Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr1 | 55518053 | . | C | A | CCDS603.1:NM_174936.3:c.626cCc>cAc_NP_777596.2:p.209P>H | Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 2p4e | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2007-04-10 | PRO | A:209 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| PRO | B:209 | A:209 | 35.0 | 0.241 | -76.9 | 159.9 | NA | NA | NA | ||||||||||||||
| 6u2f | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | PRO | A:209 | A:209 | 35.0 | 0.241 | -76.4 | 157.4 | 35.0 | 0.241 | 0.0 | |||||||
| 5vlp | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2017-08-16 | PRO | A:209 | A:209 | 33.0 | 0.228 | -71.8 | 155.2 | 33.0 | 0.228 | 0.0 | |||||||
| 6u3i | 1 | Q8NBP7 | 99.71 | 0.0 |
X-RAY |
2020-02-05 | PRO | A:209 | A:209 | 36.0 | 0.248 | -71.9 | 159.9 | 36.0 | 0.248 | 0.0 | |||||||
| 6u26 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | PRO | A:179 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| PRO | B:179 | B:209 | 28.0 | 0.193 | -78.5 | 159.6 | NA | NA | NA | ||||||||||||||
| 6u2n | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | PRO | A:179 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| PRO | B:179 | B:209 | 38.0 | 0.262 | -74.5 | 159.3 | 38.0 | 0.262 | 0.0 |
HOH |
3.835 |
CG |
O |
||||||||||
| 6u2p | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | PRO | A:179 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| PRO | B:179 | B:209 | 33.0 | 0.228 | -76.8 | 155.7 | 33.0 | 0.228 | 0.0 |
HOH |
3.628 |
CG |
O |
||||||||||
| 6u36 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | PRO | A:179 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| PRO | B:179 | B:209 | 28.0 | 0.193 | S | -89.6 | 169.9 | 28.0 | 0.193 | 0.0 | |||||||||||||
| 6u38 | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | PRO | A:179 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| PRO | B:179 | B:209 | 39.0 | 0.269 | -85.9 | 118.3 | 39.0 | 0.269 | 0.0 |
HOH |
3.974 |
CB |
O |
||||||||||
| 6u3x | 1 | Q8NBP7 | 99.7 | 0.0 |
X-RAY |
2019-11-06 | PRO | A:179 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| PRO | B:179 | B:209 | 32.0 | 0.221 | -77.0 | 157.7 | 32.0 | 0.221 | 0.0 |
HOH |
6.079 |
N |
O |
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| 2pmw | 2 | Q5SZQ2 | 100.0 | 0.0 |
X-RAY |
2007-05-08 | PRO | B:57 | B:209 | 33.0 | 0.228 | -71.3 | 161.5 | 32.0 | 0.221 | 0.007 |
A:Q5SZQ2:0.007 |
HOH |
3.439 |
CA |
O |
||
| 3p5b | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | PRO | B:57 | A:209 | 21.0 | 0.145 | -76.9 | 169.2 | 21.0 | 0.145 | 0.0 | |||||||
| 3p5c | 2 | Q8NBP7 | 99.81 | 0.0 |
X-RAY |
2011-10-26 | PRO | B:57 | A:209 | 22.0 | 0.152 | -77.0 | 169.2 | 22.0 | 0.152 | 0.0 | |||||||
| 3bps | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2008-02-12 | PRO | B:57 | A:209 | 39.0 | 0.269 | S | -50.6 | -173.8 | 39.0 | 0.269 | 0.0 |
HOH |
3.063 |
CD |
O |
||
| 3gcw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | PRO | B:57 | A:209 | 36.0 | 0.248 | -54.2 | 153.4 | 36.0 | 0.248 | 0.0 | |||||||
| 3gcx | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2009-03-03 | PRO | B:57 | A:209 | 33.0 | 0.228 | -36.5 | 160.7 | 33.0 | 0.228 | 0.0 | |||||||
| 3sqo | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2012-05-16 | PRO | A:57 | A:209 | 22.0 | 0.152 | -77.0 | 152.7 | 22.0 | 0.152 | 0.0 |
HOH |
4.047 |
CD |
O |
|||
| 4ne9 | 1 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2014-09-10 | PRO | A:57 | A:209 | 31.0 | 0.214 | -77.7 | 160.7 | 30.0 | 0.207 | 0.007 |
E:Q8NBP7:0.007 |
HOH |
8.825 |
N |
O |
||
| PRO | B:57 | B:209 | 30.0 | 0.207 | -75.8 | 160.0 | NA | NA | NA | ||||||||||||||
| 4k8r | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2013-05-08 | PRO | B:57 | B:209 | 37.0 | 0.255 | -81.3 | 152.0 | 36.0 | 0.248 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
5.942 |
O |
O |
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| 5vl7 | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2017-08-16 | PRO | B:57 | B:209 | 30.0 | 0.207 | -70.6 | 143.0 | 28.0 | 0.193 | 0.014 |
A:Q8NBP7:0.014 |
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| 2qtw | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2007-09-18 | PRO | B:57 | B:209 | 28.0 | 0.193 | -76.6 | 160.3 | 27.0 | 0.186 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
3.345 |
CA |
O |
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| 7kev | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-24 | PRO | B:57 | B:209 | 39.0 | 0.269 | -74.2 | 162.0 | 39.0 | 0.269 | 0.0 |
HOH |
3.793 |
CG |
O |
|||
| 7kfa | 2 | Q8NBP7 | 99.63 | 0.0 |
X-RAY |
