Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 23397841 | . | G | A | CCDS30627.1:NM_015013.3:c.1465Gcc>Acc_NP_055828.2:p.489A>T | Homo sapiens lysine demethylase 1A (KDM1A), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3zmu | 1 | O60341 | 99.54 | 0.0 |
X-RAY |
2013-06-12 | ALA | A:509 | A:489 | 30.0 | 0.261 | H | -63.9 | -40.6 | 30.0 | 0.261 | 0.0 | ||||||
| 3zmv | 1 | O60341 | 99.54 | 0.0 |
X-RAY |
2013-06-12 | ALA | A:509 | A:489 | 33.0 | 0.287 | H | -67.8 | -38.0 | 33.0 | 0.287 | 0.0 | ||||||
| 3zms | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | ALA | A:509 | A:489 | 31.0 | 0.27 | H | -65.1 | -43.2 | 31.0 | 0.27 | 0.0 | ||||||
| 3zmt | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | ALA | A:509 | A:489 | 30.0 | 0.261 | H | -63.8 | -43.9 | 30.0 | 0.261 | 0.0 | ||||||
| 3zmz | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | ALA | A:509 | A:489 | 30.0 | 0.261 | H | -69.0 | -43.6 | 30.0 | 0.261 | 0.0 | ||||||
| 3zn0 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | ALA | A:509 | A:489 | 30.0 | 0.261 | H | -66.8 | -42.4 | 30.0 | 0.261 | 0.0 | ||||||
| 3zn1 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2013-06-12 | ALA | A:509 | A:489 | 28.0 | 0.243 | H | -68.4 | -45.8 | 28.0 | 0.243 | 0.0 | ||||||
| 4czz | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-06-11 | ALA | A:509 | A:489 | 19.0 | 0.165 | H | -39.4 | -54.0 | 19.0 | 0.165 | 0.0 | ||||||
| 4uv8 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | ALA | A:509 | A:489 | 27.0 | 0.235 | H | -65.5 | -41.8 | 27.0 | 0.235 | 0.0 | ||||||
| 4uv9 | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | ALA | A:509 | A:489 | 26.0 | 0.226 | H | -65.9 | -42.3 | 26.0 | 0.226 | 0.0 | ||||||
| 4uva | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | ALA | A:509 | A:489 | 27.0 | 0.235 | H | -65.6 | -45.7 | 27.0 | 0.235 | 0.0 | ||||||
| 4uvb | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | ALA | A:509 | A:489 | 29.0 | 0.252 | H | -67.9 | -45.7 | 29.0 | 0.252 | 0.0 | ||||||
| 4uvc | 1 | O60341 | 99.43 | 0.0 |
X-RAY |
2014-09-10 | ALA | A:509 | A:489 | 24.0 | 0.209 | H | -57.4 | -47.7 | 24.0 | 0.209 | 0.0 | ||||||
| 6tuy | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2021-07-21 | ALA | A:489 | A:489 | 30.0 | 0.261 | H | -48.6 | -50.9 | 30.0 | 0.261 | 0.0 | ||||||
| 2xaf | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ALA | A:489 | A:489 | 27.0 | 0.235 | H | -57.0 | -59.1 | 27.0 | 0.235 | 0.0 | ||||||
| 2xag | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ALA | A:489 | A:489 | 19.0 | 0.165 | H | -51.2 | -45.3 | 19.0 | 0.165 | 0.0 | ||||||
| 2xah | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ALA | A:489 | A:489 | 26.0 | 0.226 | H | -49.9 | -48.0 | 26.0 | 0.226 | 0.0 | ||||||
| 2xaj | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ALA | A:489 | A:489 | 29.0 | 0.252 | H | -62.6 | -62.5 | 29.0 | 0.252 | 0.0 | ||||||
| 2xaq | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ALA | A:489 | A:489 | 30.0 | 0.261 | H | -36.7 | -31.4 | 28.0 | 0.243 | 0.018 |
B:Q9UKL0:0.017 |
|||||
| 2xas | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2010-05-05 | ALA | A:489 | A:489 | 29.0 | 0.252 | H | -51.4 | -53.2 | 29.0 | 0.252 | 0.0 | ||||||
