Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55525192 | . | A | C | CCDS603.1:NM_174936.3:c.1537Aac>Cac_NP_777596.2:p.513N>H | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | ASN | A:513 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ASN | B:513 | A:513 | 4.0 | 0.025 | E | -62.6 | 143.6 | NA | NA | NA | |||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ASN | A:513 | A:513 | 0.0 | 0.0 | E | -73.4 | 153.0 | 0.0 | 0.0 | 0.0 | ||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | ASN | A:513 | A:513 | 0.0 | 0.0 | E | -74.5 | 158.6 | 0.0 | 0.0 | 0.0 | ||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | ASN | A:513 | A:513 | 0.0 | 0.0 | E | -77.1 | 157.9 | 0.0 | 0.0 | 0.0 | ||||||
| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ASN | A:483 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ASN | B:483 | B:513 | 0.0 | 0.0 | E | -88.0 | 148.3 | NA | NA | NA | |||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ASN | A:483 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ASN | B:483 | B:513 | 0.0 | 0.0 | E | -88.6 | 161.9 | 0.0 | 0.0 | 0.0 |
HOH |
4.201 |
O |
O |
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| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ASN | A:483 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ASN | B:483 | B:513 | 0.0 | 0.0 | E | -84.0 | 165.8 | 0.0 | 0.0 | 0.0 |
HOH |
5.781 |
O |
O |
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| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ASN | A:483 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ASN | B:483 | B:513 | 0.0 | 0.0 | E | -94.7 | 150.9 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ASN | A:483 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ASN | B:483 | B:513 | 0.0 | 0.0 | E | -91.4 | 149.2 | 0.0 | 0.0 | 0.0 | |||||||||||||
| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | ASN | A:483 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| ASN | B:483 | B:513 | 1.0 | 0.006 | E | -105.7 | 144.2 | 1.0 | 0.006 | 0.0 | |||||||||||||
| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | ASN | B:361 | B:513 | 1.0 | 0.006 | E | -76.9 | 149.9 | 1.0 | 0.006 | 0.0 |
HOH |
2.922 |
OD1 |
O |
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| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ASN | B:361 | A:513 | 0.0 | 0.0 | E | -98.3 | 140.9 | 0.0 | 0.0 | 0.0 | ||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | ASN | B:361 | A:513 | 0.0 | 0.0 | E | -98.3 | 141.0 | 0.0 | 0.0 | 0.0 | ||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | ASN | B:361 | A:513 | 0.0 | 0.0 | E | -82.7 | 122.1 | 0.0 | 0.0 | 0.0 |
HOH |
6.703 |
ND2 |
O |
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| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ASN | B:361 | A:513 | 1.0 | 0.006 | E | -80.2 | 121.3 | 1.0 | 0.006 | 0.0 | ||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | ASN | B:361 | A:513 | 1.0 | 0.006 | E | -83.0 | 128.2 | 1.0 | 0.006 | 0.0 | ||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | ASN | A:361 | A:513 | 0.0 | 0.0 | E | -104.3 | 156.7 | 0.0 | 0.0 | 0.0 |
HOH |
2.746 |
O |
O |
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| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | ASN | A:361 | A:513 | 3.0 | 0.019 | E | -70.1 | 146.3 | 3.0 | 0.019 | 0.0 | ||||||
| ASN | B:361 | B:513 | 3.0 | 0.019 | E | -72.0 | 146.7 | NA | NA | NA | |||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | ASN | B:361 | B:513 | 2.0 | 0.013 | E | -90.4 | 140.1 | 2.0 | 0.013 | 0.0 |
HOH |
8.654 |
ND2 |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | ASN | B:361 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | ASN | B:361 | B:513 | 0.0 | 0.0 | E | -78.7 | 153.0 | 0.0 | 0.0 | 0.0 |
HOH |
3.515 |
OD1 |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | ASN | B:361 | B:513 | 0.0 | 0.0 | E | -95.2 | 154.8 | 0.0 | 0.0 | 0.0 | ||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | ASN | B:361 | B:513 | 0.0 | 0.0 | E | -80.4 | 148.5 | 0.0 | 0.0 | 0.0 | ||||||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | ASN | B:361 | B:513 | 0.0 | 0.0 | E | -78.8 | 153.1 | 0.0 | 0.0 | 0.0 | ||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | ASN | B:361 | B:513 | 0.0 | 0.0 | E | -87.4 | 149.6 | 0.0 | 0.0 | 0.0 | ||||||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | ASN | B:361 | B:513 | 1.0 | 0.006 | E | -86.1 | 154.3 | 1.0 | 0.006 | 0.0 |
HOH |
3.193 |
N |
O |
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| 7anq | 1 | Q8NBP7 | 100.0 | 6e-167 |
X-RAY |
2021-10-20 | ASN | A:62 | A:513 | 0.0 | 0.0 | E | -90.2 | 153.1 | 0.0 | 0.0 | 0.0 |
HOH |
4.820 |
O |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | ASN | A:513 | A:513 | 2.0 | 0.013 | E | -65.6 | 160.9 | |