Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 116930811 . A C CCDS887.1:NM_000701.7:c.446tAt>tCt_NP_000692.2:p.149Y>S Homo sapiens ATPase Na+/K+ transporting subunit alpha 1 (ATP1A1), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4hqj 1 P05024 98.14 0.0 X-RAY
 2013-10-02 TYR A:147 A:142 136.0 0.591 H -64.6 -49.5 136.0 0.591 0.0
TYR D:147 C:142 135.0 0.587 H -64.0 -49.2 NA NA NA
4hyt 1 P05024 98.14 0.0 X-RAY
 2013-06-26 TYR A:147 A:142 116.0 0.504 H -57.4 -39.9 116.0 0.504 0.0
TYR D:147 C:142 117.0 0.509 H -58.4 -39.5 NA NA NA
4res 1 P05024 98.14 0.0 X-RAY
 2015-01-28 TYR A:147 A:142 132.0 0.574 H -63.4 -45.2 132.0 0.574 0.0
TYR D:147 C:142 127.0 0.552 H -63.7 -44.9 NA NA NA
4ret 1 P05024 98.14 0.0 X-RAY
 2015-01-28 TYR A:147 A:142 117.0 0.509 H -62.6 -37.7 117.0 0.509 0.0
TYR D:147 C:142 115.0 0.5 H -63.0 -37.4 NA NA NA
7evx 1 P05024 98.14 0.0 X-RAY
 2021-07-07 TYR A:147 A:142 136.0 0.591 H -64.4 -34.3 136.0 0.591 0.0 PCW
 3.244
 CE2
 O3P
TYR D:147 C:142 113.0 0.491 H -63.8 -37.1 NA NA NA
3wgu 1 I7HD36 98.62 0.0 X-RAY
 2013-10-09 TYR A:142 A:142 114.0 0.496 H -54.9 -39.7 114.0 0.496 0.0 PC1
 3.506
 CE2
 O21
TYR D:142 C:142 143.0 0.622 H -64.4 -36.3 NA NA NA
3wgv 1 I7HD36 98.62 0.0 X-RAY
 2013-10-09 TYR A:142 A:142 117.0 0.509 H -60.4 -35.2 117.0 0.509 0.0 PC1
 3.649
 CE2
 O22
TYR D:142 C:142 145.0 0.63 H -64.4 -35.0 NA NA NA
7d91 1 P05024 98.13 0.0 X-RAY
 2021-01-27 TYR A:142 A:142 131.0 0.57 H -61.5 -47.1 131.0 0.57 0.0 PCW
PCW
 3.176
6.547
 CE2
CE2
 O3P
O1P
7d92 1 P05024 98.13 0.0 X-RAY
 2021-01-27 TYR A:142 A:142 130.0 0.565 H -62.6 -44.3 130.0 0.565 0.0 PCW
PCW
 3.303
9.607
 CE2
CE2
 O3P
O1P
7d93 1 P05024 98.13 0.0 X-RAY
 2021-01-27 TYR A:142 A:142 104.0 0.452 H -62.5 -34.1 104.0 0.452 0.0 PCW
PCW
 3.474
9.339
 OH
OH
 C7
C8
TYR C:142 C:142 114.0 0.496 H -62.8 -34.3 NA NA NA
7d94 1 P05024 98.13 0.0 X-RAY
 2021-01-27 TYR A:142 A:142 137.0 0.596 H -62.2 -33.8 137.0 0.596 0.0 PCW
PCW
PCW
 3.428
9.665
4.100
 CB
CE2
CE1
 O31
O1P
O4P
TYR D:142 C:142 117.0 0.509 H -62.2 -34.9 NA NA NA
7ddf 1 P05024 98.13 0.0 X-RAY
 2021-01-27 TYR A:142 A:142 137.0 0.596 H -64.0 -34.6 137.0 0.596 0.0 PCW
PCW
 3.657
6.237
 CD2
CD1
 O31
C12
TYR D:142 C:142 117.0 0.509 H -64.7 -36.5 NA NA NA
7ddh 1 P05024 98.13 0.0 X-RAY
 2021-01-27 TYR A:142 A:142 139.0 0.604 H -62.9 -31.0 139.0 0.604 0.0 PCW
PCW
 3.059
4.640
 CE2
CE1
 O3P
C5
TYR D:142 C:142 118.0 0.513 H -63.0 -32.9 NA NA NA
7ddi 1 P05024 98.13 0.0 X-RAY
 2021-01-27 TYR A:142 A:142 137.0 0.596 H -65.3 -36.4 137.0 0.596 0.0 PCW
PCW
 3.205
3.553
 CE2
CE1
 O3P
O4P
TYR D:142 C:142 126.0 0.548 H -65.0 -38.9 NA NA NA
7ddj 1 P05024 98.13 0.0 X-RAY
 2021-01-27 TYR A:142 A:142 144.0 0.626 H -62.7 -34.8 144.0 0.626 0.0 PCW
PCW
 3.165
3.292
 CD2
OH
 O31
C8
TYR D:142 C:142 114.0 0.496 H -62.5 -33.7 NA NA NA
7ddk 1 P05024 98.13 0.0 X-RAY
 2021-01-27 TYR A:142 A:142 137.0 0.596 H -64.8 -34.7 137.0 0.596 0.0 PCW
PCW
 3.191
4.489
 CE2
CE1
 O3P
O4P
TYR D:142 C:142 138.0 0.6 H -64.7 -36.2 NA NA NA
7ddl 1 P05024 98.13 0.0 X-RAY