| 4uxn | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2015-02-25 | ALA | A:489 | A:489 | 26.0 | 0.226 | H | -40.3 | -60.8 | 26.0 | 0.226 | 0.0 | ||||||
| 5lhg | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2017-02-22 | ALA | A:489 | A:489 | 24.0 | 0.209 | H | -69.8 | -39.9 | 24.0 | 0.209 | 0.0 | ||||||
| 5lhh | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2017-02-22 | ALA | A:489 | A:489 | 35.0 | 0.304 | H | -67.1 | -43.5 | 35.0 | 0.304 | 0.0 | ||||||
| 5lhi | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2017-02-22 | ALA | A:489 | A:489 | 38.0 | 0.33 | T | -119.9 | 83.0 | 33.0 | 0.287 | 0.043 |
B:Q9UKL0:0.043 |
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| 6te1 | 1 | O60341 | 94.98 | 0.0 |
X-RAY |
2020-06-03 | ALA | A:489 | A:489 | 27.0 | 0.235 | H | -70.4 | -39.0 | 27.0 | 0.235 | 0.0 | ||||||
| 5l3c | 1 | O60341 | 94.86 | 0.0 |
X-RAY |
2016-05-04 | ALA | A:489 | A:489 | 25.0 | 0.217 | H | -56.8 | -50.0 | 25.0 | 0.217 | 0.0 | ||||||
| 5l3d | 1 | O60341 | 94.86 | 0.0 |
X-RAY |
2016-05-04 | ALA | A:489 | A:489 | 24.0 | 0.209 | H | -57.6 | -43.3 | 24.0 | 0.209 | 0.0 | ||||||
| 5l3b | 1 | O60341 | 94.86 | 0.0 |
X-RAY |
2016-05-04 | ALA | A:489 | A:489 | 27.0 | 0.235 | H | -61.6 | -49.0 | 27.0 | 0.235 | 0.0 | ||||||
| 2x0l | 1 | O60341 | 100.0 | 0.0 |
X-RAY |
2010-03-02 | ALA | A:371 | A:489 | 31.0 | 0.27 | H | -46.2 | -54.4 | 31.0 | 0.27 | 0.0 | ||||||
| 4bay | 1 | O60341 | 99.85 | 0.0 |
X-RAY |
2013-11-27 | ALA | A:323 | A:489 | 25.0 | 0.217 | H | -65.4 | -36.9 | 25.0 | 0.217 | 0.0 | ||||||
| 2v1d | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2007-05-29 | ALA | A:367 | A:489 | 29.0 | 0.252 | H | -37.3 | -53.7 | 29.0 | 0.252 | 0.0 | ||||||
| 2y48 | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2011-02-16 | ALA | A:367 | A:489 | 30.0 | 0.261 | H | -59.6 | -47.7 | 30.0 | 0.261 | 0.0 | ||||||
| 5l3e | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | ALA | A:367 | A:489 | 25.0 | 0.217 | H | -56.5 | -45.7 | 25.0 | 0.217 | 0.0 | ||||||
| 5l3f | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | ALA | A:367 | A:489 | 28.0 | 0.243 | H | -55.6 | -63.4 | 28.0 | 0.243 | 0.0 | ||||||
| 5l3g | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | ALA | A:367 | A:489 | 27.0 | 0.235 | H | -53.8 | -64.7 | 27.0 | 0.235 | 0.0 | ||||||
| 5lbq | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2016-09-21 | ALA | A:367 | A:489 | 33.0 | 0.287 | H | -55.4 | -56.7 | 33.0 | 0.287 | 0.0 | ||||||
| 5lgt | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2017-02-22 | ALA | A:367 | A:489 | 24.0 | 0.209 | H | -55.2 | -44.0 | 24.0 | 0.209 | 0.0 | ||||||
| 5lgu | 1 | O60341 | 99.42 | 0.0 |
X-RAY |
2017-02-22 | ALA | A:367 | A:489 | 19.0 | 0.165 | H | -56.6 | -52.7 | 19.0 | 0.165 | 0.0 | ||||||
| 6vyp | 7 | O60341 | 98.69 | 0.0 |
X-RAY |
2020-05-27 | ALA | S:321 | M:489 | 27.0 | 0.235 | H | -66.3 | -37.1 | 27.0 | 0.235 | 0.0 | ||||||
| ALA | U:321 | m:489 | 28.0 | 0.243 | H | -66.5 | -37.4 | NA | NA | NA | |||||||||||||
| ALA | W:321 | K:489 | 28.0 | 0.243 | H | -66.4 | -40.0 | 28.0 | 0.243 | 0.0 | |||||||||||||
| ALA | Y:321 | k:489 | 21.0 | 0.183 | H | -66.8 | -38.9 | NA | NA | NA | |||||||||||||
| 5lgn | 1 | O60341 | 99.85 | 0.0 |
X-RAY |
