Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55524243 | . | C | A | CCDS603.1:NM_174936.3:c.1426Cgc>Agc_NP_777596.2:p.476R>S | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
|---|---|---|---|---|---|---|---|
|
|
|
|
|
PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | ARG | A:476 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:476 | A:476 | 135.0 | 0.6 | -113.3 | 147.9 | NA | NA | NA | ||||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ARG | A:476 | A:476 | 150.0 | 0.667 | E | -113.6 | 147.3 | 150.0 | 0.667 | 0.0 | ||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | ARG | A:476 | A:476 | 134.0 | 0.596 | -109.2 | 148.5 | 134.0 | 0.596 | 0.0 | |||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ARG | A:476 | A:476 | 146.0 | 0.649 | E | -112.9 | 147.4 | 146.0 | 0.649 | 0.0 |
HOH |
4.760 |
HH12 |
O |
||
| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:446 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:446 | B:476 | 140.0 | 0.622 | -136.9 | 148.8 | NA | NA | NA | ||||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:446 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:446 | B:476 | 167.0 | 0.742 | -130.2 | 160.5 | 167.0 | 0.742 | 0.0 |
PV7 HOH |
3.045 3.761 |
NE CA |
O27 O |
||||||||||
| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:446 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:446 | B:476 | 165.0 | 0.733 | -131.6 | 156.7 | 165.0 | 0.733 | 0.0 |
PUV HOH |
2.882 3.524 |
NE CA |
O28 O |
||||||||||
| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:446 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:446 | B:476 | 171.0 | 0.76 | -126.5 | 166.6 | 171.0 | 0.76 | 0.0 |
PVM HOH |
3.049 8.070 |
NE O |
O50 O |
||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:446 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:446 | B:476 | 136.0 | 0.604 | -112.7 | 164.4 | 136.0 | 0.604 | 0.0 |
PVJ HOH |
3.087 8.016 |
CD CD |
O34 O |
||||||||||
| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ARG | A:446 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ARG | B:446 | B:476 | 136.0 | 0.604 | -114.5 | 164.7 | 136.0 | 0.604 | 0.0 |
PVV HOH |
3.092 6.792 |
O C |
C12 O |
||||||||||
| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | ARG | B:324 | B:476 | 140.0 | 0.622 | -111.3 | 147.9 | 140.0 | 0.622 | 0.0 |
HOH |
3.197 |
N |
O |
|||
| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ARG | B:324 | A:476 | 136.0 | 0.604 | -116.2 | 152.8 | 136.0 | 0.604 | 0.0 | |||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ARG | B:324 | A:476 | 135.0 | 0.6 | -116.2 | 152.7 | 135.0 | 0.6 | 0.0 | |||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | ARG | B:324 | A:476 | 130.0 | 0.578 | -123.0 | 157.2 | 130.0 | 0.578 | 0.0 |
HOH |
3.336 |
N |
O |
|||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ARG | B:324 | A:476 | 135.0 | 0.6 | -121.0 | 154.3 | 135.0 | 0.6 | 0.0 | |||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ARG | B:324 | A:476 | 130.0 | 0.578 | -120.7 | 156.6 | 130.0 | 0.578 | 0.0 | |||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | ARG | A:324 | A:476 | 139.0 | 0.618 | -118.5 | 145.4 | 139.0 | 0.618 | 0.0 |
HOH |
7.382 |
NH2 |
O |
|||
| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | ARG | A:324 | A:476 | 134.0 | 0.596 | -117.0 | 153.5 | 134.0 | 0.596 | 0.0 |
HOH |
9.260 |
O |
O |
|||
| ARG | B:324 | B:476 | 130.0 | 0.578 | -119.7 | 153.0 | NA | NA | NA | ||||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | ARG | B:324 | B:476 | 141.0 | 0.627 | E | -132.1 | 154.0 | 141.0 | 0.627 | 0.0 |
HOH |
2.838 |
N |
O |
||
| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | ARG | B:324 | B:476 | 150.0 | 0.667 | -107.6 | 150.2 | 150.0 | 0.667 | 0.0 | |||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | ARG | B:324 | B:476 | 130.0 | 0.578 | -112.9 | 156.1 | 130.0 | 0.578 | 0.0 |
HOH |
2.662 |
O |
O |
|||
| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | ARG | B:324 | B:476 | 127.0 | 0.564 | -132.4 | 151.9 | 127.0 | 0.564 | 0.0 |
HOH |
9.536 |
O |
O |
|||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | ARG | B:324 | B:476 | 120.0 | 0.533 | -127.5 | 162.2 | 120.0 | 0.533 | 0.0 |
HOH |
6.878 |
O |
O |
|||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | ARG | B:324 | B:476 | 129.0 | 0.573 | -113.0 | 156.0 | 129.0 | 0.573 | 0.0 | |||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | ARG | B:324 | B:476 | 138.0 | 0.613 | -120.4 | 156.5 | 138.0 | 0.613 | 0.0 |
HOH |
2.902 |
N |
O |
|||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | ARG | B:324 | B:476 | 127.0 | 0.564 | -127.8 | 155.8 | 127.0 | 0.564 | 0.0 |
HOH |
2.877 |
N |
O |
|||
| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | ARG | A:25 | A:476 | 161.0 | 0.716 | -128.1 | 151.5 | 93.0 | 0.413 | 0.303 |
B:None:0.302 |
HOH |
2.719 |
O |
O |
||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | ARG | A:476 | A:476 | 131.0 | 0.582 | -135.0 | 141.2 | ||