Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 160106149 | . | A | C | CCDS1196.1:NM_000702.3:c.2552tAc>tCc_NP_000693.1:p.851Y>S | Homo sapiens ATPase Na+/K+ transporting subunit alpha 2 (ATP1A2), mRNA. |
|---|---|---|---|---|---|---|---|
|
|
|
|
|
PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 4xe5 | 1 | Q08DA1 | 86.79 | 0.0 |
X-RAY |
2016-03-09 | TYR | A:852 | A:852 | 25.0 | 0.109 | I | -70.7 | -44.3 | 25.0 | 0.109 | 0.0 |
MG HOH |
7.173 7.191 |
OH OH |
MG O |
||
| 3wgu | 1 | I7HD36 | 87.32 | 0.0 |
X-RAY |
2013-10-09 | TYR | A:847 | A:847 | 65.0 | 0.283 | I | -100.1 | -60.6 | 65.0 | 0.283 | 0.0 |
NA NA NA PC1 PC1 CLR HOH |
8.580 6.980 9.472 3.467 7.353 3.855 9.166 |
OH OH CE1 CD2 CE2 CB OH |
NA NA NA C38 C39 C15 O |
||
| TYR | D:847 | C:847 | 56.0 | 0.243 | I | -79.1 | -42.1 | NA | NA | NA | |||||||||||||
| 3wgv | 1 | I7HD36 | 87.32 | 0.0 |
X-RAY |
2013-10-09 | TYR | A:847 | A:847 | 64.0 | 0.278 | I | -104.6 | -52.9 | 64.0 | 0.278 | 0.0 |
NA NA NA CLR PC1 PC1 HOH |
9.047 7.080 9.728 3.570 3.474 7.454 8.910 |
OH OH CE1 CB CD2 CE2 OH |
NA NA NA C15 C38 C39 O |
||
| TYR | D:847 | C:847 | 57.0 | 0.248 | I | -81.5 | -42.5 | NA | NA | NA | |||||||||||||
| 4hqj | 1 | P05024 | 86.69 | 0.0 |
X-RAY |
2013-10-02 | TYR | A:852 | A:847 | 63.0 | 0.274 | I | -100.8 | -47.7 | 63.0 | 0.274 | 0.0 |
NA NA |
7.521 8.587 |
OH CE1 |
NA NA |
||
| TYR | D:852 | C:847 | 63.0 | 0.274 | I | -101.0 | -47.8 | NA | NA | NA | |||||||||||||
| 4hyt | 1 | P05024 | 86.69 | 0.0 |
X-RAY |
2013-06-26 | TYR | A:852 | A:847 | 24.0 | 0.104 | I | -78.4 | -42.8 | 24.0 | 0.104 | 0.0 |
MG 17F 17F 17F HOH |
7.813 6.026 7.398 5.195 7.100 |
OH CB CD2 C OH |
MG O10 O10 C20 O |
||
| TYR | D:852 | C:847 | 25.0 | 0.109 | I | -78.3 | -42.8 | NA | NA | NA | |||||||||||||
| 4res | 1 | P05024 | 86.69 | 0.0 |
X-RAY |
2015-01-28 | TYR | A:852 | A:847 | 26.0 | 0.113 | I | -76.5 | -45.8 | 25.0 | 0.109 | 0.004 |
B:P05027:0.004 |
K K |
6.715 7.614 |
OH OH |
K K |
|
| TYR | D:852 | C:847 | 26.0 | 0.113 | I | -76.6 | -46.7 | NA | NA | NA | |||||||||||||
| 4ret | 1 | P05024 | 86.69 | 0.0 |
X-RAY |
2015-01-28 | TYR | A:852 | A:847 | 21.0 | 0.091 | I | -75.1 | -44.5 | 21.0 | 0.091 | 0.0 |
MG 17F 17F HOH |
7.761 8.548 5.279 7.127 |
OH CD2 O OH |
MG C6 C1Y O |
||
| TYR | D:852 | C:847 | 21.0 | 0.091 | I | -75.2 | -44.5 | NA | NA | NA | |||||||||||||
| 7evx | 1 | P05024 | 86.69 | 0.0 |
X-RAY |
2021-07-07 | TYR | A:852 | A:847 | 22.0 | 0.096 | I | -73.8 | -28.4 | 22.0 | 0.096 | 0.0 |
MG PCW CLR HOH |
7.880 9.993 5.513 6.076 |
OH CD2 O OH |
MG O11 C15 O |
||
| TYR | D:852 | C:847 | 22.0 | 0.096 | I | -72.0 | -26.9 | NA | NA | NA | |||||||||||||
| 7d91 | 1 | P05024 | 86.82 | 0.0 |
X-RAY |
2021-01-27 | TYR | A:847 | A:847 | 18.0 | 0.078 | I | -73.4 | -27.3 | 18.0 | 0.078 | 0.0 |
