Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 226555998 . A C CCDS1554.1:NM_001618.3:c.2179Tct>Gct_NP_001609.2:p.727S>A Homo sapiens poly(ADP-ribose) polymerase 1 (PARP1), mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4opx 2 P09874 100.0 0.0 X-RAY
2014-07-02 SER B:210 C:727 94.0 0.817 H -62.1 -46.1 43.0 0.374 0.443 A:P09874:0.443
ZN
9.208
OG
ZN
SER D:210 F:727 94.0 0.817 H -62.0 -46.0 NA NA NA
4oqa 2 P09874 100.0 0.0 X-RAY
2014-07-02 SER B:210 C:727 94.0 0.817 H -63.2 -45.2 51.0 0.443 0.374 A:P09874:0.374
ZN
9.446
OG
ZN
SER D:210 F:727 94.0 0.817 H -63.1 -45.2 NA NA NA
4oqb 2 P09874 100.0 0.0 X-RAY
2014-07-02 SER B:210 C:727 94.0 0.817 H -61.9 -45.7 45.0 0.391 0.426 A:P09874:0.426
ZN
9.224
OG
ZN
SER D:210 F:727 93.0 0.809 H -61.7 -45.7 NA NA NA
4dqy 3 P09874 99.8 0.0 X-RAY
2012-05-30 SER C:211 C:727 91.0 0.791 H -51.7 -67.4 46.0 0.4 0.391 B:P09874:0.391
ZN
9.681
OG
ZN
SER F:211 F:727 90.0 0.783 H -52.3 -66.9 NA NA NA
4zzz 1 P09874 100.0 0.0 X-RAY
2015-08-12 SER A:75 A:727 77.0 0.67 H -50.3 -45.2 77.0 0.67 0.0 HOH
3.684
N
O
SER B:75 B:727 84.0 0.73 H -77.9 -34.0 84.0 0.73 0.0 HOH
2.778
OG
O
5a00 1 P09874 100.0 0.0 X-RAY
2015-08-12 SER A:75 A:727 83.0 0.722 H -79.6 -27.7 83.0 0.722 0.0
4xhu 1 P09874 99.44 0.0 X-RAY
2015-09-30 SER A:72 C:727 84.0 0.73 H -84.7 -29.6 84.0 0.73 0.0
SER C:72 NA:NA DO NA DO DO DO NA NA NA
6xvw 1 P09874 100.0 0.0 X-RAY
2020-06-03 SER A:67 A:727 92.0 0.8 S -125.3 -24.6 92.0 0.8 0.0 HOH
6.275
O
O
SER B:67 B:727 77.0 0.67 S -86.6 -60.2 NA NA NA
7kk2 1 P09874 99.72 0.0 X-RAY
2021-01-06 SER A:68 A:727 81.0 0.704 H -71.3 -41.5 81.0 0.704 0.0 HOH
3.456
CB
O
SER B:68 B:727 94.0 0.817 H -70.1 -40.6 NA NA NA
7kk3 1 P09874 99.72 0.0 X-RAY
2021-01-06 SER A:68 A:727 95.0 0.826 H -57.0 -43.0 95.0 0.826 0.0
SER B:68 B:727 96.0 0.835 H -68.5 -44.5 NA NA NA
SER C:68 C:727 74.0 0.643 H -76.0 -50.6 NA NA NA
SER D:68 D:727 125.0 1.0 360.0 -51.4 NA NA NA
7kk4 1 P09874 99.72 0.0 X-RAY
2021-01-06 SER A:68 A:727 87.0 0.757 H -57.9 -43.5 87.0 0.757 0.0 HOH
6.220
C
O
SER B:68 B:727 85.0 0.739 H -78.7 -38.6 NA NA NA
7kk5 1 P09874 99.72 0.0 X-RAY
2021-01-06 SER A:68 A:727 92.0 0.8 H -72.3 -42.0 92.0 0.8 0.0
SER B:68 B:727 102.0 0.887 H -71.1 -32.2 NA NA NA
