Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 226555302 . A C CCDS1554.1:NM_001618.3:c.2285gTg>gGg_NP_001609.2:p.762V>G Homo sapiens poly(ADP-ribose) polymerase 1 (PARP1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4opx 2 P09874 100.0 0.0 X-RAY
 2014-07-02 VAL B:245 C:762 9.0 NA H -69.8 -42.5 9.0 NA NA
VAL D:245 F:762 8.0 NA H -69.8 -42.4 NA NA NA
4oqa 2 P09874 100.0 0.0 X-RAY
 2014-07-02 VAL B:245 C:762 8.0 NA H -69.9 -42.4 8.0 NA NA 2US
 5.872
 C
 O2
VAL D:245 F:762 8.0 NA H -69.8 -42.4 NA NA NA
4oqb 2 P09874 100.0 0.0 X-RAY
 2014-07-02 VAL B:245 C:762 8.0 NA H -69.9 -42.7 8.0 NA NA 2UT
 6.605
 O
 C10
VAL D:245 F:762 8.0 NA H -69.9 -42.7 NA NA NA
4dqy 3 P09874 99.8 0.0 X-RAY
 2012-05-30 ALA C:246 C:762 8.0 0.07 H -66.4 -50.1 8.0 0.07 0.0
ALA F:246 F:762 8.0 0.07 H -64.9 -51.6 NA NA NA
4zzz 1 P09874 100.0 0.0 X-RAY
 2015-08-12 VAL A:110 A:762 2.0 0.013 H -58.1 -46.1 2.0 0.013 0.0 GOL
FSU
HOH
 7.057
7.333
7.269
 O
CG1
N
 O3
C14
O
VAL B:110 B:762 0.0 0.0 H -53.8 -51.5 0.0 0.0 0.0 FSU
HOH
 7.328
7.123
 CG1
N
 O16
O
5a00 1 P09874 100.0 0.0 X-RAY
 2015-08-12 VAL A:110 A:762 13.0 0.084 H -57.1 -50.1 13.0 0.084 0.0 D7N
HOH
 3.428
6.388
 CB
CG2
 F27
O
4xhu 1 P09874 99.44 0.0 X-RAY
 2015-09-30 VAL A:107 C:762 0.0 NA H -63.9 -42.4 0.0 NA NA GOL
HOH
 7.228
5.383
 O
O
 O3
O
VAL C:107 A:762 0.0 NA H -63.6 -42.1 NA NA NA
6xvw 1 P09874 100.0 0.0 X-RAY
 2020-06-03 VAL A:102 A:762 0.0 0.0 H -73.7 -28.3 0.0 0.0 0.0 O3H
HOH
 6.799
3.680
 O
CG1
 C10
O
VAL B:102 B:762 0.0 0.0 H -76.7 -39.5 NA NA NA
7kk2 1 P09874 99.72 0.0 X-RAY
 2021-01-06 VAL A:103 A:762 0.0 0.0 H -64.3 -42.3 0.0 0.0 0.0 SO4
HOH
 9.162
6.075
 O
N
 O3
O
VAL B:103 B:762 0.0 0.0 H -58.9 -49.6 NA NA NA
7kk3 1 P09874 99.72 0.0 X-RAY
 2021-01-06 VAL A:103 A:762 10.0 0.065 H -61.0 -50.2 10.0 0.065 0.0 2YQ
HOH
 6.901
8.075
 CG1
CG1
 F2
O
VAL B:103 B:762 13.0 0.084 H -63.0 -52.4 NA NA NA
VAL C:103 C:762 10.0 0.065 H -62.1 -48.7 NA NA NA
VAL D:103 D:762 0.0 0.0 H -63.1 -48.2 NA NA NA
7kk4 1 P09874 99.72 0.0 X-RAY
 2021-01-06 VAL A:103 A:762 1.0 0.006 H -67.8 -43.2 1.0 0.006 0.0 09L
HOH
 6.602
5.111
 O
C
