Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 226553735 . C A CCDS1554.1:NM_001618.3:c.2425Gaa>Taa_NP_001609.2:p.809E>* Homo sapiens poly(ADP-ribose) polymerase 1 (PARP1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4opx 2 P09874 100.0 0.0 X-RAY
 2014-07-02 GLU B:292 C:809 137.0 0.721 H -74.4 -34.0 137.0 0.721 0.0
GLU D:292 F:809 137.0 0.721 H -74.4 -34.0 NA NA NA
4oqa 2 P09874 100.0 0.0 X-RAY
 2014-07-02 GLU B:292 C:809 138.0 0.726 H -74.5 -35.0 138.0 0.726 0.0
GLU D:292 F:809 138.0 0.726 H -74.5 -35.0 NA NA NA
4oqb 2 P09874 100.0 0.0 X-RAY
 2014-07-02 GLU B:292 C:809 139.0 0.732 H -74.3 -33.5 139.0 0.732 0.0
GLU D:292 F:809 139.0 0.732 H -74.2 -33.6 NA NA NA
4dqy 3 P09874 99.8 0.0 X-RAY
 2012-05-30 GLU C:293 C:809 138.0 0.726 H -74.7 -32.6 138.0 0.726 0.0
GLU F:293 F:809 137.0 0.721 H -74.6 -32.2 NA NA NA
4zzz 1 P09874 100.0 0.0 X-RAY
 2015-08-12 GLU A:157 A:809 146.0 0.768 H -66.5 -26.7 146.0 0.768 0.0
GLU B:157 B:809 131.0 0.689 H -59.6 -40.2 131.0 0.689 0.0
5a00 1 P09874 100.0 0.0 X-RAY
 2015-08-12 GLU A:157 A:809 126.0 0.663 H -68.5 -41.3 126.0 0.663 0.0 HOH
 3.125
 N
 O
4xhu 1 P09874 99.44 0.0 X-RAY
 2015-09-30 GLU A:154 C:809 125.0 0.658 H -64.1 -42.8 125.0 0.658 0.0 HOH
 7.128
 N
 O
GLU C:154 A:809 154.0 0.811 H -69.7 -31.5 NA NA NA
6xvw 1 P09874 100.0 0.0 X-RAY
 2020-06-03 GLU A:149 A:809 141.0 0.742 H -62.6 -40.5 141.0 0.742 0.0 HOH
 2.602
 OE2
 O
GLU B:149 B:809 147.0 0.774 H -73.1 -37.9 NA NA NA
7kk2 1 P09874 99.72 0.0 X-RAY
 2021-01-06 GLU A:150 A:809 146.0 0.768 H -64.2 -50.7 146.0 0.768 0.0 HOH
 6.584
 N
 O
GLU B:150 B:809 140.0 0.737 H -66.1 -37.2 NA NA NA
7kk3 1 P09874 99.72 0.0 X-RAY
 2021-01-06 GLU A:150 A:809 138.0 0.726 H -66.6 -36.5 138.0 0.726 0.0 HOH
 2.833
 N
 O
GLU B:150 B:809 141.0 0.742 H -67.0 -36.0 NA NA NA
GLU C:150 C:809 137.0 0.721 H -67.5 -34.5 NA NA NA
GLU D:150 D:809 168.0 0.884 H -57.5 -40.3 NA NA NA
7kk4 1 P09874 99.72 0.0 X-RAY
 2021-01-06 GLU A:150 A:809 154.0 0.811 S -69.7 -36.7 154.0 0.811 0.0 HOH
 3.663
 CB
 O
GLU B:150 B:809 155.0 0.816 H -62.0 -47.7 NA NA NA
7kk5 1 P09874 99.72 0.0 X-RAY
 2021-01-06 GLU A:150 A:809 173.0 0.911 H -63.5 -42.4 173.0 0.911 0.0 HOH
 2.974
 N
 O
GLU B:150 B:809 139.0 0.732 H -67.9 -29.3 NA NA NA
GLU C:150 C:809 138.0 0.726 H -69.7 -31.3 NA NA NA
GLU D:150 D:809 173.0 0.911 H -63.2 -42.4 NA NA NA
7kk6 1 P09874 99.72 0.0 X-RAY
 2021-01-06 GLU A:150 A:809 147.0 0.774 S 102.1 -95.6 147.0 0.774 0.0 HOH
 5.911
 N
 O
GLU B:150 B:809 139.0 0.732 H -61.8 -35.5 NA NA NA
7aaa 1 P09874 99.43 0.0 X-RAY
