Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 226555973 . C A CCDS1554.1:NM_001618.3:c.2204cGc>cTc_NP_001609.2:p.735R>L Homo sapiens poly(ADP-ribose) polymerase 1 (PARP1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4opx 2 P09874 100.0 0.0 X-RAY
 2014-07-02 ARG B:218 C:735 102.0 0.453 H -51.7 -43.5 59.0 0.262 0.191 A:P09874:0.191
ARG D:218 F:735 103.0 0.458 H -51.8 -43.4 NA NA NA
4oqa 2 P09874 100.0 0.0 X-RAY
 2014-07-02 ARG B:218 C:735 103.0 0.458 H -51.2 -42.5 60.0 0.267 0.191 A:P09874:0.191
ARG D:218 F:735 103.0 0.458 H -51.4 -42.4 NA NA NA
4oqb 2 P09874 100.0 0.0 X-RAY
 2014-07-02 ARG B:218 C:735 101.0 0.449 H -51.5 -44.1 59.0 0.262 0.187 A:P09874:0.187
ARG D:218 F:735 103.0 0.458 H -51.6 -44.1 NA NA NA
4dqy 3 P09874 99.8 0.0 X-RAY
 2012-05-30 ARG C:219 C:735 97.0 0.431 H -57.5 -43.1 57.0 0.253 0.178 B:P09874:0.178
ARG F:219 F:735 99.0 0.44 H -57.6 -43.6 NA NA NA
4zzz 1 P09874 100.0 0.0 X-RAY
 2015-08-12 ARG A:83 A:735 122.0 0.542 H -66.0 -44.7 122.0 0.542 0.0
ARG B:83 B:735 137.0 0.609 H -56.7 -43.1 137.0 0.609 0.0 HOH
 4.713
 CA
 O
5a00 1 P09874 100.0 0.0 X-RAY
 2015-08-12 ARG A:83 A:735 103.0 0.458 H -58.6 -45.0 103.0 0.458 0.0
4xhu 1 P09874 99.44 0.0 X-RAY
 2015-09-30 ARG A:80 C:735 96.0 0.427 H -61.0 -44.7 96.0 0.427 0.0 HOH
 3.458
 NH2
 O
ARG C:80 A:735 94.0 0.418 H -64.4 -37.4 NA NA NA
6xvw 1 P09874 100.0 0.0 X-RAY
 2020-06-03 ARG A:75 A:735 92.0 0.409 H -65.5 -44.9 92.0 0.409 0.0 EDO
EDO
HOH
 7.678
8.666
2.889
 O
NH2
NH2
 O2
O1
O
ARG B:75 B:735 136.0 0.604 H -60.5 -46.7 NA NA NA
7kk2 1 P09874 99.72 0.0 X-RAY
 2021-01-06 ARG A:76 A:735 106.0 0.471 H -61.0 -37.5 106.0 0.471 0.0 HOH
 3.322
 NH2
 O
ARG B:76 B:735 140.0 0.622 H -67.3 -35.0 NA NA NA
7kk3 1 P09874 99.72 0.0 X-RAY
 2021-01-06 ARG A:76 A:735 118.0 0.524 H -67.2 -27.2 118.0 0.524 0.0
ARG B:76 B:735 95.0 0.422 H -61.3 -44.2 NA NA NA
ARG C:76 C:735 133.0 0.591 H -60.0 -40.7 NA NA NA
ARG D:76 D:735 103.0 0.458 H -71.5 -26.8 NA NA NA
7kk4 1 P09874 99.72 0.0 X-RAY
 2021-01-06 ARG A:76 A:735 102.0 0.453 H -66.0 -38.7 102.0 0.453 0.0 HOH
 8.756
 NH2
 O
ARG B:76 B:735 112.0 0.498 H -60.6 -37.4 NA NA NA
7kk5 1 P09874 99.72 0.0 X-RAY
 2021-01-06 ARG A:76 A:735 123.0 0.547 H -65.7 -33.3 123.0 0.547 0.0 HOH
 4.838
 N
 O
ARG B:76 B:735 103.0 0.458 H -62.4 -40.8 NA NA NA
ARG C:76 C:735 135.0 0.6 H -58.6 -40.2 NA NA NA
