Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 226553726 . C A CCDS1554.1:NM_001618.3:c.2434Gag>Tag_NP_001609.2:p.812E>* Homo sapiens poly(ADP-ribose) polymerase 1 (PARP1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4opx 2 P09874 100.0 0.0 X-RAY
 2014-07-02 GLU B:295 C:812 103.0 0.542 H -66.3 -29.6 103.0 0.542 0.0
GLU D:295 F:812 102.0 0.537 H -66.2 -29.7 NA NA NA
4oqa 2 P09874 100.0 0.0 X-RAY
 2014-07-02 GLU B:295 C:812 102.0 0.537 H -66.1 -29.0 102.0 0.537 0.0
GLU D:295 F:812 102.0 0.537 H -66.0 -29.0 NA NA NA
4oqb 2 P09874 100.0 0.0 X-RAY
 2014-07-02 GLU B:295 C:812 104.0 0.547 H -65.8 -29.9 104.0 0.547 0.0
GLU D:295 F:812 103.0 0.542 H -65.9 -29.8 NA NA NA
4dqy 3 P09874 99.8 0.0 X-RAY
 2012-05-30 GLU C:296 C:812 105.0 0.553 H -56.9 -37.3 105.0 0.553 0.0
GLU F:296 F:812 106.0 0.558 H -57.5 -37.5 NA NA NA
4zzz 1 P09874 100.0 0.0 X-RAY
 2015-08-12 GLU A:160 A:812 82.0 0.432 H -66.5 -46.9 82.0 0.432 0.0 HOH
 7.081
 N
 O
GLU B:160 B:812 102.0 0.537 H -74.4 -34.8 102.0 0.537 0.0 HOH
 8.717
 O
 O
5a00 1 P09874 100.0 0.0 X-RAY
 2015-08-12 GLU A:160 A:812 111.0 0.584 H -63.8 -45.8 111.0 0.584 0.0 HOH
 6.837
 N
 O
4xhu 1 P09874 99.44 0.0 X-RAY
 2015-09-30 GLU A:157 C:812 104.0 0.547 H -57.6 -52.0 104.0 0.547 0.0 HOH
 6.250
 N
 O
GLU C:157 A:812 58.0 NA H -59.7 -50.8 NA NA NA
6xvw 1 P09874 100.0 0.0 X-RAY
 2020-06-03 GLU A:152 A:812 102.0 0.537 H -66.3 -41.2 102.0 0.537 0.0 HOH
 2.768
 O
 O
GLU B:152 B:812 105.0 0.553 H -67.9 -47.1 NA NA NA
7kk2 1 P09874 99.72 0.0 X-RAY
 2021-01-06 GLU A:153 A:812 107.0 0.563 H -63.4 -45.3 107.0 0.563 0.0 HOH
 3.843
 OE1
 O
GLU B:153 B:812 107.0 0.563 H -62.2 -45.3 NA NA NA
7kk3 1 P09874 99.72 0.0 X-RAY
 2021-01-06 GLU A:153 A:812 68.0 0.358 H -60.2 -46.1 68.0 0.358 0.0 HOH
 2.672
 OE2
 O
GLU B:153 B:812 105.0 0.553 H -62.9 -45.8 NA NA NA
GLU C:153 C:812 108.0 0.568 H -60.8 -47.1 NA NA NA
GLU D:153 D:812 92.0 0.484 H -61.6 -47.1 NA NA NA
7kk4 1 P09874 99.72 0.0 X-RAY
 2021-01-06 GLU A:153 A:812 97.0 0.511 H -78.2 -53.2 97.0 0.511 0.0 HOH
 2.654
 O
 O
GLU B:153 B:812 109.0 0.574 H -55.8 -49.0 NA NA NA
7kk5 1 P09874 99.72 0.0 X-RAY
 2021-01-06 GLU A:153 A:812 79.0 0.416 H -67.2 -44.6 79.0 0.416 0.0 HOH
 2.698
 OE2
 O
GLU B:153 B:812 108.0 0.568 H -60.4 -42.2 NA NA NA
GLU C:153 C:812 109.0 0.574 H -62.7 -46.6 NA NA NA
GLU D:153 D:812 88.0 0.463 H -65.1 -46.7 NA NA NA
7kk6 1 P09874 99.72 0.0 X-RAY
 2021-01-06 GLU A:153 A:812 112.0 0.589 H -81.3 -36.8 112.0 0.589 0.0 HOH
 3.208
 OE1
 O
GLU B:153 B:812 97.0 0.511 H -63.6 -39.4 NA NA NA
7aaa 1 P09874 99.43 0.0 X-RAY
 2021-01-13 GLU A:153 A:812 110.0 0.579 H -60.0 -45.9 110.0 0.579 0.0 HOH
