Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55512254 | . | G | A | CCDS603.1:NM_174936.3:c.458aGc>aAc_NP_777596.2:p.153S>N | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | SER | A:153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| SER | B:153 | A:153 | 171.0 | 1.0 | 360.0 | -32.4 | NA | NA | NA | ||||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | SER | A:153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | SER | A:153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | SER | A:153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | SER | A:123 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| SER | B:123 | B:153 | 169.0 | 1.0 | 360.0 | -56.0 | NA | NA | NA | ||||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | SER | A:123 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| SER | B:123 | B:153 | 173.0 | 1.0 | 360.0 | -171.3 | 173.0 | 1.0 | 0.0 |
HOH |
6.886 |
OG |
O |
||||||||||
| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | SER | A:123 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| SER | B:123 | B:153 | 170.0 | 1.0 | 360.0 | -24.7 | 170.0 | 1.0 | 0.0 |
HOH |
5.975 |
N |
O |
||||||||||
| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | SER | A:123 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| SER | B:123 | B:153 | 164.0 | 1.0 | 360.0 | -145.3 | 96.0 | 0.835 | 0.165 |
D:None:0.591 |
|||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | SER | A:123 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| SER | B:123 | B:153 | 169.0 | 1.0 | 360.0 | -145.2 | 99.0 | 0.861 | 0.139 |
D:None:0.609 |
HOH |
8.648 |
O |
O |
|||||||||
| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | SER | A:123 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| SER | B:123 | B:153 | 170.0 | 1.0 | 360.0 | -57.9 | 170.0 | 1.0 | 0.0 |
HOH |
4.236 |
O |
O |
||||||||||
| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | SER | B:1 | B:153 | 168.0 | 1.0 | 360.0 | -28.2 | 168.0 | 1.0 | 0.0 |
HOH |
2.748 |
OG |
O |
|||
| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | SER | B:1 | A:153 | 155.0 | 1.0 | 360.0 | 111.2 | 124.0 | 1.0 | 0.0 |
C:Q59FQ1:0.27 |
||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | SER | B:1 | A:153 | 154.0 | 1.0 | 360.0 | 111.3 | 124.0 | 1.0 | 0.0 |
C:Q59FQ1:0.261 |
||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | SER | B:1 | A:153 | 179.0 | 1.0 | 360.0 | -87.2 | 108.0 | 0.939 | 0.061 |
C:P01130:0.617 |
HOH |
5.093 |
N |
O |
||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | SER | B:1 | A:153 | 180.0 | 1.0 | 360.0 | -41.1 | 120.0 | 1.0 | 0.0 |
C:P01130:0.522 |
||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | SER | B:1 | A:153 | 180.0 | 1.0 | 360.0 | -49.8 | 119.0 | 1.0 | 0.0 |
C:P01130:0.53 |
||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | SER | A:1 | A:153 | 166.0 | 1.0 | 360.0 | 85.6 | 56.0 | 0.487 | 0.513 |
B:None:0.235 C:None:0.87 |
HOH |
7.582 |
O |
O |
||
| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | SER | A:1 | A:153 | 170.0 | 1.0 | 360.0 | -33.3 | 170.0 | 1.0 | 0.0 | |||||||
| SER | B:1 | B:153 | 167.0 | 1.0 | 360.0 | -34.0 | NA | NA | NA | ||||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | SER | B:1 | B:153 | 175.0 | 1.0 | 360.0 | -29.7 | 175.0 | 1.0 | 0.0 |
HOH |
3.337 |
CB |
O |
|||
| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | SER | B:1 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | SER | B:1 | B:153 | 167.0 | 1.0 | 360.0 | -32.7 | 167.0 | 1.0 | 0.0 |
HOH |
2.348 |
OG |
O |
|||
| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | SER | B:1 | B:153 | 174.0 | 1.0 | 360.0 | 27.6 | 174.0 | 1.0 | 0.0 | |||||||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | SER | B:1 | B:153 | 168.0 | 1.0 | 360.0 | -84.5 | 168.0 | 1.0 | 0.0 |