 2021-01-13 GLU A:150 A:809 63.0 NA H -62.4 -46.4 63.0 NA NA HOH
 6.698
 O
 O
GLU B:150 B:809 157.0 0.826 H -61.8 -46.8 NA NA NA
7aab 1 P09874 99.43 0.0 X-RAY
 2021-01-13 GLU A:150 A:809 165.0 0.868 H -66.6 -39.5 165.0 0.868 0.0 HOH
 3.259
 N
 O
GLU B:150 B:809 164.0 0.863 H -67.0 -38.9 NA NA NA
7aac 1 P09874 99.43 0.0 X-RAY
 2021-01-13 GLU A:150 A:809 60.0 NA H -61.7 -39.4 60.0 NA NA HOH
 6.403
 O
 O
GLU B:150 B:809 142.0 0.747 H -60.8 -39.6 NA NA NA
7aad 1 P09874 99.43 0.0 X-RAY
 2021-01-13 GLU A:150 A:809 63.0 NA H -62.2 -39.0 63.0 NA NA HOH
 6.988
 N
 O
GLU B:150 B:809 138.0 0.726 H -62.2 -39.2 NA NA NA
7onr 1 P09874 99.43 0.0 X-RAY
 2021-09-15 GLU A:150 A:809 64.0 NA H -66.2 -43.7 64.0 NA NA HOH
 3.654
 N
 O
GLU B:150 B:809 144.0 0.758 H -65.3 -43.9 NA NA NA
7ons 1 P09874 99.43 0.0 X-RAY
 2021-09-15 GLU A:150 A:809 63.0 NA H -66.2 -36.8 63.0 NA NA HOH
 6.710
 O
 O
GLU B:150 B:809 141.0 0.742 H -66.5 -36.6 NA NA NA
7ont 1 P09874 99.43 0.0 X-RAY
 2021-09-15 GLU A:150 A:809 68.0 NA H -63.7 -38.2 68.0 NA NA HOH
 3.157
 N
 O
GLU B:150 B:809 159.0 0.837 H -63.1 -38.9 NA NA NA
5ha9 1 P09874 100.0 0.0 X-RAY
 2016-03-09 GLU A:149 A:148 140.0 0.737 H -52.3 -32.1 140.0 0.737 0.0
GLU B:149 B:148 133.0 0.7 H -46.6 -36.7 133.0 0.7 0.0
4hhy 1 P09874 99.43 0.0 X-RAY
 2013-03-27 GLU A:153 A:148 173.0 0.911 H -65.7 -36.8 NA NA NA
GLU B:153 B:148 144.0 0.758 H -71.8 -29.0 NA NA NA
GLU C:153 C:148 148.0 0.779 S -77.3 -36.8 148.0 0.779 0.0
GLU D:153 D:148 183.0 0.963 T -66.6 -1.6 NA NA NA
4hhz 1 P09874 99.43 0.0 X-RAY
 2013-03-27 GLU A:153 A:148 140.0 0.737 H -65.5 -34.2 NA NA NA
GLU B:153 B:148 167.0 0.879 H -60.8 -30.9 NA NA NA
GLU C:153 C:148 149.0 0.784 H -79.0 -41.3 149.0 0.784 0.0
GLU D:153 D:148 153.0 0.805 H -70.4 -44.3 NA NA NA
5xsr 1 P09874 99.43 0.0 X-RAY
 2018-04-25 GLU A:153 A:148 145.0 0.763 H -61.5 -34.2 145.0 0.763 0.0 HOH
 2.986
 OE1
 O
5xsu 1 P09874 99.43 0.0 X-RAY
 2018-04-25 GLU A:153 A:148 85.0 NA H -69.1 -30.0 85.0 NA NA HOH
 8.520
 O
 O
GLU B:153 B:148 96.0 NA H -67.7 -33.2 NA NA NA
GLU C:153 C:148 87.0 NA H -70.0 -31.2 NA NA NA
GLU D:153 D:148 85.0 NA H -67.6 -30.2 NA NA NA
1uk0 1 P09874 100.0 0.0 X-RAY
 2004-01-27 GLU A:148 A:148 148.0 0.779 H -44.6 -31.8 148.0 0.779 0.0 HOH
 3.145
 N
 O
GLU B:148 B:148 157.0 0.826 H -85.8 -19.5 NA NA NA
1uk1 1 P09874 100.0 0.0 X-RAY
 2004-09-14 GLU A:148 A:809 152.0 0.8 H -20.2 -41.4 152.0 0.8 0.0 HOH
 4.113
 N
 O
GLU B:148 B:809 146.0 0.768 H -53.1 -48.5 NA NA NA
1wok 1 P09874 100.0 0.0 X-RAY
 2005-03-15 GLU A:148 A:809 156.0 0.821 H -43.6 -46.4 156.0 0.821 0.0
GLU B:148 B:809 138.0 0.726 H -53.5 -70.1 138.0 0.726 0.0
