Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 22405033 | . | T | A | CCDS221.1:NM_001039802.1:c.62aTa>aAa_NP_001034891.1:p.21I>K | Homo sapiens cell division cycle 42 (CDC42), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2odb | 1 | P60953 | 100.0 | 1e-141 |
X-RAY |
2007-01-30 | ILE | A:22 | A:21 | 32.0 | 0.183 | H | -69.7 | -36.8 | 28.0 | 0.16 | 0.023 |
B:Q9NQU5:0.023 |
MG GCP HOH |
8.163 7.490 4.038 |
CG1 CG1 CD1 |
MG O1A O |
|
| 5c2j | 2 | P60766 | 100.0 | 1e-141 |
X-RAY |
2016-06-22 | ILE | B:28 | B:21 | 33.0 | 0.189 | H | -73.8 | -47.9 | 33.0 | 0.189 | 0.0 |
MG GDP AF3 HOH |
7.382 6.856 9.514 3.944 |
CD1 CD1 CD1 CD1 |
MG O1A F3 O |
||
| 2dfk | 2 | P60953 | 100.0 | 1e-141 |
X-RAY |
2006-05-02 | ILE | B:24 | B:21 | 11.0 | 0.063 | H | -61.8 | -44.1 | 11.0 | 0.063 | 0.0 |
SO4 GOL HOH |
8.360 5.801 3.947 |
CD1 O O |
O2 O3 O |
||
| ILE | D:24 | D:21 | 13.0 | 0.074 | H | -66.6 | -44.6 | NA | NA | NA | |||||||||||||
| 1grn | 1 | P60953 | 100.0 | 2e-141 |
X-RAY |
1999-12-22 | ILE | A:21 | A:21 | 41.0 | 0.234 | H | -72.6 | -38.5 | 41.0 | 0.234 | 0.0 |
MG GDP AF3 HOH |
7.769 7.189 9.606 5.950 |
CD1 CD1 CD1 CD1 |
MG O1A F3 O |
||
| 2ngr | 1 | P60953 | 100.0 | 2e-141 |
X-RAY |
1999-01-06 | ILE | A:21 | A:21 | 44.0 | 0.251 | H | -63.3 | -37.7 | 44.0 | 0.251 | 0.0 |
MG GDP AF3 HOH |
7.859 7.326 9.527 3.411 |
CD1 CD1 CD1 CD1 |
MG O1A F3 O |
||
| 4itr | 2 | P60953 | 100.0 | 2e-141 |
X-RAY |
2013-02-20 | ILE | C:21 | C:21 | 21.0 | 0.12 | H | -70.4 | -41.4 | 21.0 | 0.12 | 0.0 |
GDP MG HOH |
7.067 8.076 4.226 |
CD1 CD1 CG2 |
O2A MG O |
||
| ILE | D:21 | D:21 | 20.0 | 0.114 | H | -69.4 | -44.6 | 20.0 | 0.114 | 0.0 |
GDP MG HOH |
7.107 8.183 3.896 |
CD1 CD1 CD1 |
O2A MG O |
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| 6siu | 2 | P60953 | 100.0 | 3e-141 |
X-RAY |
2020-03-18 | ILE | C:22 | C:21 | 24.0 | 0.137 | H | -65.0 | -44.7 | 24.0 | 0.137 | 0.0 |
GDP HOH |
6.624 7.886 |
CD1 CD1 |
O2A O |
||
| ILE | D:22 | D:21 | 23.0 | 0.131 | H | -67.9 | -43.9 | 23.0 | 0.131 | 0.0 |
GDP HOH |
6.658 7.567 |
CD1 CD1 |
O2A O |
|||||||||
| 5fi1 | 2 | P60953 | 100.0 | 3e-141 |
X-RAY |
2016-04-20 | ILE | B:24 | B:21 | 22.0 | 0.126 | H | -64.9 | -43.4 | 22.0 | 0.126 | 0.0 | ||||||
| 1an0 | 1 | P60953 | 100.0 | 1e-140 |
X-RAY |
1999-01-13 | ILE | A:21 | A:21 | 18.0 | 0.103 | H | -52.5 | -35.7 | 18.0 | 0.103 | 0.0 |
MG GDP HOH |
7.917 6.583 4.612 |
CD1 CD1 CA |
MG O2A O |
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| ILE | B:21 | B:21 | 24.0 | 0.137 | H | -47.3 | -44.8 | 24.0 | 0.137 | 0.0 |