 CAI
O
VAL B:103 B:762 1.0 0.006 H -63.1 -49.6 NA NA NA
7kk5 1 P09874 99.72 0.0 X-RAY
 2021-01-06 VAL A:103 A:762 5.0 0.032 H -66.6 -44.6 5.0 0.032 0.0 3JD
SO4
SO4
HOH
 3.786
9.395
9.881
3.239
 CG1
O
CG1
CG1
 NAP
O3
O4
O
VAL B:103 B:762 4.0 0.026 H -63.8 -45.7 NA NA NA
VAL C:103 C:762 4.0 0.026 H -60.7 -45.9 NA NA NA
VAL D:103 D:762 4.0 0.026 H -69.8 -49.3 NA NA NA
7kk6 1 P09874 99.72 0.0 X-RAY
 2021-01-06 VAL A:103 A:762 0.0 NA H -72.4 -27.8 0.0 NA NA 78P
SO4
HOH
 7.913
8.451
8.596
 O
O
O
 C15
O3
O
VAL B:103 B:762 2.0 NA H -65.2 -38.7 NA NA NA
7aaa 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ALA A:103 A:762 0.0 0.0 H -67.1 -40.8 0.0 0.0 0.0 HOH
 6.102
 N
 O
ALA B:103 B:762 0.0 0.0 H -65.2 -40.9 NA NA NA
7aab 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ALA A:103 A:762 9.0 0.078 H -69.3 -36.4 9.0 0.078 0.0 UHB
 8.405
 O
 C17
ALA B:103 B:762 8.0 0.07 H -71.4 -36.6 NA NA NA
7aac 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ALA A:103 A:762 0.0 0.0 H -61.7 -44.9 0.0 0.0 0.0 78P
HOH
 8.060
5.268
 O
O
 C15
O
ALA B:103 B:762 0.0 0.0 H -60.8 -45.1 NA NA NA
7aad 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ALA A:103 A:762 1.0 0.009 H -75.2 -38.9 1.0 0.009 0.0 09L
HOH
 6.815
5.434
 O
CB
 CAI
O
ALA B:103 B:762 1.0 0.009 H -64.7 -40.8 NA NA NA
7onr 1 P09874 99.43 0.0 X-RAY
 2021-09-15 ALA A:103 A:762 0.0 0.0 H -67.5 -40.3 0.0 0.0 0.0 VKW
HOH
 6.859
5.257
 O
O
 C4
O
ALA B:103 B:762 0.0 0.0 H -67.0 -33.4 NA NA NA
7ons 1 P09874 99.43 0.0 X-RAY
 2021-09-15 ALA A:103 A:762 0.0 0.0 H -71.2 -39.2 0.0 0.0 0.0 VKT
HOH
 6.671
5.033
 O
O
 C19
O
ALA B:103 B:762 0.0 0.0 H -66.5 -36.9 NA NA NA
7ont 1 P09874 99.43 0.0 X-RAY
 2021-09-15 ALA A:103 A:762 0.0 0.0 H -64.2 -38.8 0.0 0.0 0.0 VKQ
HOH
 7.241
4.877
 O
O
 C15
O
ALA B:103 B:762 0.0 0.0 H -64.2 -38.8 NA NA NA
5ha9 1 P09874 100.0 0.0 X-RAY
 2016-03-09 VAL A:102 A:101 0.0 0.0 H -59.2 -37.1 0.0 0.0 0.0 GOL
 7.286
 O
 C1
VAL B:102 B:101 0.0 0.0 H -74.0 -51.1 0.0 0.0 0.0 GOL
TP0
 6.598
6.858
 CG1
C
 O1
C16
4hhy 1 P09874 99.43 0.0 X-RAY
 2013-03-27 ALA A:106 A:101 11.0 0.096 H -68.8 -35.2 NA NA NA
