Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 226553677 . G A CCDS1554.1:NM_001618.3:c.2483gCg>gTg_NP_001609.2:p.828A>V Homo sapiens poly(ADP-ribose) polymerase 1 (PARP1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4opx 2 P09874 100.0 0.0 X-RAY
 2014-07-02 ALA B:311 C:828 69.0 0.6 S -71.5 -28.0 69.0 0.6 0.0
ALA D:311 F:828 69.0 0.6 S -71.4 -27.9 NA NA NA
4oqa 2 P09874 100.0 0.0 X-RAY
 2014-07-02 ALA B:311 C:828 71.0 0.617 S -71.4 -28.2 71.0 0.617 0.0
ALA D:311 F:828 70.0 0.609 S -71.5 -28.0 NA NA NA
4oqb 2 P09874 100.0 0.0 X-RAY
 2014-07-02 ALA B:311 C:828 70.0 0.609 S -71.2 -28.2 70.0 0.609 0.0
ALA D:311 F:828 69.0 0.6 S -71.2 -28.1 NA NA NA
4dqy 3 P09874 99.8 0.0 X-RAY
 2012-05-30 ALA C:312 C:828 70.0 0.609 T -64.6 -29.5 70.0 0.609 0.0
ALA F:312 F:828 68.0 0.591 T -64.2 -29.5 NA NA NA
4zzz 1 P09874 100.0 0.0 X-RAY
 2015-08-12 ALA A:176 A:828 55.0 0.478 T -63.7 -25.5 55.0 0.478 0.0 HOH
 3.122
 N
 O
ALA B:176 B:828 55.0 0.478 T -51.7 -12.9 55.0 0.478 0.0 HOH
 8.932
 N
 O
5a00 1 P09874 100.0 0.0 X-RAY
 2015-08-12 ALA A:176 A:828 56.0 0.487 T -84.5 -11.0 56.0 0.487 0.0 HOH
 3.020
 N
 O
4xhu 1 P09874 99.44 0.0 X-RAY
 2015-09-30 ALA A:173 C:828 111.0 0.965 360.0 -54.5 111.0 0.965 0.0 HOH
 9.509
 CB
 O
ALA C:173 A:828 54.0 0.47 T -80.6 -15.3 NA NA NA
6xvw 1 P09874 100.0 0.0 X-RAY
 2020-06-03 ALA A:168 A:828 49.0 0.426 T -87.8 -43.8 49.0 0.426 0.0 NI
HOH
 9.827
3.447
 C
CB
 NI
O
ALA B:168 B:828 48.0 0.417 T -97.2 -39.6 NA NA NA
7kk2 1 P09874 99.72 0.0 X-RAY
 2021-01-06 ALA A:169 A:828 44.0 0.383 T -71.1 -14.0 44.0 0.383 0.0 HOH
 5.521
 N
 O
ALA B:169 B:828 60.0 0.522 S -70.4 -16.4 NA NA NA
7kk3 1 P09874 99.72 0.0 X-RAY
 2021-01-06 ALA A:169 A:828 61.0 0.53 S -96.8 -21.1 61.0 0.53 0.0 HOH
 3.155
 N
 O
ALA B:169 B:828 99.0 0.861 360.0 -45.2 NA NA NA
ALA C:169 C:828 67.0 0.583 -94.7 -34.6 NA NA NA
ALA D:169 D:828 67.0 0.583 -61.2 -30.3 NA NA NA
7kk4 1 P09874 99.72 0.0 X-RAY
 2021-01-06 ALA A:169 A:828 55.0 0.478 T -53.2 -23.8 55.0 0.478 0.0 HOH
 7.485
 CB
 O
ALA B:169 B:828 50.0 0.435 T -59.4 -27.7 NA NA NA
7kk5 1 P09874 99.72 0.0 X-RAY
 2021-01-06 ALA A:169 A:828 61.0 0.53 S -72.3 -24.2 61.0 0.53 0.0 HOH
 5.204
 N
 O
ALA B:169 B:828 57.0 0.496 T -74.3 -17.3 NA NA NA
ALA C:169 C:828 59.0 0.513 T -74.7 -16.2 NA NA NA
ALA D:169 D:828 55.0 0.478 T -68.2 -23.3 NA NA NA
7kk6 1 P09874 99.72 0.0 X-RAY
 2021-01-06 ALA A:169 A:828 38.0 0.33 T -77.1 -16.8 38.0 0.33 0.0 HOH
 5.385
 N
 O
ALA B:169 B:828 55.0 0.478 T -67.2 -25.2 NA NA NA
7aaa 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ALA A:169 A:828 43.0 0.374 T -66.3 -18.9 43.0 0.374 0.0 HOH