SER C:68 C:727 75.0 0.652 H -67.2 -40.1 NA NA NA
SER D:68 D:727 129.0 1.0 360.0 -49.1 NA NA NA
7kk6 1 P09874 99.72 0.0 X-RAY
2021-01-06 SER A:68 A:727 81.0 0.704 H -84.5 -35.8 81.0 0.704 0.0 HOH
6.732
N
O
SER B:68 B:727 95.0 0.826 H -69.7 -34.9 NA NA NA
7aaa 1 P09874 99.43 0.0 X-RAY
2021-01-13 SER A:68 A:727 95.0 0.826 H -63.5 -39.2 95.0 0.826 0.0 HOH
6.318
O
O
SER B:68 B:727 75.0 0.652 H -65.4 -35.6 NA NA NA
7aab 1 P09874 99.43 0.0 X-RAY
2021-01-13 SER A:68 A:727 81.0 0.704 H -63.1 -43.5 81.0 0.704 0.0 HOH
8.530
N
O
SER B:68 B:727 82.0 0.713 H -64.0 -37.2 NA NA NA
7aac 1 P09874 99.43 0.0 X-RAY
2021-01-13 SER A:68 A:727 93.0 0.809 H -63.4 -34.4 93.0 0.809 0.0 HOH
3.100
N
O
SER B:68 B:727 102.0 0.887 H -68.2 -35.6 NA NA NA
7aad 1 P09874 99.43 0.0 X-RAY
2021-01-13 SER A:68 A:727 91.0 0.791 H -81.7 -17.5 91.0 0.791 0.0
SER B:68 B:727 78.0 0.678 H -57.9 -44.3 NA NA NA
7onr 1 P09874 99.43 0.0 X-RAY
2021-09-15 SER A:68 A:727 90.0 0.783 H -69.0 -37.2 90.0 0.783 0.0 HOH
3.255
OG
O
SER B:68 B:727 90.0 0.783 H -66.1 -35.6 NA NA NA
7ons 1 P09874 99.43 0.0 X-RAY
2021-09-15 SER A:68 A:727 97.0 0.843 H -63.8 -41.6 97.0 0.843 0.0 HOH
7.355
N
O
SER B:68 B:727 91.0 0.791 H -61.8 -47.2 NA NA NA
7ont 1 P09874 99.43 0.0 X-RAY
2021-09-15 SER A:68 A:727 96.0 0.835 H -67.8 -35.4 96.0 0.835 0.0 HOH
3.866
N
O
SER B:68 B:727 88.0 0.765 H -66.5 -44.8 NA NA NA
5ha9 1 P09874 100.0 0.0 X-RAY
2016-03-09 SER A:67 A:66 79.0 0.687 H -60.5 -53.5 79.0 0.687 0.0
SER B:67 B:66 90.0 0.783 H -74.2 -29.7 90.0 0.783 0.0
4hhy 1 P09874 99.43 0.0 X-RAY
2013-03-27 SER A:71 A:66 92.0 0.8 T 45.0 -77.3 NA NA NA
SER B:71 B:66 84.0 0.73 H -73.8 -39.7 NA NA NA
SER C:71 C:66 89.0 0.774 -91.3 -151.6 89.0 0.774 0.0
SER D:71 D:66 59.0 0.513 T 39.5 -68.4 NA NA NA
4hhz 1 P09874 99.43 0.0 X-RAY
2013-03-27 SER A:71 A:66 81.0 0.704 S 57.9 -19.7 NA NA NA
SER B:71 B:66 95.0 0.826 S 58.5 -45.7 NA NA NA
SER C:71 C:66 75.0 0.652 S -137.8 -22.0 75.0 0.652 0.0
SER D:71 NA:NA DO NA DO DO DO NA NA NA
5xsr 1 P09874 99.43 0.0 X-RAY
2018-04-25 SER A:71 A:66 81.0 NA H -62.7 -31.3 81.0 NA NA HOH
5.471
C
O
5xsu 1 P09874 99.43 0.0 X-RAY
2018-04-25 SER A:71 A:66 75.0 NA H -69.3 -39.6 75.0 NA NA
SER B:71 B:66 91.0 NA H -59.3 -13.1 NA NA NA
