Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 23397728 | . | T | A | CCDS30627.1:NM_015013.3:c.1352tTg>tAg_NP_055828.2:p.451L>* | Homo sapiens lysine demethylase 1A (KDM1A), transcript variant 1, mRNA. |
|---|---|---|---|---|---|---|---|
|
|
|
|
|
PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3zmu | 1 | O60341 | 99.54 | 0.0 |
X-RAY |
2013-06-12 | LEU | A:471 | A:451 | 14.0 | 0.082 | H | -80.6 | -42.8 | 14.0 | 0.082 | 0.0 | ||||||
| 3zmv | 1 | O60341 | 99.54 | 0.0 |
X-RAY |
2013-06-12 | LEU | A:471 | A:451 | 17.0 | 0.1 | H | -76.2 | -39.7 | 17.0 | 0.1 | 0.0 | ||||||
| 3zms | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | LEU | A:471 | A:451 | 20.0 | 0.118 | H | -84.0 | -37.9 | 20.0 | 0.118 | 0.0 | ||||||
| 3zmt | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | LEU | A:471 | A:451 | 18.0 | 0.106 | H | -86.7 | -38.0 | 18.0 | 0.106 | 0.0 | ||||||
| 3zmz | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | LEU | A:471 | A:451 | 16.0 | 0.094 | H | -83.1 | -44.4 | 16.0 | 0.094 | 0.0 | ||||||
| 3zn0 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | LEU | A:471 | A:451 | 18.0 | 0.106 | H | -97.1 | -44.1 | 18.0 | 0.106 | 0.0 | ||||||
| 3zn1 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | LEU | A:471 | A:451 | 22.0 | 0.129 | H | -79.8 | -42.4 | 22.0 | 0.129 | 0.0 | ||||||
| 4czz | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-06-11 | LEU | A:471 | A:451 | 18.0 | 0.106 | H | -74.7 | -48.3 | 18.0 | 0.106 | 0.0 | ||||||
| 4uv8 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | LEU | A:471 | A:451 | 16.0 | 0.094 | H | -80.9 | -41.1 | 16.0 | 0.094 | 0.0 | ||||||
| 4uv9 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | LEU | A:471 | A:451 | 14.0 | 0.082 | H | -86.7 | -42.1 | 14.0 | 0.082 | 0.0 | ||||||
| 4uva | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | LEU | A:471 | A:451 | 17.0 | 0.1 | H | -84.6 | -42.2 | 17.0 | 0.1 | 0.0 | ||||||
| 4uvb | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | LEU | A:471 | A:451 | 17.0 | 0.1 | H | -80.6 | -43.2 | 17.0 | 0.1 | 0.0 | ||||||
| 4uvc | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | LEU | A:471 | A:451 | 22.0 | 0.129 | H | -95.8 | -54.7 | 22.0 | 0.129 | 0.0 | ||||||
| 6tuy | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2021-07-21 | LEU | A:451 | A:451 | 7.0 | 0.041 | H | -91.6 | -43.4 | 7.0 | 0.041 | 0.0 | ||||||
| 2xaf | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | LEU | A:451 | A:451 | 19.0 | 0.112 | H | -111.3 | -53.7 | 19.0 | 0.112 | 0.0 | ||||||
| 2xag | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | LEU | A:451 | A:451 | 17.0 | 0.1 | H | -85.3 | -53.0 | 17.0 | 0.1 | 0.0 | ||||||
| 2xah | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | LEU | A:451 | A:451 | 20.0 | 0.118 | H | -84.7 | -50.5 | 20.0 | 0.118 | 0.0 | ||||||
| 2xaj | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | LEU | A:451 | A:451 | 23.0 | 0.135 | H | -85.9 | -55.3 | 23.0 | 0.135 | 0.0 | ||||||
| 2xaq | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | LEU | A:451 | A:451 | 21.0 | 0.124 | H | -117.6 | -34.8 | 21.0 | 0.124 | 0.0 | ||||||