MG GDP HOH |
8.171 7.299 7.910 |
CD1 CD1 O |
MG O2A O |
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| 1a4r | 1 | P60953 | 99.48 | 4e-140 |
X-RAY |
1999-03-02 | ILE | A:21 | A:21 | 15.0 | 0.086 | H | -66.7 | -48.6 | 15.0 | 0.086 | 0.0 |
MG GDP HOH |
7.965 6.938 3.641 |
CD1 CD1 CG2 |
MG O2A O |
||
| ILE | B:21 | B:221 | 21.0 | 0.12 | H | -60.9 | -51.6 | 21.0 | 0.12 | 0.0 |
GNH HOH |
6.792 8.644 |
CD1 O |
O2A O |
|||||||||
| 2qrz | 1 | P60953 | 100.0 | 4e-140 |
X-RAY |
2008-03-18 | ILE | A:21 | A:21 | 20.0 | 0.114 | H | -63.1 | -47.2 | 20.0 | 0.114 | 0.0 |
MG GCP HOH |
8.100 7.341 3.827 |
CG1 CG1 CD1 |
MG O1A O |
||
| ILE | B:21 | B:21 | 23.0 | 0.131 | H | -65.2 | -41.2 | 23.0 | 0.131 | 0.0 |
MG GCP HOH |
7.914 7.221 5.575 |
CG1 CG1 CD1 |
MG O1A O |
|||||||||
| 2wm9 | 2 | P60953 | 100.0 | 1e-139 |
X-RAY |
2009-09-22 | ILE | B:23 | B:21 | 13.0 | 0.074 | H | -65.4 | -44.1 | 6.0 | 0.034 | 0.04 |
A:Q9BZ29:0.04 |
GOL HOH |
6.607 4.755 |
CD1 CG2 |
O3 O |
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| 2wmn | 2 | P60953 | 100.0 | 1e-139 |
X-RAY |
2009-09-22 | ILE | B:23 | B:21 | 28.0 | 0.16 | H | -62.2 | -42.6 | 26.0 | 0.149 | 0.011 |
A:Q9BZ29:0.011 |
GDP HOH |
6.451 6.392 |
CD1 CG1 |
O2A O |
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| 2wmo | 2 | P60953 | 100.0 | 1e-139 |
X-RAY |
2009-09-22 | ILE | B:23 | B:21 | 22.0 | 0.126 | H | -65.7 | -45.8 | 22.0 | 0.126 | 0.0 |
GTP MG HOH |
6.859 7.162 3.710 |
CD1 CD1 CD1 |
O2A MG O |
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| 1nf3 | 1 | P60953 | 98.95 | 1e-139 |
X-RAY |
2003-03-04 | ILE | A:25 | A:21 | 29.0 | 0.166 | H | -69.8 | -36.1 | 24.0 | 0.137 | 0.029 |
C:Q9JK83:0.029 |
MG GNP HOH |
8.331 7.245 3.547 |
CG1 CG1 CG2 |
MG O1A O |
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| ILE | B:25 | B:21 | 36.0 | 0.206 | H | -68.6 | -38.1 | NA | NA | NA | |||||||||||||
| 1doa | 1 | P60953 | 100.0 | 1e-139 |
X-RAY |
2000-02-09 | ILE | A:24 | A:21 | 28.0 | 0.16 | H | -72.5 | -36.6 | 28.0 | 0.16 | 0.0 |
MG GDP HOH |
8.849 7.902 5.789 |
CD1 CD1 CG2 |
MG O1A O |
||
| 6tky | 2 | P60953 | 100.0 | 2e-139 |
X-RAY |
2020-01-22 | ILE | B:21 | C:21 | 12.0 | 0.069 | H | -60.0 | -44.5 | NA | NA | NA | ||||||
| ILE | C:21 | D:21 | 14.0 | 0.08 | H | -65.2 | -44.4 | 10.0 | 0.057 | 0.023 |
A:Q96BY6:0.023 |
GOL HOH |
6.343 3.900 |
CD1 CD1 |
O1 O |
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| 6tkz | 2 | P60953 | 100.0 | 2e-139 |
X-RAY |