 2021-01-27 TYR A:142 A:142 137.0 0.596 H -62.7 -34.8 137.0 0.596 0.0 PCW
PCW
 3.419
4.112
 CB
CE1
 O31
O4P
TYR D:142 C:142 121.0 0.526 H -63.1 -35.0 NA NA NA
4xe5 1 Q08DA1 97.46 0.0 X-RAY
 2016-03-09 TYR A:147 A:147 121.0 0.526 H -69.8 -37.1 121.0 0.526 0.0
3b8e 1 P05024 98.4 0.0 X-RAY
 2007-12-18 TYR A:124 A:142 110.0 0.478 T -55.1 -1.3 110.0 0.478 0.0
TYR D:124 C:142 138.0 0.6 T -55.1 -1.3 NA NA NA
3kdp 1 P05024 98.4 0.0 X-RAY
 2010-02-16 TYR A:124 A:142 132.0 0.574 S -63.0 31.5 132.0 0.574 0.0
TYR D:124 C:142 128.0 0.557 G -47.2 -28.6 NA NA NA
3n23 1 P05024 98.59 0.0 X-RAY
 2011-01-19 TYR A:118 A:142 86.0 0.374 T -74.9 -17.8 86.0 0.374 0.0
TYR D:118 C:142 85.0 0.37 T -73.8 -17.5 NA NA NA
2zxe 1 Q4H132 87.84 0.0 X-RAY
 2009-05-19 TYR A:154 A:149 142.0 0.617 H -64.3 -33.0 142.0 0.617 0.0 HOH
 2.742
 O
 O
3a3y 1 Q4H132 87.84 0.0 X-RAY
 2009-09-08 TYR A:154 A:149 118.0 0.513 H -109.3 -28.4 118.0 0.513 0.0 HOH
 4.410
 CE1
 O
5avq 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.0 142.0 0.617 0.0
5avr 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.0 142.0 0.617 0.0
5avs 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.2 -33.1 142.0 0.617 0.0
5avt 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.1 142.0 0.617 0.0
5avu 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.0 142.0 0.617 0.0
5avv 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.4 -32.9 142.0 0.617 0.0
5avw 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.0 142.0 0.617 0.0
5avx 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 143.0 0.622 H -64.3 -33.0 143.0 0.622 0.0
5avy 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 143.0 0.622 H -64.3 -33.1 143.0 0.622 0.0
5avz 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.2 -33.1 142.0 0.617 0.0
5aw0 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.1 142.0 0.617 0.0
5aw1 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.1 142.0 0.617 0.0
5aw2 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.2 -33.1 142.0 0.617 0.0
5aw3 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.1 142.0 0.617 0.0
5aw4 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.4 -33.1 142.0 0.617 0.0
5aw5 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.4 -33.0 142.0 0.617 0.0
5aw6 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.0 142.0 0.617 0.0
5aw7 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.1 142.0 0.617 0.0
5aw8 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 142.0 0.617 H -64.3 -33.1 142.0 0.617 0.0
5aw9 1 Q4H132 87.84 0.0 X-RAY
 2015-09-02 TYR A:154 A:149 143.0 0.622 H -58.5 -36.7 143.0 0.622 0.0 HOH
 2.830
 O
 O
1bg5 1 P08515 100.0 6e-07 X-RAY
 1999-01-13 TYR A:229 A:229 196.0 0.852 T -31.0 -19.9 196.0 0.852 0.0 HOH
 6.178
 C
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p05023-f1 1 P05023 100.0 0.0 TYR A:149 A:149 150.0 0.652 H -58.4 -36.7
af-p13637-f1 1 P13637 87.88 0.0 TYR A:139 A:139 155.0 0.674 H -58.6 -35.9
af-p50993-f1 1 P50993 86.71 0.0 TYR A:147 A:147 144.0 0.626 H -61.8 -32.3