Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55524216 . C A CCDS603.1:NM_174936.3:c.1399Cct>Act_NP_777596.2:p.467P>T Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 PRO A:467 NA:NA DO NA DO DO DO NA NA NA
PRO B:467 A:467 94.0 0.648 S -81.3 -3.5 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 PRO A:467 A:467 99.0 0.683 S -81.9 -8.6 99.0 0.683 0.0
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 PRO A:467 A:467 98.0 0.676 S -84.6 -11.4 98.0 0.676 0.0
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 PRO A:467 A:467 97.0 0.669 S -83.7 -2.5 97.0 0.669 0.0
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:437 NA:NA DO NA DO DO DO NA NA NA
PRO B:437 B:467 101.0 0.697 S -70.5 -15.9 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:437 NA:NA DO NA DO DO DO NA NA NA
PRO B:437 B:467 105.0 0.724 -75.5 -16.3 105.0 0.724 0.0 HOH
 5.979
 O
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:437 NA:NA DO NA DO DO DO NA NA NA
PRO B:437 B:467 96.0 0.662 S -89.5 -22.2 96.0 0.662 0.0 HOH
 9.093
 CA
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:437 NA:NA DO NA DO DO DO NA NA NA
PRO B:437 B:467 106.0 0.731 S -78.3 109.3 106.0 0.731 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:437 NA:NA DO NA DO DO DO NA NA NA
PRO B:437 B:467 108.0 0.745 S -70.9 -4.0 108.0 0.745 0.0
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 PRO A:437 NA:NA DO NA DO DO DO NA NA NA
PRO B:437 B:467 105.0 0.724 S -92.4 11.7 105.0 0.724 0.0
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 PRO B:315 B:467 93.0 0.641 S -82.8 -11.5 93.0 0.641 0.0 HOH
 3.483
 N
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 PRO B:315 A:467 110.0 0.759 S -75.1 -10.5 110.0 0.759 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 PRO B:315 A:467 110.0 0.759 S -75.1 -10.5 110.0 0.759 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 PRO B:315 A:467 98.0 0.676 S -74.0 -39.1 98.0 0.676 0.0 HOH
 5.543
 O
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 PRO B:315 A:467 78.0 0.538 S -64.1 -33.2 78.0 0.538 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 PRO B:315 A:467 89.0 0.614 S -69.4 -37.4 89.0 0.614 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 PRO A:315 A:467 95.0 0.655 S -80.6 9.2 95.0 0.655 0.0 HOH
 4.485
 C
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 PRO A:315 A:467 94.0 0.648 S -84.2 -4.0 94.0 0.648 0.0
PRO B:315 B:467 94.0 0.648 S -84.9 -3.7 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 PRO B:315 B:467 95.0 0.655 S -67.4 5.6 95.0 0.655 0.0 HOH
 3.615
 CD
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 PRO B:315 NA:NA DO NA DO DO DO NA NA NA
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 PRO B:315 B:467 80.0 0.552 S -85.4 -0.8 80.0 0.552 0.0 HOH
 3.360
 N
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 PRO B:315 B:467 102.0 0.703 S -97.4 1.2 102.0 0.703 0.0
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 PRO B:315 B:467 96.0 0.662 S -98.4 17.0 96.0 0.662 0.0
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 PRO B:315 B:467 78.0 0.538 S -85.4 -0.7 78.0 0.538 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 PRO B:315 B:467 98.0 0.676 S -66.3 -17.5 98.0 0.676 0.0
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 PRO B:315 B:467 96.0 0.662 S -76.8 3.5 96.0 0.662 0.0 HOH
 7.352
 N
 O
7anq 1 Q8NBP7 100.0 6e-167 X-RAY
 2021-10-20 PRO A:16 A:467 101.0 0.697 S -91.9 17.9 101.0 0.697 0.0 HOH
 5.013
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 PRO A:467 A:467 98.0 0.676 S -80.4 1.2