ARG D:76 D:735 110.0 0.489 H -66.2 -22.0 NA NA NA
7kk6 1 P09874 99.72 0.0 X-RAY
 2021-01-06 ARG A:76 A:735 109.0 0.484 H -57.6 -33.4 109.0 0.484 0.0 HOH
 3.878
 N
 O
ARG B:76 B:735 130.0 0.578 H -61.8 -43.3 NA NA NA
7aaa 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ARG A:76 A:735 98.0 0.436 H -63.7 -39.0 98.0 0.436 0.0 HOH
 2.732
 NH2
 O
ARG B:76 B:735 138.0 0.613 H -59.7 -41.7 NA NA NA
7aab 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ARG A:76 A:735 125.0 0.556 H -52.5 -43.9 125.0 0.556 0.0 HOH
 9.195
 N
 O
ARG B:76 B:735 98.0 0.436 H -61.8 -38.1 NA NA NA
7aac 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ARG A:76 A:735 103.0 0.458 H -55.7 -43.4 103.0 0.458 0.0 HOH
 2.789
 NH2
 O
ARG B:76 B:735 125.0 0.556 H -59.2 -42.0 NA NA NA
7aad 1 P09874 99.43 0.0 X-RAY
 2021-01-13 ARG A:76 A:735 105.0 0.467 H -62.3 -38.3 105.0 0.467 0.0
ARG B:76 B:735 148.0 0.658 H -65.4 -35.3 NA NA NA
7onr 1 P09874 99.43 0.0 X-RAY
 2021-09-15 ARG A:76 A:735 101.0 0.449 H -54.7 -45.1 101.0 0.449 0.0 HOH
 2.765
 NH2
 O
ARG B:76 B:735 136.0 0.604 H -67.1 -37.6 NA NA NA
7ons 1 P09874 99.43 0.0 X-RAY
 2021-09-15 ARG A:76 A:735 104.0 0.462 H -56.5 -45.7 104.0 0.462 0.0 HOH
 3.630
 CA
 O
ARG B:76 B:735 115.0 0.511 H -66.0 -34.8 NA NA NA
7ont 1 P09874 99.43 0.0 X-RAY
 2021-09-15 ARG A:76 A:735 101.0 0.449 H -59.9 -36.2 101.0 0.449 0.0 HOH
 3.535
 CA
 O
ARG B:76 B:735 137.0 0.609 H -60.1 -44.6 NA NA NA
5ha9 1 P09874 100.0 0.0 X-RAY
 2016-03-09 ARG A:75 A:74 139.0 0.618 H -64.2 -32.6 139.0 0.618 0.0
ARG B:75 B:74 117.0 0.52 H -58.7 -41.6 117.0 0.52 0.0
4hhy 1 P09874 99.43 0.0 X-RAY
 2013-03-27 ARG A:79 A:74 84.0 0.373 H -70.2 -38.0 NA NA NA
ARG B:79 B:74 35.0 NA H -62.4 -44.2 NA NA NA
ARG C:79 C:74 113.0 0.502 H -70.4 -42.0 113.0 0.502 0.0 HOH
 7.965
 N
 O
ARG D:79 D:74 124.0 0.551 H -70.7 -29.3 NA NA NA
4hhz 1 P09874 99.43 0.0 X-RAY
 2013-03-27 ARG A:79 A:74 127.0 0.564 H -52.2 -43.6 NA NA NA
ARG B:79 B:74 108.0 0.48 H -75.2 -34.7 NA NA NA
ARG C:79 C:74 104.0 0.462 H -60.4 -26.3 104.0 0.462 0.0
ARG D:79 D:74 167.0 0.742 -94.4 74.9 NA NA NA
5xsr 1 P09874 99.43 0.0 X-RAY
 2018-04-25 ARG A:79 A:74 42.0 NA H -57.8 -36.1 42.0 NA NA HOH
 6.089
 N
 O
5xsu 1 P09874 99.43 0.0 X-RAY
 2018-04-25 ARG A:79 A:74 30.0 NA H -59.5 -42.6 30.0 NA NA HOH
 8.400
 O
 O
ARG B:79 B:74 35.0 NA H -63.6 -28.5 NA NA NA