MG PCW HOH |
7.129 6.829 7.651 |
OH CD2 OH |
MG O11 O |
||
| 7d92 | 1 | P05024 | 86.82 | 0.0 |
X-RAY |
2021-01-27 | TYR | A:847 | A:847 | 23.0 | 0.1 | I | -70.6 | -23.9 | 22.0 | 0.096 | 0.004 |
B:P05027:0.004 |
MG PCW CLR HOH |
7.955 7.495 4.064 6.051 |
OH CD2 O OH |
MG O31 C15 O |
|
| 7d93 | 1 | P05024 | 86.82 | 0.0 |
X-RAY |
2021-01-27 | TYR | A:847 | A:847 | 20.0 | 0.087 | I | -71.3 | -34.0 | 20.0 | 0.087 | 0.0 |
MG PCW HOH |
8.261 8.139 6.585 |
OH CD2 OH |
MG O31 O |
||
| TYR | C:847 | C:847 | 20.0 | 0.087 | I | -72.5 | -32.4 | NA | NA | NA | |||||||||||||
| 7d94 | 1 | P05024 | 86.82 | 0.0 |
X-RAY |
2021-01-27 | TYR | A:847 | A:847 | 21.0 | 0.091 | I | -74.1 | -26.5 | 21.0 | 0.091 | 0.0 |
MG RB PCW HOH |
7.184 6.984 9.621 8.425 |
OH OH CD2 OH |
MG RB O11 O |
||
| TYR | D:847 | C:847 | 20.0 | 0.087 | I | -74.4 | -27.0 | NA | NA | NA | |||||||||||||
| 7ddf | 1 | P05024 | 86.82 | 0.0 |
X-RAY |
2021-01-27 | TYR | A:847 | A:847 | 23.0 | 0.1 | I | -73.4 | -26.4 | 22.0 | 0.096 | 0.004 |
B:P05027:0.004 |
MG PCW CLR HOH |
7.960 9.272 5.459 6.508 |
OH CD2 O OH |
MG O11 C15 O |
|
| TYR | D:847 | C:847 | 19.0 | 0.083 | I | -71.8 | -25.5 | NA | NA | NA | |||||||||||||
| 7ddh | 1 | P05024 | 86.82 | 0.0 |
X-RAY |
2021-01-27 | TYR | A:847 | A:847 | 21.0 | 0.091 | I | -68.3 | -27.6 | 21.0 | 0.091 | 0.0 |
MG PCW CLR HOH |
7.857 9.749 5.434 6.249 |
OH CD2 O OH |
MG O11 C15 O |
||
| TYR | D:847 | C:847 | 21.0 | 0.091 | I | -68.2 | -28.5 | NA | NA | NA | |||||||||||||
| 7ddi | 1 | P05024 | 86.82 | 0.0 |
X-RAY |
2021-01-27 | TYR | A:847 | A:847 | 21.0 | 0.091 | I | -68.3 | -25.9 | 21.0 | 0.091 | 0.0 |
MG PCW HOH |
7.826 9.388 6.195 |
OH CD2 OH |
MG O11 O |
||
| TYR | D:847 | C:847 | 20.0 | 0.087 | I | -68.5 | -26.1 | NA | NA | NA | |||||||||||||
| 7ddj | 1 | P05024 | 86.82 | 0.0 |
X-RAY |
2021-01-27 | TYR | A:847 | A:847 | 21.0 | 0.091 | I | -71.1 | -34.1 | 21.0 | 0.091 | 0.0 |
MG PCW PCW HOH |
8.322 7.578 8.772 6.618 |
OH CD2 CE2 OH |
MG O31 O31 O |
||
| TYR | D:847 | C:847 | 19.0 | 0.083 | I | -72.0 | -32.8 | NA | NA | NA | |||||||||||||
| 7ddk | 1 | P05024 | 86.82 | 0.0 |
X-RAY |
2021-01-27 | TYR | A:847 | A:847 | 21.0 | 0.091 | I | -73.2 | -22.9 | 21.0 | 0.091 | 0.0 |
MG PCW CLR HOH |
7.999 9.696 5.210 6.281 |
OH CD2 O OH |
MG O11 C15 O |
||
| TYR | D:847 | C:847 | 21.0 | 0.091 | I | -71.9 | -22.6 | NA | NA | NA | |||||||||||||
| 7ddl | 1 | P05024 | 86.82 | 0.0 |
X-RAY |
2021-01-27 | TYR | A:847 | A:847 | 19.0 | 0.083 | I | -71.6 | -33.9 | 19.0 | 0.083 | 0.0 |
MG PCW CLR HOH |
8.296 9.378 5.647 6.504 |
OH CE2 O OH |
MG O11 C15 O |
||
| TYR | D:847 | C:847 | 19.0 | 0.083 | I | -72.5 | -33.9 | NA | NA | NA | |||||||||||||
| 3b8e | 1 | P05024 | 87.56 | 0.0 |