SER C:71 NA:NA DO NA DO DO DO NA NA NA
SER D:71 D:66 82.0 NA -101.7 -29.5 NA NA NA
1uk0 1 P09874 100.0 0.0 X-RAY
2004-01-27 SER A:66 A:66 98.0 0.852 H -46.1 13.2 98.0 0.852 0.0 HOH
3.393
N
O
SER B:66 B:66 60.0 0.522 H -43.2 -76.7 NA NA NA
1uk1 1 P09874 100.0 0.0 X-RAY
2004-09-14 SER A:66 A:727 69.0 0.6 H -55.7 -28.1 69.0 0.6 0.0 HOH
6.607
OG
O
SER B:66 B:727 84.0 0.73 H -36.2 -66.3 NA NA NA
1wok 1 P09874 100.0 0.0 X-RAY
2005-03-15 SER A:66 A:727 64.0 0.557 H -50.5 -37.1 16.0 0.139 0.418 C:P09874:0.417
SER B:66 B:727 90.0 0.783 H -85.7 8.0 36.0 0.313 0.47 D:P09874:0.47
SER C:66 C:727 81.0 0.704 H -51.0 -46.5 46.0 0.4 0.304 A:P09874:0.304
SER D:66 D:727 68.0 0.591 H -56.2 -55.7 28.0 0.243 0.348 B:P09874:0.348
2rcw 1 P09874 100.0 0.0 X-RAY
2008-09-23 SER A:66 A:66 89.0 0.774 T 52.6 -86.3 89.0 0.774 0.0 HOH
3.174
OG
O
6vkk 1 P09874 99.72 0.0 X-RAY
2020-06-17 SER A:88 A:727 91.0 0.791 H -59.0 -51.4 91.0 0.791 0.0
SER B:88 D:727 94.0 0.817 H -58.6 -51.7 NA NA NA
SER C:88 C:727 81.0 0.704 H -59.2 -51.2 NA NA NA
SER D:88 B:727 67.0 0.583 H -58.8 -51.2 NA NA NA
6vko 1 P09874 99.72 0.0 X-RAY
2020-06-17 SER A:88 A:727 110.0 0.957 H -43.9 -40.9 110.0 0.957 0.0
SER B:88 B:727 112.0 0.974 H -43.8 -40.9 NA NA NA
SER C:88 C:727 113.0 0.983 H -43.7 -40.9 NA NA NA
SER D:88 D:727 112.0 0.974 H -43.7 -41.0 NA NA NA
6vkq 1 P09874 99.72 0.0 X-RAY
2020-06-17 SER A:88 A:727 112.0 0.974 T -64.6 -36.4 112.0 0.974 0.0
SER B:88 B:727 110.0 0.957 T -64.5 -36.4 NA NA NA
SER C:88 C:727 110.0 0.957 T -64.4 -36.4 NA NA NA
SER D:88 D:727 110.0 0.957 T -64.5 -36.4 NA NA NA
4gv7 1 P09874 99.43 0.0 X-RAY
2013-06-19 SER A:67 A:727 73.0 0.635 H -67.7 -46.8 73.0 0.635 0.0
SER B:67 B:727 74.0 0.643 H -54.0 -44.8 NA NA NA
SER C:67 C:727 83.0 0.722 H -68.7 -43.6 NA NA NA
SER D:67 D:727 86.0 0.748 H -54.4 -34.4 NA NA NA
4r5w 1 P09874 99.43 0.0 X-RAY
2015-09-02 SER A:67 A:727 83.0 0.722 H -65.2 -38.6 83.0 0.722 0.0
SER B:67 B:727 83.0 0.722 H -65.0 -38.6 NA NA NA
4r6e 1 P09874 99.43 0.0 X-RAY
2015-09-09 SER A:67 A:727 85.0 0.739 H -68.5 -39.2 85.0 0.739 0.0
SER B:67 B:727 92.0 0.8 H -67.6 -39.2 NA NA NA
SER C:67 C:727 90.0 0.783 H -67.0 -40.1 NA NA NA
SER D:67 D:727 90.0 0.783 H -67.5 -40.0 NA NA NA