ALA B:106 B:101 16.0 0.139 H -68.1 -48.9 NA NA NA
ALA C:106 C:101 2.0 0.017 H -74.8 -36.1 2.0 0.017 0.0 15R
HOH
 6.569
3.575
 O
CB
 CAL
O
ALA D:106 D:101 12.0 0.104 H -68.1 -46.7 NA NA NA
4hhz 1 P09874 99.43 0.0 X-RAY
 2013-03-27 ALA A:106 A:101 5.0 0.043 H -66.4 -43.3 NA NA NA
ALA B:106 B:101 15.0 0.13 H -64.0 -40.0 NA NA NA
ALA C:106 C:101 2.0 0.017 H -73.3 -46.2 2.0 0.017 0.0 15S
HOH
 6.463
8.386
 O
C
 CAM
O
ALA D:106 D:101 14.0 0.122 H -74.2 -36.6 NA NA NA
5xsr 1 P09874 99.43 0.0 X-RAY
 2018-04-25 ALA A:106 A:101 10.0 0.087 H -67.7 -47.8 10.0 0.087 0.0 8EC
HOH
 5.716
3.267
 C
CB
 C16
O
5xsu 1 P09874 99.43 0.0 X-RAY
 2018-04-25 ALA A:106 A:101 8.0 0.07 H -69.7 -44.1 8.0 0.07 0.0 SO4
8E3
HOH
 8.814
6.149
6.192
 O
C
C
 O2
C19
O
ALA B:106 B:101 13.0 0.113 H -69.2 -42.6 NA NA NA
ALA C:106 C:101 8.0 0.07 H -67.6 -42.9 NA NA NA
ALA D:106 D:101 12.0 0.104 H -69.8 -45.2 NA NA NA
1uk0 1 P09874 100.0 0.0 X-RAY
 2004-01-27 VAL A:101 A:101 3.0 0.019 H -63.1 -42.0 3.0 0.019 0.0 FRM
HOH
 6.856
4.931
 O
CG1
 C29
O
VAL B:101 B:101 0.0 0.0 H -64.4 -44.7 NA NA NA
1uk1 1 P09874 100.0 0.0 X-RAY
 2004-09-14 VAL A:101 A:762 3.0 0.019 H -66.1 -20.8 3.0 0.019 0.0 FRQ
HOH
 6.526
3.176
 O
CB
 C32
O
VAL B:101 B:762 0.0 0.0 H -73.7 -41.5 NA NA NA
1wok 1 P09874 100.0 0.0 X-RAY
 2005-03-15 VAL A:101 A:762 1.0 0.006 H -64.0 -47.2 1.0 0.006 0.0 CNQ
 4.193
 O
 CL24
VAL B:101 B:762 3.0 0.019 H -53.6 -41.2 3.0 0.019 0.0 CNQ
 4.865
 O
 CL24
VAL C:101 C:762 3.0 0.019 H -74.0 -41.2 3.0 0.019 0.0 CNQ
 4.245
 O
 CL24
VAL D:101 D:762 3.0 0.019 H -58.9 -49.0 3.0 0.019 0.0 CNQ
 4.937
 O
 CL24
2rcw 1 P09874 100.0 0.0 X-RAY
 2008-09-23 VAL A:101 A:101 7.0 NA H -64.4 -29.1 7.0 NA NA AAI
HOH
 3.568
8.185
 O
N
 C21
O
6vkk 1 P09874 99.72 0.0 X-RAY
 2020-06-17 ALA A:123 A:762 7.0 0.061 H -64.4 -45.5 7.0 0.061 0.0 RPB
HOH
 5.842
3.345
 CB
CB
 N3
O
ALA B:123 D:762 9.0 0.078 H -64.0 -44.6 NA NA NA
ALA C:123 C:762 5.0 0.043 H -64.1 -44.3 NA NA NA
ALA D:123 B:762 7.0 0.061 H -64.1 -44.8 NA NA NA
6vko 1 P09874 99.72 0.0 X-RAY
 2020-06-17 ALA A:123 A:762 20.0 0.174 H -59.0 -50.1 20.0 0.174 0.0 L1S
HOH
 3.678
6.886
