Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 104162225 . A C CCDS783.1:NM_000699.2:c.563gAt>gCt_NP_000690.1:p.188D>A Homo sapiens amylase, alpha 2A (pancreatic) (AMY2A), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1b2y 1 P04746 100.0 0.0 X-RAY
 2000-02-16 ASP A:173 A:173 92.0 0.613 H -65.4 -30.1 92.0 0.613 0.0 HOH
 3.203
 OD2
 O
1bsi 1 P04746 99.8 0.0 X-RAY
 1999-05-18 ASP A:173 A:173 96.0 0.64 H -59.7 -36.2 96.0 0.64 0.0 HOH
 2.941
 OD1
 O
1cpu 1 P04746 99.8 0.0 X-RAY
 1999-06-14 ASP A:173 A:173 94.0 0.627 H -60.6 -34.4 94.0 0.627 0.0 HOH
 2.641
 OD1
 O
1hny 1 P04746 99.8 0.0 X-RAY
 1996-03-08 ASP A:173 A:173 91.0 0.607 H -61.5 -31.5 91.0 0.607 0.0 HOH
 2.588
 OD1
 O
1u2y 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ASP A:173 A:173 96.0 0.64 H -59.5 -39.3 96.0 0.64 0.0 HOH
 2.945
 N
 O
1u30 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ASP A:173 A:173 92.0 0.613 H -65.7 -30.4 92.0 0.613 0.0 HOH
 2.533
 OD1
 O
1u33 1 P04746 99.8 0.0 X-RAY
 2004-09-07 ASP A:173 A:173 97.0 0.647 H -59.5 -34.2 97.0 0.647 0.0 HOH
 2.572
 OD1
 O
1xcw 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ASP A:173 A:173 100.0 0.667 H -55.5 -38.6 100.0 0.667 0.0 HOH
 2.677
 OD1
 O
1xcx 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ASP A:173 A:173 93.0 0.62 H -61.5 -35.5 93.0 0.62 0.0 HOH
 2.934
 N
 O
1xd0 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ASP A:173 A:173 94.0 0.627 H -60.5 -36.4 94.0 0.627 0.0 HOH
 2.966
 N
 O
1xd1 1 P04746 99.8 0.0 X-RAY
 2004-12-07 ASP A:173 A:173 94.0 0.627 H -59.6 -39.3 94.0 0.627 0.0 HOH
 2.976
 N
 O
2qmk 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ASP A:173 A:173 102.0 0.68 H -61.9 -35.9 102.0 0.68 0.0 HOH
 2.606
 OD1
 O
2qv4 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ASP A:173 A:173 96.0 0.64 H -63.3 -30.1 96.0 0.64 0.0 HOH
 2.719
 OD1
 O
3bai 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ASP A:173 A:173 94.0 0.627 H -63.1 -30.3 94.0 0.627 0.0 HOH
 2.713
 OD1
 O
3baj 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ASP A:173 A:173 98.0 0.653 H -60.6 -36.3 98.0 0.653 0.0 HOH
 2.779
 OD1
 O
3baw 1 P04746 99.8 0.0 X-RAY
 2008-03-25 ASP A:173 A:173 96.0 0.64 H -62.5 -32.9 96.0 0.64 0.0 HOH
 2.808
 OD1
 O