GLU C:148 C:809 154.0 0.811 H -45.1 -34.4 154.0 0.811 0.0
GLU D:148 D:809 121.0 0.637 S -151.7 -69.8 121.0 0.637 0.0
2rcw 1 P09874 100.0 0.0 X-RAY
 2008-09-23 GLU A:148 A:148 143.0 0.753 H -52.5 -60.2 143.0 0.753 0.0 HOH
 3.160
 OE1
 O
6vkk 1 P09874 99.72 0.0 X-RAY
 2020-06-17 GLU A:170 A:809 171.0 0.9 H -62.3 -31.0 171.0 0.9 0.0
GLU B:170 D:809 174.0 0.916 H -61.3 -31.5 NA NA NA
GLU C:170 C:809 146.0 0.768 H -62.5 -30.5 NA NA NA
GLU D:170 B:809 144.0 0.758 H -62.7 -30.7 NA NA NA
6vko 1 P09874 99.72 0.0 X-RAY
 2020-06-17 GLU A:170 A:809 142.0 0.747 H -90.2 -58.9 142.0 0.747 0.0
GLU B:170 B:809 139.0 0.732 H -89.8 -59.6 NA NA NA
GLU C:170 C:809 140.0 0.737 H -89.7 -59.3 NA NA NA
GLU D:170 D:809 139.0 0.732 H -89.4 -59.8 NA NA NA
6vkq 1 P09874 99.72 0.0 X-RAY
 2020-06-17 GLU A:170 A:809 137.0 0.721 S -68.1 -56.7 137.0 0.721 0.0
GLU B:170 B:809 139.0 0.732 S -67.9 -56.9 NA NA NA
GLU C:170 C:809 136.0 0.716 S -67.4 -57.3 NA NA NA
GLU D:170 D:809 139.0 0.732 S -67.9 -57.0 NA NA NA
4gv7 1 P09874 99.43 0.0 X-RAY
 2013-06-19 GLU A:149 A:809 145.0 0.763 H -59.2 -56.6 145.0 0.763 0.0
GLU B:149 B:809 156.0 0.821 H -67.5 -47.9 NA NA NA
GLU C:149 C:809 170.0 0.895 H -62.1 -36.3 NA NA NA
GLU D:149 D:809 150.0 0.789 H -65.8 -22.7 NA NA NA
4r5w 1 P09874 99.43 0.0 X-RAY
 2015-09-02 GLU A:149 A:809 151.0 0.795 H -63.3 -46.2 151.0 0.795 0.0
GLU B:149 B:809 152.0 0.8 H -63.8 -46.2 NA NA NA
4r6e 1 P09874 99.43 0.0 X-RAY
 2015-09-09 GLU A:149 A:809 163.0 0.858 H -67.1 -34.3 163.0 0.858 0.0
GLU B:149 B:809 125.0 0.658 H -67.0 -34.3 NA NA NA
GLU C:149 C:809 175.0 0.921 H -64.7 -37.7 NA NA NA
GLU D:149 D:809 140.0 0.737 H -64.9 -36.6 NA NA NA
6ghk 1 P09874 99.43 0.0 X-RAY
 2019-05-22 GLU A:149 A:809 138.0 0.726 H -72.8 -33.3 138.0 0.726 0.0 HOH
 7.304
 N
 O
GLU B:149 B:809 156.0 0.821 H -73.5 -34.3 NA NA NA
4pjt 1 P09874 100.0 0.0 X-RAY
 2014-09-24 GLU A:168 A:809 122.0 0.642 H -72.6 -33.4 122.0 0.642 0.0 SO4
HOH
 2.965
5.143
 N
N
 O2
O
GLU B:168 B:809 137.0 0.721 H -71.7 -33.0 NA NA NA
GLU C:168 C:809 147.0 0.774 H -71.1 -34.1 NA NA NA
GLU D:168 D:809 78.0 NA H -69.9 -35.1 NA NA NA
4rv6 1 P09874 99.71 0.0 X-RAY
 2015-12-09 GLU A:150 A:809 166.0 0.874 H -61.9 -39.4 166.0 0.874 0.0
GLU B:150 B:809 166.0 0.874 H -61.4 -39.3 NA NA NA
GLU C:150 C:809 165.0 0.868 H -59.9 -40.6 NA NA NA
GLU D:150 D:809 168.0 0.884 H -60.1 -40.7 NA NA NA
4uxb 1 P09874 99.71 0.0 X-RAY
 2015-09-02 GLU A:150 A:809 132.0 0.695 H -58.9 -45.3 132.0 0.695 0.0
GLU B:150 B:809 137.0 0.721 H -59.1 -45.1 NA NA NA
4l6s 1 P09874 99.71 0.0 X-RAY
