Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 226558167 . C A CCDS1554.1:NM_001618.3:c.2122Gcc>Tcc_NP_001609.2:p.708A>S Homo sapiens poly(ADP-ribose) polymerase 1 (PARP1), mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4opx 2 P09874 100.0 0.0 X-RAY
2014-07-02 ALA B:191 C:708 33.0 0.287 H -70.9 -35.9 33.0 0.287 0.0
ALA D:191 F:708 33.0 0.287 H -71.0 -35.7 NA NA NA
4oqa 2 P09874 100.0 0.0 X-RAY
2014-07-02 ALA B:191 C:708 34.0 0.296 H -71.0 -36.0 34.0 0.296 0.0
ALA D:191 F:708 33.0 0.287 H -71.1 -35.9 NA NA NA
4oqb 2 P09874 100.0 0.0 X-RAY
2014-07-02 ALA B:191 C:708 34.0 0.296 H -70.1 -35.9 34.0 0.296 0.0
ALA D:191 F:708 34.0 0.296 H -70.2 -35.9 NA NA NA
4dqy 3 P09874 99.8 0.0 X-RAY
2012-05-30 ALA C:192 C:708 31.0 0.27 H -69.6 -45.1 31.0 0.27 0.0
ALA F:192 F:708 30.0 0.261 H -70.0 -44.9 NA NA NA
4zzz 1 P09874 100.0 0.0 X-RAY
2015-08-12 ALA A:56 A:708 40.0 0.348 H -62.9 -37.4 40.0 0.348 0.0 HOH
9.839
O
O
ALA B:56 B:708 42.0 0.365 H -60.6 -42.6 42.0 0.365 0.0 HOH
2.906
O
O
5a00 1 P09874 100.0 0.0 X-RAY
2015-08-12 ALA A:56 A:708 42.0 0.365 H -68.6 -28.8 42.0 0.365 0.0
4xhu 1 P09874 99.44 0.0 X-RAY
2015-09-30 ALA A:53 C:708 40.0 0.348 H -69.4 -31.0 40.0 0.348 0.0 HOH
2.703
O
O
ALA C:53 A:708 35.0 0.304 H -64.9 -31.7 NA NA NA
6xvw 1 P09874 100.0 0.0 X-RAY
2020-06-03 ALA A:48 A:708 40.0 0.348 H -71.4 -33.1 40.0 0.348 0.0 EDO
HOH
7.954
2.781
O
O
C1
O
ALA B:48 B:708 28.0 0.243 H -83.0 -34.0 NA NA NA
7kk2 1 P09874 99.72 0.0 X-RAY
2021-01-06 ALA A:49 A:708 39.0 0.339 H -63.5 -39.3 39.0 0.339 0.0 HOH
3.770
N
O
ALA B:49 B:708 40.0 0.348 H -65.9 -39.4 NA NA NA
7kk3 1 P09874 99.72 0.0 X-RAY
2021-01-06 ALA A:49 A:708 40.0 0.348 H -72.6 -29.4 40.0 0.348 0.0
ALA B:49 B:708 39.0 0.339 H -57.2 -38.2 NA NA NA
ALA C:49 C:708 36.0 0.313 H -62.5 -38.4 NA NA NA
ALA D:49 D:708 40.0 0.348 H -69.2 -36.4 NA NA NA
7kk4 1 P09874 99.72 0.0 X-RAY
2021-01-06 ALA A:49 A:708 42.0 0.365 H -72.6 -31.7 42.0 0.365 0.0 HOH
7.154
O
O
ALA B:49 B:708 42.0 0.365 H -69.8 -25.5 NA NA NA
7kk5 1 P09874 99.72 0.0 X-RAY
2021-01-06 ALA A:49 A:708 40.0 0.348 H -67.3 -33.7 40.0 0.348 0.0 HOH
7.109
N
O
ALA B:49 B:708 41.0 0.357 H -61.5 -37.3 NA NA NA
ALA C:49 C:708 38.0 0.33 H -64.2 -35.0 NA NA NA
ALA D:49 D:708 38.0 0.33 H -69.0 -32.9 NA NA NA
