Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 23381591 . A C CCDS30627.1:NM_015013.3:c.760Agt>Cgt_NP_055828.2:p.254S>R Homo sapiens lysine demethylase 1A (KDM1A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3zmu 1 O60341 99.54 0.0 X-RAY
 2013-06-12 SER A:274 A:254 28.0 0.243 H -63.7 -41.9 28.0 0.243 0.0
3zmv 1 O60341 99.54 0.0 X-RAY
 2013-06-12 SER A:274 A:254 21.0 0.183 H -61.8 -43.5 21.0 0.183 0.0
3zms 1 O60341 99.43 0.0 X-RAY
 2013-06-12 SER A:274 A:254 26.0 0.226 H -66.0 -44.8 26.0 0.226 0.0
3zmt 1 O60341 99.43 0.0 X-RAY
 2013-06-12 SER A:274 A:254 26.0 0.226 H -61.0 -44.2 26.0 0.226 0.0
3zmz 1 O60341 99.43 0.0 X-RAY
 2013-06-12 SER A:274 A:254 27.0 0.235 H -65.8 -41.0 27.0 0.235 0.0
3zn0 1 O60341 99.43 0.0 X-RAY
 2013-06-12 SER A:274 A:254 28.0 0.243 H -65.0 -45.0 28.0 0.243 0.0
3zn1 1 O60341 99.43 0.0 X-RAY
 2013-06-12 SER A:274 A:254 28.0 0.243 H -66.7 -49.7 28.0 0.243 0.0
4czz 1 O60341 99.43 0.0 X-RAY
 2014-06-11 SER A:274 A:254 28.0 0.243 H -76.6 -32.2 28.0 0.243 0.0
4uv8 1 O60341 99.43 0.0 X-RAY
 2014-09-10 SER A:274 A:254 27.0 0.235 H -60.8 -41.7 27.0 0.235 0.0
4uv9 1 O60341 99.43 0.0 X-RAY
 2014-09-10 SER A:274 A:254 28.0 0.243 H -65.1 -41.7 28.0 0.243 0.0
4uva 1 O60341 99.43 0.0 X-RAY
 2014-09-10 SER A:274 A:254 28.0 0.243 H -63.9 -45.7 28.0 0.243 0.0
4uvb 1 O60341 99.43 0.0 X-RAY
 2014-09-10 SER A:274 A:254 26.0 0.226 H -63.6 -46.7 26.0 0.226 0.0
4uvc 1 O60341 99.43 0.0 X-RAY
 2014-09-10 SER A:274 A:254 23.0 0.2 H -78.3 -49.8 23.0 0.2 0.0
6tuy 1 O60341 94.98 0.0 X-RAY
 2021-07-21 SER A:254 A:254 26.0 0.226 H -74.8 -43.7 26.0 0.226 0.0 HOH
 4.399
 OG
 O
2xaf 1 O60341 94.98 0.0 X-RAY
 2010-05-05 SER A:254 A:254 24.0 0.209 H -71.7 -53.5 24.0 0.209 0.0
2xag 1 O60341 94.98 0.0 X-RAY
 2010-05-05 SER A:254 A:254 25.0 0.217 H -62.4 -52.9 25.0 0.217 0.0
2xah 1 O60341 94.98 0.0 X-RAY
 2010-05-05 SER A:254 A:254 28.0 0.243 H -72.6 -32.4 28.0 0.243 0.0
2xaj 1 O60341 94.98 0.0 X-RAY
 2010-05-05 SER A:254 A:254 25.0 0.217 H -77.7 -54.9 25.0 0.217 0.0
2xaq 1 O60341 94.98 0.0 X-RAY
 2010-05-05 SER A:254 A:254 26.0 0.226 H -68.6 -31.9 26.0 0.226 0.0
2xas 1 O60341 94.98 0.0 X-RAY
 2010-05-05 SER A:254 A:254 25.0 0.217 H -81.2 -39.8 25.0 0.217 0.0
4uxn 1 O60341 94.98 0.0 X-RAY
 2015-02-25 SER A:254 A:254 24.0 0.209 H -75.5 -38.6 24.0 0.209 0.0