| 2xas | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | LEU | A:451 | A:451 | 19.0 | 0.112 | H | -89.1 | -49.5 | 19.0 | 0.112 | 0.0 | ||||||
| 4uxn | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2015-02-25 | LEU | A:451 | A:451 | 8.0 | 0.047 | H | -54.4 | -48.6 | 8.0 | 0.047 | 0.0 | ||||||
| 5lhg | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2017-02-22 | LEU | A:451 | A:451 | 10.0 | 0.059 | H | -72.7 | -38.5 | 10.0 | 0.059 | 0.0 | ||||||
| 5lhh | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2017-02-22 | LEU | A:451 | A:451 | 2.0 | 0.012 | H | -76.8 | -38.3 | 2.0 | 0.012 | 0.0 | ||||||
| 5lhi | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2017-02-22 | LEU | A:451 | A:451 | 16.0 | 0.094 | H | -82.9 | -44.4 | 16.0 | 0.094 | 0.0 | ||||||
| 6te1 | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2020-06-03 | LEU | A:451 | A:451 | 9.0 | 0.053 | H | -69.2 | -43.5 | 9.0 | 0.053 | 0.0 | ||||||
| 5l3c | 1 | O60341 | 94.86 | 0.0 |
X-RAY |
2016-05-04 | LEU | A:451 | A:451 | 14.0 | 0.082 | H | -78.3 | -40.1 | 14.0 | 0.082 | 0.0 | ||||||
| 5l3d | 1 | O60341 | 94.86 | 0.0 |
X-RAY |
2016-05-04 | LEU | A:451 | A:451 | 20.0 | 0.118 | H | -70.1 | -36.7 | 20.0 | 0.118 | 0.0 | ||||||
| 5l3b | 1 | O60341 | 94.86 | 0.0 |
X-RAY |
2016-05-04 | LEU | A:451 | A:451 | 9.0 | 0.053 | H | -68.4 | -38.0 | 9.0 | 0.053 | 0.0 | ||||||
| 2x0l | 1 | O60341 | 100.0 | 0.0 |
X-RAY |
2010-03-02 | LEU | A:333 | A:451 | 21.0 | 0.124 | H | -81.9 | -37.7 | 21.0 | 0.124 | 0.0 | ||||||
| 4bay | 1 | O60341 | 99.85 | 0.0 |
X-RAY |
2013-11-27 | LEU | A:285 | A:451 | 25.0 | 0.147 | H | -71.1 | -37.8 | 25.0 | 0.147 | 0.0 | ||||||
| 2v1d | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2007-05-29 | LEU | A:329 | A:451 | 16.0 | 0.094 | H | -87.2 | -48.2 | 16.0 | 0.094 | 0.0 | ||||||
| 2y48 | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2011-02-16 | LEU | A:329 | A:451 | 22.0 | 0.129 | H | -85.7 | -47.8 | 22.0 | 0.129 | 0.0 | ||||||
| 5l3e | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | LEU | A:329 | A:451 | 7.0 | 0.041 | H | -81.3 | -48.4 | 7.0 | 0.041 | 0.0 | ||||||
| 5l3f | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | LEU | A:329 | A:451 | 2.0 | 0.012 | H | -59.9 | -46.4 | 2.0 | 0.012 | 0.0 | ||||||
| 5l3g | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | LEU | A:329 | A:451 | 7.0 | 0.041 | H | -63.7 | -41.4 | 7.0 | 0.041 | 0.0 | ||||||
| 5lbq | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | LEU | A:329 | A:451 | 22.0 | 0.129 | H | -70.4 | -58.1 | 22.0 | 0.129 | 0.0 | ||||||
| 5lgt | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2017-02-22 | LEU | A:329 | A:451 | 10.0 | 0.059 | H | -70.7 | -46.5 | 10.0 | 0.059 | 0.0 | ||||||
| 5lgu | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2017-02-22 | LEU | A:329 | A:451 | 18.0 | 0.106 | H | -61.7 | -38.2 | 18.0 | 0.106 | 0.0 | ||||||
| 6vyp | 7 | O60341 | 98.69 | 0.0 |
X-RAY |
2020-05-27 | LEU | S:283 | M:451 | 40.0 | 0.235 | H | -69.5 | -38.9 | 40.0 | 0.235 | 0.0 | ||||||
| LEU | U:283 | m:451 | 42.0 | 0.247 | H | -68.7 | -39.0 | NA | NA | NA | |||||||||||||
| LEU | W:283 | K:451 | 21.0 | 0.124 | H | -71.0 | -34.2 | 21.0 | 0.124 | 0.0 | |||||||||||||