7kk6 1 P09874 99.72 0.0 X-RAY
2021-01-06 ALA A:49 A:708 32.0 0.278 H -65.6 -34.7 32.0 0.278 0.0 HOH
7.905
O
O
ALA B:49 B:708 40.0 0.348 H -74.0 -37.6 NA NA NA
7aaa 1 P09874 99.43 0.0 X-RAY
2021-01-13 ALA A:49 A:708 37.0 0.322 H -64.6 -40.3 37.0 0.322 0.0 HOH
3.614
N
O
ALA B:49 B:708 36.0 0.313 H -63.7 -42.4 NA NA NA
7aab 1 P09874 99.43 0.0 X-RAY
2021-01-13 ALA A:49 A:708 33.0 0.287 H -75.7 -30.8 33.0 0.287 0.0
ALA B:49 B:708 34.0 0.296 H -75.5 -28.5 NA NA NA
7aac 1 P09874 99.43 0.0 X-RAY
2021-01-13 ALA A:49 A:708 38.0 0.33 H -65.9 -37.3 38.0 0.33 0.0 HOH
6.994
N
O
ALA B:49 B:708 37.0 0.322 H -66.1 -36.7 NA NA NA
7aad 1 P09874 99.43 0.0 X-RAY
2021-01-13 ALA A:49 A:708 38.0 0.33 H -65.1 -38.6 38.0 0.33 0.0
ALA B:49 B:708 37.0 0.322 H -71.0 -39.9 NA NA NA
7onr 1 P09874 99.43 0.0 X-RAY
2021-09-15 ALA A:49 A:708 40.0 0.348 H -65.8 -37.0 40.0 0.348 0.0 HOH
9.145
CB
O
ALA B:49 B:708 39.0 0.339 H -65.6 -36.6 NA NA NA
7ons 1 P09874 99.43 0.0 X-RAY
2021-09-15 ALA A:49 A:708 36.0 0.313 H -63.5 -35.8 36.0 0.313 0.0 HOH
2.854
O
O
ALA B:49 B:708 40.0 0.348 H -67.7 -40.1 NA NA NA
7ont 1 P09874 99.43 0.0 X-RAY
2021-09-15 ALA A:49 A:708 39.0 0.339 H -69.0 -37.9 39.0 0.339 0.0 HOH
3.769
N
O
ALA B:49 B:708 40.0 0.348 H -69.4 -37.0 NA NA NA
5ha9 1 P09874 100.0 0.0 X-RAY
2016-03-09 ALA A:48 A:47 41.0 0.357 H -67.1 -44.6 41.0 0.357 0.0
ALA B:48 B:47 37.0 0.322 H -66.0 -39.9 37.0 0.322 0.0
4hhy 1 P09874 99.43 0.0 X-RAY
2013-03-27 ALA A:52 A:47 38.0 0.33 H -64.8 -39.1 NA NA NA
ALA B:52 B:47 41.0 0.357 H -62.2 -34.5 NA NA NA
ALA C:52 C:47 51.0 0.443 H -68.0 -33.7 51.0 0.443 0.0
ALA D:52 D:47 37.0 0.322 H -65.7 -46.2 NA NA NA
4hhz 1 P09874 99.43 0.0 X-RAY
2013-03-27 ALA A:52 A:47 40.0 0.348 H -55.8 -43.8 NA NA NA
ALA B:52 B:47 40.0 0.348 H -63.6 -37.5 NA NA NA
ALA C:52 C:47 39.0 0.339 H -66.2 -40.5 39.0 0.339 0.0 15S
9.885
N
FAE
ALA D:52 D:47 44.0 0.383 62.0 8.6 NA NA NA
5xsr 1 P09874 99.43 0.0 X-RAY
2018-04-25 ALA A:52 A:47 45.0 0.391 H -62.3 -37.7 45.0 0.391 0.0 HOH
5.938
N
O
5xsu 1 P09874 99.43 0.0 X-RAY
2018-04-25 ALA A:52 A:47 41.0 0.357 H -65.4 -35.7 41.0 0.357 0.0 SO4
HOH
9.167
8.697
N
CB
O4
O
ALA B:52 B:47 39.0 0.339 H -64.9 -41.0 NA NA NA
ALA C:52 C:47 55.0 0.478 H -67.3 -42.7 NA NA NA