 2013-08-07 GLU A:151 A:809 141.0 0.742 H -73.2 -44.4 141.0 0.742 0.0 HOH
 6.514
 O
 O
GLU B:151 B:809 162.0 0.853 H -71.7 -45.3 NA NA NA
4und 1 P09874 99.71 0.0 X-RAY
 2015-06-17 GLU A:171 A:809 136.0 0.716 H -57.5 -46.1 136.0 0.716 0.0
GLU B:171 B:809 150.0 0.789 H -58.9 -43.5 NA NA NA
5kpn 1 P09874 99.71 0.0 X-RAY
 2016-12-21 GLU A:150 A:809 138.0 0.726 H -67.9 -39.3 138.0 0.726 0.0
GLU B:150 B:809 151.0 0.795 H -70.1 -46.1 NA NA NA
5kpo 1 P09874 99.71 0.0 X-RAY
 2016-12-21 GLU A:150 A:809 139.0 0.732 H -65.4 -41.8 139.0 0.732 0.0
GLU B:150 B:809 150.0 0.789 H -70.9 -46.1 NA NA NA
5wrq 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:150 A:809 148.0 0.779 H -64.4 -44.4 148.0 0.779 0.0
GLU B:150 B:809 150.0 0.789 H -71.0 -46.0 NA NA NA
5wry 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:150 A:809 146.0 0.768 H -71.8 -46.6 146.0 0.768 0.0 HOH
 4.061
 OE1
 O
GLU B:150 B:809 147.0 0.774 H -67.1 -40.0 NA NA NA
5wrz 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:150 A:809 137.0 0.721 H -70.1 -41.4 137.0 0.721 0.0
GLU B:150 B:809 157.0 0.826 H -61.3 -50.0 NA NA NA
5ws0 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:150 A:809 138.0 0.726 H -82.0 -32.1 138.0 0.726 0.0
GLU B:150 B:809 158.0 0.832 H -62.9 -47.4 NA NA NA
5ws1 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:150 A:809 119.0 0.626 H -62.2 -45.0 119.0 0.626 0.0
GLU B:150 B:809 151.0 0.795 H -65.3 -42.7 NA NA NA
5wtc 1 P09874 99.71 0.0 X-RAY
 2017-01-25 GLU A:150 A:809 140.0 0.737 H -69.8 -41.4 140.0 0.737 0.0
GLU B:150 B:809 157.0 0.826 H -68.5 -49.7 NA NA NA
2rd6 1 P09874 99.71 0.0 X-RAY
 2008-09-23 GLU A:148 A:148 142.0 0.747 H -67.9 -42.4 142.0 0.747 0.0 HOH
 3.281
 CB
 O
3gjw 1 P09874 99.71 0.0 X-RAY
 2010-03-09 GLU A:148 A:148 145.0 0.763 H -56.3 -37.9 145.0 0.763 0.0 HOH
 3.838
 OE2
 O
3gn7 1 P09874 99.71 0.0 X-RAY
 2010-03-16 GLU A:148 A:148 138.0 0.726 H -62.5 -25.7 138.0 0.726 0.0 HOH
 7.104
 N
 O
3l3l 1 P09874 99.71 0.0 X-RAY
 2010-12-22 GLU A:148 A:148 143.0 0.753 H -55.9 -44.5 143.0 0.753 0.0 HOH
 9.324
 CB
 O
3l3m 1 P09874 99.71 0.0 X-RAY
 2010-06-23 GLU A:148 A:148 162.0 0.853 H -60.4 -33.5 162.0 0.853 0.0 HOH
 3.391
 N
 O
5kpp 1 P09874 99.71 0.0 X-RAY
 2016-11-30 GLU A:148 A:809 141.0 0.742 H -66.2 -52.5 141.0 0.742 0.0 HOH
 3.001
 OE1
 O
GLU B:148 B:809 145.0 0.763 H -67.0 -43.8 NA NA NA
5kpq 1 P09874 99.71 0.0 X-RAY
 2016-12-14 GLU A:148 A:809 144.0 0.758 H -71.1 -40.2 144.0 0.758 0.0 HOH
 4.458
 CG
 O
GLU B:148 B:809 149.0 0.784 H -65.0 -43.6 NA NA NA
7cmw 1 P09874 99.71 0.0 X-RAY
