g7i 1 P08603 100.0 6e-81 X-RAY
 2006-05-23 ARG A:109 A:1215 142.0 0.631 E -85.4 127.9 142.0 0.631 0.0 HOH
 3.044
 N
 O
3r62 1 P08603 99.2 3e-80 X-RAY
 2011-06-29 ARG A:113 A:1215 133.0 0.591 E -135.5 121.6 133.0 0.591 0.0 HOH
 2.820
 NH2
 O
ARG B:113 B:1215 133.0 0.591 E -131.3 139.6 NA NA NA
3rj3 2 Q03591 99.2 3e-80 X-RAY
 2012-03-14 ARG D:113 D:1215 133.0 0.591 E -99.0 130.2 133.0 0.591 0.0 HOH
 3.959
 N
 O
ARG E:113 E:1215 128.0 0.569 E -79.0 128.1 NA NA NA
ARG F:113 F:1215 159.0 0.707 E -104.3 107.3 NA NA NA
4muc 1 Q03591 98.4 1e-79 X-RAY
 2015-02-18 ARG A:110 A:314 132.0 0.587 E -77.1 135.2 132.0 0.587 0.0
ARG B:110 B:314 153.0 0.68 E -109.0 134.8 153.0 0.68 0.0 SO4
SO4
 3.439
3.242
 O
NH2
 O4
O4
5wtb 2 P08603 100.0 8e-07 X-RAY
 2017-07-19 ARG E:10 E:1215 237.0 1.0 -126.7 130.3 NA NA NA
ARG F:10 F:1215 196.0 0.871 -68.1 -8.2 NA NA NA
ARG G:10 G:1215 179.0 0.796 -74.3 -44.5 NA NA NA
ARG H:10 H:1215 242.0 1.0 -131.8 138.0 145.0 0.644 0.356 A:Q932F7:0.431

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p08603-f1 1 P08603 99.92 0.0 ARG A:1215 A:1215 146.0 0.649 E -111.1 113.9