2020-01-22 | ILE | B:21 | C:21 | 11.0 | 0.063 | H | -75.8 | -33.8 | NA | NA | NA | ||||||
| ILE | C:21 | D:21 | 13.0 | 0.074 | H | -72.5 | -38.3 | 11.0 | 0.063 | 0.011 |
A:Q96BY6:0.011 |
GDP HOH |
6.568 4.038 |
CD1 CD1 |
O2A O |
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| 6aj4 | 2 | P60953 | 100.0 | 1e-138 |
X-RAY |
2019-03-20 | ILE | B:28 | B:21 | 12.0 | 0.069 | H | -71.4 | -34.4 | 12.0 | 0.069 | 0.0 | ||||||
| ILE | D:28 | D:21 | 14.0 | 0.08 | H | -65.2 | -22.8 | NA | NA | NA | |||||||||||||
| ILE | F:28 | F:21 | 13.0 | 0.074 | H | -78.7 | -12.9 | NA | NA | NA | |||||||||||||
| ILE | H:28 | H:21 | 13.0 | 0.074 | H | -70.9 | -39.5 | NA | NA | NA | |||||||||||||
| 6ajl | 2 | P60953 | 100.0 | 1e-138 |
X-RAY |
2019-03-20 | ILE | B:28 | B:21 | 10.0 | 0.057 | H | -67.3 | -23.8 | 9.0 | 0.051 | 0.006 |
A:Q96N67:0.006 |
|||||
| ILE | D:28 | D:21 | 11.0 | 0.063 | H | -69.3 | -28.8 | NA | NA | NA | |||||||||||||
| ILE | F:28 | F:21 | 8.0 | 0.046 | H | -66.2 | -37.4 | NA | NA | NA | |||||||||||||
| ILE | H:28 | H:21 | 12.0 | 0.069 | H | -84.9 | -37.4 | NA | NA | NA | |||||||||||||
| 1ki1 | 1 | P60953 | 100.0 | 1e-138 |
X-RAY |
2002-05-29 | ILE | A:21 | A:21 | 14.0 | 0.08 | H | -65.7 | -42.4 | 14.0 | 0.08 | 0.0 |
SO4 HOH |
8.458 5.241 |
CD1 CA |
O4 O |
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| ILE | C:21 | C:21 | 13.0 | 0.074 | H | -65.8 | -42.7 | NA | NA | NA | |||||||||||||
| 1kz7 | 2 | P60953 | 100.0 | 1e-138 |
X-RAY |
2002-03-20 | ILE | B:21 | B:21 | 13.0 | 0.074 | H | -67.9 | -42.6 | 13.0 | 0.074 | 0.0 |
HOH |
4.680 |
CA |
O |
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| ILE | D:21 | D:1021 | 15.0 | 0.086 | H | -67.1 | -36.9 | NA | NA | NA | |||||||||||||
| 1kzg | 2 | P60953 | 100.0 | 1e-138 |
X-RAY |
2002-03-20 | ILE | B:21 | B:21 | 15.0 | 0.086 | H | -57.3 | -50.8 | 15.0 | 0.086 | 0.0 |
HOH |
6.574 |
CG1 |
O |
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| ILE | D:21 | D:1021 | 15.0 | 0.086 | H | -61.4 | -46.5 | NA | NA | NA | |||||||||||||
| 3vhl | 2 | P60953 | 99.47 | 6e-138 |
X-RAY |
2012-06-20 | ILE | B:28 | B:21 | 7.0 | 0.04 | H | -74.2 | -36.5 | 7.0 | 0.04 | 0.0 |
PO4 HOH |
8.719 3.799 |
CG2 CD1 |
O3 O |
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| 4did | 1 | P60953 | 100.0 | 2e-135 |
X-RAY |
2012-02-29 | ILE | A:31 | A:21 | 21.0 | 0.12 | H | -71.0 | -42.5 | 21.0 | 0.12 | 0.0 |
GDP MG HOH |
6.806 8.171 3.890 |
CD1 CD1 CD1 |
O2A MG O |
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| 1e0a | 1 | P60953 | 99.46 | 1e-134 |