 2020-12-16 GLU A:152 A:809 138.0 0.726 H -85.3 -30.6 138.0 0.726 0.0
GLU B:152 B:809 140.0 0.737 H -85.8 -31.7 NA NA NA
5xst 1 P09874 99.43 0.0 X-RAY
 2018-04-25 GLU A:149 A:148 129.0 0.679 H -59.4 -39.1 129.0 0.679 0.0 HOH
 3.180
 OE1
 O
6i8m 1 P26446 86.7 0.0 X-RAY
 2019-05-01 GLU A:158 A:809 154.0 0.811 H -61.7 -29.1 154.0 0.811 0.0
6i8t 1 P26446 86.7 0.0 X-RAY
 2019-05-01 GLU A:158 A:809 154.0 0.811 H -57.2 -38.6 154.0 0.811 0.0
1a26 1 P26446 86.67 0.0 X-RAY
 1998-05-27 GLU A:156 A:809 131.0 0.689 H -62.4 -42.6 131.0 0.689 0.0
1pax 1 P26446 86.67 0.0 X-RAY
 1997-05-15 GLU A:156 A:809 125.0 0.658 H -64.7 -38.8 125.0 0.658 0.0
2paw 1 P26446 86.67 0.0 X-RAY
 1998-05-27 GLU A:156 A:809 119.0 0.626 H -74.2 -36.4 119.0 0.626 0.0
2pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 GLU A:156 A:809 126.0 0.663 H -68.3 -36.0 126.0 0.663 0.0
3pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 GLU A:156 A:809 127.0 0.668 H -64.0 -38.4 127.0 0.668 0.0
4pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 GLU A:156 A:809 126.0 0.663 H -58.8 -38.2 126.0 0.663 0.0
1efy 1 P26446 86.86 0.0 X-RAY
 2001-01-17 GLU A:148 A:809 126.0 0.663 H -83.9 -39.2 126.0 0.663 0.0 HOH
 9.417
 C
 O
6m3i 2 P09874 100.0 3e-162 X-RAY
 2021-03-03 GLU B:48 B:809 138.0 0.726 H -72.4 -39.4 138.0 0.726 0.0 HOH
 4.883
 OE1
 O
5ds3 1 P09874 100.0 5e-160 X-RAY
 2016-07-27 GLU A:68 A:809 146.0 0.768 H -72.0 -37.3 146.0 0.768 0.0 HOH
 2.891
 N
 O
6bhv 1 P09874 100.0 5e-160 X-RAY
 2018-02-28 GLU A:68 A:809 164.0 0.863 H -61.7 -41.7 164.0 0.863 0.0
GLU B:68 B:809 147.0 0.774 H -59.1 -44.0 NA NA NA
GLU C:68 C:809 150.0 0.789 H -59.3 -43.7 NA NA NA
GLU D:68 D:809 137.0 0.721 H -60.9 -43.1 NA NA NA
6nrf 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 GLU A:68 A:809 142.0 0.747 H -63.5 -41.7 142.0 0.747 0.0 HOH
 7.093
 N
 O
6nrg 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 GLU A:68 A:809 147.0 0.774 H -54.5 -50.0 147.0 0.774 0.0 HOH
 2.989
 N
 O
6nrh 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 GLU A:68 A:809 152.0 0.8 H -60.0 -44.0 152.0 0.8 0.0 HOH
 2.886
 N
 O
6nri 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 GLU A:68 A:809 146.0 0.768 H -68.6 -40.2 146.0 0.768 0.0 HOH
 7.190
 O
 O
6nrj 1 P09874 100.0 5e-160 X-RAY
 2019-08-14 GLU A:68 A:809 145.0 0.763 H -59.9 -45.3 145.0 0.763 0.0 HOH
 7.035
 O
 O
6ntu 1 P09874 100.0 5e-160 X-RAY
 2020-02-05 GLU A:68 A:809 151.0 0.795 H -58.5 -45.4 151.0 0.795 0.0 HOH
 2.845
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p09874-f1 1 P09874 100.0 0.0 GLU A:809 A:809 151.0 0.795 H -59.4 -39.3