2021-11-10 | PRO | B:57 | B:209 | 30.0 | 0.207 | -74.5 | 158.1 | 29.0 | 0.2 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
3.428 |
N |
O |
||
| 3m0c | 2 | Q8NBP7 | 99.44 | 0.0 |
X-RAY |
2011-03-16 | PRO | B:57 | B:209 | 28.0 | 0.193 | -76.7 | 160.4 | 28.0 | 0.193 | 0.0 | |||||||
| 3h42 | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2009-05-05 | PRO | B:57 | B:209 | 34.0 | 0.234 | -69.4 | 153.2 | 34.0 | 0.234 | 0.0 |
HOH |
3.416 |
CB |
O |
|||
| 5oca | 2 | Q8NBP7 | 99.26 | 0.0 |
X-RAY |
2017-09-20 | PRO | B:57 | B:209 | 37.0 | 0.255 | -72.7 | 154.1 | 37.0 | 0.255 | 0.0 |
HOH |
3.448 |
CB |
O |
|||
| 5vla | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | PRO | A:209 | A:209 | 34.0 | 0.234 | -78.0 | 159.0 | 34.0 | 0.234 | 0.0 |
HOH |
3.419 |
N |
O |
|||
| 5vlh | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | PRO | A:209 | A:209 | 32.0 | 0.221 | -75.9 | 155.5 | 32.0 | 0.221 | 0.0 | |||||||
| 5vlk | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | PRO | A:209 | A:209 | 37.0 | 0.255 | -80.0 | 152.8 | 37.0 | 0.255 | 0.0 |
HOH |
3.452 |
N |
O |
|||
| 5vll | 1 | Q8NBP7 | 99.78 | 0.0 |
X-RAY |
2017-08-16 | PRO | A:209 | A:209 | 33.0 | 0.228 | -73.5 | 153.1 | 33.0 | 0.228 | 0.0 |
HOH |
3.598 |
N |
O |
|||
| 4nmx | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2013-12-04 | PRO | B:57 | B:209 | 24.0 | 0.166 | -75.8 | 158.1 | 23.0 | 0.159 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
3.412 |
N |
O |
||
| 6xib | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | PRO | B:57 | B:209 | 36.0 | 0.248 | -77.9 | 160.0 | 35.0 | 0.241 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
3.158 |
O |
O |
||
| 6xic | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | PRO | B:57 | B:209 | 36.0 | 0.248 | -78.3 | 160.7 | 35.0 | 0.241 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
2.966 |
O |
O |
||
| 6xid | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | PRO | B:57 | B:209 | 37.0 | 0.255 | -78.4 | 159.2 | 36.0 | 0.248 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
3.095 |
O |
O |
||
| 6xie | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | PRO | B:57 | B:209 | 36.0 | 0.248 | -79.1 | 159.9 | 35.0 | 0.241 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
3.467 |
CA |
O |
||
| 6xif | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2020-11-18 | PRO | B:57 | B:209 | 39.0 | 0.269 | -77.2 | 160.4 | 38.0 | 0.262 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
2.848 |
O |
O |
||
| 7s5g | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2021-11-03 | PRO | B:57 | B:209 | 37.0 | 0.255 | -74.4 | 163.0 | 36.0 | 0.248 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
3.449 |
CA |
O |
||
| 7s5h | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2021-11-03 | PRO | B:57 | B:209 | 27.0 | 0.186 | -73.4 | 162.1 | 27.0 | 0.186 | 0.0 |
HOH |
3.389 |
CB |
O |
|||
| 2w2m | 1 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2008-11-18 | PRO | A:57 | A:209 | 26.0 | 0.179 | -76.1 | 158.6 | 26.0 | 0.179 | 0.0 |
HOH |
3.029 |
O |
O |
|||
| 2w2n | 1 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2008-11-18 | PRO | A:57 | A:209 | 30.0 | 0.207 | -73.4 | 158.1 | 30.0 | 0.207 | 0.0 |
HOH |
3.434 |
CA |
O |
|||
| 2w2p | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2008-11-18 | PRO | A:57 | A:209 | 28.0 | 0.193 | -74.3 | 157.7 | 28.0 | 0.193 | 0.0 |
HOH |
9.997 |
O |
O |
|||
| 2w2q | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2008-11-18 | PRO | A:57 | A:209 | 30.0 | 0.207 | -73.4 | 161.4 | 30.0 | 0.207 | 0.0 |
HOH |
3.547 |
CD |
O |
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| 2w2o | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2008-11-18 | PRO | A:57 | A:209 | 30.0 | 0.207 | -72.7 | 160.2 | 30.0 | 0.207 | 0.0 |
HOH |
9.555 |
N |
O |
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| 2xtj | 1 | Q8NBP7 | 99.67 | 0.0 |
X-RAY |
2010-11-03 | PRO | A:57 | A:209 | 33.0 | 0.228 | -74.2 | 158.4 | 32.0 | 0.221 | 0.007 |
F:Q8NBP7:0.007 |
HOH |
3.484 |
CA |
O |
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| 4ov6 | 2 | Q8NBP7 | 100.0 | 0.0 |
X-RAY |
2014-07-02 | PRO | B:57 | B:209 | 61.0 | 0.421 | S | -78.8 | 74.7 | 60.0 | 0.414 | 0.007 |
A:Q8NBP7:0.007 |
HOH |
3.553 |
N |
O |
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| PRO | D:57 | E:209 | 37.0 | 0.255 | -77.8 | 158.5 | NA | NA | NA | ||||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
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| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q8nbp7-f1 | 1 | Q8NBP7 | 100.0 | 0.0 | PRO | A:209 | A:209 | 25.0 | 0.172 | -72.4 | 150.1 | ||