ALA D:52 D:47 56.0 0.487 H -69.0 -44.3 NA NA NA
1uk0 1 P09874 100.0 0.0 X-RAY
2004-01-27 ALA A:47 A:47 39.0 0.339 H -48.4 -41.2 39.0 0.339 0.0 HOH
4.300
CA
O
ALA B:47 B:47 41.0 0.357 H -50.5 -72.7 NA NA NA
1uk1 1 P09874 100.0 0.0 X-RAY
2004-09-14 ALA A:47 A:708 47.0 0.409 H -54.8 -35.2 47.0 0.409 0.0 HOH
3.884
O
O
ALA B:47 B:708 41.0 0.357 H -42.1 -51.2 NA NA NA
1wok 1 P09874 100.0 0.0 X-RAY
2005-03-15 ALA A:47 A:708 49.0 0.426 H -56.2 -34.5 49.0 0.426 0.0
ALA B:47 B:708 46.0 0.4 H -74.6 -43.5 46.0 0.4 0.0
ALA C:47 C:708 44.0 0.383 H -59.9 -27.6 44.0 0.383 0.0
ALA D:47 D:708 47.0 0.409 H -66.8 -31.5 47.0 0.409 0.0
2rcw 1 P09874 100.0 0.0 X-RAY
2008-09-23 ALA A:47 A:47 44.0 0.383 H -56.1 -30.2 44.0 0.383 0.0 HOH
4.276
N
O
6vkk 1 P09874 99.72 0.0 X-RAY
2020-06-17 ALA A:69 A:708 38.0 0.33 H -61.7 -37.0 38.0 0.33 0.0
ALA B:69 D:708 39.0 0.339 H -61.6 -37.1 NA NA NA
ALA C:69 C:708 40.0 0.348 H -62.1 -36.2 NA NA NA
ALA D:69 B:708 38.0 0.33 H -61.4 -36.4 NA NA NA
6vko 1 P09874 99.72 0.0 X-RAY
2020-06-17 ALA A:69 A:708 30.0 0.261 H -77.9 -22.6 30.0 0.261 0.0
ALA B:69 B:708 32.0 0.278 H -78.1 -22.4 NA NA NA
ALA C:69 C:708 31.0 0.27 H -78.1 -22.4 NA NA NA
ALA D:69 D:708 31.0 0.27 H -78.3 -22.3 NA NA NA
6vkq 1 P09874 99.72 0.0 X-RAY
2020-06-17 ALA A:69 A:708 25.0 0.217 H -63.4 -40.8 25.0 0.217 0.0
ALA B:69 B:708 25.0 0.217 H -63.6 -40.8 NA NA NA
ALA C:69 C:708 26.0 0.226 H -63.6 -40.8 NA NA NA
ALA D:69 D:708 24.0 0.209 H -63.6 -40.8 NA NA NA
4gv7 1 P09874 99.43 0.0 X-RAY
2013-06-19 ALA A:48 A:708 34.0 0.296 H -67.6 -38.5 34.0 0.296 0.0
ALA B:48 B:708 40.0 0.348 H -67.2 -33.2 NA NA NA
ALA C:48 C:708 46.0 0.4 H -64.7 -34.2 NA NA NA
ALA D:48 D:708 40.0 0.348 H -67.2 -52.5 NA NA NA
4r5w 1 P09874 99.43 0.0 X-RAY
2015-09-02 ALA A:48 A:708 37.0 0.322 H -65.8 -36.8 37.0 0.322 0.0 SO4
8.768
N
O3
ALA B:48 B:708 37.0 0.322 H -66.0 -37.4 NA NA NA
4r6e 1 P09874 99.43 0.0 X-RAY
2015-09-09 ALA A:48 A:708 41.0 0.357 H -69.2 -32.1 41.0 0.357 0.0 HOH
6.059
N
O
ALA B:48 B:708 40.0 0.348 H -68.2 -32.5 NA NA NA
ALA C:48 C:708 41.0 0.357 H -69.1 -32.0 NA NA NA
ALA D:48 D:708 41.0 0.357 H -68.6 -32.4 NA NA NA
6ghk 1 P09874 99.43 0.0 X-RAY
2019-05-22 ALA A:48 A:708 41.0 0.357 H -61.7 -35.4 41.0 0.357 0.0 SO4
HOH