NMR |
2000-04-18 | ILE | A:21 | A:21 | 12.0 | 0.069 | I | -48.7 | -69.0 | 8.0 | 0.046 | 0.023 |
B:P35465:0.023 |
GNP MG HOH |
2.264 5.604 3.631 |
HG23 HD12 HG12 |
HO2' MG H2 |
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| 5hzk | 1 | P60953 | 96.79 | 3e-134 |
X-RAY |
2016-12-21 | ILE | A:23 | A:21 | 8.0 | 0.046 | H | -67.6 | -44.6 | 8.0 | 0.046 | 0.0 |
GDP |
6.904 |
CD1 |
O2A |
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| ILE | C:23 | C:21 | 7.0 | 0.04 | H | -66.4 | -44.5 | NA | NA | NA | |||||||||||||
| 4yc7 | 2 | P60953 | 99.44 | 1e-131 |
X-RAY |
2015-05-13 | ILE | B:23 | A:20 | 47.0 | 0.269 | H | -81.6 | -41.1 | 47.0 | 0.269 | 0.0 |
GNP MG HOH |
7.559 7.543 6.136 |
CD1 CD1 CD1 |
O1A MG O |
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| 4ydh | 2 | P60953 | 99.44 | 1e-131 |
X-RAY |
2015-05-13 | ILE | B:23 | B:21 | 47.0 | 0.269 | H | -92.8 | -33.4 | 47.0 | 0.269 | 0.0 |
GNP MG |
7.167 7.921 |
CD1 CD1 |
O2A MG |
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| ILE | D:23 | D:21 | 44.0 | 0.251 | H | -94.5 | -34.2 | 44.0 | 0.251 | 0.0 |
GNP MG |
7.515 8.362 |
N CD1 |
O1A MG |
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| 1gzs | 1 | P25763 | 100.0 | 3e-131 |
X-RAY |
2002-09-12 | ILE | A:23 | A:21 | 13.0 | 0.074 | H | -66.5 | -48.9 | 13.0 | 0.074 | 0.0 |
SO4 HOH |
8.704 4.111 |
CD1 CG1 |
O3 O |
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| ILE | C:23 | C:21 | 15.0 | 0.086 | H | -66.1 | -44.1 | NA | NA | NA | |||||||||||||
| 3eg5 | 1 | P60766 | 99.44 | 6e-131 |
X-RAY |
2008-10-14 | ILE | A:21 | A:21 | 30.0 | 0.171 | H | -62.1 | -51.3 | 30.0 | 0.171 | 0.0 |
GNP MG HOH |
7.024 7.948 7.684 |
CG1 CG1 CG1 |
O1A MG O |
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| ILE | C:21 | C:21 | 31.0 | 0.177 | H | -62.7 | -51.1 | 31.0 | 0.177 | 0.0 |
GNP MG HOH |
6.977 7.951 7.683 |
CG1 CG1 CG1 |
O1A MG O |
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| 5upl | 2 | P60953 | 100.0 | 1e-130 |
X-RAY |
2017-12-27 | ILE | B:21 | B:21 | 30.0 | 0.171 | H | -66.4 | -39.1 | 30.0 | 0.171 | 0.0 | ||||||
| 3gcg | 1 | P60953 | 100.0 | 6e-130 |
X-RAY |
2009-07-21 | ILE | A:25 | A:21 | 25.0 | 0.143 | H | -67.1 | -44.9 | 25.0 | 0.143 | 0.0 |
HOH |
3.025 |
CD1 |
O |
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| 4js0 | 1 | P60953 | 99.44 | 6e-130 |
X-RAY |
2014-03-05 | ILE | A:21 | A:21 | 34.0 | 0.194 | H | -70.9 | -36.9 | 17.0 | 0.097 | 0.097 |
B:Q9UQB8:0.097 |
GNP MG PE4 HOH |