 5.319
 N
 O
ALA B:169 B:828 64.0 0.557 T -72.1 -17.4 NA NA NA
7aab 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ALA A:169 A:828 60.0 0.522 T -76.7 -36.7 60.0 0.522 0.0 HOH
 7.960
 CB
 O
ALA B:169 B:828 61.0 0.53 T -76.5 -36.6 NA NA NA
7aac 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ALA A:169 A:828 44.0 0.383 T -69.1 -16.5 44.0 0.383 0.0 HOH
 4.855
 N
 O
ALA B:169 B:828 62.0 0.539 T -70.4 -4.9 NA NA NA
7aad 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ALA A:169 A:828 41.0 0.357 S -72.4 -15.1 41.0 0.357 0.0
ALA B:169 B:828 48.0 0.417 T -64.3 -14.0 NA NA NA
7onr 1 P09874 99.43 0.0 X-RAY
 2021-09-15 ALA A:169 A:828 41.0 0.357 T -70.5 -21.3 41.0 0.357 0.0 HOH
 5.488
 N
 O
ALA B:169 B:828 59.0 0.513 T -68.7 -27.7 NA NA NA
7ons 1 P09874 99.43 0.0 X-RAY
 2021-09-15 ALA A:169 A:828 39.0 0.339 T -61.9 -25.8 39.0 0.339 0.0 HOH
 5.266
 N
 O
ALA B:169 B:828 57.0 0.496 T -63.2 -28.4 NA NA NA
7ont 1 P09874 99.43 0.0 X-RAY
 2021-09-15 ALA A:169 A:828 42.0 0.365 T -67.1 -17.5 42.0 0.365 0.0 HOH
 4.672
 N
 O
ALA B:169 B:828 63.0 0.548 T -65.6 -18.6 NA NA NA
5ha9 1 P09874 100.0 0.0 X-RAY
 2016-03-09 ALA A:168 A:167 57.0 0.496 T -58.5 -15.1 57.0 0.496 0.0
ALA B:168 B:167 69.0 0.6 T -54.8 -27.7 69.0 0.6 0.0
4hhy 1 P09874 99.43 0.0 X-RAY
 2013-03-27 ALA A:172 A:167 60.0 0.522 S -100.9 -8.9 NA NA NA
ALA B:172 B:167 58.0 0.504 T -63.7 -19.2 NA NA NA
ALA C:172 C:167 61.0 0.53 S -87.6 -8.0 61.0 0.53 0.0
ALA D:172 D:167 102.0 0.887 S -161.1 -31.9 NA NA NA
4hhz 1 P09874 99.43 0.0 X-RAY
 2013-03-27 ALA A:172 A:167 51.0 0.443 T -89.6 -14.1 NA NA NA
ALA B:172 B:167 55.0 0.478 S -91.6 7.0 NA NA NA
ALA C:172 C:167 55.0 0.478 S -102.6 -0.1 55.0 0.478 0.0
ALA D:172 D:167 64.0 0.557 T -58.1 -33.7 NA NA NA
5xsr 1 P09874 99.43 0.0 X-RAY
 2018-04-25 ALA A:172 A:167 118.0 1.0 360.0 -0.1 118.0 1.0 0.0 HOH
 8.352
 N
 O
5xsu 1 P09874 99.43 0.0 X-RAY
 2018-04-25 ALA A:172 A:167 55.0 0.478 T -73.4 -14.5 55.0 0.478 0.0
ALA B:172 B:167 61.0 0.53 T -71.6 -14.1 NA NA NA
ALA C:172 C:167 66.0 0.574 S -73.1 -13.9 NA NA NA
ALA D:172 D:167 83.0 0.722 T -75.3 -16.3 NA NA NA
1uk0 1 P09874 100.0 0.0 X-RAY
 2004-01-27 ALA A:167 A:167 50.0 0.435 S -167.4 172.9 50.0 0.435 0.0 HOH
 5.558
 CB
 O
ALA B:167 B:167 43.0 0.374 S 125.0 66.6 NA NA NA
1uk1 1 P09874 100.0 0.0 X-RAY
 2004-09-14 ALA A:167 A:828 68.0 0.591 S -171.0 99.4 68.0 0.591 0.0 HOH
 6.295
 CB
 O
ALA B:167 B:828 65.0 0.565 S -139.3 82.0 NA NA NA
1wok 1 P09874 100.0 0.0 X-RAY
 2005-03-15 ALA A:167 A:828 63.0 0.548 S -94.4 16.4 16.0 0.139 0.409 C:P09874:0.409
