Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55518452 . G A CCDS603.1:NM_174936.3:c.787Ggc>Agc_NP_777596.2:p.263G>S Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 GLY A:263 NA:NA DO NA DO DO DO NA NA NA
GLY B:263 A:263 0.0 0.0 H -66.2 -41.3 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 GLY A:263 A:263 0.0 0.0 H -66.3 -39.5 0.0 0.0 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 GLY A:263 A:263 0.0 0.0 H -70.5 -35.9 0.0 0.0 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 GLY A:263 A:263 0.0 0.0 H -70.9 -38.5 0.0 0.0 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:233 NA:NA DO NA DO DO DO NA NA NA
GLY B:233 B:263 0.0 0.0 H -62.6 -40.4 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:233 NA:NA DO NA DO DO DO NA NA NA
GLY B:233 B:263 0.0 0.0 H -67.1 -34.9 0.0 0.0 0.0 HOH
 3.418
 CA
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:233 NA:NA DO NA DO DO DO NA NA NA
GLY B:233 B:263 0.0 0.0 H -64.8 -38.2 0.0 0.0 0.0 HOH
 3.378
 CA
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:233 NA:NA DO NA DO DO DO NA NA NA
GLY B:233 B:263 0.0 0.0 H -64.0 -32.5 0.0 0.0 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:233 NA:NA DO NA DO DO DO NA NA NA
GLY B:233 B:263 1.0 0.013 H -67.7 -33.0 1.0 0.013 0.0 HOH
 3.670
 CA
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 GLY A:233 NA:NA DO NA DO DO DO NA NA NA
GLY B:233 B:263 1.0 0.013 H -61.9 -39.4 1.0 0.013 0.0 HOH
 7.977
 CA
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 GLY B:111 B:263 0.0 0.0 H -54.7 -45.5 0.0 0.0 0.0 HOH
 3.540
 CA
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 GLY B:111 A:263 1.0 0.013 H -70.1 -30.4 1.0 0.013 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 GLY B:111 A:263 1.0 0.013 H -70.1 -30.4 1.0 0.013 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 GLY B:111 A:263 16.0 0.213 H -66.7 -34.0 16.0 0.213 0.0 HOH
 3.524
 CA
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 GLY B:111 A:263 4.0 0.053 H -63.5 -40.2 4.0 0.053 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 GLY B:111 A:263 10.0 0.133 H -65.1 -39.5 10.0 0.133 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 GLY A:111 A:263 0.0 0.0 H -61.0 -40.5 0.0 0.0 0.0 HOH
 3.646
 CA
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 GLY A:111 A:263 0.0 0.0 H -65.1 -41.6 0.0 0.0 0.0 HOH
 6.332
 CA
 O
GLY B:111 B:263 0.0 0.0 H -63.3 -42.3 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 GLY B:111 B:263 0.0 0.0 H -65.2 -43.6 0.0 0.0 0.0 HOH
 6.767
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 GLY B:111 B:263 0.0 0.0 H -51.0 -57.3 0.0 0.0 0.0
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 GLY B:111 B:263 0.0 0.0 H -61.2 -37.8 0.0 0.0 0.0 HOH
 3.604
 N
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 GLY B:111 B:263 0.0 0.0 H -59.6 -39.8 0.0 0.0 0.0 HOH
 6.545
 N
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 GLY B:111 B:263 0.0 0.0 H -63.3 -37.7 0.0 0.0 0.0 HOH
 3.826
 N
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 GLY B:111 B:263 0.0 0.0 H -61.2 -37.7 0.0 0.0 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 GLY B:111 B:263 0.0 0.0 H -65.9 -36.3 0.0 0.0 0.0 HOH
 3.810
 CA
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 GLY B:111 B:263 0.0 0.0 H -65.3 -37.5 0.0 0.0 0.0 HOH
 3.822
 N
 O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 GLY A:263 A:263 0.0 0.0 H -61.4 -41.7 0.0 0.0 0.0 HOH
 3.410
 CA
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 GLY A:263 A:263 0.0 0.0 H -56.7 -45.5 0.0 0.0 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 GLY A:263 A:263 0.0 0.0 H -61.2 -37.5 0.0 0.0 0.0 HOH
 3.625
 N
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 GLY A:263 A:263 0.0 0.0 H -56.6 -43.8 0.0 0.0 0.0 HOH
 3.512
 CA
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 GLY B:111 B:263 0.0 0.0 H -60.5 -43.1 0.0 0.0 0.0 HOH
 3.539
 CA
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 GLY B:111 B:263 0.0 0.0 H -63.6 -40.4 0.0 0.0 0.0 HOH
 3.647
 CA
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 GLY B:111 B:263 0.0 0.0 H -64.5 -38.5 0.0 0.0 0.0 HOH
 3.647
 CA
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 GLY B:111 B:263 0.0 0.0 H -65.4 -40.8 0.0 0.0 0.0 HOH
 3.618
 CA
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 GLY B:111 B:263 1.0 0.013 H -63.2 -39.4 1.0 0.013 0.0 HOH
 3.622
 CA
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 GLY B:111 B:263 0.0 0.0 H -61.2 -41.7 0.0 0.0 0.0 HOH
 3.554
 CA
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 GLY B:111 B:263 0.0 0.0 H -66.9 -41.7 0.0 0.0 0.0 HOH
 3.713
 CA
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 GLY B:111 B:263 0.0 0.0 H -67.3 -39.3 0.0 0.0 0.0 HOH
 3.608
 N
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 GLY A:111 A:263 0.0 0.0 H -67.6 -34.0 0.0 0.0 0.0 HOH
 3.777
 CA
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 GLY A:111 A:263 0.0 0.0 H -71.3 -40.5 0.0 0.0 0.0 HOH
 3.598
 CA
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 GLY A:111 A:263 0.0 0.0 H -63.9 -36.8 0.0 0.0 0.0 HOH
 6.716
 O
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 GLY A:111 A:263 0.0 0.0 H -58.8 -40.8 0.0 0.0 0.0 HOH
 3.615
 N
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 GLY A:111 A:263 0.0 0.0 H -63.8 -44.5 0.0 0.0 0.0 HOH
 6.822
 CA
 O
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 GLY A:111 A:263 0.0 0.0 H -62.7 -39.4 0.0 0.0 0.0 HOH
 3.493
 N
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 GLY B:111 B:263 0.0 0.0 H -65.0 -36.3 0.0 0.0 0.0 HOH
 3.950
 CA
 O
GLY D:111 E:263 0.0 0.0 H -60.2 -41.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 GLY A:263 A:263 0.0 0.0 H -67.0 -44.2