6.712 7.508 7.395 3.069 |
H HG12 O HD12 |
O1A MG C6 O |
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| 3qbv | 1 | P60953 | 99.44 | 6e-130 |
X-RAY |
2012-02-08 | ILE | A:21 | A:21 | 22.0 | 0.126 | H | -62.2 | -49.4 | 22.0 | 0.126 | 0.0 |
GDP HOH |
6.742 8.128 |
CD1 N |
O2A O |
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| ILE | C:21 | C:21 | 21.0 | 0.12 | H | -62.8 | -49.9 | NA | NA | NA | |||||||||||||
| 5cjp | 1 | A0A024RAE4 | 99.44 | 3e-129 |
X-RAY |
2016-08-10 | ILE | A:23 | A:21 | 40.0 | 0.229 | H | -63.0 | -41.3 | 4.0 | 0.023 | 0.206 |
E:Q13576:0.206 |
GTP MG HOH |
7.427 8.308 6.922 |
CD1 CD1 CD1 |
O2A MG O |
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| ILE | B:23 | B:21 | 37.0 | 0.211 | H | -65.8 | -46.1 | 6.0 | 0.034 | 0.177 |
F:Q13576:0.177 |
GTP MG HOH |
7.501 8.601 6.074 |
CG1 CG1 CG1 |
O1A MG O |
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| ILE | C:23 | C:21 | 35.0 | 0.2 | H | -83.2 | -54.7 | 35.0 | 0.2 | 0.0 |
GTP MG HOH |
6.983 8.310 5.492 |
CD1 CD1 CD1 |
O2A MG O |
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| ILE | D:23 | D:21 | 35.0 | 0.2 | H | -85.9 | -52.8 | 35.0 | 0.2 | 0.0 |
GTP MG HOH |
7.306 8.651 7.223 |
CD1 CD1 CD1 |
O1A MG O |
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| 5upk | 3 | P60953 | 98.87 | 4e-129 |
X-RAY |
2017-12-27 | ILE | C:21 | C:21 | 35.0 | 0.2 | H | -72.7 | -36.9 | 30.0 | 0.171 | 0.029 |
A:O96013:0.029 |
GNP MG HOH |
7.502 8.116 7.529 |
CG1 CG1 CG1 |
O1A MG O |
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| 1am4 | 2 | P60953 | 99.43 | 7e-129 |
X-RAY |
1998-07-15 | ILE | B:21 | D:521 | 45.0 | 0.257 | H | -95.4 | -43.2 | 45.0 | 0.257 | 0.0 |
MG GNP HOH |
8.034 7.334 7.078 |
CD1 CD1 N |
MG O1A O |
||
| ILE | D:21 | E:521 | 48.0 | 0.274 | H | -94.9 | -42.8 | NA | NA | NA | |||||||||||||
| ILE | F:21 | F:521 | 43.0 | 0.246 | H | -95.7 | -41.5 | NA | NA | NA | |||||||||||||
| 7s0y | 2 | P60953 | 99.43 | 8e-129 |
X-RAY |
2021-09-08 | ILE | B:22 | B:21 | 22.0 | 0.126 | H | -68.8 | -53.6 | 9.0 | 0.051 | 0.075 |
A:P18177:0.074 |
SO4 GDP MG HOH |
9.873 7.149 8.195 7.759 |
O CD1 CD1 CD1 |
O4 O2A MG O |
|
| 5hzh | 1 | P63000,O49003 | 81.25 | 5e-21 |
X-RAY |
2016-12-21 | ILE | A:24 | A:21 | 36.0 | 0.206 | H | -72.8 | -42.7 | 36.0 | 0.206 | 0.0 |
GTP MG HOH |
7.061 8.107 7.047 |
CD1 CD1 CD1 |
O2A MG O |
||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p60953-f1 | 1 | P60953 | 100.0 | 8e-142 | ILE | A:21 | A:21 | 39.0 | 0.223 | H | -62.8 | -44.5 | |