Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 23381582 | . | C | A | CCDS30627.1:NM_015013.3:c.751Cga>Aga_NP_055828.2:p.251R>R | Homo sapiens lysine demethylase 1A (KDM1A), transcript variant 1, mRNA. |
|---|---|---|---|---|---|---|---|
|
|
|
|
|
PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3zmu | 1 | O60341 | 99.54 | 0.0 |
X-RAY |
2013-06-12 | ARG | A:271 | A:251 | 26.0 | 0.116 | H | -59.8 | -48.3 | 26.0 | 0.116 | 0.0 | ||||||
| 3zmv | 1 | O60341 | 99.54 | 0.0 |
X-RAY |
2013-06-12 | ARG | A:271 | A:251 | 29.0 | 0.129 | H | -53.3 | -50.1 | 29.0 | 0.129 | 0.0 | ||||||
| 3zms | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | ARG | A:271 | A:251 | 30.0 | 0.133 | H | -56.6 | -41.3 | 30.0 | 0.133 | 0.0 | ||||||
| 3zmt | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | ARG | A:271 | A:251 | 30.0 | 0.133 | H | -58.6 | -46.5 | 30.0 | 0.133 | 0.0 | ||||||
| 3zmz | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | ARG | A:271 | A:251 | 32.0 | 0.142 | H | -60.6 | -46.3 | 32.0 | 0.142 | 0.0 | ||||||
| 3zn0 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | ARG | A:271 | A:251 | 33.0 | 0.147 | H | -59.5 | -43.5 | 33.0 | 0.147 | 0.0 | ||||||
| 3zn1 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | ARG | A:271 | A:251 | 27.0 | 0.12 | H | -57.9 | -43.7 | 27.0 | 0.12 | 0.0 | ||||||
| 4czz | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-06-11 | ARG | A:271 | A:251 | 31.0 | 0.138 | H | -44.7 | -56.6 | 31.0 | 0.138 | 0.0 | ||||||
| 4uv8 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | ARG | A:271 | A:251 | 34.0 | 0.151 | H | -65.6 | -44.2 | 34.0 | 0.151 | 0.0 | ||||||
| 4uv9 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | ARG | A:271 | A:251 | 34.0 | 0.151 | H | -56.5 | -50.2 | 34.0 | 0.151 | 0.0 | ||||||
| 4uva | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | ARG | A:271 | A:251 | 33.0 | 0.147 | H | -66.1 | -46.6 | 33.0 | 0.147 | 0.0 | ||||||
| 4uvb | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | ARG | A:271 | A:251 | 32.0 | 0.142 | H | -66.5 | -45.2 | 32.0 | 0.142 | 0.0 | ||||||
| 4uvc | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | ARG | A:271 | A:251 | 23.0 | 0.102 | H | -52.9 | -40.1 | 23.0 | 0.102 | 0.0 | ||||||
| 6tuy | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2021-07-21 | ARG | A:251 | A:251 | 15.0 | 0.067 | H | -58.0 | -45.4 | 15.0 | 0.067 | 0.0 |
HOH |
3.955 |
CA |
O |
||
| 2xaf | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ARG | A:251 | A:251 | 25.0 | 0.111 | H | -48.7 | -36.0 | 25.0 | 0.111 | 0.0 | ||||||
| 2xag | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ARG | A:251 | A:251 | 28.0 | 0.124 | H | -41.7 | -48.2 | 28.0 | 0.124 | 0.0 | ||||||
| 2xah | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ARG | A:251 | A:251 | 33.0 | 0.147 | H | -51.5 | -56.4 | 33.0 | 0.147 | 0.0 | ||||||
| 2xaj | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ARG | A:251 | A:251 | 28.0 | 0.124 | H | -50.9 | -41.6 | 28.0 | 0.124 | 0.0 | ||||||
| 2xaq | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ARG | A:251 | A:251 | 32.0 | 0.142 | H | -57.4 | -66.6 | 32.0 | 0.142 | 0.0 | ||||||
| 2xas | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ARG | A:251 | A:251 | 28.0 | 0.124 | H | -46.4 | -47.1 | 28.0 | 0.124 | 0.0 | ||||||
| 4uxn | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2015-02-25 | ARG | A:251 | A:251 | 35.0 | 0.156 | H | -52.6 | -50.9 | 35.0 | 0.156 | 0.0 | ||||||
