Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55518037 . G A CCDS603.1:NM_174936.3:c.610Gac>Aac_NP_777596.2:p.204D>N Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
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alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 ASP A:204 NA:NA DO NA DO DO DO NA NA NA
ASP B:204 A:204 127.0 0.847 E 62.5 13.9 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASP A:204 A:204 149.0 0.993 E 84.4 -15.6 149.0 0.993 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 ASP A:204 A:204 144.0 0.96 E 84.2 -1.9 144.0 0.96 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 ASP A:204 A:204 145.0 0.967 E 81.9 -6.5 145.0 0.967 0.0 HOH
 2.377
 H
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:174 NA:NA DO NA DO DO DO NA NA NA
ASP B:174 B:204 141.0 0.94 E 70.0 2.1 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:174 NA:NA DO NA DO DO DO NA NA NA
ASP B:174 B:204 129.0 0.86 E 65.7 18.7 129.0 0.86 0.0 HOH
 6.556
 OD1
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:174 NA:NA DO NA DO DO DO NA NA NA
ASP B:174 B:204 76.0 0.507 E 51.5 46.8 76.0 0.507 0.0 HOH
 3.113
 OD2
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:174 NA:NA DO NA DO DO DO NA NA NA
ASP B:174 B:204 146.0 0.973 E -82.1 4.3 146.0 0.973 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:174 NA:NA DO NA DO DO DO NA NA NA
ASP B:174 B:204 103.0 NA E -81.1 -7.4 103.0 NA NA HOH
 5.963
 O
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 ASP A:174 NA:NA DO NA DO DO DO NA NA NA
ASP B:174 B:204 140.0 0.933 E 62.8 22.4 140.0 0.933 0.0 HOH
 8.224
 O
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 ASP B:52 B:204 124.0 0.827 E 70.5 12.8 124.0 0.827 0.0 HOH
 2.964
 OD1
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASP B:52 A:204 149.0 0.993 E 60.5 35.5 149.0 0.993 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 ASP B:52 A:204 151.0 1.0 E 60.5 35.6 151.0 1.0 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 ASP B:52 A:204 108.0 0.72 -109.7 140.9 108.0 0.72 0.0 HOH
 3.613
 C
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASP B:52 A:204 111.0 0.74 -107.5 144.5 111.0 0.74 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 ASP B:52 A:204 110.0 0.733 -111.8 141.1 110.0 0.733 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 ASP A:52 A:204 149.0 0.993 E 69.3 47.6 149.0 0.993 0.0 HOH
 4.446
 N
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 ASP A:52 A:204 158.0 1.0 E 102.7 -26.4 158.0 1.0 0.0 HOH
 4.139
 O
 O
ASP B:52 B:204 157.0 1.0 E 104.4 -29.0 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 ASP B:52 B:204 170.0 1.0 E -69.4 -15.1 170.0 1.0 0.0 HOH
 3.107
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 ASP B:52 B:204 148.0 0.987 E -68.2 23.9 148.0 0.987 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 ASP B:52 B:204 137.0 0.913 E 61.9 15.4 137.0 0.913 0.0 HOH
 2.858
 OD1
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 ASP B:52 B:204 137.0 0.913 E 65.0 13.1 137.0 0.913 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 ASP B:52 B:204 125.0 0.833 E 48.8 17.6 125.0 0.833 0.0 HOH
 3.023
 N
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 ASP B:52 B:204 137.0 0.913 E 61.9 15.4 137.0 0.913 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 ASP B:52 B:204 149.0 0.993 E -91.5 17.7 149.0 0.993 0.0 HOH
 3.192
 CB
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 ASP B:52 B:204 149.0 0.993 E -88.5 14.7 149.0 0.993 0.0 HOH
 3.101
 CB
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:204 A:204 149.0 0.993 E -84.6 3.3 149.0 0.993 0.0 HOH
 4.748
 C
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:204 A:204 157.0 1.0 E -70.5 -9.1 157.0 1.0 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:204 A:204 149.0 0.993 E -84.7 9.1 149.0 0.993 0.0 HOH
 3.090
 N
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 ASP A:204 A:204 149.0 0.993 E -87.6 6.4 149.0 0.993 0.0 HOH
 4.426
 C
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 ASP B:52 B:204 146.0 0.973 E -73.1 4.9 146.0 0.973 0.0 HOH
 3.106
 N
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:52 B:204 169.0 1.0 E -77.2 1.0 169.0 1.0 0.0 HOH
 3.164
 N
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:52 B:204 168.0 1.0 E -77.3 1.8 168.0 1.0 0.0 HOH
 3.213
 N
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:52 B:204 169.0 1.0 E -78.3 3.9 169.0 1.0 0.0 HOH
 3.134
 N
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:52 B:204 168.0 1.0 E -76.2 2.3 168.0 1.0 0.0 HOH
 3.112
 N
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 ASP B:52 B:204 145.0 0.967 E -75.6 -4.6 145.0 0.967 0.0 HOH
 3.043
 N
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASP B:52 B:204 166.0 1.0 E -75.8 5.2 166.0 1.0 0.0 HOH
 3.196
 N
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 ASP B:52 B:204 156.0 1.0 E -68.9 -16.2 156.0 1.0 0.0 HOH
 2.588
 OD2
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASP A:52 A:204 153.0 1.0 E -88.3 9.6 153.0 1.0 0.0 HOH
 3.732
 O
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 ASP A:52 A:204 150.0 1.0 E -83.4 7.2 150.0 1.0 0.0 HOH
 3.486
 OD2
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASP A:52 A:204 146.0 0.973 E -90.8 12.5 146.0 0.973 0.0 HOH
 3.095
 OD2
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASP A:52 A:204 142.0 0.947 E -79.4 -3.8 142.0 0.947 0.0 HOH
 3.625
 O
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 ASP A:52 A:204 149.0 0.993 E -81.1 9.0 149.0 0.993 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 ASP A:52 A:204 146.0 0.973 E -99.0 11.2 146.0 0.973 0.0 HOH
 2.766
 N
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 ASP B:52 B:204 170.0 1.0 E -77.3 -8.8 170.0 1.0 0.0 HOH
 3.222
 N
 O
ASP D:52 E:204 143.0 0.953 E -76.9 -10.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 ASP A:204 A:204 155.0 1.0 E 56.6 9.3