2017-02-22 | ALA | A:323 | A:493 | 25.0 | 0.217 | H | -65.0 | -36.6 | 25.0 | 0.217 | 0.0 | ||||||
| 2iw5 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2006-08-09 | ALA | A:319 | A:489 | 30.0 | 0.261 | H | -55.5 | -45.7 | 30.0 | 0.261 | 0.0 | ||||||
| 2uxn | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2007-05-29 | ALA | A:319 | A:489 | 31.0 | 0.27 | H | -60.8 | -49.9 | 31.0 | 0.27 | 0.0 | ||||||
| 2uxx | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2007-08-21 | ALA | A:319 | A:489 | 30.0 | 0.261 | H | -62.6 | -42.8 | 30.0 | 0.261 | 0.0 | ||||||
| 4kum | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2014-05-07 | ALA | A:319 | A:489 | 30.0 | 0.261 | H | -54.6 | -46.4 | 30.0 | 0.261 | 0.0 | ||||||
| 4xbf | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2016-04-27 | ALA | A:319 | A:489 | 30.0 | 0.261 | H | -55.0 | -45.7 | 30.0 | 0.261 | 0.0 | ||||||
| 6wc6 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-30 | ALA | A:319 | A:489 | 33.0 | 0.287 | H | -58.4 | -48.5 | 33.0 | 0.287 | 0.0 | ||||||
| 2h94 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2006-07-04 | ALA | A:318 | A:489 | 44.0 | 0.383 | H | -39.5 | -51.8 | 44.0 | 0.383 | 0.0 | ||||||
| 2hko | 1 | O60341 | 99.25 | 0.0 |
X-RAY |
2006-08-29 | ALA | A:318 | A:489 | 59.0 | 0.513 | H | -92.4 | -46.0 | 59.0 | 0.513 | 0.0 | ||||||
| 7e0g | 1 | O60341 | 99.1 | 0.0 |
X-RAY |
2021-03-24 | ALA | A:321 | A:489 | 56.0 | 0.487 | H | -68.1 | -37.1 | 56.0 | 0.487 | 0.0 |
HOH |
8.977 |
N |
O |
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| 6s35 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-02-26 | ALA | A:322 | A:489 | 27.0 | 0.235 | H | -66.4 | -59.7 | 27.0 | 0.235 | 0.0 | ||||||
| 5h6q | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2017-04-12 | ALA | A:325 | A:489 | 29.0 | 0.252 | H | -59.7 | -42.3 | 29.0 | 0.252 | 0.0 | ||||||
| 5h6r | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2017-04-12 | ALA | A:325 | A:489 | 37.0 | 0.322 | H | -65.7 | -39.4 | 37.0 | 0.322 | 0.0 | ||||||
| 5x60 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2017-04-12 | ALA | A:325 | A:489 | 26.0 | 0.226 | H | -63.6 | -40.2 | 26.0 | 0.226 | 0.0 | ||||||
| 5yjb | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2018-07-04 | ALA | A:325 | A:489 | 32.0 | 0.278 | H | -64.8 | -48.8 | 32.0 | 0.278 | 0.0 | ||||||
| 6kgk | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ALA | A:325 | A:489 | 30.0 | 0.261 | H | -63.3 | -48.1 | 30.0 | 0.261 | 0.0 | ||||||
| 6kgl | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ALA | A:325 | A:489 | 31.0 | 0.27 | H | -63.6 | -46.9 | 31.0 | 0.27 | 0.0 | ||||||
| 6kgm | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ALA | A:325 | A:489 | 31.0 | 0.27 | H | -65.6 | -48.1 | 31.0 | 0.27 | 0.0 | ||||||
| 6kgn | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ALA | A:325 | A:489 | 31.0 | 0.27 | H | -65.8 | -47.9 | 31.0 | 0.27 | 0.0 | ||||||
| 6kgo | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ALA | A:325 | A:489 | 57.0 | 0.496 | H | -80.1 | -41.0 | 57.0 | 0.496 | 0.0 |
HOH |
6.651 |
O |
O |
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| 6kgp | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ALA | A:325 | A:489 | 57.0 | 0.496 | H | -80.8 | -40.7 | 57.0 | 0.496 | 0.0 |