ARG C:79 C:74 54.0 NA H -63.7 -26.3 NA NA NA
ARG D:79 D:74 49.0 NA -63.3 360.0 NA NA NA
1uk0 1 P09874 100.0 0.0 X-RAY
 2004-01-27 ARG A:74 A:74 114.0 0.507 H -65.0 -39.0 114.0 0.507 0.0 HOH
 3.185
 CG
 O
ARG B:74 B:74 103.0 0.458 H -87.3 -15.2 NA NA NA
1uk1 1 P09874 100.0 0.0 X-RAY
 2004-09-14 ARG A:74 A:735 104.0 0.462 H -42.8 -51.2 104.0 0.462 0.0 HOH
 3.406
 CG
 O
ARG B:74 B:735 114.0 0.507 H -74.4 -28.1 NA NA NA
1wok 1 P09874 100.0 0.0 X-RAY
 2005-03-15 ARG A:74 A:735 111.0 0.493 H -55.0 -30.1 111.0 0.493 0.0
ARG B:74 B:735 126.0 0.56 H -47.4 -62.8 126.0 0.56 0.0
ARG C:74 C:735 141.0 0.627 H -39.6 -43.7 141.0 0.627 0.0
ARG D:74 D:735 135.0 0.6 H -61.7 -44.5 135.0 0.6 0.0
2rcw 1 P09874 100.0 0.0 X-RAY
 2008-09-23 ARG A:74 A:74 133.0 0.591 H -62.1 -18.8 133.0 0.591 0.0 HOH
 3.806
 NH2
 O
6vkk 1 P09874 99.72 0.0 X-RAY
 2020-06-17 ARG A:96 A:735 118.0 0.524 H -64.3 -42.3 118.0 0.524 0.0
ARG B:96 D:735 106.0 0.471 H -64.1 -42.3 NA NA NA
ARG C:96 C:735 136.0 0.604 H -64.6 -41.9 NA NA NA
ARG D:96 B:735 131.0 0.582 H -64.4 -42.0 NA NA NA
6vko 1 P09874 99.72 0.0 X-RAY
 2020-06-17 ARG A:96 A:735 125.0 0.556 H -66.3 -14.0 125.0 0.556 0.0
ARG B:96 B:735 124.0 0.551 H -66.5 -13.8 NA NA NA
ARG C:96 C:735 120.0 0.533 H -66.5 -13.8 NA NA NA
ARG D:96 D:735 126.0 0.56 H -66.6 -13.9 NA NA NA
6vkq 1 P09874 99.72 0.0 X-RAY
 2020-06-17 ARG A:96 A:735 136.0 0.604 H -72.2 -16.5 136.0 0.604 0.0
ARG B:96 B:735 138.0 0.613 H -72.3 -16.4 NA NA NA
ARG C:96 C:735 135.0 0.6 H -72.0 -16.6 NA NA NA
ARG D:96 D:735 137.0 0.609 H -72.1 -16.7 NA NA NA
4gv7 1 P09874 99.43 0.0 X-RAY
 2013-06-19 ARG A:75 A:735 110.0 0.489 H -57.2 -46.5 110.0 0.489 0.0
ARG B:75 B:735 104.0 0.462 H -61.3 -45.3 NA NA NA
ARG C:75 C:735 123.0 0.547 H -41.7 -49.0 NA NA NA
ARG D:75 D:735 123.0 0.547 H -69.1 -40.9 NA NA NA
4r5w 1 P09874 99.43 0.0 X-RAY
 2015-09-02 ARG A:75 A:735 124.0 0.551 H -63.0 -45.1 124.0 0.551 0.0
ARG B:75 B:735 121.0 0.538 H -62.6 -44.4 NA NA NA
4r6e 1 P09874 99.43 0.0 X-RAY
 2015-09-09 ARG A:75 A:735 129.0 0.573 H -63.6 -38.3 129.0 0.573 0.0 HOH
 9.808
 NE
 O
ARG B:75 B:735 103.0 0.458 H -62.4 -39.6 NA NA NA
ARG C:75 C:735 102.0 0.453 H -64.0 -38.4 NA NA NA
ARG D:75 D:735 104.0 0.462 H -63.2 -38.9 NA NA NA
6ghk 1 P09874 99.43 0.0 X-RAY
 2019-05-22 ARG A:75 A:735 121.0 0.538 H -63.9 -39.2 121.0 0.538 0.0 HOH
 3.704
 NH2
 O