ALA B:167 B:828 51.0 0.443 S 165.3 -19.1 9.0 0.078 0.365 D:P09874:0.365
ALA C:167 C:828 54.0 0.47 S -88.7 14.2 12.0 0.104 0.366 A:P09874:0.365
ALA D:167 D:828 65.0 0.565 T -102.4 1.3 8.0 0.07 0.495 B:P09874:0.496
2rcw 1 P09874 100.0 0.0 X-RAY
 2008-09-23 ALA A:167 A:167 63.0 0.548 S -78.8 10.5 63.0 0.548 0.0 HOH
 6.249
 CA
 O
6vkk 1 P09874 99.72 0.0 X-RAY
 2020-06-17 ALA A:189 A:828 60.0 0.522 S -78.0 -23.1 60.0 0.522 0.0 HOH
 3.037
 N
 O
ALA B:189 D:828 58.0 0.504 S -76.2 -22.8 NA NA NA
ALA C:189 C:828 44.0 0.383 S -77.0 -22.3 NA NA NA
ALA D:189 B:828 54.0 0.47 S -76.2 -22.6 NA NA NA
6vko 1 P09874 99.72 0.0 X-RAY
 2020-06-17 ALA A:189 A:828 51.0 0.443 S -80.4 -21.1 51.0 0.443 0.0
ALA B:189 B:828 50.0 0.435 S -80.1 -20.8 NA NA NA
ALA C:189 C:828 51.0 0.443 S -81.0 -20.6 NA NA NA
ALA D:189 D:828 51.0 0.443 S -80.8 -21.0 NA NA NA
6vkq 1 P09874 99.72 0.0 X-RAY
 2020-06-17 ALA A:189 A:828 58.0 0.504 T -95.9 -39.6 58.0 0.504 0.0
ALA B:189 B:828 59.0 0.513 T -96.2 -40.1 NA NA NA
ALA C:189 C:828 58.0 0.504 T -95.6 -40.0 NA NA NA
ALA D:189 D:828 59.0 0.513 T -95.7 -39.9 NA NA NA
4gv7 1 P09874 99.43 0.0 X-RAY
 2013-06-19 ALA A:168 A:828 55.0 0.478 T -103.9 -13.3 55.0 0.478 0.0
ALA B:168 B:828 58.0 0.504 T -70.6 -24.5 NA NA NA
ALA C:168 C:828 51.0 0.443 S 73.5 -13.9 NA NA NA
ALA D:168 D:828 64.0 0.557 T -74.8 -22.0 NA NA NA
4r5w 1 P09874 99.43 0.0 X-RAY
 2015-09-02 ALA A:168 A:828 55.0 0.478 S -115.3 2.6 55.0 0.478 0.0 SO4
 9.604
 CA
 O1
ALA B:168 B:828 56.0 0.487 S -115.5 2.9 NA NA NA
4r6e 1 P09874 99.43 0.0 X-RAY
 2015-09-09 ALA A:168 A:828 51.0 0.443 T -73.5 -22.4 51.0 0.443 0.0 HOH
 8.394
 CB
 O
ALA B:168 B:828 60.0 0.522 T -74.6 -20.8 NA NA NA
ALA C:168 C:828 62.0 0.539 T -75.2 -21.2 NA NA NA
ALA D:168 D:828 60.0 0.522 T -74.9 -22.8 NA NA NA
6ghk 1 P09874 99.43 0.0 X-RAY
 2019-05-22 ALA A:168 A:828 48.0 0.417 -91.8 52.4 48.0 0.417 0.0 SO4
HOH
 9.929
3.552
 CB
CB
 O1
O
ALA B:168 B:828 45.0 0.391 S -87.9 56.3 NA NA NA
4pjt 1 P09874 100.0 0.0 X-RAY
 2014-09-24 ALA A:187 A:828 64.0 0.557 T -60.3 -18.8 64.0 0.557 0.0 HOH
 2.985
 O
 O
ALA B:187 B:828 57.0 0.496 T -62.9 -18.3 NA NA NA
ALA C:187 C:828 57.0 0.496 T -62.6 -18.9 NA NA NA
ALA D:187 D:828 64.0 0.557 T -63.1 -18.3 NA NA NA
4rv6 1 P09874 99.71 0.0 X-RAY
 2015-12-09 ALA A:169 A:828 58.0 0.504 T -87.7 -20.2 58.0 0.504 0.0
ALA B:169 B:828 61.0 0.53 T -87.5 -20.3 NA NA NA
ALA C:169 C:828 61.0 0.53 T -88.1 -21.8 NA NA NA
ALA D:169 D:828 61.0 0.53 T -87.9 -22.0 NA NA NA
4uxb 1 P09874 99.71 0.0 X-RAY
 2015-09-02 ALA A:169 A:828 74.0 0.643 -123.0 -14.4 74.0 0.643 0.0 HOH
 8.906
 O
 O