| LEU | Y:283 | k:451 | 17.0 | 0.1 | H | -74.0 | -37.2 | NA | NA | NA | |||||||||||||
| 5lgn | 1 | O60341 | 99.85 | 0.0 |
X-RAY |
2017-02-22 | LEU | A:285 | A:455 | 26.0 | 0.153 | H | -89.4 | -53.2 | 26.0 | 0.153 | 0.0 | ||||||
| 2iw5 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2006-08-09 | LEU | A:281 | A:451 | 11.0 | 0.065 | H | -69.0 | -35.4 | 11.0 | 0.065 | 0.0 | ||||||
| 2uxn | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2007-05-29 | LEU | A:281 | A:451 | 20.0 | 0.118 | H | -71.4 | -35.3 | 20.0 | 0.118 | 0.0 | ||||||
| 2uxx | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2007-08-21 | LEU | A:281 | A:451 | 12.0 | 0.071 | H | -73.8 | -36.4 | 12.0 | 0.071 | 0.0 | ||||||
| 4kum | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2014-05-07 | LEU | A:281 | A:451 | 16.0 | 0.094 | H | -68.6 | -35.8 | 16.0 | 0.094 | 0.0 | ||||||
| 4xbf | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2016-04-27 | LEU | A:281 | A:451 | 8.0 | 0.047 | H | -97.5 | -30.9 | 8.0 | 0.047 | 0.0 | ||||||
| 6wc6 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-30 | LEU | A:281 | A:451 | 13.0 | 0.076 | H | -66.5 | -41.3 | 13.0 | 0.076 | 0.0 | ||||||
| 2h94 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2006-07-04 | LEU | A:280 | A:451 | 7.0 | 0.041 | H | -85.4 | -15.7 | 7.0 | 0.041 | 0.0 | ||||||
| 2hko | 1 | O60341 | 99.25 | 0.0 |
X-RAY |
2006-08-29 | LEU | A:280 | A:451 | 10.0 | 0.059 | H | -81.1 | -41.1 | 10.0 | 0.059 | 0.0 | ||||||
| 7e0g | 1 | O60341 | 99.1 | 0.0 |
X-RAY |
2021-03-24 | LEU | A:283 | A:451 | 8.0 | 0.047 | H | -68.2 | -37.0 | 8.0 | 0.047 | 0.0 | ||||||
| 6s35 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-02-26 | LEU | A:284 | A:451 | 22.0 | 0.129 | H | -78.3 | -46.4 | 22.0 | 0.129 | 0.0 | ||||||
| 5h6q | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2017-04-12 | LEU | A:287 | A:451 | 16.0 | 0.094 | H | -69.1 | -31.3 | 16.0 | 0.094 | 0.0 | ||||||
| 5h6r | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2017-04-12 | LEU | A:287 | A:451 | 14.0 | 0.082 | H | -77.7 | -32.4 | 14.0 | 0.082 | 0.0 | ||||||
| 5x60 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2017-04-12 | LEU | A:287 | A:451 | 19.0 | 0.112 | H | -69.1 | -43.3 | 19.0 | 0.112 | 0.0 | ||||||
| 5yjb | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2018-07-04 | LEU | A:287 | A:451 | 14.0 | 0.082 | H | -75.1 | -39.2 | 14.0 | 0.082 | 0.0 | ||||||
| 6kgk | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | LEU | A:287 | A:451 | 9.0 | 0.053 | H | -67.7 | -36.7 | 9.0 | 0.053 | 0.0 | ||||||
| 6kgl | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | LEU | A:287 | A:451 | 9.0 | 0.053 | H | -68.6 | -36.6 | 9.0 | 0.053 | 0.0 | ||||||
| 6kgm | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | LEU | A:287 | A:451 | 10.0 | 0.059 | H | -66.8 | -37.7 | 10.0 | 0.059 | 0.0 | ||||||
| 6kgn | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | LEU | A:287 | A:451 | 11.0 | 0.065 | H | -66.7 | -37.7 | 11.0 | 0.065 | 0.0 | ||||||
| 6kgo | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | LEU | A:287 | A:451 | 10.0 | 0.059 | H | -75.3 | -30.1 | 10.0 | 0.059 | 0.0 |
HOH |
5.150 |
CD1 |
O |
||