ARG B:75 B:735 122.0 0.542 H -61.7 -36.7 NA NA NA
4pjt 1 P09874 100.0 0.0 X-RAY
 2014-09-24 ARG A:94 A:735 36.0 NA H -63.6 -39.2 36.0 NA NA HOH
 8.216
 O
 O
ARG B:94 B:735 33.0 NA H -62.4 -40.2 NA NA NA
ARG C:94 C:735 148.0 0.658 H -61.9 -39.7 NA NA NA
ARG D:94 D:735 37.0 NA H -61.5 -40.0 NA NA NA
4rv6 1 P09874 99.71 0.0 X-RAY
 2015-12-09 ARG A:76 A:735 95.0 0.422 H -58.4 -38.9 95.0 0.422 0.0
ARG B:76 B:735 116.0 0.516 H -57.8 -38.7 NA NA NA
ARG C:76 C:735 93.0 0.413 H -57.3 -39.6 NA NA NA
ARG D:76 D:735 97.0 0.431 H -58.3 -39.7 NA NA NA
4uxb 1 P09874 99.71 0.0 X-RAY
 2015-09-02 ARG A:76 A:735 105.0 0.467 H -64.3 -25.2 105.0 0.467 0.0
ARG B:76 B:735 144.0 0.64 H -70.5 -32.4 NA NA NA
4l6s 1 P09874 99.71 0.0 X-RAY
 2013-08-07 ARG A:77 A:735 118.0 0.524 H -60.3 -37.4 118.0 0.524 0.0 HOH
 3.106
 NE
 O
ARG B:77 B:735 140.0 0.622 H -61.9 -41.2 NA NA NA
4und 1 P09874 99.71 0.0 X-RAY
 2015-06-17 ARG A:97 A:735 117.0 0.52 H -69.0 -40.7 117.0 0.52 0.0 HOH
 2.816
 O
 O
ARG B:97 B:735 127.0 0.564 H -63.9 -42.5 NA NA NA
5kpn 1 P09874 99.71 0.0 X-RAY
 2016-12-21 ARG A:76 A:735 119.0 0.529 H -63.3 -35.6 119.0 0.529 0.0
ARG B:76 B:735 129.0 0.573 H -55.5 -44.1 NA NA NA
5kpo 1 P09874 99.71 0.0 X-RAY
 2016-12-21 ARG A:76 A:735 128.0 0.569 H -63.8 -33.7 128.0 0.569 0.0
ARG B:76 B:735 126.0 0.56 H -58.9 -41.3 NA NA NA
5wrq 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ARG A:76 A:735 131.0 0.582 H -65.6 -30.4 131.0 0.582 0.0
ARG B:76 B:735 121.0 0.538 H -59.0 -41.2 NA NA NA
5wry 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ARG A:76 A:735 116.0 0.516 H -59.1 -40.6 116.0 0.516 0.0 HOH
 2.787
 NH1
 O
ARG B:76 B:735 129.0 0.573 H -61.4 -38.7 NA NA NA
5wrz 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ARG A:76 A:735 122.0 0.542 H -71.0 -33.3 122.0 0.542 0.0
ARG B:76 B:735 137.0 0.609 H -59.2 -38.8 NA NA NA
5ws0 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ARG A:76 A:735 120.0 0.533 H -67.5 -37.1 120.0 0.533 0.0
ARG B:76 B:735 122.0 0.542 H -49.2 -49.2 NA NA NA
5ws1 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ARG A:76 A:735 113.0 0.502 H -64.4 -37.6 113.0 0.502 0.0
ARG B:76 B:735 137.0 0.609 H -59.6 -41.7 NA NA NA
5wtc 1 P09874 99.71 0.0 X-RAY
 2017-01-25 ARG A:76 A:735 116.0 0.516 H -65.7 -30.8 116.0 0.516 0.0
ARG B:76 B:735 131.0 0.582 H -54.5 -42.5 NA NA NA
2rd6 1 P09874 99.71 0.0 X-RAY