ALA B:169 B:828 80.0 0.696 T -68.2 -22.8 NA NA NA
4l6s 1 P09874 99.71 0.0 X-RAY
 2013-08-07 ALA A:170 A:828 47.0 0.409 T -69.3 -6.1 47.0 0.409 0.0 HOH
 5.174
 N
 O
ALA B:170 B:828 58.0 0.504 T -61.6 -18.9 NA NA NA
4und 1 P09874 99.71 0.0 X-RAY
 2015-06-17 ALA A:190 A:828 56.0 0.487 T -64.8 -38.2 56.0 0.487 0.0 HOH
 8.567
 CB
 O
ALA B:190 B:828 57.0 0.496 T -63.4 -40.3 NA NA NA
5kpn 1 P09874 99.71 0.0 X-RAY
 2016-12-21 ALA A:169 A:828 45.0 0.391 T -65.5 -10.1 45.0 0.391 0.0
ALA B:169 B:828 46.0 0.4 T -53.0 -30.0 NA NA NA
5kpo 1 P09874 99.71 0.0 X-RAY
 2016-12-21 ALA A:169 A:828 45.0 0.391 T -63.0 -18.5 45.0 0.391 0.0
ALA B:169 B:828 46.0 0.4 T -62.2 -13.2 NA NA NA
5wrq 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:169 A:828 43.0 0.374 T -66.9 -19.4 43.0 0.374 0.0
ALA B:169 B:828 46.0 0.4 T -63.1 -20.0 NA NA NA
5wry 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:169 A:828 41.0 0.357 T -63.3 -16.8 41.0 0.357 0.0 HOH
 7.233
 N
 O
ALA B:169 B:828 57.0 0.496 S -65.2 -24.8 NA NA NA
5wrz 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:169 A:828 45.0 0.391 T -69.1 -12.6 45.0 0.391 0.0
ALA B:169 B:828 47.0 0.409 S -69.8 -24.0 NA NA NA
5ws0 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:169 A:828 50.0 0.435 T -63.6 -20.8 50.0 0.435 0.0
ALA B:169 B:828 50.0 0.435 T -48.5 -33.4 NA NA NA
5ws1 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:169 A:828 44.0 0.383 T -68.2 -19.6 44.0 0.383 0.0
ALA B:169 B:828 56.0 0.487 T -70.8 -11.9 NA NA NA
5wtc 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:169 A:828 46.0 0.4 T -60.5 -15.5 46.0 0.4 0.0
ALA B:169 B:828 44.0 0.383 T -63.7 -29.0 NA NA NA
2rd6 1 P09874 99.71 0.0 X-RAY
 2008-09-23 ALA A:167 A:167 57.0 0.496 S -92.4 -1.6 30.0 0.261 0.235 A:P09874:0.235
 HOH
 2.925
 O
 O
3gjw 1 P09874 99.71 0.0 X-RAY
 2010-03-09 ALA A:167 A:167 54.0 0.47 S -95.0 11.7 54.0 0.47 0.0 HOH
 4.785
 O
 O
3gn7 1 P09874 99.71 0.0 X-RAY
 2010-03-16 ALA A:167 A:167 58.0 0.504 S -98.5 -17.9 58.0 0.504 0.0 HOH
 7.144
 N
 O
3l3l 1 P09874 99.71 0.0 X-RAY
 2010-12-22 ALA A:167 A:167 60.0 0.522 T -80.3 -17.7 60.0 0.522 0.0 HOH
 7.197
 O
 O
3l3m 1 P09874 99.71 0.0 X-RAY
 2010-06-23 ALA A:167 A:167 63.0 0.548 S -89.2 -10.1 63.0 0.548 0.0 HOH
 5.473
 N
 O
5kpp 1 P09874 99.71 0.0 X-RAY
 2016-11-30 ALA A:167 A:828 45.0 0.391 T -66.4 -17.6 45.0 0.391 0.0 HOH
 5.432
 N
 O
ALA B:167 B:828 39.0 0.339 S -65.1 -23.6 NA NA NA
5kpq 1 P09874 99.71 0.0 X-RAY
 2016-12-14 ALA A:167 A:828 41.0 0.357 T -62.9 -19.6 41.0 0.357 0.0
ALA B:167 B:828 50.0 0.435 T -59.4 -23.0 NA NA NA
7cmw 1 P09874 99.71 0.0 X-RAY