 2.681
 O
 O
GLU B:153 B:812 106.0 0.558 H -60.5 -46.0 NA NA NA
7aab 1 P09874 99.43 0.0 X-RAY
 2021-01-13 GLU A:153 A:812 102.0 0.537 H -64.2 -38.1 102.0 0.537 0.0 HOH
 7.361
 N
 O
GLU B:153 B:812 102.0 0.537 H -63.4 -39.0 NA NA NA
7aac 1 P09874 99.43 0.0 X-RAY
 2021-01-13 GLU A:153 A:812 109.0 0.574 H -60.2 -45.6 109.0 0.574 0.0 HOH
 2.717
 O
 O
GLU B:153 B:812 102.0 0.537 H -60.7 -44.1 NA NA NA
7aad 1 P09874 99.43 0.0 X-RAY
 2021-01-13 GLU A:153 A:812 107.0 0.563 H -67.0 -40.9 107.0 0.563 0.0 HOH
 7.888
 N
 O
GLU B:153 B:812 104.0 0.547 H -67.2 -40.8 NA NA NA
7onr 1 P09874 99.43 0.0 X-RAY
 2021-09-15 GLU A:153 A:812 123.0 0.647 H -64.3 -44.7 123.0 0.647 0.0 HOH
 2.700
 O
 O
GLU B:153 B:812 108.0 0.568 H -63.7 -45.0 NA NA NA
7ons 1 P09874 99.43 0.0 X-RAY
 2021-09-15 GLU A:153 A:812 107.0 0.563 H -67.0 -43.5 107.0 0.563 0.0 HOH
 2.680
 O
 O
GLU B:153 B:812 104.0 0.547 H -65.8 -43.5 NA NA NA
7ont 1 P09874 99.43 0.0 X-RAY
 2021-09-15 GLU A:153 A:812 107.0 0.563 H -62.6 -39.6 107.0 0.563 0.0 HOH
 2.677
 O
 O
GLU B:153 B:812 105.0 0.553 H -66.7 -40.9 NA NA NA
5ha9 1 P09874 100.0 0.0 X-RAY
 2016-03-09 GLU A:152 A:151 112.0 0.589 H -54.3 -44.1 112.0 0.589 0.0
GLU B:152 B:151 123.0 0.647 H -65.5 -31.0 123.0 0.647 0.0 SO4
 9.390
 O
 O4
4hhy 1 P09874 99.43 0.0 X-RAY
 2013-03-27 GLU A:156 A:151 90.0 0.474 H -63.3 -38.1 NA NA NA
GLU B:156 B:151 123.0 0.647 H -58.5 -41.8 NA NA NA
GLU C:156 C:151 87.0 0.458 H -79.2 -43.9 87.0 0.458 0.0
GLU D:156 D:151 105.0 0.553 H -54.4 -34.1 NA NA NA
4hhz 1 P09874 99.43 0.0 X-RAY
 2013-03-27 GLU A:156 A:151 96.0 0.505 H -68.9 -38.0 NA NA NA
GLU B:156 B:151 90.0 0.474 H -70.7 -31.5 NA NA NA
GLU C:156 C:151 95.0 0.5 H -80.6 -34.9 95.0 0.5 0.0 HOH
 8.763
 N
 O
GLU D:156 D:151 93.0 0.489 H -64.4 -29.4 NA NA NA
5xsr 1 P09874 99.43 0.0 X-RAY
 2018-04-25 GLU A:156 A:151 107.0 0.563 H -68.1 -42.4 107.0 0.563 0.0 HOH
 3.020
 O
 O
5xsu 1 P09874 99.43 0.0 X-RAY
 2018-04-25 GLU A:156 A:151 52.0 NA H -64.2 -41.3 52.0 NA NA HOH
 6.936
 O
 O
GLU B:156 B:151 109.0 0.574 H -66.7 -45.2 NA NA NA
GLU C:156 C:151 44.0 NA H -64.8 -42.0 NA NA NA
GLU D:156 D:151 45.0 NA H -67.1 -45.0 NA NA NA
1uk0 1 P09874 100.0 0.0 X-RAY
 2004-01-27 GLU A:151 A:151 42.0 0.221 H -51.6 -59.6 42.0 0.221 0.0 HOH
 3.025
 OE2
 O
GLU B:151 B:151 103.0 0.542 H -53.6 -52.2 NA NA NA
1uk1 1 P09874 100.0 0.0 X-RAY
 2004-09-14 GLU A:151 A:812 50.0 0.263 H -61.6 -43.1 50.0 0.263 0.0 HOH
 4.233
 OE2
 O
GLU B:151 B:812 103.0 0.542 H -71.0 -65.7 NA NA NA
1wok 1 P09874 100.0 0.0 X-RAY
 2005-03-15 GLU A:151 A:812 119.0 0.626 H -67.6 -27.4 119.0 0.626 0.0