 CB
O
 C23
O
ALA B:123 B:762 20.0 0.174 H -59.0 -50.3 NA NA NA
ALA C:123 C:762 19.0 0.165 H -59.0 -50.2 NA NA NA
ALA D:123 D:762 18.0 0.157 H -59.0 -50.1 NA NA NA
6vkq 1 P09874 99.72 0.0 X-RAY
 2020-06-17 ALA A:123 A:762 8.0 0.07 H -79.8 -33.7 8.0 0.07 0.0 UHB
 7.221
 O
 C17
ALA B:123 B:762 8.0 0.07 H -79.8 -33.8 NA NA NA
ALA C:123 C:762 8.0 0.07 H -79.8 -33.6 NA NA NA
ALA D:123 D:762 9.0 0.078 H -79.8 -33.6 NA NA NA
4gv7 1 P09874 99.43 0.0 X-RAY
 2013-06-19 ALA A:102 A:762 12.0 0.104 H -64.1 -34.4 12.0 0.104 0.0 MEW
 9.907
 O
 CAN
ALA B:102 B:762 8.0 0.07 H -62.6 -46.1 NA NA NA
ALA C:102 C:762 4.0 0.035 H -74.8 -44.3 NA NA NA
ALA D:102 D:762 4.0 0.035 H -76.2 -44.3 NA NA NA
4r5w 1 P09874 99.43 0.0 X-RAY
 2015-09-02 ALA A:102 A:762 0.0 0.0 H -66.7 -43.8 0.0 0.0 0.0 SO4
XAV
HOH
 6.719
5.791
9.420
 O
O
CB
 O2
FAB
O
ALA B:102 B:762 0.0 0.0 H -65.6 -44.1 NA NA NA
4r6e 1 P09874 99.43 0.0 X-RAY
 2015-09-09 ALA A:102 A:762 15.0 0.13 H -67.5 -38.3 15.0 0.13 0.0 3JD
GOL
HOH
 3.874
8.385
3.647
 CB
O
CB
 CAL
O1
O
ALA B:102 B:762 13.0 0.113 H -68.0 -38.1 NA NA NA
ALA C:102 C:762 14.0 0.122 H -68.7 -38.3 NA NA NA
ALA D:102 D:762 14.0 0.122 H -67.3 -38.6 NA NA NA
6ghk 1 P09874 99.43 0.0 X-RAY
 2019-05-22 ALA A:102 A:762 0.0 0.0 H -61.6 -44.5 0.0 0.0 0.0 EZ2
HOH
 6.102
5.251
 O
O
 CAM
O
ALA B:102 B:762 0.0 0.0 H -61.3 -44.3 NA NA NA
4pjt 1 P09874 100.0 0.0 X-RAY
 2014-09-24 VAL A:121 A:762 10.0 0.065 H -63.4 -46.4 10.0 0.065 0.0 2YQ
HOH
 7.179
3.467
 CG1
CG1
 F2
O
VAL B:121 B:762 7.0 0.045 H -64.4 -46.1 NA NA NA
VAL C:121 C:762 9.0 0.058 H -63.6 -47.3 NA NA NA
VAL D:121 D:762 9.0 0.058 H -62.3 -46.7 NA NA NA
4rv6 1 P09874 99.71 0.0 X-RAY
 2015-12-09 ALA A:103 A:762 4.0 0.035 H -65.7 -41.2 4.0 0.035 0.0 RPB
 4.761
 CB
 C19
ALA B:103 B:762 4.0 0.035 H -65.8 -42.0 NA NA NA
ALA C:103 C:762 4.0 0.035 H -66.2 -41.5 NA NA NA
ALA D:103 D:762 4.0 0.035 H -66.6 -41.1 NA NA NA
4uxb 1 P09874 99.71 0.0 X-RAY
 2015-09-02 ALA A:103 A:762 6.0 0.052 H -66.7 -44.8 6.0 0.052 0.0 P34
HOH
 6.267
9.588
 C
O
 O
O
ALA B:103 B:762 5.0 0.043 H -66.6 -44.7 NA NA NA
4l6s 1 P09874 99.71 0.0 X-RAY