 2020-12-16 ALA A:171 A:828 51.0 0.443 T -75.3 -20.7 51.0 0.443 0.0 HOH
 7.425
 O
 O
ALA B:171 B:828 62.0 0.539 T -66.1 -12.7 NA NA NA
5xst 1 P09874 99.43 0.0 X-RAY
 2018-04-25 ALA A:168 A:167 65.0 0.565 -90.2 35.7 65.0 0.565 0.0
6i8m 1 P26446 86.7 0.0 X-RAY
 2019-05-01 ALA A:177 A:828 64.0 0.557 T -46.2 -29.3 64.0 0.557 0.0 HOH
 3.889
 O
 O
6i8t 1 P26446 86.7 0.0 X-RAY
 2019-05-01 ALA A:177 A:828 68.0 0.591 T -62.5 -18.1 68.0 0.591 0.0 HOH
 9.021
 CB
 O
1a26 1 P26446 86.67 0.0 X-RAY
 1998-05-27 ALA A:175 A:828 62.0 0.539 T -92.2 -1.6 62.0 0.539 0.0 HOH
 3.704
 N
 O
1pax 1 P26446 86.67 0.0 X-RAY
 1997-05-15 ALA A:175 A:828 61.0 0.53 T -108.1 1.9 61.0 0.53 0.0
2paw 1 P26446 86.67 0.0 X-RAY
 1998-05-27 ALA A:175 A:828 75.0 0.652 T -85.0 -2.0 75.0 0.652 0.0
2pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 ALA A:175 A:828 63.0 0.548 S -110.7 4.3 63.0 0.548 0.0
3pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 ALA A:175 A:828 61.0 0.53 T -105.6 -0.2 61.0 0.53 0.0
4pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 ALA A:175 A:828 60.0 0.522 S -106.6 4.7 60.0 0.522 0.0
1efy 1 P26446 86.86 0.0 X-RAY
 2001-01-17 ALA A:167 A:828 65.0 0.565 S -92.6 -0.8 65.0 0.565 0.0 HOH
 7.728
 O
 O
6m3i 2 P09874 100.0 3e-162 X-RAY
 2021-03-03 ALA B:67 B:828 57.0 0.496 S -74.2 -22.0 26.0 0.226 0.27 A:Q9NWY4:0.27
 HOH
 2.812
 O
 O
5ds3 1 P09874 100.0 5e-160 X-RAY
 2016-07-27 ALA A:87 A:828 53.0 0.461 S 109.2 -73.2 53.0 0.461 0.0
6bhv 1 P09874 100.0 5e-160 X-RAY
 2018-02-28 ALA A:87 A:828 61.0 0.53 T -58.0 -25.3 61.0 0.53 0.0
ALA B:87 B:828 63.0 0.548 S -81.4 23.5 NA NA NA
ALA C:87 C:828 66.0 0.574 T -72.9 -8.7 NA NA NA
ALA D:87 D:828 59.0 0.513 T -51.8 -28.4 NA NA NA
6nrf 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 ALA A:87 A:828 62.0 0.539 S -69.2 -24.5 62.0 0.539 0.0 HOH
 3.089
 CB
 O
6nrg 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 ALA A:87 A:828 59.0 0.513 T -70.9 -19.4 59.0 0.513 0.0 HOH
 3.090
 N
 O
6nrh 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 ALA A:87 A:828 59.0 0.513 T -71.3 -19.6 59.0 0.513 0.0 SO4
HOH
 9.906
2.995
 CB
N
 O4
O
6nri 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 ALA A:87 A:828 51.0 0.443 T -76.5 -14.2 51.0 0.443 0.0
6nrj 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 ALA A:87 A:828 59.0 0.513 T -72.9 -18.9 59.0 0.513 0.0 SO4
HOH
 9.919
2.986
 CB
N
 O4
O
6ntu 1 P09874 100.0 5e-160 X-RAY
 2020-02-05 ALA A:87 A:828 59.0 0.513 T -66.1 -26.0 59.0 0.513 0.0 HOH
 8.525
 CB
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p09874-f1 1 P09874 100.0 0.0 ALA A:828 A:828 52.0 0.452 T -66.6 -20.6