GLU B:151 B:812 106.0 0.558 H -56.0 -54.6 106.0 0.558 0.0
GLU C:151 C:812 96.0 0.505 H -66.2 -26.6 96.0 0.505 0.0
GLU D:151 D:812 67.0 0.353 H -41.2 -46.0 67.0 0.353 0.0
2rcw 1 P09874 100.0 0.0 X-RAY
 2008-09-23 GLU A:151 A:151 97.0 0.511 H -57.4 -47.2 97.0 0.511 0.0 HOH
 2.964
 OE2
 O
6vkk 1 P09874 99.72 0.0 X-RAY
 2020-06-17 GLU A:173 A:812 98.0 0.516 H -60.1 -45.4 98.0 0.516 0.0 HOH
 9.164
 N
 O
GLU B:173 D:812 88.0 0.463 H -59.9 -45.3 NA NA NA
GLU C:173 C:812 101.0 0.532 H -60.4 -44.6 NA NA NA
GLU D:173 B:812 122.0 0.642 H -60.2 -44.6 NA NA NA
6vko 1 P09874 99.72 0.0 X-RAY
 2020-06-17 GLU A:173 A:812 69.0 0.363 H -74.9 -31.9 69.0 0.363 0.0
GLU B:173 B:812 68.0 0.358 H -75.1 -31.6 NA NA NA
GLU C:173 C:812 67.0 0.353 H -75.1 -31.6 NA NA NA
GLU D:173 D:812 71.0 0.374 H -75.3 -31.3 NA NA NA
6vkq 1 P09874 99.72 0.0 X-RAY
 2020-06-17 GLU A:173 A:812 55.0 0.289 H -88.8 -42.6 55.0 0.289 0.0
GLU B:173 B:812 56.0 0.295 H -88.6 -42.5 NA NA NA
GLU C:173 C:812 59.0 0.311 H -88.7 -42.6 NA NA NA
GLU D:173 D:812 55.0 0.289 H -88.8 -42.8 NA NA NA
4gv7 1 P09874 99.43 0.0 X-RAY
 2013-06-19 GLU A:152 A:812 89.0 0.468 H -68.9 -41.5 89.0 0.468 0.0
GLU B:152 B:812 112.0 0.589 H -57.9 -41.4 NA NA NA
GLU C:152 C:812 105.0 0.553 H -58.0 -42.7 NA NA NA
GLU D:152 D:812 115.0 0.605 H -59.6 -46.2 NA NA NA
4r5w 1 P09874 99.43 0.0 X-RAY
 2015-09-02 GLU A:152 A:812 87.0 0.458 H -64.0 -40.3 87.0 0.458 0.0
GLU B:152 B:812 87.0 0.458 H -64.1 -40.8 NA NA NA
4r6e 1 P09874 99.43 0.0 X-RAY
 2015-09-09 GLU A:152 A:812 107.0 0.563 H -60.7 -46.5 107.0 0.563 0.0 HOH
 8.556
 O
 O
GLU B:152 B:812 102.0 0.537 H -61.3 -46.1 NA NA NA
GLU C:152 C:812 103.0 0.542 H -61.7 -47.0 NA NA NA
GLU D:152 D:812 108.0 0.568 H -61.1 -45.7 NA NA NA
6ghk 1 P09874 99.43 0.0 X-RAY
 2019-05-22 GLU A:152 A:812 102.0 0.537 H -65.4 -39.7 102.0 0.537 0.0 HOH
 6.828
 N
 O
GLU B:152 B:812 99.0 0.521 H -64.2 -40.3 NA NA NA
4pjt 1 P09874 100.0 0.0 X-RAY
 2014-09-24 GLU A:171 A:812 63.0 0.332 H -63.9 -45.5 63.0 0.332 0.0 SO4
HOH
 7.064
6.627
 N
N
 O3
O
GLU B:171 B:812 107.0 0.563 H -63.0 -47.4 NA NA NA
GLU C:171 C:812 42.0 NA H -65.8 -43.3 NA NA NA
GLU D:171 D:812 109.0 0.574 H -65.1 -43.6 NA NA NA
4rv6 1 P09874 99.71 0.0 X-RAY
 2015-12-09 GLU A:153 A:812 90.0 0.474 H -59.2 -49.5 90.0 0.474 0.0
GLU B:153 B:812 89.0 0.468 H -59.4 -49.2 NA NA NA
GLU C:153 C:812 90.0 0.474 H -59.0 -49.1 NA NA NA
GLU D:153 D:812 98.0 0.516 H -59.3 -48.9 NA NA NA
4uxb 1 P09874 99.71 0.0 X-RAY
 2015-09-02 GLU A:153 A:812 105.0 0.553 H -64.9 -44.3 105.0 0.553 0.0
GLU B:153 B:812 108.0 0.568 H -64.3 -44.7 NA NA NA