8.597
2.758
N
O
O4
O
ALA B:48 B:708 42.0 0.365 H -61.9 -34.9 NA NA NA
4pjt 1 P09874 100.0 0.0 X-RAY
2014-09-24 ALA A:67 A:708 39.0 0.339 H -67.9 -34.3 39.0 0.339 0.0 HOH
9.858
O
O
ALA B:67 B:708 38.0 0.33 H -68.2 -35.2 NA NA NA
ALA C:67 C:708 35.0 0.304 H -67.0 -36.3 NA NA NA
ALA D:67 D:708 40.0 0.348 H -68.1 -34.7 NA NA NA
4rv6 1 P09874 99.71 0.0 X-RAY
2015-12-09 ALA A:49 A:708 39.0 0.339 H -59.0 -43.0 39.0 0.339 0.0 SO4
8.884
N
O2
ALA B:49 B:708 40.0 0.348 H -58.3 -43.0 NA NA NA
ALA C:49 C:708 39.0 0.339 H -58.9 -43.4 NA NA NA
ALA D:49 D:708 37.0 0.322 H -58.2 -43.0 NA NA NA
4uxb 1 P09874 99.71 0.0 X-RAY
2015-09-02 ALA A:49 A:708 22.0 0.191 H -70.5 -39.8 22.0 0.191 0.0
ALA B:49 B:708 34.0 0.296 H -70.2 -39.8 NA NA NA
4l6s 1 P09874 99.71 0.0 X-RAY
2013-08-07 ALA A:50 A:708 32.0 0.278 H -53.6 -41.4 32.0 0.278 0.0 HOH
4.213
O
O
ALA B:50 B:708 38.0 0.33 H -62.9 -49.8 NA NA NA
4und 1 P09874 99.71 0.0 X-RAY
2015-06-17 ALA A:70 A:708 39.0 0.339 H -62.4 -36.5 39.0 0.339 0.0 HOH
2.754
O
O
ALA B:70 B:708 31.0 0.27 H -63.7 -34.6 NA NA NA
5kpn 1 P09874 99.71 0.0 X-RAY
2016-12-21 ALA A:49 A:708 35.0 0.304 H -60.7 -39.0 35.0 0.304 0.0
ALA B:49 B:708 33.0 0.287 H -62.1 -43.9 NA NA NA
5kpo 1 P09874 99.71 0.0 X-RAY
2016-12-21 ALA A:49 A:708 32.0 0.278 H -60.4 -41.2 32.0 0.278 0.0
ALA B:49 B:708 29.0 0.252 H -61.5 -42.3 NA NA NA
5wrq 1 P09874 99.71 0.0 X-RAY
2017-01-25 ALA A:49 A:708 32.0 0.278 H -60.1 -43.1 32.0 0.278 0.0
ALA B:49 B:708 30.0 0.261 H -63.3 -42.1 NA NA NA
5wry 1 P09874 99.71 0.0 X-RAY
2017-01-25 ALA A:49 A:708 32.0 0.278 H -63.8 -42.6 32.0 0.278 0.0 HOH
3.518
CA
O
ALA B:49 B:708 39.0 0.339 H -63.7 -39.2 NA NA NA
5wrz 1 P09874 99.71 0.0 X-RAY
2017-01-25 ALA A:49 A:708 36.0 0.313 H -64.3 -36.9 36.0 0.313 0.0
ALA B:49 B:708 36.0 0.313 H -63.1 -41.1 NA NA NA
5ws0 1 P09874 99.71 0.0 X-RAY
2017-01-25 ALA A:49 A:708 32.0 0.278 H -64.4 -47.1 32.0 0.278 0.0
ALA B:49 B:708 36.0 0.313 H -67.7 -40.6 NA NA NA
5ws1 1 P09874 99.71 0.0 X-RAY
2017-01-25 ALA A:49 A:708 34.0 0.296 H -60.9 -38.3 34.0 0.296 0.0
ALA B:49 B:708 39.0 0.339 H -56.8 -45.3 NA NA NA
5wtc 1 P09874 99.71 0.0 X-RAY
2017-01-25 ALA A:49 A:708 35.0 0.304 H -70.7 -33.5 35.0 0.304 0.0
ALA B:49 B:708 36.0 0.313 H -62.0 -41.8 NA NA NA