5lhg 1 O60341 94.98 0.0 X-RAY
 2017-02-22 SER A:254 A:254 29.0 0.252 H -68.6 -28.6 29.0 0.252 0.0 HOH
 8.719
 O
 O
5lhh 1 O60341 94.98 0.0 X-RAY
 2017-02-22 SER A:254 A:254 33.0 0.287 H -62.8 -32.8 33.0 0.287 0.0
5lhi 1 O60341 94.98 0.0 X-RAY
 2017-02-22 SER A:254 A:254 24.0 0.209 H -70.8 -10.5 24.0 0.209 0.0
6te1 1 O60341 94.98 0.0 X-RAY
 2020-06-03 SER A:254 A:254 31.0 0.27 H -71.4 -32.8 31.0 0.27 0.0 HOH
 8.639
 O
 O
5l3c 1 O60341 94.86 0.0 X-RAY
 2016-05-04 SER A:254 A:254 26.0 0.226 H -68.7 -51.9 26.0 0.226 0.0
5l3d 1 O60341 94.86 0.0 X-RAY
 2016-05-04 SER A:254 A:254 26.0 0.226 H -67.5 -41.9 26.0 0.226 0.0 HOH
 3.168
 O
 O
5l3b 1 O60341 94.86 0.0 X-RAY
 2016-05-04 SER A:254 A:254 24.0 0.209 H -63.3 -52.9 24.0 0.209 0.0
2x0l 1 O60341 100.0 0.0 X-RAY
 2010-03-02 SER A:132 A:254 20.0 0.174 H -70.8 -49.0 20.0 0.174 0.0
4bay 1 O60341 99.85 0.0 X-RAY
 2013-11-27 SER A:84 A:254 9.0 0.078 H -65.8 -43.1 9.0 0.078 0.0
2v1d 1 O60341 99.42 0.0 X-RAY
 2007-05-29 SER A:132 A:254 29.0 0.252 H -77.1 -40.5 29.0 0.252 0.0
2y48 1 O60341 99.42 0.0 X-RAY
 2011-02-16 SER A:132 A:254 28.0 0.243 H -69.2 -47.7 28.0 0.243 0.0
5l3e 1 O60341 99.42 0.0 X-RAY
 2016-09-21 SER A:132 A:254 25.0 0.217 H -82.2 -44.1 25.0 0.217 0.0
5l3f 1 O60341 99.42 0.0 X-RAY
 2016-09-21 SER A:132 A:254 28.0 0.243 H -68.9 -46.0 28.0 0.243 0.0
5l3g 1 O60341 99.42 0.0 X-RAY
 2016-09-21 SER A:132 A:254 26.0 0.226 H -65.7 -41.6 26.0 0.226 0.0
5lbq 1 O60341 99.42 0.0 X-RAY
 2016-09-21 SER A:132 A:254 21.0 0.183 H -70.2 -47.5 21.0 0.183 0.0
5lgt 1 O60341 99.42 0.0 X-RAY
 2017-02-22 SER A:132 A:254 29.0 0.252 H -66.2 -33.3 29.0 0.252 0.0
5lgu 1 O60341 99.42 0.0 X-RAY
 2017-02-22 SER A:132 A:254 27.0 0.235 H -64.7 -52.1 27.0 0.235 0.0
6vyp 7 O60341 98.69 0.0 X-RAY
 2020-05-27 SER S:86 M:254 20.0 0.174 H -68.2 -36.2 20.0 0.174 0.0
SER U:86 m:254 29.0 0.252 H -67.9 -36.1 NA NA NA
SER W:86 K:254 55.0 0.478 H -68.0 -31.9 55.0 0.478 0.0
SER Y:86 k:254 34.0 0.296 H -65.1 -40.8 NA NA NA
5lgn 1 O60341 99.85 0.0 X-RAY
 2017-02-22 SER A:84 A:254 15.0 0.13 H -65.3 -50.7 15.0 0.13 0.0
2iw5 1 O60341 99.4 0.0 X-RAY
 2006-08-09 SER A:84 A:254 30.0 0.261 H -60.9 -36.8 30.0 0.261 0.0 HOH
 6.844
 OG
 O
2uxn 1 O60341 99.4 0.0 X-RAY
 2007-05-29 SER A:84 A:254 16.0 0.139 H -63.5 -40.4 16.0 0.139 0.0 HOH
