Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr1 55518363 . T A CCDS603.1:NM_174936.3:c.698gTg>gAg_NP_777596.2:p.233V>E Homo sapiens proprotein convertase subtilisin/kexin type 9 (PCSK9), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2p4e 1 Q8NBP7 99.71 0.0 X-RAY
 2007-04-10 VAL A:233 NA:NA DO NA DO DO DO NA NA NA
VAL B:233 A:233 1.0 0.006 H -57.1 -46.9 NA NA NA
6u2f 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 VAL A:233 A:233 2.0 0.013 H -61.9 -37.3 1.0 0.006 0.007 B:None:0.006
5vlp 1 Q8NBP7 99.71 0.0 X-RAY
 2017-08-16 VAL A:233 A:233 1.0 0.006 H -66.9 -40.1 0.0 0.0 0.006 D:None:0.006
6u3i 1 Q8NBP7 99.71 0.0 X-RAY
 2020-02-05 VAL A:233 A:233 2.0 0.013 H -65.4 -39.6 1.0 0.006 0.007 B:None:0.006
 HOH
 7.978
 HG21
 O
6u26 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:203 NA:NA DO NA DO DO DO NA NA NA
VAL B:203 B:233 0.0 0.0 H -61.0 -41.9 NA NA NA
6u2n 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:203 NA:NA DO NA DO DO DO NA NA NA
VAL B:203 B:233 1.0 0.006 H -57.6 -48.4 1.0 0.006 0.0 HOH
 4.042
 N
 O
6u2p 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:203 NA:NA DO NA DO DO DO NA NA NA
VAL B:203 B:233 2.0 0.013 H -59.2 -44.1 2.0 0.013 0.0 HOH
 3.344
 CA
 O
6u36 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:203 NA:NA DO NA DO DO DO NA NA NA
VAL B:203 B:233 4.0 0.026 H -68.9 -42.6 4.0 0.026 0.0
6u38 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:203 NA:NA DO NA DO DO DO NA NA NA
VAL B:203 B:233 5.0 0.032 H -71.6 -42.9 5.0 0.032 0.0 HOH
 8.465
 CG2
 O
6u3x 1 Q8NBP7 99.7 0.0 X-RAY
 2019-11-06 VAL A:203 NA:NA DO NA DO DO DO NA NA NA
VAL B:203 B:233 0.0 0.0 H -63.3 -38.5 0.0 0.0 0.0 HOH
 8.559
 CG2
 O
2pmw 2 Q5SZQ2 100.0 0.0 X-RAY
 2007-05-08 VAL B:81 B:233 2.0 0.013 H -61.0 -42.0 2.0 0.013 0.0 HOH
 3.170
 CA
 O
3p5b 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 VAL B:81 A:233 1.0 0.006 H -98.9 -40.2 1.0 0.006 0.0
3p5c 2 Q8NBP7 99.81 0.0 X-RAY
 2011-10-26 VAL B:81 A:233 1.0 0.006 H -98.9 -40.4 1.0 0.006 0.0
3bps 2 Q8NBP7 99.63 0.0 X-RAY
 2008-02-12 VAL B:81 A:233 0.0 0.0 H -64.0 -44.2 0.0 0.0 0.0 HOH
 3.374
 CA
 O
3gcw 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 VAL B:81 A:233 1.0 0.006 H -68.1 -42.1 1.0 0.006 0.0
3gcx 2 Q8NBP7 99.63 0.0 X-RAY
 2009-03-03 VAL B:81 A:233 1.0 0.006 H -70.0 -39.8 1.0 0.006 0.0
3sqo 1 Q8NBP7 99.63 0.0 X-RAY
 2012-05-16 VAL A:81 A:233 1.0 0.006 H -59.6 -44.7 1.0 0.006 0.0 HOH
 8.053
 CG2
 O
4ne9 1 Q8NBP7 99.63 0.0 X-RAY
 2014-09-10 VAL A:81 A:233 0.0 0.0 H -62.1 -42.3 0.0 0.0 0.0 HOH
 9.255
 N
 O
VAL B:81 B:233 1.0 0.006 H -62.9 -42.1 NA NA NA
4k8r 2 Q8NBP7 99.63 0.0 X-RAY
 2013-05-08 VAL B:81 B:233 1.0 0.006 H -70.9 -47.2 1.0 0.006 0.0 HOH
 7.810
 O
 O
5vl7 2 Q8NBP7 99.63 0.0 X-RAY
 2017-08-16 VAL B:81 B:233 6.0 0.039 H -58.5 -42.4 4.0 0.026 0.013 C:None:0.013
2qtw 2 Q8NBP7 99.63 0.0 X-RAY
 2007-09-18 VAL B:81 B:233 0.0 0.0 H -60.0 -41.3 0.0 0.0 0.0 HOH
 3.146
 N
 O