3ij7 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ASP A:173 A:173 94.0 0.627 H -62.7 -34.6 94.0 0.627 0.0 HOH
 2.576
 OD1
 O
3ij8 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ASP A:173 A:173 95.0 0.633 H -61.6 -36.0 95.0 0.633 0.0 B0D
HOH
 9.063
2.707
 N
OD2
 O4
O
3ij9 1 P04746 99.8 0.0 X-RAY
 2009-10-27 ASP A:173 A:173 94.0 0.627 H -61.4 -35.2 94.0 0.627 0.0 B0D
HOH
 8.944
2.667
 N
OD1
 O4
O
4gqq 1 P04746 99.8 0.0 X-RAY
 2012-10-24 ASP A:173 A:173 84.0 0.56 H -65.2 -24.6 84.0 0.56 0.0 HOH
 3.747
 N
 O
4gqr 1 P04746 99.8 0.0 X-RAY
 2012-10-24 ASP A:173 A:173 95.0 0.633 H -60.7 -34.2 95.0 0.633 0.0 HOH
 2.588
 OD1
 O
4w93 1 P04746 99.8 0.0 X-RAY
 2015-07-15 ASP A:173 A:173 94.0 0.627 H -61.8 -29.6 94.0 0.627 0.0 HOH
 2.641
 OD1
 O
4x9y 1 P04746 99.8 0.0 X-RAY
 2014-12-31 ASP A:173 A:173 93.0 0.62 H -59.7 -35.7 93.0 0.62 0.0 HOH
 1.967
 H
 O
5e0f 1 P04746 99.8 0.0 X-RAY
 2016-09-07 ASP A:173 A:173 95.0 0.633 H -59.7 -35.5 95.0 0.633 0.0 HOH
 2.091
 H
 O
5emy 1 P04746 99.8 0.0 X-RAY
 2016-07-06 ASP A:173 A:173 96.0 0.64 H -59.7 -36.4 96.0 0.64 0.0 HOH
 1.986
 H
 O
5kez 1 P04746 99.8 0.0 X-RAY
 2017-03-29 ASP A:173 A:173 97.0 0.647 H -57.7 -38.9 97.0 0.647 0.0 HOH
 2.663
 OD2
 O
5u3a 1 P04746 99.8 0.0 X-RAY
 2017-12-06 ASP A:173 A:173 95.0 0.633 H -58.5 -36.5 95.0 0.633 0.0 HOH
 1.970
 H
 O
5va9 1 P04746 99.8 0.0 X-RAY
 2018-03-28 ASP A:173 A:173 96.0 0.64 H -59.5 -34.4 96.0 0.64 0.0 HOH
 5.313
 OD1
 O
ASP B:173 B:173 96.0 0.64 H -60.5 -32.7 NA NA NA
6obx 1 P04746 99.8 0.0 X-RAY
 2020-02-12 ASP A:173 A:173 99.0 0.66 H -59.1 -37.5 99.0 0.66 0.0 HOH
 1.974
 H
 O
6ocn 1 P04746 99.8 0.0 X-RAY
 2020-02-12 ASP A:173 A:173 96.0 0.64 H -60.3 -36.1 96.0 0.64 0.0 HOH
 1.955
 H
 O
3old 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ASP A:173 A:173 94.0 0.627 H -64.0 -32.5 94.0 0.627 0.0 GLC
GLC
HOH
 6.448
8.832
2.769
 N
C
OD1
 O2
C1
O
3ole 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ASP A:173 A:173 96.0 0.64 H -62.8 -34.1 96.0 0.64 0.0 GLC
GLC
HOH
 6.478
8.823
2.749
 N
C
OD2
 O2
C1
O
3olg 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ASP A:173 A:173 97.0 0.647 H -62.2 -30.5 97.0 0.647 0.0 BGC
GLC
GLC
BGC
HOH
 8.679
6.466
8.888
8.521
2.489
 N
N
C
N
OD2
 O3
O2
C1
O1
O
3oli 1 P04746 99.8 0.0 X-RAY