 6.607
 OG
 O
2uxx 1 O60341 99.4 0.0 X-RAY
 2007-08-21 SER A:84 A:254 30.0 0.261 H -64.2 -38.7 30.0 0.261 0.0
4kum 1 O60341 99.4 0.0 X-RAY
 2014-05-07 SER A:84 A:254 33.0 0.287 H -61.0 -36.9 33.0 0.287 0.0 HOH
 7.125
 OG
 O
4xbf 1 O60341 99.4 0.0 X-RAY
 2016-04-27 SER A:84 A:254 29.0 0.252 H -64.5 -36.6 29.0 0.252 0.0 HOH
 8.330
 O
 O
6wc6 1 O60341 99.4 0.0 X-RAY
 2021-06-30 SER A:84 A:254 28.0 0.243 H -68.5 -31.7 28.0 0.243 0.0
2h94 1 O60341 99.4 0.0 X-RAY
 2006-07-04 SER A:83 A:254 31.0 0.27 H -54.5 -46.3 31.0 0.27 0.0
2hko 1 O60341 99.25 0.0 X-RAY
 2006-08-29 SER A:83 A:254 50.0 0.435 H -64.4 -42.2 50.0 0.435 0.0 HOH
 5.045
 OG
 O
7e0g 1 O60341 99.1 0.0 X-RAY
 2021-03-24 SER A:86 A:254 19.0 0.165 H -60.4 -48.3 19.0 0.165 0.0 HOH
 2.720
 OG
 O
6s35 1 O60341 99.4 0.0 X-RAY
 2020-02-26 SER A:87 A:254 7.0 0.061 H -75.6 -22.5 7.0 0.061 0.0
5h6q 1 O60341 99.4 0.0 X-RAY
 2017-04-12 SER A:90 A:254 47.0 0.409 H -75.4 -43.4 47.0 0.409 0.0
5h6r 1 O60341 99.4 0.0 X-RAY
 2017-04-12 SER A:90 A:254 17.0 0.148 H -64.5 -43.7 17.0 0.148 0.0 HOH
 8.218
 O
 O
5x60 1 O60341 99.4 0.0 X-RAY
 2017-04-12 SER A:90 A:254 19.0 0.165 H -66.7 -41.5 19.0 0.165 0.0
5yjb 1 O60341 99.4 0.0 X-RAY
 2018-07-04 SER A:90 A:254 42.0 0.365 H -66.8 -36.4 42.0 0.365 0.0
6kgk 1 O60341 99.4 0.0 X-RAY
 2020-03-25 SER A:90 A:254 42.0 0.365 H -63.6 -37.1 42.0 0.365 0.0 HOH
 7.903
 CB
 O
6kgl 1 O60341 99.4 0.0 X-RAY
 2020-03-25 SER A:90 A:254 40.0 0.348 H -63.1 -37.9 40.0 0.348 0.0 HOH
 8.036
 CB
 O
6kgm 1 O60341 99.4 0.0 X-RAY
 2020-03-25 SER A:90 A:254 42.0 0.365 H -65.7 -38.5 42.0 0.365 0.0 HOH
 8.302
 O
 O
6kgn 1 O60341 99.4 0.0 X-RAY
 2020-03-25 SER A:90 A:254 43.0 0.374 H -65.9 -38.7 43.0 0.374 0.0 HOH
 8.302
 O
 O
6kgo 1 O60341 99.4 0.0 X-RAY
 2020-03-25 SER A:90 A:254 40.0 0.348 H -61.0 -41.8 40.0 0.348 0.0 TLA
HOH
 4.512
2.708
 OG
OG
 O41
O
6kgp 1 O60341 99.4 0.0 X-RAY
 2020-03-25 SER A:90 A:254 41.0 0.357 H -60.6 -42.0 41.0 0.357 0.0 TLA
HOH
 4.464
2.713
 OG
OG
 O41
O
6kgq 1 O60341 99.4 0.0 X-RAY
 2020-03-25 SER A:90 A:254 40.0 0.348 H -60.1 -43.4 40.0 0.348 0.0 HOH
 2.773
 OG
 O
6kgr 1 O60341 99.4 0.0 X-RAY
 2020-03-25 SER A:90 A:254 40.0 0.348 H -60.2 -43.3 40.0 0.348 0.0 HOH
 2.760
 OG
 O
7cdc 1 O60341 99.4 0.0 X-RAY
 2021-06-23 SER A:90 A:254 46.0 0.4 H -62.1 -49.6 46.0 0.4 0.0 HOH