7kev 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-24 VAL B:81 B:233 0.0 0.0 H -64.9 -35.9 0.0 0.0 0.0 HOH
 8.678
 CG2
 O
7kfa 2 Q8NBP7 99.63 0.0 X-RAY
 2021-11-10 VAL B:81 B:233 0.0 0.0 H -62.0 -36.5 0.0 0.0 0.0 HOH
 3.306
 CA
 O
3m0c 2 Q8NBP7 99.44 0.0 X-RAY
 2011-03-16 VAL B:81 B:233 0.0 0.0 H -60.0 -41.3 0.0 0.0 0.0
3h42 2 Q8NBP7 99.26 0.0 X-RAY
 2009-05-05 VAL B:81 B:233 1.0 0.006 H -63.5 -38.2 1.0 0.006 0.0 HOH
 3.818
 N
 O
5oca 2 Q8NBP7 99.26 0.0 X-RAY
 2017-09-20 VAL B:81 B:233 2.0 0.013 H -61.9 -40.1 2.0 0.013 0.0 NA
HOH
 3.326
3.921
 CA
N
 NA
O
5vla 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:233 A:233 1.0 0.006 H -68.1 -36.3 0.0 0.0 0.006 B:None:0.006
 HOH
 3.235
 CA
 O
5vlh 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:233 A:233 1.0 0.006 H -67.4 -43.2 1.0 0.006 0.0
5vlk 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:233 A:233 2.0 0.013 H -64.2 -39.6 2.0 0.013 0.0 HOH
 3.375
 CA
 O
5vll 1 Q8NBP7 99.78 0.0 X-RAY
 2017-08-16 VAL A:233 A:233 1.0 0.006 H -67.8 -45.4 0.0 0.0 0.006 B:None:0.006
 HOH
 3.377
 CA
 O
4nmx 2 Q8NBP7 100.0 0.0 X-RAY
 2013-12-04 VAL B:81 B:233 2.0 0.013 H -64.1 -42.1 2.0 0.013 0.0 HOH
 3.285
 CA
 O
6xib 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:81 B:233 2.0 0.013 H -61.7 -40.4 2.0 0.013 0.0 HOH
 3.327
 CA
 O
6xic 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:81 B:233 1.0 0.006 H -60.2 -41.6 1.0 0.006 0.0 HOH
 3.282
 CA
 O
6xid 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:81 B:233 1.0 0.006 H -59.9 -40.2 1.0 0.006 0.0 HOH
 3.327
 CA
 O
6xie 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:81 B:233 1.0 0.006 H -59.5 -42.7 1.0 0.006 0.0 HOH
 3.359
 CA
 O
6xif 2 Q8NBP7 100.0 0.0 X-RAY
 2020-11-18 VAL B:81 B:233 1.0 0.006 H -61.6 -41.4 1.0 0.006 0.0 HOH
 3.248
 CA
 O
7s5g 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 VAL B:81 B:233 1.0 0.006 H -62.3 -39.8 1.0 0.006 0.0 HOH
 3.294
 CA
 O
7s5h 2 Q8NBP7 100.0 0.0 X-RAY
 2021-11-03 VAL B:81 B:233 5.0 0.032 H -58.8 -39.4 5.0 0.032 0.0 HOH
 3.304
 CA
 O
2w2m 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 VAL A:81 A:233 1.0 0.006 H -62.5 -41.6 1.0 0.006 0.0 HOH
 3.357
 CA
 O
2w2n 1 Q8NBP7 100.0 0.0 X-RAY
 2008-11-18 VAL A:81 A:233 2.0 0.013 H -63.6 -42.3 2.0 0.013 0.0 HOH
 3.267
 CA
 O
2w2p 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:81 A:233 1.0 0.006 H -61.3 -48.5 1.0 0.006 0.0 HOH
 9.453
 CG2
 O
2w2q 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:81 A:233 2.0 0.013 H -58.7 -43.6 2.0 0.013 0.0 HOH
 3.367
 CA
 O
2w2o 1 Q8NBP7 99.67 0.0 X-RAY
 2008-11-18 VAL A:81 A:233 0.0 0.0 H -59.1 -39.8 0.0 0.0 0.0
2xtj 1 Q8NBP7 99.67 0.0 X-RAY
 2010-11-03 VAL A:81 A:233 1.0 0.006 H -50.7 154.3 1.0 0.006 0.0 HOH
 3.984
 N
 O
4ov6 2 Q8NBP7 100.0 0.0 X-RAY
 2014-07-02 VAL B:81 B:233 2.0 0.013 H -64.1 -39.3 2.0 0.013 0.0 HOH
 7.967
 CG2
 O
VAL D:81 E:233 2.0 0.013 H -64.1 -39.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q8nbp7-f1 1 Q8NBP7 100.0 0.0 VAL A:233 A:233 2.0 0.013 H -68.1 -44.0