6ghk 1 P09874 99.43 0.0 X-RAY
2019-05-22 SER A:67 A:727 85.0 0.739 H -67.4 -44.0 85.0 0.739 0.0
SER B:67 B:727 87.0 0.757 H -66.7 -46.1 NA NA NA
4pjt 1 P09874 100.0 0.0 X-RAY
2014-09-24 SER A:86 A:727 107.0 0.93 H -71.6 -47.9 107.0 0.93 0.0
SER B:86 B:727 87.0 NA H -61.0 -39.4 NA NA NA
SER C:86 C:727 90.0 0.783 H -65.7 -41.0 NA NA NA
SER D:86 NA:NA DO NA DO DO DO NA NA NA
4rv6 1 P09874 99.71 0.0 X-RAY
2015-12-09 SER A:68 A:727 88.0 0.765 H -58.8 -42.0 88.0 0.765 0.0
SER B:68 B:727 76.0 0.661 H -59.4 -41.5 NA NA NA
SER C:68 C:727 93.0 0.809 H -59.5 -42.2 NA NA NA
SER D:68 D:727 94.0 0.817 H -59.8 -41.5 NA NA NA
4uxb 1 P09874 99.71 0.0 X-RAY
2015-09-02 SER A:68 A:727 79.0 0.687 T -63.0 -28.2 79.0 0.687 0.0
SER B:68 B:727 75.0 0.652 H -64.1 -38.1 NA NA NA
4l6s 1 P09874 99.71 0.0 X-RAY
2013-08-07 SER A:69 A:727 91.0 0.791 H -52.8 -73.9 91.0 0.791 0.0
SER B:69 B:727 100.0 0.87 H -65.3 -40.9 NA NA NA
4und 1 P09874 99.71 0.0 X-RAY
2015-06-17 SER A:89 A:727 81.0 0.704 H -58.9 -50.9 81.0 0.704 0.0 HOH
6.225
O
O
SER B:89 B:727 79.0 0.687 H -60.0 -48.7 NA NA NA
5kpn 1 P09874 99.71 0.0 X-RAY
2016-12-21 SER A:68 A:727 99.0 0.861 H -60.6 -66.5 99.0 0.861 0.0
SER B:68 B:727 86.0 0.748 H -72.2 -60.5 NA NA NA
5kpo 1 P09874 99.71 0.0 X-RAY
2016-12-21 SER A:68 A:727 92.0 0.8 H -71.1 -53.2 92.0 0.8 0.0
SER B:68 B:727 92.0 0.8 H -57.3 -52.8 NA NA NA
5wrq 1 P09874 99.71 0.0 X-RAY
2017-01-25 SER A:68 A:727 93.0 0.809 H -69.0 -51.5 93.0 0.809 0.0
SER B:68 B:727 92.0 0.8 H -60.3 -54.1 NA NA NA
5wry 1 P09874 99.71 0.0 X-RAY
2017-01-25 SER A:68 A:727 96.0 0.835 H -59.5 -58.5 96.0 0.835 0.0 HOH
2.714
OG
O
SER B:68 B:727 105.0 0.913 H -57.8 -46.4 NA NA NA
5wrz 1 P09874 99.71 0.0 X-RAY
2017-01-25 SER A:68 A:727 92.0 0.8 H -74.2 -59.3 92.0 0.8 0.0
SER B:68 B:727 100.0 0.87 H -67.7 -54.7 NA NA NA
5ws0 1 P09874 99.71 0.0 X-RAY
2017-01-25 SER A:68 A:727 93.0 0.809 S -95.3 -41.1 93.0 0.809 0.0
SER B:68 B:727 102.0 0.887 H -72.4 -54.2 NA NA NA
5ws1 1 P09874 99.71 0.0 X-RAY
2017-01-25 SER A:68 A:727 100.0 0.87 H -57.7 -50.9 100.0 0.87 0.0
SER B:68 B:727 95.0 0.826 H -62.8 -44.2 NA NA NA
5wtc 1 P09874 99.71 0.0 X-RAY
2017-01-25 SER A:68 A:727 95.0 0.826 H -69.8 -52.8 95.0 0.826 0.0