 2013-08-07 ALA A:104 A:762 0.0 0.0 H -65.8 -44.0 0.0 0.0 0.0 1WQ
HOH
 6.723
4.326
 O
CB
 C14
O
ALA B:104 B:762 0.0 0.0 H -56.2 -44.1 NA NA NA
4und 1 P09874 99.71 0.0 X-RAY
 2015-06-17 ALA A:124 A:762 11.0 0.096 H -64.0 -40.4 11.0 0.096 0.0 2YQ
HOH
 6.024
3.559
 CB
CB
 F2
O
ALA B:124 B:762 12.0 0.104 H -63.7 -35.7 NA NA NA
5kpn 1 P09874 99.71 0.0 X-RAY
 2016-12-21 ALA A:103 A:762 0.0 0.0 H -64.7 -43.3 0.0 0.0 0.0 6WX
 7.127
 O
 CAP
ALA B:103 B:762 0.0 0.0 H -58.6 -45.6 NA NA NA
5kpo 1 P09874 99.71 0.0 X-RAY
 2016-12-21 ALA A:103 A:762 0.0 0.0 H -66.1 -44.9 0.0 0.0 0.0 6WY
 7.261
 O
 CAO
ALA B:103 B:762 0.0 0.0 H -60.7 -41.9 NA NA NA
5wrq 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:103 A:762 0.0 0.0 H -65.9 -42.2 0.0 0.0 0.0 7TX
 6.469
 O
 CAB
ALA B:103 B:762 0.0 0.0 H -62.6 -41.2 NA NA NA
5wry 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:103 A:762 0.0 0.0 H -60.8 -42.1 0.0 0.0 0.0 4YR
HOH
 7.241
4.111
 O
CB
 C45
O
ALA B:103 B:762 0.0 0.0 H -60.1 -45.9 NA NA NA
5wrz 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:103 A:762 0.0 0.0 H -70.4 -36.7 0.0 0.0 0.0 7U3
 7.658
 O
 CAG
ALA B:103 B:762 0.0 0.0 H -64.0 -42.4 NA NA NA
5ws0 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:103 A:762 0.0 0.0 H -77.5 -28.8 0.0 0.0 0.0 7U6
 5.633
 O
 CAH
ALA B:103 B:762 0.0 0.0 H -62.0 -42.2 NA NA NA
5ws1 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:103 A:762 0.0 0.0 H -67.7 -40.0 0.0 0.0 0.0 7U9
 4.933
 O
 NAB
ALA B:103 B:762 0.0 0.0 H -55.8 -45.9 NA NA NA
5wtc 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ALA A:103 A:762 0.0 0.0 H -61.4 -42.9 0.0 0.0 0.0 7UL
 6.187
 O
 FAF
ALA B:103 B:762 0.0 0.0 H -59.8 -44.6 NA NA NA
2rd6 1 P09874 99.71 0.0 X-RAY
 2008-09-23 ALA A:101 A:101 7.0 0.061 H -66.7 -44.5 7.0 0.061 0.0 78P
HOH
 9.099
3.456
 O
CB
 C15
O
3gjw 1 P09874 99.71 0.0 X-RAY
 2010-03-09 ALA A:101 A:101 9.0 0.078 H -68.0 -38.5 9.0 0.078 0.0 GJW
HOH
 7.290
5.276
 O
O
 C25
O
3gn7 1 P09874 99.71 0.0 X-RAY
 2010-03-16 ALA A:101 A:101 11.0 0.096 H -72.5 -39.7 11.0 0.096 0.0 3GN
HOH
 8.855
6.054
 C
O
 C15
O
3l3l 1 P09874 99.71 0.0 X-RAY