X-RAY |
2007-12-18 | TYR | A:829 | A:847 | 24.0 | 0.104 | T | -111.1 | -50.0 | 24.0 | 0.104 | 0.0 |
RB RB PC1 |
7.311 7.210 5.505 |
CE1 OH C |
RB RB O12 |
||
| TYR | D:829 | C:847 | 34.0 | 0.148 | T | -46.0 | -17.7 | NA | NA | NA | |||||||||||||
| 3kdp | 1 | P05024 | 87.56 | 0.0 |
X-RAY |
2010-02-16 | TYR | A:829 | A:847 | 24.0 | 0.104 | T | -105.0 | -62.7 | 24.0 | 0.104 | 0.0 |
RB RB CLR |
7.752 7.550 4.878 |
CE1 OH C |
RB RB C15 |
||
| TYR | D:829 | C:847 | 27.0 | 0.117 | T | -102.8 | -63.6 | NA | NA | NA | |||||||||||||
| 3n23 | 1 | P05024 | 87.8 | 0.0 |
X-RAY |
2011-01-19 | TYR | A:823 | A:847 | 29.0 | 0.126 | I | -88.3 | -62.9 | 29.0 | 0.126 | 0.0 | ||||||
| TYR | D:823 | C:847 | 28.0 | 0.122 | I | -88.9 | -62.2 | NA | NA | NA | |||||||||||||
| 2zxe | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2009-05-19 | TYR | A:859 | A:854 | 25.0 | 0.109 | I | -91.2 | -42.1 | 25.0 | 0.109 | 0.0 |
K K CLR HOH |
7.531 7.386 4.380 2.523 |
OH OH C OH |
K K C15 O |
||
| 3a3y | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2009-09-08 | TYR | A:859 | A:854 | 22.0 | 0.096 | I | -85.0 | -81.9 | 22.0 | 0.096 | 0.0 |
K K OBN CLR HOH |
7.587 7.700 9.756 3.960 9.611 |
OH OH OH CB OH |
K K O23 C15 O |
||
| 5avq | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 25.0 | 0.109 | I | -91.2 | -42.1 | 25.0 | 0.109 | 0.0 |
K TL K TL CLR HOH |
7.531 7.531 7.386 7.386 4.379 9.953 |
OH OH OH OH C CE1 |
K TL K TL C15 O |
||
| 5avr | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.2 | -42.1 | 26.0 | 0.113 | 0.0 |
K TL K TL CLR HOH |
7.531 7.531 7.386 7.386 4.380 9.954 |
OH OH OH OH C CE1 |
K TL K TL C15 O |
||
| 5avs | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.1 | -42.1 | 26.0 | 0.113 | 0.0 |
K TL TL CLR HOH |
7.531 7.531 7.386 4.379 9.952 |
OH OH OH C CE1 |
K TL TL C15 O |
||
| 5avt | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 25.0 | 0.109 | I | -91.3 | -42.1 | 25.0 | 0.109 | 0.0 |
K TL TL CLR HOH |
7.532 7.532 7.388 4.380 9.953 |
OH OH OH C CE1 |
K TL TL C15 O |
||
| 5avu | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 25.0 | 0.109 | I | -91.2 | -42.1 | 25.0 | 0.109 | 0.0 |
K TL TL CLR HOH |
7.531 7.531 7.386 4.379 9.954 |
OH OH OH C CE1 |
K TL TL C15 O |
||
| 5avv | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 25.0 | 0.109 | I | -91.1 | -42.2 | 25.0 | 0.109 | 0.0 |
TL TL CLR HOH |
7.532 7.386 4.380 9.953 |
OH OH C CE1 |
TL TL C15 O |
||
| 5avw | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.2 | -42.1 | 26.0 | 0.113 | 0.0 |
TL TL CLR HOH |
7.533 7.387 4.381 9.954 |
OH OH C CE1 |
TL TL C15 O |
||
| 5avx | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.3 | -42.1 | 26.0 | 0.113 | 0.0 |
TL TL CLR HOH |
7.531 7.387 4.380 9.952 |
OH OH C CE1 |
TL TL C15 O |