4l6s 1 P09874 99.71 0.0 X-RAY
 2013-08-07 GLU A:154 A:812 110.0 0.579 H -63.5 -55.8 110.0 0.579 0.0 HOH
 2.741
 O
 O
GLU B:154 B:812 114.0 0.6 H -72.5 -39.1 NA NA NA
4und 1 P09874 99.71 0.0 X-RAY
 2015-06-17 GLU A:174 A:812 96.0 0.505 H -65.8 -42.3 96.0 0.505 0.0
GLU B:174 B:812 82.0 0.432 H -66.2 -41.6 NA NA NA
5kpn 1 P09874 99.71 0.0 X-RAY
 2016-12-21 GLU A:153 A:812 112.0 0.589 H -62.1 -48.5 112.0 0.589 0.0
GLU B:153 B:812 110.0 0.579 H -65.0 -44.5 NA NA NA
5kpo 1 P09874 99.71 0.0 X-RAY
 2016-12-21 GLU A:153 A:812 109.0 0.574 H -63.5 -42.8 109.0 0.574 0.0
GLU B:153 B:812 112.0 0.589 H -63.0 -39.2 NA NA NA
5wrq 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:153 A:812 109.0 0.574 H -62.8 -42.9 109.0 0.574 0.0
GLU B:153 B:812 113.0 0.595 H -63.3 -37.6 NA NA NA
5wry 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:153 A:812 111.0 0.584 H -62.3 -42.9 111.0 0.584 0.0 HOH
 3.031
 OE2
 O
GLU B:153 B:812 107.0 0.563 H -64.2 -41.0 NA NA NA
5wrz 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:153 A:812 115.0 0.605 H -65.7 -45.1 115.0 0.605 0.0
GLU B:153 B:812 108.0 0.568 H -61.7 -42.5 NA NA NA
5ws0 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:153 A:812 108.0 0.568 H -64.6 -52.7 108.0 0.568 0.0
GLU B:153 B:812 104.0 0.547 H -75.9 -40.4 NA NA NA
5ws1 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:153 A:812 94.0 0.495 H -62.9 -43.2 94.0 0.495 0.0
GLU B:153 B:812 111.0 0.584 H -67.4 -39.9 NA NA NA
5wtc 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:153 A:812 119.0 0.626 H -64.9 -43.4 119.0 0.626 0.0
GLU B:153 B:812 115.0 0.605 H -66.2 -39.1 NA NA NA
2rd6 1 P09874 99.71 0.0 X-RAY
 2008-09-23 GLU A:151 A:151 94.0 0.495 H -63.2 -47.3 94.0 0.495 0.0 HOH
 3.214
 OE2
 O
3gjw 1 P09874 99.71 0.0 X-RAY
 2010-03-09 GLU A:151 A:151 74.0 0.389 H -63.4 -42.3 74.0 0.389 0.0 HOH
 4.287
 CB
 O
3gn7 1 P09874 99.71 0.0 X-RAY
 2010-03-16 GLU A:151 A:151 85.0 0.447 H -61.3 -45.1 85.0 0.447 0.0 HOH
 6.687
 N
 O
3l3l 1 P09874 99.71 0.0 X-RAY
 2010-12-22 GLU A:151 A:151 94.0 0.495 H -53.4 -48.5 94.0 0.495 0.0 HOH
 8.637
 N
 O
3l3m 1 P09874 99.71 0.0 X-RAY
 2010-06-23 GLU A:151 A:151 109.0 0.574 H -60.9 -45.7 109.0 0.574 0.0 HOH
 2.685
 OE1
 O
5kpp 1 P09874 99.71 0.0 X-RAY
 2016-11-30 GLU A:151 A:812 107.0 0.563 H -64.2 -41.6 107.0 0.563 0.0 HOH
 5.306
 O
 O
GLU B:151 B:812 106.0 0.558 H -58.7 -41.6 NA NA NA
5kpq 1 P09874 99.71 0.0 X-RAY
 2016-12-14 GLU A:151 A:812 109.0 0.574 H -61.0 -39.3 109.0 0.574 0.0 HOH
 3.108
 OE1
 O
GLU B:151 B:812 111.0 0.584 H -63.7 -38.0 NA NA NA
7cmw 1 P09874 99.71 0.0 X-RAY
 2020-12-16 GLU A:155 A:812 107.0 0.563 H -51.9 -54.7 107.0 0.563 0.0 HOH