 2008-09-23 ARG A:74 A:74 127.0 0.564 H -66.0 -40.3 127.0 0.564 0.0 HOH
 2.467
 NH1
 O
3gjw 1 P09874 99.71 0.0 X-RAY
 2010-03-09 ARG A:74 A:74 113.0 0.502 H -62.3 -44.8 113.0 0.502 0.0 HOH
 7.816
 NH1
 O
3gn7 1 P09874 99.71 0.0 X-RAY
 2010-03-16 ARG A:74 A:74 112.0 0.498 H -61.7 -35.7 112.0 0.498 0.0 HOH
 3.681
 NH2
 O
3l3l 1 P09874 99.71 0.0 X-RAY
 2010-12-22 ARG A:74 A:74 114.0 0.507 H -55.4 -46.0 114.0 0.507 0.0 HOH
 4.001
 CA
 O
3l3m 1 P09874 99.71 0.0 X-RAY
 2010-06-23 ARG A:74 A:74 123.0 0.547 H -63.0 -39.6 123.0 0.547 0.0 HOH
 3.855
 NH1
 O
5kpp 1 P09874 99.71 0.0 X-RAY
 2016-11-30 ARG A:74 A:735 126.0 0.56 H -60.8 -36.2 126.0 0.56 0.0 HOH
 7.806
 O
 O
ARG B:74 B:735 128.0 0.569 H -64.6 -37.7 NA NA NA
5kpq 1 P09874 99.71 0.0 X-RAY
 2016-12-14 ARG A:74 A:735 138.0 0.613 H -67.7 -31.7 138.0 0.613 0.0 HOH
 7.850
 O
 O
ARG B:74 B:735 130.0 0.578 H -64.5 -42.6 NA NA NA
7cmw 1 P09874 99.71 0.0 X-RAY
 2020-12-16 ARG A:78 A:735 138.0 0.613 H -63.5 -41.4 138.0 0.613 0.0
ARG B:78 B:735 116.0 0.516 H -62.4 -44.0 NA NA NA
5xst 1 P09874 99.43 0.0 X-RAY
 2018-04-25 ARG A:75 A:74 129.0 0.573 H -61.5 -37.4 129.0 0.573 0.0 HOH
 9.206
 NH1
 O
6i8m 1 P26446 86.7 0.0 X-RAY
 2019-05-01 ARG A:84 A:735 100.0 0.444 H -63.3 -38.1 100.0 0.444 0.0 HOH
 9.223
 NH1
 O
6i8t 1 P26446 86.7 0.0 X-RAY
 2019-05-01 ARG A:84 A:735 102.0 0.453 H -59.4 -41.9 102.0 0.453 0.0 HOH
 2.495
 O
 O
1a26 1 P26446 86.67 0.0 X-RAY
 1998-05-27 ARG A:82 A:735 105.0 0.467 H -63.2 -40.9 105.0 0.467 0.0 HOH
 2.743
 O
 O
1pax 1 P26446 86.67 0.0 X-RAY
 1997-05-15 ARG A:82 A:735 105.0 0.467 H -66.8 -38.9 105.0 0.467 0.0 HOH
 2.574
 NH2
 O
2paw 1 P26446 86.67 0.0 X-RAY
 1998-05-27 ARG A:82 A:735 102.0 0.453 H -66.4 -33.3 102.0 0.453 0.0 HOH
 3.004
 O
 O
2pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 ARG A:82 A:735 109.0 0.484 H -67.1 -37.6 109.0 0.484 0.0 HOH
 2.543
 NH2
 O
3pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 ARG A:82 A:735 109.0 0.484 H -67.4 -37.4 109.0 0.484 0.0 HOH
 2.586
 NH2
 O
4pax 1 P26446 86.67 0.0 X-RAY
 1998-05-27 ARG A:82 A:735 108.0 0.48 H -69.8 -37.4 108.0 0.48 0.0 HOH
 2.546
 NH2
 O
1efy 1 P26446 86.86 0.0 X-RAY
 2001-01-17 ARG A:74 A:735 96.0 0.427 H -69.8 -35.9 96.0 0.427 0.0 HOH
 6.255
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p09874-f1 1 P09874 100.0 0.0 ARG A:735 A:735 53.0 0.236 H -59.8 -48.5