 4.304
 OG
 O
7cdd 1 O60341 99.4 0.0 X-RAY
 2021-06-23 SER A:90 A:254 45.0 0.391 H -66.3 -49.4 45.0 0.391 0.0 HOH
 6.980
 CB
 O
7cde 1 O60341 99.4 0.0 X-RAY
 2021-06-23 SER A:90 A:254 46.0 0.4 H -62.6 -47.8 46.0 0.4 0.0 HOH
 7.033
 CB
 O
7cdf 1 O60341 99.4 0.0 X-RAY
 2021-06-23 SER A:90 A:254 48.0 0.417 H -61.2 -48.9 48.0 0.417 0.0 HOH
 6.967
 CB
 O
7cdg 1 O60341 99.4 0.0 X-RAY
 2021-06-23 SER A:90 A:254 47.0 0.409 H -63.6 -50.9 47.0 0.409 0.0 HOH
 4.074
 OG
 O
2ejr 1 O60341 99.4 0.0 X-RAY
 2008-01-01 SER A:83 A:254 43.0 0.374 H -65.5 -44.3 43.0 0.374 0.0 HOH
 2.593
 OG
 O
2z3y 1 O60341 99.4 0.0 X-RAY
 2008-01-01 SER A:83 A:254 41.0 0.357 H -65.9 -43.0 41.0 0.357 0.0 HOH
 2.667
 OG
 O
2z5u 1 O60341 99.4 0.0 X-RAY
 2008-04-01 SER A:83 A:254 43.0 0.374 H -66.6 -40.5 43.0 0.374 0.0 HOH
 2.769
 OG
 O
3abt 1 O60341 99.4 0.0 X-RAY
 2010-07-07 SER A:83 A:254 38.0 0.33 H -54.6 -51.5 38.0 0.33 0.0
3abu 1 O60341 99.4 0.0 X-RAY
 2010-07-07 SER A:83 A:254 16.0 0.139 H -60.4 -66.9 16.0 0.139 0.0
6k3e 1 O60341 99.4 0.0 X-RAY
 2020-05-20 SER A:83 A:254 8.0 0.07 H -60.7 -48.1 8.0 0.07 0.0 DTT
 7.451
 O
 S4
2dw4 1 O60341 99.4 0.0 X-RAY
 2007-09-04 SER A:83 A:254 42.0 0.365 H -61.9 -40.1 42.0 0.365 0.0 HOH
 2.650
 OG
 O
6w4k 1 O60341 99.4 0.0 X-RAY
 2020-10-21 SER A:81 A:254 44.0 0.383 H -56.0 -50.4 44.0 0.383 0.0 HOH
 7.073
 OG
 O
6nqm 1 O60341 99.4 0.0 X-RAY
 2019-02-13 SER A:82 A:254 46.0 0.4 H -62.5 -46.8 46.0 0.4 0.0
6nqu 1 O60341 99.4 0.0 X-RAY
 2019-02-13 SER A:82 A:254 44.0 0.383 H -63.7 -43.5 44.0 0.383 0.0
6nr5 1 O60341 99.4 0.0 X-RAY
 2019-07-17 SER A:82 A:254 43.0 0.374 H -65.5 -44.2 43.0 0.374 0.0
2l3d 1 O60341 99.01 2e-65 NMR
 2011-09-21 SER A:83 A:83 62.0 0.539 H -55.3 -51.0 62.0 0.539 0.0
5it3 1 O60341 100.0 1e-55 X-RAY
 2016-05-18 SER A:72 A:254 27.0 0.235 H -60.0 -45.7 27.0 0.235 0.0 HOH
 7.572
 O
 O
SER B:72 B:254 29.0 0.252 H -63.2 -42.4 NA NA NA
6e1f 1 O60341 100.0 1e-54 X-RAY
 2019-07-10 SER A:76 A:254 14.0 0.122 H -61.2 -47.5 14.0 0.122 0.0 HOH
 2.794
 OG
 O
SER B:76 B:254 25.0 0.217 H -64.0 -41.4 NA NA NA
SER C:76 C:254 38.0 0.33 H -58.7 -46.0 NA NA NA
SER D:76 D:254 29.0 0.252 H -64.0 -43.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o60341-f1 1 O60341 94.98 0.0 SER A:254 A:254 27.0 0.235 H -60.2 -41.5