2rd6 1 P09874 99.71 0.0 X-RAY
2008-09-23 ALA A:47 A:47 41.0 0.357 H -59.5 -46.0 41.0 0.357 0.0 HOH
4.118
N
O
3gjw 1 P09874 99.71 0.0 X-RAY
2010-03-09 ALA A:47 A:47 37.0 0.322 H -66.6 -33.5 37.0 0.322 0.0 HOH
3.575
N
O
3gn7 1 P09874 99.71 0.0 X-RAY
2010-03-16 ALA A:47 A:47 43.0 0.374 H -56.7 -47.1 43.0 0.374 0.0 HOH
3.154
O
O
3l3l 1 P09874 99.71 0.0 X-RAY
2010-12-22 ALA A:47 A:47 42.0 0.365 H -53.7 -42.8 42.0 0.365 0.0 HOH
3.683
N
O
3l3m 1 P09874 99.71 0.0 X-RAY
2010-06-23 ALA A:47 A:47 42.0 0.365 H -59.3 -38.0 42.0 0.365 0.0 HOH
3.768
N
O
5kpp 1 P09874 99.71 0.0 X-RAY
2016-11-30 ALA A:47 A:708 32.0 0.278 H -65.0 -38.9 32.0 0.278 0.0 HOH
7.089
O
O
ALA B:47 B:708 31.0 0.27 H -68.6 -43.6 NA NA NA
5kpq 1 P09874 99.71 0.0 X-RAY
2016-12-14 ALA A:47 A:708 36.0 0.313 H -64.5 -39.5 36.0 0.313 0.0 HOH
7.094
O
O
ALA B:47 B:708 36.0 0.313 H -61.7 -42.8 NA NA NA
7cmw 1 P09874 99.71 0.0 X-RAY
2020-12-16 ALA A:51 A:708 41.0 0.357 H -64.1 -38.4 41.0 0.357 0.0 HOH
6.084
CA
O
ALA B:51 B:708 36.0 0.313 H -63.4 -39.4 NA NA NA
5xst 1 P09874 99.43 0.0 X-RAY
2018-04-25 ALA A:48 A:47 42.0 0.365 H -66.0 -36.2 42.0 0.365 0.0 HOH
3.694
CA
O
6i8m 1 P26446 86.7 0.0 X-RAY
2019-05-01 SER A:57 A:708 54.0 0.47 H -61.8 -40.7 54.0 0.47 0.0
6i8t 1 P26446 86.7 0.0 X-RAY
2019-05-01 SER A:57 A:708 51.0 0.443 H -63.1 -40.9 51.0 0.443 0.0 HOH
6.105
N
O
1a26 1 P26446 86.67 0.0 X-RAY
1998-05-27 SER A:55 A:708 61.0 0.53 H -58.9 -42.6 61.0 0.53 0.0 HOH
7.324
CB
O
1pax 1 P26446 86.67 0.0 X-RAY
1997-05-15 SER A:55 A:708 57.0 0.496 H -58.7 -38.4 57.0 0.496 0.0 HOH
8.436
O
O
2paw 1 P26446 86.67 0.0 X-RAY
1998-05-27 SER A:55 A:708 61.0 0.53 H -62.9 -39.9 61.0 0.53 0.0 HOH
7.495
CB
O
2pax 1 P26446 86.67 0.0 X-RAY
1998-05-27 SER A:55 A:708 59.0 0.513 H -59.0 -38.7 59.0 0.513 0.0 HOH
8.389
O
O
3pax 1 P26446 86.67 0.0 X-RAY
1998-05-27 SER A:55 A:708 58.0 0.504 H -55.0 -43.0 58.0 0.504 0.0 HOH
8.245
O
O
4pax 1 P26446 86.67 0.0 X-RAY
1998-05-27 SER A:55 A:708 55.0 0.478 H -60.6 -41.5 55.0 0.478 0.0 HOH
8.388
O
O
1efy 1 P26446 86.86 0.0 X-RAY
2001-01-17 SER A:47 A:708 47.0 0.409 H -69.9 -35.9 47.0 0.409 0.0 HOH
8.558
CB
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p09874-f1 1 P09874 100.0 0.0 ALA A:708 A:708 43.0 0.374 H -65.4 -36.7