SER B:68 B:727 88.0 0.765 H -77.1 -60.8 NA NA NA
2rd6 1 P09874 99.71 0.0 X-RAY
2008-09-23 SER A:66 A:66 96.0 0.835 S 64.9 -56.6 96.0 0.835 0.0 HOH
3.689
CB
O
3gjw 1 P09874 99.71 0.0 X-RAY
2010-03-09 SER A:66 A:66 86.0 0.748 T -7.6 -38.9 86.0 0.748 0.0 HOH
2.726
OG
O
3gn7 1 P09874 99.71 0.0 X-RAY
2010-03-16 SER A:66 A:66 85.0 0.739 S -81.6 -33.3 85.0 0.739 0.0 HOH
2.806
CB
O
3l3l 1 P09874 99.71 0.0 X-RAY
2010-12-22 SER A:66 A:66 84.0 0.73 S 64.1 -52.7 84.0 0.73 0.0 HOH
2.777
O
O
3l3m 1 P09874 99.71 0.0 X-RAY
2010-06-23 SER A:66 A:66 92.0 0.8 S 63.6 -47.9 92.0 0.8 0.0 HOH
4.311
O
O
5kpp 1 P09874 99.71 0.0 X-RAY
2016-11-30 SER A:66 A:727 100.0 0.87 H -67.1 -50.3 100.0 0.87 0.0
SER B:66 B:727 94.0 0.817 H -65.4 -51.7 NA NA NA
5kpq 1 P09874 99.71 0.0 X-RAY
2016-12-14 SER A:66 A:727 99.0 0.861 H -74.3 -50.3 99.0 0.861 0.0 HOH
2.662
OG
O
SER B:66 B:727 99.0 0.861 H -50.5 -44.4 NA NA NA
7cmw 1 P09874 99.71 0.0 X-RAY
2020-12-16 SER A:70 A:727 87.0 0.757 H -37.3 -55.7 87.0 0.757 0.0
SER B:70 B:727 92.0 0.8 H -46.5 -62.8 NA NA NA
5xst 1 P09874 99.43 0.0 X-RAY
2018-04-25 SER A:67 A:66 97.0 0.843 H -88.8 -30.1 97.0 0.843 0.0
6i8m 1 P26446 86.7 0.0 X-RAY
2019-05-01 SER A:76 A:727 84.0 0.73 H -77.6 -29.1 84.0 0.73 0.0 HOH
5.022
N
O
6i8t 1 P26446 86.7 0.0 X-RAY
2019-05-01 SER A:76 A:727 82.0 0.713 H -82.5 -33.7 82.0 0.713 0.0 HOH
2.925
CB
O
1a26 1 P26446 86.67 0.0 X-RAY
1998-05-27 SER A:74 A:727 88.0 0.765 H -58.8 -46.0 88.0 0.765 0.0 HOH
2.779
OG
O
1pax 1 P26446 86.67 0.0 X-RAY
1997-05-15 SER A:74 A:727 86.0 0.748 H -64.6 -37.4 86.0 0.748 0.0 HOH
3.158
N
O
2paw 1 P26446 86.67 0.0 X-RAY
1998-05-27 SER A:74 A:727 82.0 0.713 H -66.2 -32.8 82.0 0.713 0.0 HOH
2.751
N
O
2pax 1 P26446 86.67 0.0 X-RAY
1998-05-27 SER A:74 A:727 84.0 0.73 H -67.6 -33.4 84.0 0.73 0.0 HOH
2.888
N
O
3pax 1 P26446 86.67 0.0 X-RAY
1998-05-27 SER A:74 A:727 84.0 0.73 H -66.4 -33.4 84.0 0.73 0.0 HOH
3.118
N
O
4pax 1 P26446 86.67 0.0 X-RAY
1998-05-27 SER A:74 A:727 84.0 0.73 H -66.7 -34.4 84.0 0.73 0.0
1efy 1 P26446 86.86 0.0 X-RAY
2001-01-17 SER A:66 A:727 81.0 0.704 H -76.5 -26.7 81.0 0.704 0.0 HOH
5.722
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p09874-f1 1 P09874 100.0 0.0 SER A:727 A:727 12.0 0.104 H -59.9 -42.9