 2011-04-13 ASP A:173 A:173 97.0 0.647 H -63.8 -33.4 97.0 0.647 0.0 GLC
GLC
GLC
HOH
 6.328
8.722
8.967
2.625
 N
C
N
OD1
 O2
C1
O4
O
1kgw 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ASP A:173 A:173 94.0 0.627 H -61.2 -28.1 94.0 0.627 0.0 HOH
 3.008
 N
 O
1xgz 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ASP A:173 A:173 94.0 0.627 H -60.8 -36.6 94.0 0.627 0.0 HOH
 2.927
 N
 O
1xh0 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ASP A:173 A:173 91.0 0.607 H -60.6 -36.2 91.0 0.607 0.0 HOH
 2.805
 N
 O
1xh1 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ASP A:173 A:173 94.0 0.627 H -59.4 -35.9 94.0 0.627 0.0 HOH
 2.792
 OD2
 O
1xh2 1 P04746 99.6 0.0 X-RAY
 2005-05-24 ASP A:173 A:173 95.0 0.633 H -59.4 -35.8 95.0 0.633 0.0 HOH
 2.747
 OD1
 O
3bak 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ASP A:173 A:173 95.0 0.633 H -62.5 -31.0 95.0 0.633 0.0 HOH
 2.580
 OD1
 O
3bax 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ASP A:173 A:173 95.0 0.633 H -65.9 -32.0 95.0 0.633 0.0 HOH
 2.717
 OD2
 O
3bay 1 P04746 99.6 0.0 X-RAY
 2008-03-25 ASP A:173 A:173 98.0 0.653 H -66.8 -28.5 98.0 0.653 0.0 HOH
 2.697
 OD1
 O
1kgx 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ASP A:173 A:173 95.0 0.633 H -59.7 -38.9 95.0 0.633 0.0 HOH
 2.787
 OD1
 O
6z8l 1 P04746 99.6 0.0 X-RAY
 2020-12-02 ASP A:173 A:173 95.0 0.633 H -62.3 -35.9 95.0 0.633 0.0 GLC
HOH
 8.113
2.078
 H
H
 HO4
O
1kgu 1 P04746 99.6 0.0 X-RAY
 2002-01-16 ASP A:173 A:173 100.0 0.667 H -56.0 -32.2 100.0 0.667 0.0 HOH
 2.696
 OD1
 O
2cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 ASP A:173 A:173 94.0 0.627 H -60.0 -39.5 94.0 0.627 0.0 HOH
 2.970
 N
 O
3cpu 1 P04746 99.6 0.0 X-RAY
 2001-06-30 ASP A:173 A:173 90.0 0.6 H -62.5 -31.2 90.0 0.6 0.0 HOH
 2.842
 N
 O
5td4 1 P04746 99.6 0.0 X-RAY
 2016-11-02 ASP A:173 A:173 96.0 0.64 H -65.6 -26.5 96.0 0.64 0.0 GLC
GLC
GLC
GLC
HOH
 8.532
6.483
8.941
8.656
2.754
 N
N
C
N
N
 O3
O2
C1
O4
O
1kb3 1 P04746 99.6 0.0 X-RAY
 2002-05-01 ASP A:173 A:173 97.0 0.647 H -59.8 -36.5 97.0 0.647 0.0 HOH
 2.809
 OD1
 O
1kbb 1 P04746 99.6 0.0 X-RAY
 2002-04-10 ASP A:173 A:173 93.0 0.62 H -60.0 -28.9 93.0 0.62 0.0 HOH
 4.546
 OD1
 O
1kbk 1 P04746 99.6 0.0 X-RAY