||
| 5avy | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.2 | -42.1 | 26.0 | 0.113 | 0.0 |
TL TL CLR HOH |
7.531 7.386 4.380 9.953 |
OH OH C CE1 |
TL TL C15 O |
||
| 5avz | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.1 | -42.2 | 26.0 | 0.113 | 0.0 |
TL TL CLR HOH |
7.532 7.388 4.380 9.953 |
OH OH C CE1 |
TL TL C15 O |
||
| 5aw0 | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.2 | -42.1 | 26.0 | 0.113 | 0.0 |
TL TL CLR HOH |
7.531 7.386 4.380 9.954 |
OH OH C CE1 |
TL TL C15 O |
||
| 5aw1 | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.2 | -42.1 | 26.0 | 0.113 | 0.0 |
K TL TL CLR HOH |
7.532 7.532 7.387 4.379 9.953 |
OH OH OH C CE1 |
K TL TL C15 O |
||
| 5aw2 | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.1 | -42.2 | 26.0 | 0.113 | 0.0 |
TL TL CLR HOH |
7.532 7.386 4.380 9.954 |
OH OH C CE1 |
TL TL C15 O |
||
| 5aw3 | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.3 | -42.1 | 26.0 | 0.113 | 0.0 |
TL TL CLR HOH |
7.532 7.386 4.379 9.954 |
OH OH C CE1 |
TL TL C15 O |
||
| 5aw4 | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 25.0 | 0.109 | I | -91.2 | -42.1 | 25.0 | 0.109 | 0.0 |
K RB K RB CLR HOH |
7.531 7.531 7.386 7.386 4.380 9.953 |
OH OH OH OH C CE1 |
K RB K RB C15 O |
||
| 5aw5 | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.2 | -42.0 | 26.0 | 0.113 | 0.0 |
K RB K RB CLR HOH |
7.530 7.530 7.386 7.386 4.379 9.954 |
OH OH OH OH C CE1 |
K RB K RB C15 O |
||
| 5aw6 | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 25.0 | 0.109 | I | -91.2 | -42.0 | 25.0 | 0.109 | 0.0 |
K RB K RB CLR HOH |
7.530 7.530 7.386 7.386 4.379 9.953 |
OH OH OH OH C CE1 |
K RB K RB C15 O |
||
| 5aw7 | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 26.0 | 0.113 | I | -91.2 | -42.1 | 26.0 | 0.113 | 0.0 |
K RB RB CLR HOH |
7.530 7.530 7.386 4.380 9.954 |
OH OH OH C CE1 |
K RB RB C15 O |
||
| 5aw8 | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 25.0 | 0.109 | I | -91.1 | -42.1 | 25.0 | 0.109 | 0.0 |
RB RB CLR HOH |
7.531 7.386 4.380 9.954 |
OH OH C CE1 |
RB RB C15 O |
||
| 5aw9 | 1 | Q4H132 | 84.65 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:859 | A:854 | 25.0 | 0.109 | I | -95.0 | -37.8 | 25.0 | 0.109 | 0.0 |
K K CLR HOH |
7.392 7.215 4.119 2.599 |
OH OH CB OH |
K K C15 O |
||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p50993-f1 | 1 | P50993 | 100.0 | 0.0 | TYR | A:851 | A:851 | 21.0 | 0.091 | I | -76.1 | -43.1 | |
| af-p13637-f1 | 1 | P13637 | 88.37 | 0.0 | TYR | A:844 | A:844 | 19.0 | 0.083 | I | -76.4 | -43.0 | |
| af-p05023-f1 | 1 | P05023 | 86.71 | 0.0 | TYR | A:854 | A:854 | 20.0 | 0.087 | I | -74.4 | -43.3 | |
| af-q13733-f1 | 1 | Q13733 | 80.48 | 0.0 | TYR | A:860 | A:860 | 25.0 | 0.109 | I | -78.6 | -39.7 | |