| 5lhg | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2017-02-22 | ARG | A:251 | A:251 | 32.0 | 0.142 | H | -66.4 | -39.7 | 32.0 | 0.142 | 0.0 | ||||||
| 5lhh | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2017-02-22 | ARG | A:251 | A:251 | 29.0 | 0.129 | H | -63.7 | -43.3 | 29.0 | 0.129 | 0.0 | ||||||
| 5lhi | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2017-02-22 | ARG | A:251 | A:251 | 19.0 | 0.084 | H | -67.7 | -35.2 | 19.0 | 0.084 | 0.0 | ||||||
| 6te1 | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2020-06-03 | ARG | A:251 | A:251 | 34.0 | 0.151 | H | -62.3 | -37.7 | 34.0 | 0.151 | 0.0 | ||||||
| 5l3c | 1 | O60341 | 94.86 | 0.0 |
X-RAY |
2016-05-04 | ARG | A:251 | A:251 | 22.0 | 0.098 | H | -59.1 | -48.7 | 22.0 | 0.098 | 0.0 | ||||||
| 5l3d | 1 | O60341 | 94.86 | 0.0 |
X-RAY |
2016-05-04 | ARG | A:251 | A:251 | 30.0 | 0.133 | H | -60.7 | -49.0 | 30.0 | 0.133 | 0.0 |
HOH |
6.164 |
NH2 |
O |
||
| 5l3b | 1 | O60341 | 94.86 | 0.0 |
X-RAY |
2016-05-04 | ARG | A:251 | A:251 | 27.0 | 0.12 | H | -55.3 | -47.4 | 27.0 | 0.12 | 0.0 | ||||||
| 2x0l | 1 | O60341 | 100.0 | 0.0 |
X-RAY |
2010-03-02 | ARG | A:129 | A:251 | 29.0 | 0.129 | H | -55.5 | -48.9 | 29.0 | 0.129 | 0.0 | ||||||
| 4bay | 1 | O60341 | 99.85 | 0.0 |
X-RAY |
2013-11-27 | ARG | A:81 | A:251 | 43.0 | 0.191 | H | -55.1 | -43.5 | 43.0 | 0.191 | 0.0 | ||||||
| 2v1d | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2007-05-29 | ARG | A:129 | A:251 | 37.0 | 0.164 | H | -46.5 | -49.7 | 37.0 | 0.164 | 0.0 | ||||||
| 2y48 | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2011-02-16 | ARG | A:129 | A:251 | 29.0 | 0.129 | H | -55.5 | -59.1 | 29.0 | 0.129 | 0.0 | ||||||
| 5l3e | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | ARG | A:129 | A:251 | 23.0 | 0.102 | H | -56.0 | -41.9 | 23.0 | 0.102 | 0.0 | ||||||
| 5l3f | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | ARG | A:129 | A:251 | 26.0 | 0.116 | H | -55.0 | -46.8 | 26.0 | 0.116 | 0.0 | ||||||
| 5l3g | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | ARG | A:129 | A:251 | 23.0 | 0.102 | H | -48.9 | -50.3 | 23.0 | 0.102 | 0.0 | ||||||
| 5lbq | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | ARG | A:129 | A:251 | 22.0 | 0.098 | H | -51.6 | -48.3 | 22.0 | 0.098 | 0.0 | ||||||
| 5lgt | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2017-02-22 | ARG | A:129 | A:251 | 27.0 | 0.12 | H | -50.4 | -57.8 | 27.0 | 0.12 | 0.0 | ||||||
| 5lgu | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2017-02-22 | ARG | A:129 | A:251 | 23.0 | 0.102 | H | -51.3 | -57.4 | 23.0 | 0.102 | 0.0 | ||||||
| 6vyp | 7 | O60341 | 98.69 | 0.0 |
X-RAY |
2020-05-27 | ARG | S:83 | M:251 | 47.0 | 0.209 | H | -66.7 | -38.1 | 47.0 | 0.209 | 0.0 | ||||||
| ARG | U:83 | m:251 | 45.0 | 0.2 | H | -66.3 | -39.0 | NA | NA | NA | |||||||||||||
| ARG | W:83 | K:251 | 145.0 | 0.644 | H | -67.2 | -37.7 | 145.0 | 0.644 | 0.0 | |||||||||||||
| ARG | Y:83 | k:251 | 99.0 | 0.44 | H | -75.6 | -41.2 | NA | NA | NA | |||||||||||||
| 5lgn | 1 | O60341 | 99.85 | 0.0 |
X-RAY |
2017-02-22 | ARG | A:81 | A:251 | 29.0 | 0.129 | H | -52.0 | -57.8 | 29.0 | 0.129 | 0.0 | ||||||
| 2iw5 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2006-08-09 | ARG | A:81 | A:251 | 38.0 | 0.169 | H | -63.0 | -49.1 | 38.0 | 0.169 | 0.0 | ||||||
| 2uxn | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2007-05-29 | ARG | A:81 | A:251 | 35.0 | 0.156 | H | -64.8 | -53.1 | 35.0 | 0.156 | 0.0 |