 2002-04-10 ASP A:173 A:173 100.0 0.667 H -61.8 -36.3 100.0 0.667 0.0 HOH
 2.676
 OD1
 O
1c8q 1 P04745 96.98 0.0 X-RAY
 2001-06-13 ASP A:173 A:173 99.0 0.66 H -57.1 -32.2 99.0 0.66 0.0 HOH
 2.812
 OD2
 O
1mfv 1 P04745 96.98 0.0 X-RAY
 2002-11-20 ASP A:173 A:173 96.0 0.64 H -55.8 -37.0 96.0 0.64 0.0 HOH
 2.834
 N
 O
1smd 1 P04745 96.98 0.0 X-RAY
 1996-07-11 ASP A:173 A:173 91.0 0.607 H -66.5 -29.9 91.0 0.607 0.0 HOH
 2.501
 OD1
 O
1xv8 1 P04745 96.98 0.0 X-RAY
 2005-10-11 ASP A:173 A:173 97.0 0.647 H -69.8 -35.9 97.0 0.647 0.0 HOH
 6.250
 O
 O
ASP B:173 B:173 98.0 0.653 H -69.8 -35.9 98.0 0.653 0.0 HOH
 6.251
 O
 O
1z32 1 P04745 96.77 0.0 X-RAY
 2005-05-31 ASP A:173 X:173 98.0 0.653 H -54.3 -37.6 98.0 0.653 0.0 HOH
 2.686
 OD1
 O
1jxj 1 P04745 96.77 0.0 X-RAY
 2001-09-14 ASP A:173 A:173 93.0 0.62 H -62.5 -34.0 93.0 0.62 0.0 HOH
 2.531
 OD1
 O
1q4n 1 P04745 96.77 0.0 X-RAY
 2004-03-16 ASP A:173 X:173 94.0 0.627 H -57.5 -34.4 94.0 0.627 0.0 HOH
 2.622
 OD1
 O
1nm9 1 P04745 96.77 0.0 X-RAY
 2004-01-20 ASP A:173 A:173 96.0 0.64 H -58.4 -36.6 96.0 0.64 0.0 HOH
 2.606
 OD2
 O
3blk 1 P04745 96.77 0.0 X-RAY
 2008-11-25 ASP A:173 A:173 94.0 0.627 H -61.8 -35.0 94.0 0.627 0.0 HOH
 2.776
 OD1
 O
3blp 1 P04745 96.77 0.0 X-RAY
 2008-11-18 ASP A:173 X:173 97.0 0.647 H -55.3 -39.5 97.0 0.647 0.0 HOH
 2.723
 OD1
 O
1jxk 1 P04745 95.97 0.0 X-RAY
 2001-09-14 ASP A:173 A:173 97.0 0.647 H -60.4 -35.3 97.0 0.647 0.0 HOH
 2.700
 OD1
 O
1mfu 1 P04745 95.97 0.0 X-RAY
 2002-11-20 ASP A:173 A:173 97.0 0.647 H -57.3 -34.7 97.0 0.647 0.0 GLC
GLC
HOH
 8.588
8.564
2.588
 N
C
OD2
 O4
O4
O
3dhp 1 P04745 95.77 0.0 X-RAY
 2008-07-01 ASP A:173 A:173 97.0 0.647 H -57.4 -36.1 97.0 0.647 0.0 HOH
 2.526
 OD2
 O
1kxq 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ASP A:173 A:173 96.0 0.64 H -63.0 -29.8 96.0 0.64 0.0 HOH
 2.537
 OD1
 O
ASP B:173 B:173 98.0 0.653 H -66.5 -31.5 NA NA NA
ASP C:173 C:173 93.0 0.62 H -62.9 -32.1 NA NA NA
ASP D:173 D:173 95.0 0.633 H -61.0 -33.6 NA NA NA
1kxt 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ASP A:173 A:173 94.0 0.627 H -61.1 -38.4 94.0 0.627 0.0 HOH
 2.765
 OD1
 O
ASP C:173 C:173 98.0 0.653 H -64.9 -36.5 NA NA NA
ASP E:173 E:173 94.0 0.627 H -57.2 -31.3 NA NA NA
1kxv 1 P00690 86.9 0.0 X-RAY