HOH |
6.636 |
O |
O |
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| 6kgq | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ALA | A:325 | A:489 | 48.0 | 0.417 | H | -61.0 | -36.6 | 48.0 | 0.417 | 0.0 |
HOH |
7.922 |
O |
O |
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| 6kgr | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-03-25 | ALA | A:325 | A:489 | 48.0 | 0.417 | H | -61.2 | -36.7 | 48.0 | 0.417 | 0.0 |
HOH |
7.913 |
O |
O |
||
| 7cdc | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | ALA | A:325 | A:489 | 24.0 | 0.209 | H | -57.9 | -53.1 | 24.0 | 0.209 | 0.0 | ||||||
| 7cdd | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | ALA | A:325 | A:489 | 25.0 | 0.217 | H | -56.8 | -60.0 | 25.0 | 0.217 | 0.0 |
HOH |
9.979 |
O |
O |
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| 7cde | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | ALA | A:325 | A:489 | 26.0 | 0.226 | H | -57.3 | -56.1 | 26.0 | 0.226 | 0.0 | ||||||
| 7cdf | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | ALA | A:325 | A:489 | 29.0 | 0.252 | H | -59.7 | -46.7 | 29.0 | 0.252 | 0.0 | ||||||
| 7cdg | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2021-06-23 | ALA | A:325 | A:489 | 28.0 | 0.243 | H | -57.4 | -54.0 | 28.0 | 0.243 | 0.0 | ||||||
| 2ejr | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2008-01-01 | ALA | A:318 | A:489 | 42.0 | 0.365 | T | -55.0 | -24.6 | 42.0 | 0.365 | 0.0 | ||||||
| 2z3y | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2008-01-01 | ALA | A:318 | A:489 | 41.0 | 0.357 | T | -58.4 | -26.9 | 41.0 | 0.357 | 0.0 | ||||||
| 2z5u | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2008-04-01 | ALA | A:318 | A:489 | 40.0 | 0.348 | T | -59.3 | -26.2 | 40.0 | 0.348 | 0.0 | ||||||
| 3abt | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2010-07-07 | ALA | A:318 | A:489 | 38.0 | 0.33 | T | -61.9 | -31.5 | 38.0 | 0.33 | 0.0 | ||||||
| 3abu | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2010-07-07 | ALA | A:318 | A:489 | 42.0 | 0.365 | H | -46.0 | -26.6 | 42.0 | 0.365 | 0.0 | ||||||
| 6k3e | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-05-20 | ALA | A:318 | A:489 | 13.0 | 0.113 | H | -63.0 | -54.4 | 13.0 | 0.113 | 0.0 | ||||||
| 2dw4 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2007-09-04 | ALA | A:318 | A:489 | 50.0 | 0.435 | H | -76.1 | -34.5 | 50.0 | 0.435 | 0.0 |
HOH |
4.225 |
CB |
O |
||
| 6w4k | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2020-10-21 | ALA | A:316 | A:489 | 31.0 | 0.27 | H | -55.9 | -68.9 | 31.0 | 0.27 | 0.0 |
HOH |
3.569 |
N |
O |
||
| 6nqm | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2019-02-13 | ALA | A:317 | A:489 | 41.0 | 0.357 | H | -59.2 | -47.7 | 41.0 | 0.357 | 0.0 | ||||||
| 6nqu | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2019-02-13 | ALA | A:317 | A:489 | 54.0 | 0.47 | H | -56.9 | -53.2 | 54.0 | 0.47 | 0.0 | ||||||
| 6nr5 | 1 | O60341 | 99.4 | 0.0 |
X-RAY |
2019-07-17 | ALA | A:317 | A:489 | 35.0 | 0.304 | H | -67.9 | -42.4 | 35.0 | 0.304 | 0.0 | ||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-o60341-f1 | 1 | O60341 | 94.98 | 0.0 | ALA | A:489 | A:489 | 57.0 | 0.496 | H | -65.9 | -47.1 | |