 9.194
 N
 O
GLU B:155 B:812 102.0 0.537 H -54.5 -52.6 NA NA NA
5xst 1 P09874 99.43 0.0 X-RAY
 2018-04-25 GLU A:152 A:151 104.0 0.547 H -68.3 -50.6 104.0 0.547 0.0 HOH
 3.257
 OE2
 O
6i8m 1 P26446 86.7 0.0 X-RAY
 2019-05-01 LYS A:161 A:812 47.0 NA H -72.5 -34.0 47.0 NA NA
6i8t 1 P26446 86.7 0.0 X-RAY
 2019-05-01 LYS A:161 A:812 43.0 NA H -70.6 -39.0 43.0 NA NA
1a26 1 P26446 86.67 0.0 X-RAY
 1998-05-27 LYS A:159 A:812 107.0 0.535 H -62.2 -46.5 107.0 0.535 0.0 HOH
 8.971
 N
 O
1pax 1 P26446 86.67 0.0 X-RAY
 1997-05-15 LYS A:159 A:812 91.0 0.455 H -65.2 -47.4 91.0 0.455 0.0
2paw 1 P26446 86.67 0.0 X-RAY
 1998-05-27 LYS A:159 A:812 103.0 0.515 H -56.6 -50.3 103.0 0.515 0.0 HOH
 6.970
 O
 O
2pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 LYS A:159 A:812 94.0 0.47 H -63.4 -48.1 94.0 0.47 0.0 HOH
 9.688
 O
 O
3pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 LYS A:159 A:812 92.0 0.46 H -63.2 -49.0 92.0 0.46 0.0 HOH
 9.838
 O
 O
4pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 LYS A:159 A:812 99.0 0.495 H -58.3 -47.3 99.0 0.495 0.0
1efy 1 P26446 86.86 0.0 X-RAY
 2001-01-17 LYS A:151 A:812 104.0 0.52 H -58.3 -44.3 104.0 0.52 0.0 HOH
 7.356
 O
 O
6m3i 2 P09874 100.0 3e-162 X-RAY
 2021-03-03 GLU B:51 B:812 114.0 0.6 H -57.9 -53.1 114.0 0.6 0.0 HOH
 2.419
 O
 O
5ds3 1 P09874 100.0 5e-160 X-RAY
 2016-07-27 GLU A:71 A:812 88.0 0.463 H -61.5 -45.9 88.0 0.463 0.0 HOH
 7.582
 CB
 O
6bhv 1 P09874 100.0 5e-160 X-RAY
 2018-02-28 GLU A:71 A:812 110.0 0.579 H -61.8 -43.3 110.0 0.579 0.0
GLU B:71 B:812 113.0 0.595 H -61.7 -43.0 NA NA NA
GLU C:71 C:812 109.0 0.574 H -61.4 -43.2 NA NA NA
GLU D:71 D:812 143.0 0.753 H -61.5 -43.4 NA NA NA
6nrf 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 GLU A:71 A:812 118.0 0.621 H -56.2 -48.7 118.0 0.621 0.0 HOH
 6.992
 O
 O
6nrg 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 GLU A:71 A:812 95.0 0.5 H -60.2 -45.1 95.0 0.5 0.0 HOH
 6.670
 OE2
 O
6nrh 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 GLU A:71 A:812 102.0 0.537 H -60.7 -46.3 102.0 0.537 0.0 HOH
 2.753
 O
 O
6nri 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 GLU A:71 A:812 110.0 0.579 H -64.7 -48.7 110.0 0.579 0.0 HOH
 2.916
 O
 O
6nrj 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 GLU A:71 A:812 103.0 0.542 H -59.7 -45.0 103.0 0.542 0.0 HOH
 2.669
 O
 O
6ntu 1 P09874 100.0 5e-160 X-RAY
 2020-02-05 GLU A:71 A:812 99.0 0.521 H -64.8 -44.6 99.0 0.521 0.0 HOH
 6.855
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p09874-f1 1 P09874 100.0 0.0 GLU A:812 A:812 116.0 0.611 H -61.7 -45.4