 2002-06-19 ASP A:173 A:173 95.0 0.633 H -59.4 -32.8 95.0 0.633 0.0 HOH
 2.789
 OD1
 O
ASP B:173 B:173 94.0 0.627 H -60.1 -35.5 NA NA NA
1dhk 1 P00690 86.9 0.0 X-RAY
 1997-12-24 ASP A:173 A:173 92.0 0.613 H -63.4 -30.3 92.0 0.613 0.0 HOH
 2.201
 OD1
 H1
1ppi 1 P00690 86.9 0.0 X-RAY
 1995-05-24 ASP A:173 A:173 95.0 0.633 H -64.0 -32.2 95.0 0.633 0.0 HOH
 2.768
 OD2
 O
1vah 1 P00690 86.69 0.0 X-RAY
 2005-04-26 ASP A:173 A:173 95.0 0.633 H -65.9 -29.4 95.0 0.633 0.0 HOH
 2.995
 N
 O
3l2l 1 P00690 86.69 0.0 X-RAY
 2010-04-14 ASP A:173 A:173 95.0 0.633 H -56.6 -38.0 95.0 0.633 0.0 HOH
 2.516
 OD2
 O
3l2m 1 P00690 86.69 0.0 X-RAY
 2010-04-14 ASP A:173 A:173 95.0 0.633 H -66.0 -36.0 95.0 0.633 0.0 GLC
GLC
HOH
 8.140
9.735
2.807
 C
H
H
 H4
H1
O
1ua3 1 P00690 86.69 0.0 X-RAY
 2003-10-14 ASP A:173 A:173 96.0 0.64 H -64.3 -33.9 96.0 0.64 0.0 BGC
EDO
EDO
HOH
 9.008
8.734
6.721
2.608
 N
C
N
OD1
 O4
O2
O2
O
1jfh 1 P00690 86.69 0.0 X-RAY
 1998-12-02 ASP A:173 A:173 93.0 0.62 H -63.6 -32.2 93.0 0.62 0.0 HOH
 2.783
 OD1
 O
1ose 1 P00690 86.49 0.0 X-RAY
 1997-04-01 ASP A:173 A:173 94.0 0.627 H -67.6 -29.8 94.0 0.627 0.0 HOH
 2.809
 OD1
 O
1hx0 1 P00690 86.49 0.0 X-RAY
 2001-08-08 ASP A:173 A:173 94.0 0.627 H -61.5 -31.9 94.0 0.627 0.0 HOH
 2.536
 OD1
 O
1wo2 1 P00690 86.49 0.0 X-RAY
 2005-03-15 ASP A:173 A:173 96.0 0.64 H -65.4 -29.4 96.0 0.64 0.0 HOH
 2.674
 OD1
 O
1bvn 1 P00690 86.49 0.0 X-RAY
 1998-09-23 ASP A:173 P:173 97.0 0.647 H -69.9 -20.3 97.0 0.647 0.0 HOH
 3.592
 N
 O
1pif 1 P00690 86.29 0.0 X-RAY
 1996-12-07 ASP A:173 A:173 95.0 0.633 H -58.2 -27.8 95.0 0.633 0.0 HOH
 2.707
 OD1
 O
1pig 1 P00690 86.29 0.0 X-RAY
 1996-12-07 ASP A:173 A:173 91.0 0.607 H -60.4 -29.0 91.0 0.607 0.0 HOH
 2.891
 N
 O
4x0n 1 P00690 86.29 0.0 X-RAY
 2015-11-25 ASP A:173 A:173 125.0 0.833 H -62.1 -36.6 125.0 0.833 0.0 HOH
 2.237
 OD1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p04746-f1 1 P04746 100.0 0.0 ASP A:188 A:188 97.0 0.647 H -60.1 -32.3
af-p19961-f1 1 P19961 98.83 0.0 ASP A:188 A:188 97.0 0.647 H -59.4 -32.6
af-p0dte7-f1 1 P0DTE7 96.87 0.0 ASP A:188 A:188 94.0 0.627 H -61.1 -33.5
af-p0dte8-f1 1 P0DTE8 96.87 0.0 ASP A:188 A:188 93.0 0.62 H -60.8 -33.3
af-p0dub6-f1 1 P0DUB6 96.87 0.0 ASP A:188 A:188 93.0 0.62 H -60.7 -34.3