HOH |
4.161 |
NH2 |
O |
||
| 2uxx | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2007-08-21 | ARG | A:81 | A:251 | 56.0 | 0.249 | H | -64.5 | -41.3 | 56.0 | 0.249 | 0.0 | ||||||
| 4kum | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2014-05-07 | ARG | A:81 | A:251 | 31.0 | 0.138 | H | -62.6 | -49.2 | 31.0 | 0.138 | 0.0 | ||||||
| 4xbf | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2016-04-27 | ARG | A:81 | A:251 | 44.0 | 0.196 | H | -56.0 | -51.8 | 44.0 | 0.196 | 0.0 | ||||||
| 6wc6 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-30 | ARG | A:81 | A:251 | 35.0 | 0.156 | H | -61.2 | -45.1 | 35.0 | 0.156 | 0.0 | ||||||
| 2h94 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2006-07-04 | ARG | A:80 | A:251 | 63.0 | 0.28 | H | -51.1 | -54.6 | 63.0 | 0.28 | 0.0 |
HOH |
6.715 |
NH1 |
O |
||
| 2hko | 1 | O60341 | 99.25 | 0.0 |
X-RAY |
2006-08-29 | ARG | A:80 | A:251 | 73.0 | 0.324 | H | -51.0 | -56.1 | 73.0 | 0.324 | 0.0 |
HOH |
5.580 |
O |
O |
||
| 7e0g | 1 | O60341 | 99.1 | 0.0 |
X-RAY |
2021-03-24 | ARG | A:83 | A:251 | 76.0 | 0.338 | H | -63.8 | -42.1 | 76.0 | 0.338 | 0.0 |
HOH |
2.683 |
NH1 |
O |
||
| 6s35 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-02-26 | ARG | A:84 | A:251 | 76.0 | 0.338 | H | -67.5 | -54.5 | 76.0 | 0.338 | 0.0 | ||||||
| 5h6q | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2017-04-12 | ARG | A:87 | A:251 | 89.0 | 0.396 | H | -62.4 | -45.0 | 89.0 | 0.396 | 0.0 | ||||||
| 5h6r | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2017-04-12 | ARG | A:87 | A:251 | 86.0 | 0.382 | H | -63.7 | -44.7 | 86.0 | 0.382 | 0.0 | ||||||
| 5x60 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2017-04-12 | ARG | A:87 | A:251 | 83.0 | 0.369 | H | -63.8 | -44.2 | 83.0 | 0.369 | 0.0 | ||||||
| 5yjb | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2018-07-04 | ARG | A:87 | A:251 | 83.0 | 0.369 | H | -58.3 | -49.0 | 83.0 | 0.369 | 0.0 | ||||||
| 6kgk | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ARG | A:87 | A:251 | 82.0 | 0.364 | H | -59.4 | -46.7 | 82.0 | 0.364 | 0.0 | ||||||
| 6kgl | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ARG | A:87 | A:251 | 82.0 | 0.364 | H | -60.9 | -45.5 | 82.0 | 0.364 | 0.0 | ||||||
| 6kgm | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ARG | A:87 | A:251 | 82.0 | 0.364 | H | -63.2 | -44.5 | 82.0 | 0.364 | 0.0 | ||||||
| 6kgn | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ARG | A:87 | A:251 | 82.0 | 0.364 | H | -63.5 | -43.9 | 82.0 | 0.364 | 0.0 | ||||||
| 6kgo | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ARG | A:87 | A:251 | 76.0 | 0.338 | H | -56.0 | -42.6 | 76.0 | 0.338 | 0.0 |
TLA HOH |
7.781 2.641 |
N O |
O3 O |
||
| 6kgp | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ARG | A:87 | A:251 | 77.0 | 0.342 | H | -56.6 | -42.2 | 77.0 | 0.342 | 0.0 |
TLA HOH |
7.786 2.657 |
N O |
O3 O |
||
| 6kgq | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ARG | A:87 | A:251 | 72.0 | 0.32 | H | -58.6 | -40.2 | 72.0 | 0.32 | 0.0 |
HOH |
2.933 |
O |
O |
||
| 6kgr | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ARG | A:87 | A:251 | 72.0 | 0.32 | H | -58.8 | -40.2 | 72.0 | 0.32 | 0.0 |
HOH |
2.933 |
O |
O |
||
| 7cdc | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | ARG | A:87 | A:251 | 87.0 | 0.387 | H | -60.6 | -50.7 | 87.0 | 0.387 | 0.0 |
HOH |
2.841 |
NE |
O |
||