| 6kgp | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | LEU | A:287 | A:451 | 10.0 | 0.059 | H | -75.3 | -30.1 | 10.0 | 0.059 | 0.0 |
HOH |
5.161 |
CD1 |
O |
||
| 6kgq | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | LEU | A:287 | A:451 | 12.0 | 0.071 | H | -79.9 | -31.9 | 12.0 | 0.071 | 0.0 |
HOH |
3.375 |
CD1 |
O |
||
| 6kgr | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | LEU | A:287 | A:451 | 12.0 | 0.071 | H | -79.8 | -31.5 | 12.0 | 0.071 | 0.0 |
HOH |
3.400 |
CD1 |
O |
||
| 7cdc | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | LEU | A:287 | A:451 | 23.0 | 0.135 | H | -71.5 | -28.1 | 23.0 | 0.135 | 0.0 | ||||||
| 7cdd | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | LEU | A:287 | A:451 | 15.0 | 0.088 | H | -77.2 | -35.5 | 15.0 | 0.088 | 0.0 | ||||||
| 7cde | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | LEU | A:287 | A:451 | 15.0 | 0.088 | H | -74.3 | -34.4 | 15.0 | 0.088 | 0.0 | ||||||
| 7cdf | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | LEU | A:287 | A:451 | 16.0 | 0.094 | H | -71.3 | -31.9 | 16.0 | 0.094 | 0.0 | ||||||
| 7cdg | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | LEU | A:287 | A:451 | 13.0 | 0.076 | H | -76.3 | -35.7 | 13.0 | 0.076 | 0.0 | ||||||
| 2ejr | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2008-01-01 | LEU | A:280 | A:451 | 12.0 | 0.071 | H | -80.1 | -22.8 | 12.0 | 0.071 | 0.0 | ||||||
| 2z3y | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2008-01-01 | LEU | A:280 | A:451 | 13.0 | 0.076 | H | -78.6 | -25.5 | 13.0 | 0.076 | 0.0 |
HOH |
3.833 |
CB |
O |
||
| 2z5u | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2008-04-01 | LEU | A:280 | A:451 | 13.0 | 0.076 | H | -78.2 | -25.4 | 13.0 | 0.076 | 0.0 | ||||||
| 3abt | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2010-07-07 | LEU | A:280 | A:451 | 18.0 | 0.106 | H | -85.1 | -27.0 | 18.0 | 0.106 | 0.0 | ||||||
| 3abu | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2010-07-07 | LEU | A:280 | A:451 | 14.0 | 0.082 | H | -76.6 | -23.8 | 14.0 | 0.082 | 0.0 | ||||||
| 6k3e | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-05-20 | LEU | A:280 | A:451 | 15.0 | 0.088 | H | -138.8 | -43.7 | 15.0 | 0.088 | 0.0 | ||||||
| 2dw4 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2007-09-04 | LEU | A:280 | A:451 | 8.0 | 0.047 | H | -72.6 | -35.2 | 8.0 | 0.047 | 0.0 |
HOH |
5.023 |
CD1 |
O |
||
| 6w4k | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-10-21 | LEU | A:278 | A:451 | 13.0 | 0.076 | H | -114.7 | -51.7 | 13.0 | 0.076 | 0.0 | ||||||
| 6nqm | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2019-02-13 | LEU | A:279 | A:451 | 13.0 | 0.076 | H | -66.8 | -30.7 | 13.0 | 0.076 | 0.0 | ||||||
| 6nqu | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2019-02-13 | LEU | A:279 | A:451 | 19.0 | 0.112 | H | -74.7 | -27.4 | 19.0 | 0.112 | 0.0 | ||||||
| 6nr5 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2019-07-17 | LEU | A:279 | A:451 | 14.0 | 0.082 | H | -66.8 | -31.5 | 14.0 | 0.082 | 0.0 | ||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-o60341-f1 | 1 | O60341 | 94.98 | 0.0 | LEU | A:451 | A:451 | 3.0 | 0.018 | H | -68.5 | -36.9 | |