HOH |
5.684 |
O |
O |
|||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | SER | B:1 | B:153 | 166.0 | 1.0 | 360.0 | -32.7 | 95.0 | 0.826 | 0.174 |
C:P01130:0.617 |
||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | SER | B:1 | B:153 | 166.0 | 1.0 | 360.0 | -12.9 | 166.0 | 1.0 | 0.0 |
HOH |
5.852 |
O |
O |
|||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | SER | B:1 | B:153 | 176.0 | 1.0 | 360.0 | 8.6 | 176.0 | 1.0 | 0.0 |
HOH |
6.837 |
O |
O |
|||
| 5vla | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | SER | A:153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 5vlh | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | SER | A:153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 5vlk | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | SER | A:153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 5vll | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | SER | A:153 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 4nmx | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2013-12-04 | SER | B:1 | B:153 | 160.0 | 1.0 | 360.0 | -110.0 | 138.0 | 1.0 | 0.0 |
C:None:0.191 |
HOH |
2.810 |
O |
O |
||
| 6xib | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | SER | B:1 | B:153 | 185.0 | 1.0 | 360.0 | 162.9 | 151.0 | 1.0 | 0.0 |
C:None:0.296 |
HOH |
2.910 |
N |
O |
||
| 6xic | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | SER | B:1 | B:153 | 159.0 | 1.0 | 360.0 | -22.2 | 156.0 | 1.0 | 0.0 |
C:None:0.026 |
HOH |
5.161 |
N |
O |
||
| 6xid | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | SER | B:1 | B:153 | 181.0 | 1.0 | 360.0 | 10.9 | 150.0 | 1.0 | 0.0 |
C:None:0.27 |
HOH |
3.879 |
O |
O |
||
| 6xie | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | SER | B:1 | B:153 | 185.0 | 1.0 | 360.0 | 161.2 | 174.0 | 1.0 | 0.0 |
C:None:0.096 |
HOH |
3.543 |
CB |
O |
||
| 6xif | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | SER | B:1 | B:153 | 179.0 | 1.0 | 360.0 | 126.0 | 164.0 | 1.0 | 0.0 |
C:None:0.13 |
HOH |
7.598 |
O |
O |
||
| 7s5g | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2021-11-03 | SER | B:1 | B:153 | 167.0 | 1.0 | 360.0 | 162.9 | 163.0 | 1.0 | 0.0 |
C:None:0.035 |
HOH |
3.787 |
OG |
O |
||
| 7s5h | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2021-11-03 | SER | B:1 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 2w2m | 1 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2008-11-18 | SER | A:1 | A:153 | 172.0 | 1.0 | 360.0 | -160.5 | 113.0 | 0.983 | 0.017 |
B:P01130:0.513 |
HOH |
3.815 |
O |
O |
||
| 2w2n | 1 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2008-11-18 | SER | A:1 | A:153 | 177.0 | 1.0 | 360.0 | 177.2 | 112.0 | 0.974 | 0.026 |
B:P01130:0.565 |
HOH |
3.906 |
O |
O |
||
| 2w2p | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2008-11-18 | SER | A:1 | A:153 | 176.0 | 1.0 | 360.0 | 164.8 | 122.0 | 1.0 | 0.0 |
B:P01130:0.47 |
HOH |
8.804 |
OG |
O |
||
| 2w2q | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2008-11-18 | SER | A:1 | A:153 | 170.0 | 1.0 | 360.0 | -164.8 | 100.0 | 0.87 | 0.13 |
B:P01130:0.609 |
HOH |
2.922 |
N |
O |
||
| 2w2o | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2008-11-18 | SER | A:1 | A:153 | 174.0 | 1.0 | 360.0 | -147.4 | 123.0 | 1.0 | 0.0 |
B:P01130:0.443 |
||||||
| 2xtj | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2010-11-03 | SER | A:1 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 4ov6 | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2014-07-02 | SER | B:1 | B:153 | 173.0 | 1.0 | 360.0 | 132.5 | 173.0 | 1.0 | 0.0 |
EDO HOH |
5.993 7.722 |
O O |
O1 O |
|||
| SER | D:1 | E:153 | 173.0 | 1.0 | 360.0 | 136.2 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | SER | A:153 | A:153 | 35.0 | 0.304 | -140.7 | 157.4 | ||