 2010-12-22 ALA A:101 A:101 5.0 0.043 H -77.6 -38.9 5.0 0.043 0.0 L3L
HOH
 7.886
4.408
 CB
C
 N15
O
3l3m 1 P09874 99.71 0.0 X-RAY
 2010-06-23 ALA A:101 A:101 11.0 0.096 H -67.5 -38.9 11.0 0.096 0.0 A92
HOH
 3.826
3.186
 CB
CB
 C16
O
5kpp 1 P09874 99.71 0.0 X-RAY
 2016-11-30 ALA A:101 A:762 1.0 0.009 H -59.6 -40.0 1.0 0.009 0.0 6WZ
HOH
 6.496
5.876
 O
C
 FAF
O
ALA B:101 B:762 1.0 0.009 H -61.9 -44.4 NA NA NA
5kpq 1 P09874 99.71 0.0 X-RAY
 2016-12-14 ALA A:101 A:762 1.0 0.009 H -64.7 -36.3 1.0 0.009 0.0 6X2
HOH
 6.766
4.898
 O
C
 CAQ
O
ALA B:101 B:762 1.0 0.009 H -55.8 -43.9 NA NA NA
7cmw 1 P09874 99.71 0.0 X-RAY
 2020-12-16 ALA A:105 A:762 0.0 0.0 H -71.8 -41.5 0.0 0.0 0.0 DS9
GOL
HOH
 6.965
6.496
5.217
 O
O
CB
 C4
C1
O
ALA B:105 B:762 0.0 0.0 H -71.0 -39.2 NA NA NA
5xst 1 P09874 99.43 0.0 X-RAY
 2018-04-25 ALA A:102 A:101 11.0 0.096 H -67.7 -46.0 11.0 0.096 0.0 8E6
HOH
 5.001
3.258
 CB
CB
 C18
O
6i8m 1 P26446 86.7 0.0 X-RAY
 2019-05-01 VAL A:111 A:762 9.0 0.058 H -61.9 -52.6 9.0 0.058 0.0 H7W
HOH
 3.977
7.800
 CG1
O
 C26
O
6i8t 1 P26446 86.7 0.0 X-RAY
 2019-05-01 VAL A:111 A:762 9.0 0.058 H -67.0 -47.0 9.0 0.058 0.0 H7Z
HOH
 4.124
7.702
 CG1
O
 C26
O
1a26 1 P26446 86.67 0.0 X-RAY
 1998-05-27 VAL A:109 A:762 0.0 0.0 H -72.8 -34.7 0.0 0.0 0.0 HOH
 5.353
 O
 O
1pax 1 P26446 86.67 0.0 X-RAY
 1997-05-15 VAL A:109 A:762 0.0 0.0 H -64.5 -36.9 0.0 0.0 0.0 HOH
 9.295
 N
 O
2paw 1 P26446 86.67 0.0 X-RAY
 1998-05-27 VAL A:109 A:762 0.0 0.0 H -66.6 -39.8 0.0 0.0 0.0 HOH
 6.600
 O
 O
2pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 VAL A:109 A:762 0.0 0.0 H -67.5 -36.2 0.0 0.0 0.0 HOH
 8.477
 O
 O
3pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 VAL A:109 A:762 0.0 0.0 H -69.8 -38.0 0.0 0.0 0.0 HOH
 9.429
 N
 O
4pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 VAL A:109 A:762 0.0 0.0 H -69.3 -37.3 0.0 0.0 0.0
1efy 1 P26446 86.86 0.0 X-RAY
 2001-01-17 VAL A:101 A:762 0.0 0.0 H -65.2 -38.7 0.0 0.0 0.0 BZC
HOH
 7.248
7.672
 C
O
 O2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p09874-f1 1 P09874 100.0 0.0 VAL A:762 A:762 4.0 0.026 H -66.8 -50.7