| 7cdd | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | ARG | A:87 | A:251 | 90.0 | 0.4 | H | -63.7 | -51.5 | 90.0 | 0.4 | 0.0 |
HOH |
2.940 |
NE |
O |
||
| 7cde | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | ARG | A:87 | A:251 | 90.0 | 0.4 | H | -60.2 | -48.6 | 90.0 | 0.4 | 0.0 |
HOH |
2.866 |
NE |
O |
||
| 7cdf | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | ARG | A:87 | A:251 | 88.0 | 0.391 | H | -59.7 | -48.8 | 88.0 | 0.391 | 0.0 |
HOH |
2.936 |
NE |
O |
||
| 7cdg | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | ARG | A:87 | A:251 | 92.0 | 0.409 | H | -60.3 | -45.3 | 92.0 | 0.409 | 0.0 |
HOH |
6.434 |
O |
O |
||
| 2ejr | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2008-01-01 | ARG | A:80 | A:251 | 76.0 | 0.338 | H | -64.0 | -33.9 | 76.0 | 0.338 | 0.0 |
HOH |
5.915 |
N |
O |
||
| 2z3y | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2008-01-01 | ARG | A:80 | A:251 | 77.0 | 0.342 | H | -63.0 | -36.7 | 77.0 | 0.342 | 0.0 |
HOH |
2.830 |
O |
O |
||
| 2z5u | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2008-04-01 | ARG | A:80 | A:251 | 77.0 | 0.342 | H | -63.2 | -37.7 | 77.0 | 0.342 | 0.0 |
HOH |
2.811 |
NH1 |
O |
||
| 3abt | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2010-07-07 | ARG | A:80 | A:251 | 77.0 | 0.342 | H | -52.4 | -40.8 | 77.0 | 0.342 | 0.0 | ||||||
| 3abu | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2010-07-07 | ARG | A:80 | A:251 | 75.0 | 0.333 | H | -41.0 | -38.6 | 75.0 | 0.333 | 0.0 | ||||||
| 6k3e | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-05-20 | ARG | A:80 | A:251 | 84.0 | 0.373 | H | -46.5 | -48.1 | 84.0 | 0.373 | 0.0 |
DTT PEG |
8.108 5.091 |
O NH2 |
S4 O4 |
||
| 2dw4 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2007-09-04 | ARG | A:80 | A:251 | 78.0 | 0.347 | H | -65.3 | -35.8 | 78.0 | 0.347 | 0.0 |
HOH |
2.525 |
NH1 |
O |
||
| 6w4k | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-10-21 | ARG | A:78 | A:251 | 93.0 | 0.413 | H | -42.9 | -46.9 | 93.0 | 0.413 | 0.0 | ||||||
| 6nqm | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2019-02-13 | ARG | A:79 | A:251 | 81.0 | 0.36 | H | -55.5 | -44.0 | 81.0 | 0.36 | 0.0 | ||||||
| 6nqu | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2019-02-13 | ARG | A:79 | A:251 | 81.0 | 0.36 | H | -58.2 | -43.0 | 81.0 | 0.36 | 0.0 | ||||||
| 6nr5 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2019-07-17 | ARG | A:79 | A:251 | 76.0 | 0.338 | H | -59.7 | -47.0 | 76.0 | 0.338 | 0.0 | ||||||
| 2l3d | 1 | O60341 | 99.01 | 2e-65 |
NMR |
2011-09-21 | ARG | A:80 | A:80 | 149.0 | 0.662 | H | -57.2 | -56.9 | 149.0 | 0.662 | 0.0 | ||||||
| 5it3 | 1 | O60341 | 100.0 | 1e-55 |
X-RAY |
2016-05-18 | ARG | A:69 | A:251 | 77.0 | 0.342 | H | -60.0 | -45.2 | 77.0 | 0.342 | 0.0 |
HOH |
2.877 |
NH1 |
O |
||
| ARG | B:69 | B:251 | 74.0 | 0.329 | H | -61.1 | -42.3 | NA | NA | NA | |||||||||||||
| 6e1f | 1 | O60341 | 100.0 | 1e-54 |
X-RAY |
2019-07-10 | ARG | A:73 | A:251 | 78.0 | 0.347 | H | -58.8 | -46.9 | 78.0 | 0.347 | 0.0 |
HOH |
2.194 |
HE |
O |
||
| ARG | B:73 | B:251 | 76.0 | 0.338 | H | -61.6 | -42.2 | NA | NA | NA | |||||||||||||
| ARG | C:73 | C:251 | 78.0 | 0.347 | H | -62.1 | -44.9 | NA | NA | NA | |||||||||||||
| ARG | D:73 | D:251 | 71.0 | 0.316 | H | -60.0 | -43.6 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-o60341-f1 | 1 | O60341 | 94.98 | 0.0 | ARG | A:251 | A:251 | 11.0 | 0.049 | H | -63.1 | -44.1 | |